KEGG ORTHOLOGY: K11255

ORTHOLOGY: K11255

Entry

K11255                      KO

Symbol

NCOA2, TIF2, KAT13C

Name

nuclear receptor coactivator 2

Pathway

map04915

Estrogen signaling pathway

map04919

Thyroid hormone signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K11255  NCOA2, TIF2, KAT13C; nuclear receptor coactivator 2
   04919 Thyroid hormone signaling pathway
    K11255  NCOA2, TIF2, KAT13C; nuclear receptor coactivator 2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11255  NCOA2, TIF2, KAT13C; nuclear receptor coactivator 2
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HATs (histone acetyltransferases)
    K11255  NCOA2, TIF2, KAT13C; nuclear receptor coactivator 2

Genes

HSA:	10499(NCOA2)

PTR:	464226(NCOA2)

PPS:	100976890(NCOA2)

GGO:	101143868(NCOA2)

PON:	100458310(NCOA2)

NLE:	100594525(NCOA2)

HMH:	116813203(NCOA2)

MCC:	693455(NCOA2)

MCF:	102130545(NCOA2)

MTHB:

126961319

MNI:	105483602(NCOA2)

CSAB:

103236947(NCOA2)

CATY:

105585253(NCOA2)

PANU:

101011914(NCOA2)

TGE:	112629981(NCOA2)

MLEU:

105537013(NCOA2)

RRO:	104678873(NCOA2)

RBB:	108530079(NCOA2)

TFN:	117079273(NCOA2)

PTEH:

111520960(NCOA2)

CANG:

105510930(NCOA2)

CJC:	100409563(NCOA2)

SBQ:	101031553(NCOA2)

CIMI:

108315356(NCOA2)

CSYR:

103272916(NCOA2)

MMUR:

105874694(NCOA2)

LCAT:

123645013(NCOA2)

PCOQ:

105825414(NCOA2)

OGA:	100949489(NCOA2)

MMU:	17978(Ncoa2)

MCAL:

110300251(Ncoa2)

MPAH:

110338922(Ncoa2)

RNO:	83724(Ncoa2)

MCOC:

116088180(Ncoa2)

ANU:	117698573(Ncoa2) 117701476

MUN:	110559511(Ncoa2)

CGE:	100762955(Ncoa2)

MAUA:

101834433(Ncoa2)

PROB:

127231405(Ncoa2)

PLEU:

114690109(Ncoa2)

MORG:

121458254(Ncoa2)

MFOT:

126501413

AAMP:

119826155(Ncoa2)

NGI:	103746603(Ncoa2)

HGL:	101700727(Ncoa2)

CPOC:

100735429(Ncoa2)

CCAN:

109689156 109689158(Ncoa2)

DORD:

105994804(Ncoa2)

DSP:	122095516(Ncoa2)

PLOP:

125344526 125344541 125344899 125360653(Ncoa2)

NCAR:

124982328

MMMA:

107142438(Ncoa2)

OCU:

100348055

OPI:	101533340(NCOA2)

TUP:	102479299(NCOA2)

GVR:	103586039(NCOA2)

CFA:	486989(NCOA2)

CLUD:

112678587(NCOA2)

VVP:	112930085(NCOA2)

VLG:	121498805(NCOA2)

NPO:	129505208(NCOA2)

AML:	100468579(NCOA2)

UMR:	103681277(NCOA2)

UAH:	113253067(NCOA2)

UAR:	123800498(NCOA2)

ELK:

111156771

LLV:

125098982

MPUF:

101678798(NCOA2)

MNP:	132014071(NCOA2)

MLK:	131826726(NCOA2)

NVS:	122904530(NCOA2)

ORO:	101368651(NCOA2)

EJU:	114216428(NCOA2)

ZCA:	113923608(NCOA2)

MLX:	118014907(NCOA2)

NSU:	110579086(NCOA2)

LWW:	102736547(NCOA2)

FCA:	101094648(NCOA2)

PYU:	121038142(NCOA2)

PCOO:

112859515(NCOA2)

PBG:	122495474(NCOA2)

PVIV:

125156152(NCOA2)

LRUF:

124507704

PTG:	102954553(NCOA2)

PPAD:

109269324(NCOA2)

PUC:

125924631

AJU:

113600767

HHV:	120235861(NCOA2)

BTA:	508162(NCOA2)

BOM:	102267236(NCOA2)

BIU:	109568437(NCOA2)

BBUB:

102389410(NCOA2)

BBIS:

104994608

CHX:	102176142(NCOA2)

OAS:	101104249(NCOA2)

BTAX:

128059081(NCOA2)

ODA:	120878656(NCOA2)

CCAD:

122450990(NCOA2)

