KEGG ORTHOLOGY: K10737

ORTHOLOGY: K10737

Entry

K10737                      KO

Symbol

MCM8

Name

DNA helicase MCM8 [EC:5.6.2.4]

Disease

H00627

Premature ovarian failure

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins
    K10737  MCM8; DNA helicase MCM8
Enzymes [BR:ko01000]
5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.4  DNA 3'-5' helicase
     K10737  MCM8; DNA helicase MCM8
DNA replication proteins [BR:ko03032]
Eukaryotic type
  DNA Replication Initiation Factors
   Other initiation factors
    K10737  MCM8; DNA helicase MCM8

Other DBs

GO:

0097362

Genes

HSA:	84515(MCM8)

PTR:	747729(MCM8)

PPS:	100993730(MCM8)

GGO:	101146065(MCM8)

PON:	100459002(MCM8)

NLE:	100592004(MCM8)

HMH:	116460843(MCM8)

MCC:	718247(MCM8)

MCF:	102115584(MCM8)

MTHB:

126929144

MNI:	105481546(MCM8)

CSAB:

103246811(MCM8)

CATY:

105582100(MCM8)

PANU:

101021776(MCM8)

TGE:	112633049(MCM8)

MLEU:

105530500(MCM8)

RRO:	104674568(MCM8)

RBB:	108533238(MCM8)

TFN:	117068482(MCM8)

PTEH:

111546456(MCM8)

CANG:

105511034(MCM8)

CJC:	100405587(MCM8)

SBQ:	101037827(MCM8)

CIMI:

108300977(MCM8)

CSYR:

103266672(MCM8)

MMUR:

105865987(MCM8)

LCAT:

123622691(MCM8)

PCOQ:

105806185(MCM8)

OGA:	100953757(MCM8)

MMU:	66634(Mcm8)

MCAL:

110284767(Mcm8)

MPAH:

110318325(Mcm8)

RNO:	296178(Mcm8)

MCOC:

116090987(Mcm8)

ANU:	117703381(Mcm8)

MUN:	110557091(Mcm8)

CGE:	100772692(Mcm8)

MAUA:

101832264(Mcm8)

PROB:

127221401(Mcm8)

PLEU:

114699535(Mcm8)

MORG:

121460235(Mcm8)

MFOT:

126495341

AAMP:

119815763(Mcm8)

NGI:	103725546(Mcm8)

HGL:	101719798(Mcm8)

CPOC:

100734936(Mcm8)

CCAN:

109688465(Mcm8)

DORD:

105981446(Mcm8)

DSP:	122120247(Mcm8)

PLOP:

125353275(Mcm8)

NCAR:

124975954

MMMA:

107139874(Mcm8)

OCU:

100337967

OPI:	101522980(MCM8)

TUP:	102474920(MCM8)

GVR:	103590567(MCM8)

CFA:	477163(MCM8)

CLUD:

112673624(MCM8)

VVP:	112930059(MCM8)

VLG:	121477669(MCM8)

NPO:	129497240(MCM8)

AML:	100466603(MCM8)

UMR:	103674418(MCM8)

UAH:	113258355(MCM8)

UAR:	123799626(MCM8)

ELK:

111141454

LLV:

125108229

MPUF:

101675080(MCM8)

MNP:	132008161 132022674(MCM8)

MLK:	131808030(MCM8)

NVS:	122916249(MCM8)

ORO:	101375262(MCM8)

EJU:	114216420(MCM8)

ZCA:	113937279(MCM8)

MLX:	118011255(MCM8)

NSU:	110579329(MCM8)

LWW:	102732988(MCM8)

FCA:	101088566(MCM8)

PYU:	121012465(MCM8)

PCOO:

112868872(MCM8)

PBG:	122496547(MCM8)

PVIV:

125161789(MCM8)

LRUF:

124504237

PTG:	102969507(MCM8)

PPAD:

109274727(MCM8)

PUC:

125936799

AJU:

106976437

HHV:	120226071(MCM8)

BTA:	507507(MCM8)

BOM:	102269708(MCM8)

