KEGG   ORTHOLOGY: K11028
Entry
K11028                      KO                                     
Symbol
vacA
Name
vacuolating cytotoxin
Pathway
map03070  Bacterial secretion system
map05120  Epithelial cell signaling in Helicobacter pylori infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09131 Membrane transport
   03070 Bacterial secretion system
    K11028  vacA; vacuolating cytotoxin
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K11028  vacA; vacuolating cytotoxin
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K11028  vacA; vacuolating cytotoxin
   02044 Secretion system
    K11028  vacA; vacuolating cytotoxin
   02042 Bacterial toxins
    K11028  vacA; vacuolating cytotoxin
Transporters [BR:ko02000]
 Other transporters
  Pores ion channels
   K11028  vacA; vacuolating cytotoxin
Secretion system [BR:ko02044]
 Type V secretion system
  Autotransporter-1 (AT-1) family
   K11028  vacA; vacuolating cytotoxin
Bacterial toxins [BR:ko02042]
 Type III toxins: Intracellular toxins
  Others
   Vacuolating cytotoxin
    K11028  vacA; vacuolating cytotoxin
 Type II toxins: Membrane damaging toxins
  Pore-forming toxins, Other
   K11028  vacA; vacuolating cytotoxin
Other DBs
TC: 1.B.12.6.1
Genes
HPY: HP_0887
HPJ: jhp_0819(vacA)
HPA: HPAG1_0867
HPS: HPSH_04675
HHP: HPSH112_04640
HHR: HPSH417_04320
HPG: HPG27_840(vacA)
HPP: HPP12_0884(vacA)
HPB: HELPY_0872(vacA)
HPL: HPB8_666(vacA3)
HPC: HPPC_04470
HCA: HPPC18_04350
HPM: HPSJM_04485
HPE: HPELS_02110
HPO: HMPREF4655_21122
HPI: hp908_0900(vacA2) hp908_0901(vacA3)
HPQ: hp2017_0868(vacA2)
HPW: hp2018_0870
HPU: HPCU_04700
HEF: HPF16_0872(vacA)
HPF: HPF30_0448(vacA)
HEQ: HPF32_0462(vacA)
HEX: HPF57_0902(vacA)
HPT: HPSAT_04355
HPV: HPV225_0908
HPX: HMPREF0462_0936
HEN: HPSNT_04580
HPH: HPLT_04490
HEG: HPGAM_04550
HPN: HPIN_04490
HEP: HPPN120_04380
HEU: HPPN135_04370
HPYS: HPSA20_0934
HCN: HPB14_04310
HPD: KHP_0833(vacA)
HEY: MWE_1043
HPYA: HPAKL117_04255
HPYK: HPAKL86_02525 HPAKL86_05485
HPYO: HPOK113_0895(vacA)
HPYL: HPOK310_0844(vacA)
HPYB: HPOKI102_04615
HPYC: HPOKI112_04660
HPYD: HPOKI128_04245
HPYE: HPOKI154_04515
HPYF: HPOKI422_04630
HPYG: HPOKI673_04505
HPYJ: HPOKI898_04630
HPYR: K747_06470
HPYU: K751_03005
HPYM: K749_01120
HEM: K748_07730
HAC: Hac_1253(vacA_fragment_1) Hac_1254(vacA_fragment_2) Hac_1255(vacA_fragment_3) Hac_1256(vacA_fragment_4) Hac_1257(vacA_fragment_5) Hac_1258(vacA_fragment_6) Hac_1260(vacA_fragment_7) Hac_1261(vacA_fragment_8) Hac_1262(vacA_fragment_9) Hac_1263(vacA_fragment_10) Hac_1264(vacA_fragment_11) Hac_1265(vacA_fragment_12) Hac_1266(vacA_fragment_13)
HCE: HCW_04035
HCM: HCD_01865 HCD_01870 HCD_01875 HCD_01900
 » show all
Reference
PMID:12598897
  Authors
Fujikawa A, Shirasaka D, Yamamoto S, Ota H, Yahiro K, Fukada M, Shintani T, Wada A, Aoyama N, Hirayama T, Fukamachi H, Noda M
  Title
Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori.
  Journal
Nat Genet 33:375-81 (2003)
DOI:10.1038/ng1112
Reference
PMID:19046339
  Authors
Tegtmeyer N, Zabler D, Schmidt D, Hartig R, Brandt S, Backert S
  Title
Importance of EGF receptor, HER2/Neu and Erk1/2 kinase signalling for host cell elongation and scattering induced by the Helicobacter pylori CagA protein: antagonistic effects of the vacuolating cytotoxin VacA.
  Journal
Cell Microbiol 11:488-505 (2009)
DOI:10.1111/j.1462-5822.2008.01269.x
  Sequence
[hpy:HP_0887]
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