MBEZ:

129559847(NCOA2)

SSC:	100135658(NCOA2)

CFR:	102514348(NCOA2)

CBAI:

105078564(NCOA2)

CDK:	105103892(NCOA2)

VPC:	102526355(NCOA2)

BACU:

103011177(NCOA2)

BMUS:

118883294(NCOA2)

LVE:	103086311(NCOA2)

OOR:	101273803(NCOA2)

DLE:	111185570(NCOA2)

PCAD:

102976427(NCOA2)

PSIU:

116742161(NCOA2)

NASI:

112395690(NCOA2)

ECB:	100051656(NCOA2)

EPZ:	103547393(NCOA2)

EAI:	106844927(NCOA2)

MYB:	102263306(NCOA2)

MYD:	102770108(NCOA2)

MMYO:

118670925(NCOA2)

MLF:	102440972(NCOA2)

PKL:	118718351(NCOA2)

EFUS:

103293952(NCOA2)

MNA:	107539520(NCOA2)

DRO:	112315347(NCOA2)

SHON:

118995542(NCOA2)

AJM:	119051976(NCOA2)

PDIC:

114514481(NCOA2)

PHAS:

123832898(NCOA2)

MMF:	118631753(NCOA2)

PPAM:

129084194(NCOA2)

HAI:	109372624(NCOA2)

RFQ:	117033603(NCOA2)

PALE:

102892305(NCOA2)

PGIG:

120585473(NCOA2)

PVP:	105295104(NCOA2)

RAY:	107514828(NCOA2)

MJV:	108386902(NCOA2)

TOD:	119240786(NCOA2)

SARA:

101545721(NCOA2)

SETR:

126020349(NCOA2)

LAV:	100677439(NCOA2)

TMU:

101341463

ETF:	101649975(NCOA2)

DNM:	101411961(NCOA2)

MDO:	100028678(NCOA2)

GAS:	123238721(NCOA2)

SHR:	100933368(NCOA2)

AFZ:

127543783

PCW:	110219067(NCOA2)

OAA:	100089041(NCOA2)

GGA:	420176(NCOA2)

PCOC:

116236273(NCOA2)

MGP:	100544860(NCOA2)

CJO:	107310240(NCOA2)

TPAI:

128091582(NCOA2)

LMUT:

125690526(NCOA2)

NMEL:

110393111(NCOA2)

APLA:

101792456(NCOA2)

ACYG:

106030606(NCOA2)

CATA:

118256320(NCOA2)

AFUL:

116486730(NCOA2)

TGU:	100220180(NCOA2)

LSR:	110477537(NCOA2)

SCAN:

103812767(NCOA2)

PMOA:

120499224(NCOA2)

OTC:	121340113(NCOA2)

PRUF:

121351916(NCOA2)

GFR:	102035459(NCOA2)

FAB:	101816739(NCOA2)

OMA:	130249177(NCOA2)

PHI:	102111859(NCOA2)

PMAJ:

107200090(NCOA2)

CCAE:

111924660(NCOA2)

CCW:	104692824(NCOA2)

CBRC:

103613574(NCOA2)

ETL:	114062523(NCOA2)

ZAB:	102065502(NCOA2)

ACHL:

103797043(NCOA2)

SVG:	106857429(NCOA2)

MMEA:

130572310(NCOA2)

HRT:	120757651(NCOA2)

FPG:	101912290(NCOA2)

FCH:	102053022(NCOA2)

CLV:	102090460(NCOA2)

EGZ:	104122387(NCOA2)

NNI:	104009666(NCOA2)

PCRI:

104034616(NCOA2)

PLET:

104620761(NCOA2)

EHS:	104515583(NCOA2)

PCAO:

104051270(NCOA2)

ACUN:

113476238(NCOA2)

TALA:

104364464(NCOA2)

PADL:

103926197(NCOA2)

AFOR:

103898197(NCOA2)

ACHC:

115340124(NCOA2)

HALD:

104320328

HLE:	104837035(NCOA2)

AGEN:

126046180

GCL:

127013527

CSTI:

104559208(NCOA2)

CMAC:

104479423

MUI:	104545977(NCOA2)

BREG:

104634849(NCOA2)

FGA:	104081758(NCOA2)

GSTE:

104255166

LDI:	104353265(NCOA2)

MNB:	103776154(NCOA2)

OHA:	104334836(NCOA2)

NNT:	104408876(NCOA2)

SHAB:

115603199(NCOA2)

DPUB:

104303493(NCOA2)

PGUU:

104461415(NCOA2)

CPEA:

104386917(NCOA2)

AVIT:

104277295(NCOA2)

CVF:	104287502(NCOA2)

RTD:	128906416(NCOA2)