BIU:	109568129(MCM8)

BBUB:

102406859(MCM8)

BBIS:

104986038(MCM8)

CHX:	102174757(MCM8)

OAS:	101116498(MCM8)

BTAX:

128058576(MCM8)

ODA:	120868922(MCM8)

CCAD:

122448736(MCM8)

MBEZ:

129560095(MCM8)

SSC:	100154307(MCM8)

CFR:	102515442(MCM8)

CBAI:

105083004(MCM8)

CDK:	105101348(MCM8)

VPC:	102527484(MCM8)

BACU:

103002704(MCM8)

BMUS:

118881910(MCM8)

LVE:	103071713(MCM8)

OOR:	101290221(MCM8)

DLE:	111165632(MCM8)

PCAD:

102976097(MCM8)

PSIU:

116740823(MCM8)

NASI:

112412535(MCM8)

ECB:	100065561(MCM8)

EPZ:	103563372(MCM8)

EAI:	106823205(MCM8)

MYB:	102242674(MCM8)

MYD:	102773415(MCM8)

MMYO:

118663318(MCM8)

MLF:	102421294(MCM8)

PKL:	118708288(MCM8)

EFUS:

103285853(MCM8)

MNA:	107536376(MCM8)

DRO:	112304249(MCM8)

SHON:

118990877(MCM8)

AJM:	119051143(MCM8)

PDIC:

114506239(MCM8)

PHAS:

123814652(MCM8)

MMF:	118618943(MCM8)

PPAM:

129070843(MCM8)

HAI:	109383855(MCM8)

RFQ:	117016223(MCM8)

PALE:

102887952(MCM8)

PGIG:

120603414(MCM8)

PVP:	105299421(MCM8)

RAY:	107515560(MCM8)

MJV:	108383787(MCM8)

TOD:	119232730(MCM8)

SARA:

101548673(MCM8)

SETR:

126017289(MCM8)

LAV:	100661153(MCM8)

TMU:

101360082

ETF:	101649551(MCM8)

DNM:	101425447(MCM8)

MDO:	100033291(MCM8)

GAS:	123234743(MCM8)

SHR:	100913909(MCM8)

AFZ:

127548509

PCW:	110207768(MCM8)

OAA:	100083871(MCM8)

GGA:	421314(MCM8)

PCOC:

116231163(MCM8)

MGP:	100543243(MCM8)

CJO:	107310940(MCM8)

TPAI:

128086842(MCM8)

LMUT:

125689846(MCM8)

NMEL:

110395458(MCM8)

APLA:

101794798(MCM8)

ACYG:

106045620(MCM8)

CATA:

118251070(MCM8)

AFUL:

116487724(MCM8)

TGU:	100228136(MCM8)

LSR:	110474863(MCM8)

SCAN:

103821344(MCM8)

PMOA:

120506936(MCM8)

OTC:	121335799(MCM8)

PRUF:

121358705(MCM8)

GFR:	102037747(MCM8)

FAB:	101811512(MCM8)

OMA:	130251854(MCM8)

PHI:	102107117(MCM8)

PMAJ:

107202023(MCM8)

CCAE:

111926550(MCM8)

CCW:	104696621(MCM8)

CBRC:

108444821(MCM8)

ETL:	114067255(MCM8)

ZAB:	102065112(MCM8)

ACHL:

103802642(MCM8)

SVG:	106863247(MCM8)

MMEA:

130584348(MCM8)

HRT:	120750478(MCM8)

FPG:	101910852(MCM8)

FCH:	102047287(MCM8)

CLV:	102086967(MCM8)

EGZ:	104129786(MCM8)

NNI:	104014923(MCM8)

PCRI:

104033156(MCM8)

PLET:

104628338(MCM8)

EHS:	104515657(MCM8)

PCAO:

104052036(MCM8)

ACUN:

113478686(MCM8)

TALA:

116964165 122153758 122154316

PADL:

103919572(MCM8)

AFOR:

103901672(MCM8)

ACHC:

115345218(MCM8)

HALD:

104320743(MCM8)

HLE:	104836256(MCM8)

AGEN:

126038437

GCL:

127014639

CCRI:

104169000(MCM8)

CSTI:

104549902(MCM8)

CMAC:

104475650(MCM8)

MUI:	104533167(MCM8)

BREG:

104640887(MCM8)

FGA:	104082176(MCM8)

GSTE:

104258804(MCM8)

LDI:	104339717(MCM8)

MNB:	103781206(MCM8)

OHA:	104329665(MCM8)

NNT:	104412409(MCM8)

SHAB:

115609943(MCM8)

DPUB:

104301372(MCM8)

PGUU:

104466523(MCM8)

ACAR:

104529456(MCM8)

CPEA:

104385036(MCM8)

AVIT:

104270120(MCM8)

CVF:	104293033(MCM8)

RTD:	128907106(MCM8)

CUCA:

104055461(MCM8)

TEO:	104375954(MCM8)

BRHI:

104497211(MCM8)

AAM:	106499837(MCM8)

AROW:

112973194(MCM8)

NPD:	112942955(MCM8)

TGT:	104564973(MCM8)

DNE:

112989384

SCAM:

104151840(MCM8)

ASN:	102377063(MCM8)

AMJ:	102563019(MCM8)

CPOO:

109319477(MCM8)

GGN:	109296700(MCM8)

PSS:	102453474(MCM8)

CMY:	102939010(MCM8)

CCAY:

125633365(MCM8)

DCC:	119852828(MCM8)

CPIC:

101934478(MCM8)

TST:	117874209(MCM8)

CABI:

116824053(MCM8)

MRV:	120402014(MCM8)

ACS:	100554532(mcm8)

ASAO:

132781691(MCM8)

PVT:	110078966(MCM8)

SUND:

121919713(MCM8)

PBI:	103068233(MCM8)

PMUR:

107297361(MCM8)

CTIG:

120315288(MCM8)

TSR:	106549395(MCM8)

PGUT:

117674346(MCM8)

APRI:

131197262(MCM8)

PTEX:

113442643(MCM8)

NSS:	113412737(MCM8)

VKO:	123030310(MCM8)

PMUA:

114593651(MCM8)

PRAF:

128410039(MCM8)

ZVI:	118082794(MCM8)

HCG:	128340075(MCM8)

GJA:	107115726(MCM8)

STOW:

125434670(MCM8)

EMC:	129329165(MCM8)

XLA:	734487(mcm8.L)

XTR:	779797(mcm8)

NPR:	108795416(MCM8)

RTEM:

120938031(MCM8)

BBUF:

120998893(MCM8)

BGAR:

122935097(MCM8)

MUO:	115465663(MCM8)

GSH:	117357524(MCM8)

DRE:	100333576(mcm8)

SRX:	107737895(mcm8) 107738559

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

122334404(mcm8)

LROH:

127179346(mcm8)

OMC:	131523282(mcm8)

PPRM:

120464100(mcm8)

RKG:	130075787(mcm8)

MAMB:

125269299(mcm8)

CIDE:

127498088

MASI:

127455172

TROS:

130560134(mcm8)

TDW:	130437121(mcm8)

MANU:

129417909(mcm8)

IPU:

108270393

IFU:	128612886(mcm8)

PHYP:

113538879(mcm8)

SMEO:

124390212(mcm8)

TFD:	113659795(mcm8)

TVC:	132852352(mcm8)

AMEX:

103047810(mcm8)

CMAO:

118823811(mcm8)

EEE:	113572701(mcm8)

CHAR:

105909471(mcm8)

TRU:	101070044(mcm8)

TFS:	130534096(mcm8)

TNG:	GSTEN00018739G001

LCO:	104934992(mcm8)

TBEN:

117487225(mcm8)

CGOB:

115020301(mcm8)

PGEO:

117459450(mcm8)

EMAC:

134859193(mcm8)

ELY:	117262685(mcm8)

EFO:	125903832(mcm8)

PLEP:

121940137(mcm8)

SLUC:

116061658(mcm8)

ECRA:

117960526(mcm8)

ESP:	116704997(mcm8)

PFLV:

114571887(mcm8)

GAT:	120820844(mcm8)

PPUG:

119214473(mcm8)

AFB:	129092215(mcm8)

CLUM:

117744033(mcm8)

PSWI:

130207600

MSAM:

119912385(mcm8)

SCHU:

122884786(mcm8)

CUD:	121511099(mcm8)

ALAT:

119033866(mcm8)

MZE:	101478405(mcm8)

ONL:	100712245(mcm8)

OAU:	116323540(mcm8)

OLA:	101154800(mcm8)

OML:	112162203(mcm8)

CSAI:

133463563(mcm8)

XMA:	102227436(mcm8)

XCO:

114138370

XHE:

116712650

PRET:

103476593

PFOR:

103150349(mcm8)

PLAI:

106959959(mcm8)

PMEI:

106907852

GAF:	122842289(mcm8)

PPRL:

129353954(mcm8)

CTUL:

119773955(mcm8)

GMU:	124859225(mcm8)

NFU:	107376105(mcm8)

KMR:	108249747(mcm8)

ALIM:

106529249(mcm8)

NWH:	119420026(mcm8)

AOCE:

111577805(mcm8)

MCEP:

125018432(mcm8)

CSEM:

103387762(mcm8)

POV:	109631136(mcm8)

SSEN:

122782111(mcm8)

HHIP:

117775146(mcm8)

HSP:	118119225(mcm8)

SMAU:

118283478(mcm8)

LCF:

108872942

SDU:	111227414(mcm8)

SLAL:

111644586(mcm8)

XGL:	120796115(mcm8)

HCQ:	109510123(mcm8)

SSCV:

125978098

SBIA:

133509730(mcm8)

PEE:	133409645(mcm8)

PTAO:

133485886(mcm8)

BPEC:

110156951(mcm8)

MALB:

109961211(mcm8)

BSPL:

114842069(mcm8)

SJO:	128373313(mcm8)

SASA:

106599666(mcm8)

STRU:

115172486(mcm8)

OTW:	112261672(mcm8)

OMY:	110497801(mcm8)

OGO:	124001503(mcm8)

ONE:	115146129(mcm8)

OKI:	109894419(mcm8)

OKE:	118362615(mcm8)

SALP:

111968626(mcm8)

SNH:	120060364(mcm8)

CCLU:

121559875 121559876

ELS:	105031662(mcm8)

SFM:	108920671(mcm8)

PKI:	111857953(mcm8)

AANG:

118221809(mcm8)

LOC:	102696235(mcm8)

PSPA:

121315935(mcm8)

ARUT:

117403157(mcm8)

PSEX:

120516756(mcm8)

LCM:	102349534(MCM8)

CMK:	103181648(mcm8)

RTP:	109921831(mcm8)

CPLA:

122553078(mcm8)

HOC:	132819882(mcm8)

LERI:

129699293(mcm8)

PMRN:

116947337(MCM8)

LRJ:	133360996 133361876

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DER:

DSI:	Dsimw501_GD20327(Dsim_GD20327)

DYA:	Dyak_GE26359

DSR:

DPO:

DPE:

DMN:

DWI:

DMO:	Dmoj_GI24096

DAZ:

DNV:

DHE:

MDE:

LCQ:

CLON:

HIS:

AGA:	1273388 3290641

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ005091

CPII:

BCOO:

AME:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:	103568829 103576859

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	662910(MCM8)

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

113365475 113372796 113380865

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM171810

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_62337

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

TUT:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

TSP:

HRO:	HELRODRAFT_111248

LGI:	LOTGIDRAFT_207337

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_181870

OVI:	T265_13135

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_59235

AQU:

100641622

ATH:	AT3G09660(MCM8)

ALY:

9318699

CRB:

17891367

CSAT:

104745138 104754601

EUS:	EUTSA_v10020112mg

BRP:

103870528

BNA:	106452758 111206501

BOE:

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10013573mg

PVY:

MINC:

TCC:

GRA:

GHI:

GAB:

HSYR:

DZI:

EGR:

GMX:

GSJ:

PVU:	PHAVU_001G174700g

VRA:

VAR:

VUN:

VUM:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:	131612588 131640245

LJA:	Lj1g3v4579080.1(Lj1g3v4579080.1) Lj1g3v4579080.2(Lj1g3v4579080.2) Lj1g3v4579080.3(Lj1g3v4579080.3)

ADU:

107493387

AIP:

107648670

AHF:	112696479 112759046

LANG:

109333648

PCIN:

129305901

QSA:	O6P43_010333

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PXB:

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

JRE:

CILL:

CAVE:

QSU:	111999752 112021173 112028399

QLO:

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

CANN:

LBB:

NTA:	107788161 107821960

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

SMIL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:

BVG:

SOE:

CQI:	110697564 110702716

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

Os05t0464100-01(Os05g0464100)

OBR:

OGL:

BDI:

ATS:

TDC:	119282875 119347910

TAES:

123059428 123136317 123182297

TUA:

125521018

LPER:

127320988

LRD:	124648657 124648678

SBI:

ZMA:

SITA:

SVS:

PVIR:

PHAI:

PDA:

EGU:

MUS:

ZOF:	122001556 122005853

DCT:

PEQ:

AOF:

MSIN:

NCOL:

ATR:

SMO:	SELMODRAFT_405992 SELMODRAFT_427437

PPP:

112276777

CRE:	CHLRE_16g665950v5

VCN:	VOLCADRAFT_100419(mcm8)

MNG:

MNEG_1432

CSL:	COCSUDRAFT_56101

OLU:	OSTLU_39165

OTA:	OT_ostta12g01020

BPG:	Bathy07g03790

MIS:	MICPUN_83307

MPP:	MICPUCDRAFT_12229(JGI:MicpuC2_12229)

CME:	CYME_CMT087C

GSL:	Gasu_61190

CCP:	CHC_T00008686001

ECU:	ECU11_0800

EIN:	Eint_110670

EHE:	EHEL_110680

ERO:	EROM_110670

MBR:	MONBRDRAFT_9453

SRE:	PTSG_02565

DDI:	DDB_G0283009(mcm8)

DPP:	DICPUDRAFT_146993

DFA:	DFA_03833(mcm8)

EHI:	EHI_140670(60.t00010)

EDI:	EDI_204350

EIV:	EIN_134980

ACAN:

ACA1_206620

TAN:

TA02880

TPV:

TP01_0666

TOT:	TOT_010000621

BEQ:	BEWA_037400

BMIC:

BMR1_03g01055

BBIG:

BBBOND_0107610

TET:	TTHERM_01031060

PTM:	GSPATT00029613001

SMIN:

v1.2.032332.t1(symbB.v1.2.032332.t1)

PTI:	PHATRDRAFT_52561

FCY:	FRACYDRAFT_189062

PIF:	PITG_06421

PSOJ:

PHYSODRAFT_305241

SPAR:

SPRG_07102

EHX:	EMIHUDRAFT_452085

GTT:	GUITHDRAFT_156809(MCM8)

TBR:	Tb10.406.0500

TBG:	TbgDal_X12700

NGR:	NAEGRDRAFT_60270

TVA:	TVAG_2v0266750

» show all

Reference

PMID:22771115

Authors

Nishimura K, Ishiai M, Horikawa K, Fukagawa T, Takata M, Takisawa H, Kanemaki MT

Title

Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks.

Journal

Mol Cell 47:511-22 (2012)
DOI:10.1016/j.molcel.2012.05.047

Sequence

[hsa:84515] [gga:421314]

Reference

PMID:23401855

Authors

Park J, Long DT, Lee KY, Abbas T, Shibata E, Negishi M, Luo Y, Schimenti JC, Gambus A, Walter JC, Dutta A

Title

The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination.

Journal

Mol Cell Biol 33:1632-44 (2013)
DOI:10.1128/MCB.01503-12

Sequence

[hsa:84515]

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