CUCA:

104068065(NCOA2)

TEO:	104384687(NCOA2)

BRHI:

104496661(NCOA2)

AAM:	106484633(NCOA2)

AROW:

112961275(NCOA2)

NPD:	112944208(NCOA2)

TGT:	104568046(NCOA2)

DNE:	112992236(NCOA2)

SCAM:

104139963(NCOA2)

ASN:	102387638(NCOA2)

AMJ:	106737113(NCOA2)

CPOO:

109319439(NCOA2)

GGN:	109304946(NCOA2)

PSS:	102456412(NCOA2)

CMY:	102937245(NCOA2)

CCAY:

125632548(NCOA2)

DCC:	119850574(NCOA2)

CPIC:

101951032(NCOA2)

TST:	117873562(NCOA2)

CABI:

116833147(NCOA2)

MRV:	120397589(NCOA2)

ACS:	100567715(ncoa2)

ASAO:

132774905(NCOA2)

PVT:	110089449(NCOA2)

SUND:

121927526(NCOA2)

PBI:	103059976(NCOA2)

PMUR:

107290247(NCOA2)

CTIG:

120308844(NCOA2)

TSR:	106543691(NCOA2)

PGUT:

117672875(NCOA2)

APRI:

131194332(NCOA2)

PTEX:

113439984(NCOA2)

NSS:	113429264(NCOA2)

VKO:	123020361(NCOA2)

PMUA:

114601316(NCOA2)

PRAF:

128417371(NCOA2)

ZVI:	118090233(NCOA2)

HCG:	128322528(NCOA2)

GJA:	107121057(NCOA2)

STOW:

125438833(NCOA2)

EMC:	129333098(NCOA2)

XLA:	100301960(ncoa2.L) 394405(ncoa2.S)

XTR:	100216190(ncoa2)

NPR:	108796964(NCOA2)

RTEM:

120941114(NCOA2)

BBUF:

121002108(NCOA2)

BGAR:

122938817(NCOA2)

MUO:	115478133(NCOA2)

GSH:	117355180(NCOA2)

DRE:	81884(ncoa2)

SRX:	107740102 107758812

SANH:

107657794 107693803

SGH:	107589963 107596035

CCAR:

109049016 109089227

CAUA:

113042309(ncoa2) 113066077

CGIB:

127945905 128013430

PTET:

122329436(ncoa2)

LROH:

127155510(ncoa2)

OMC:	131532871(ncoa2)

PPRM:

120475900(ncoa2)

RKG:	130087673(ncoa2)

MAMB:

125257639(ncoa2)

CIDE:

127506363

MASI:

127432196 127434293

TROS:

130546838(ncoa2)

TDW:	130413604(ncoa2)

MANU:

129426574(ncoa2)

IPU:

108256456

IFU:	128599501(ncoa2)

PHYP:

113541135(ncoa2)

SMEO:

124403866(ncoa2)

TFD:	113660578(ncoa2)

TVC:	132840534(ncoa2)

AMEX:

103038623(ncoa2)

CMAO:

118798914(ncoa2)

EEE:

113586081

CHAR:

105890228(ncoa2)

TRU:	101064944 101075599(ncoa2)

TFS:	130513691(ncoa2) 130539433

TNG:	GSTEN00015249G001 GSTEN00015588G001

LCO:	104921439(ncoa2) 104932643

NCC:	104959314(ncoa2)

TBEN:

117483750 117484021(ncoa2)

CGOB:

115022222 115025566(ncoa2)

PGEO:

117462640

GACU:

117552810 117563170

EMAC:

134865872 134884128(ncoa2)

ELY:	117264569(ncoa2) 117271821

EFO:	125881850(ncoa2) 125901885

PLEP:

121951104 121960416(ncoa2)

SLUC:

116037850(ncoa2) 116055588

ECRA:

117938218(ncoa2) 117954230

ESP:	116672004(ncoa2) 116699374

PFLV:

114548959(ncoa2) 114565128

GAT:	120811518(ncoa2) 120816345

PPUG:

119198335(ncoa2) 119209677

AFB:	129110473(ncoa2) 129116218

CLUM:

117746101 117749373(ncoa2)

PSWI:

130198657 130206058(ncoa2)

MSAM:

119901702 119909312(ncoa2)

SCHU:

122866229(ncoa2) 122886639

CUD:	121519607 121527141(ncoa2)

ALAT:

119008372(ncoa2) 119011333

MZE:	101464197(ncoa2) 101483328

ONL:	100698057 100706110(ncoa2)

OAU:	116328314(ncoa2) 116331650

OLA:	101169987(ncoa2) 101175434

OML:	112144225 112151212(ncoa2)

CSAI:

133423704(ncoa2) 133452556

XMA:	102226120 102236393(ncoa2)

XCO:	114136787(ncoa2) 114146583

XHE:	116711750(ncoa2) 116721538

PRET:

103456662(ncoa2) 103479938

PFOR:

103137957 103139770

PLAI:

106955901 106956210(ncoa2)

PMEI:

106905193(ncoa2) 106921207

GAF:	122824556(ncoa2) 122841636

PPRL:

129353111 129364557(ncoa2)

CVG:	107093225(ncoa2) 107093636

CTUL:

119785235(ncoa2) 119788869

GMU:	124858458(ncoa2) 124869909

NFU:	107382908(ncoa2) 107383425

KMR:	108230418(ncoa2) 108243856

ALIM:

106530250(ncoa2) 106535094

NWH:	119415256 119426516(ncoa2)

AOCE:

111563871 111587689(ncoa2)

MCEP:

124995538(ncoa2) 125010700

CSEM:

103377091(ncoa2)

POV:	109629712(ncoa2) 109642880 109646331

SSEN:

122770843(ncoa2) 122780275

HHIP:

117753801(ncoa2) 117778520

HSP:	118098297(ncoa2) 118117326

SMAU:

118290927(ncoa2) 118310893

LCF:	108880950 108881805

SDU:	111220956(ncoa2) 111233890

SLAL:

111662894(ncoa2) 111669755

XGL:	120789839(ncoa2) 120798999

HCQ:	109513675(ncoa2) 109518905

SSCV:

125985862

SBIA:

133492650(ncoa2) 133511218

PEE:	133396394(ncoa2) 133411313

PTAO:

133470123(ncoa2) 133488989

BPEC:

110155739 110160934(ncoa2)

MALB:

109960120(ncoa2) 109967098

BSPL:

114844144 114853286(ncoa2)

SJO:	128369732 128382729(ncoa2)

SASA:

106568819 106579720 106590658 106599465

STRU:

115148640 115169808 115195335

OTW:	112226980 112238617 112239876 112259594

OMY:	110489533 110508769 110530268 110536532 118963860

OGO:	123991430 124009903 124039454 124041900

ONE:	115103130 115114835(ncoa2)

OKI:	109871702 109874983(ncoa2) 109885725

OKE:	118382809 118394608 118394781 118402550

SALP:

111956822 111979184 112075389

SNH:	120020383 120050913 120055920

CCLU:

121535180 121549743 121569948 121580886

ELS:	105018361(ncoa2) 105019647

SFM:	108935411(ncoa2)

PKI:	111834873(ncoa2)

AANG:

118225358(ncoa2) 118234116

LOC:	102688862(ncoa2)

PSPA:

121309364(ncoa2) 121314347

ARUT:

117394428 117400234

PSEX:

120530280(ncoa2)

LCM:	102350063 102367030(NCOA2)

CMK:	103174523(ncoa2)

CPLA:

122549410(ncoa2)

HOC:	132810820(ncoa2)

LERI:

129696492(ncoa2)

PMRN:

LRJ:

BFO:

BBEL:

SPU:

APLC:

SKO:

AME:

ACER:

ALAB:

ADR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:	656017(TcSRC)

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

BMOR:

101741527(SRC)

BMAN:

114247799

DPL:	KGM_215831

PMAC:

PPOT:

PXU:

PRAP:

AAGE:

HAW:

TNL:	113504928 113507700

SLIU:

API:

DNX:

AGS:

RMD:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

PHU:	Phum_PHUM466140 Phum_PHUM466150

FOC:

ZNE:

CSEC:

BROR:

DMK:

PVM:	113807510 113808515

PJA:

HAME:

PCLA:

PTRU:

HAZT:

DSV:

RSAN:

RMP:

VDE:

VJA:

CSCU:

PTEP:

TSP:

LGI:	LOTGIDRAFT_235614

PCAN:

BGT:

GAE:

HRF:

HRJ:

MYI:

PMAX:

OBI:

OSN:

LAK:

Reference

PMID:9430642

Authors

Voegel JJ, Heine MJ, Tini M, Vivat V, Chambon P, Gronemeyer H

Title

The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways.

Journal

EMBO J 17:507-19 (1998)
DOI:10.1093/emboj/17.2.507

Sequence

[hsa:10499]

Reference

PMID:18295965

Authors

Zhuravleva J, Solary E, Chluba J, Bastie JN, Delva L

Title

A role for the transcription intermediary factor 2 in zebrafish myelopoiesis.

Journal

Exp Hematol 36:559-67 (2008)
DOI:10.1016/j.exphem.2007.12.014

Sequence

[dre:81884]

LinkDB

DBGET integrated database retrieval system