KEGG ORTHOLOGY: K11825

ORTHOLOGY: K11825

Entry

K11825                      KO

Symbol

AP2B1

Name

AP-2 complex subunit beta-1

Pathway

map04144

Endocytosis

map04721

Synaptic vesicle cycle

map04961

Endocrine and other factor-regulated calcium reabsorption

map05016

Huntington disease

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K11825  AP2B1; AP-2 complex subunit beta-1
09150 Organismal Systems
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    K11825  AP2B1; AP-2 complex subunit beta-1
  09156 Nervous system
   04721 Synaptic vesicle cycle
    K11825  AP2B1; AP-2 complex subunit beta-1
09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    K11825  AP2B1; AP-2 complex subunit beta-1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K11825  AP2B1; AP-2 complex subunit beta-1
Membrane trafficking [BR:ko04131]
Endocytosis
  Clathrin-mediated endocytosis
   AP-2 complex
    K11825  AP2B1; AP-2 complex subunit beta-1

Other DBs

TC:	9.B.278.1.4

Genes

HSA:	163(AP2B1)

PTR:	454587(AP2B1)

PPS:	100970095(AP2B1) 100978544

GGO:	101145548(AP2B1)

PON:	100173315(AP2B1)

NLE:	100594930(AP2B1)

HMH:	116471978 116474498(AP2B1) 116811353

MCC:	100429215(AP2B1)

MCF:	101926562(AP2B1)

MTHB:

126939516

MNI:	105485130(AP2B1)

CSAB:

103242741(AP2B1)

CATY:

105589342(AP2B1)

PANU:

101020304(AP2B1)

TGE:	112609543(AP2B1)

MLEU:

105553363(AP2B1)

RRO:	104679581(AP2B1)

RBB:	108541450(AP2B1)

TFN:	117067492(AP2B1) 117077716

PTEH:

111525420(AP2B1)

CANG:

105518745(AP2B1)

CJC:	100398465(AP2B1) 100400602

SBQ:	101050435(AP2B1)

CIMI:

108308420(AP2B1) 108309251

CSYR:

103276834(AP2B1)

MMUR:

105883206(AP2B1)

LCAT:

123620343(AP2B1)

PCOQ:

105810750 105813828(AP2B1)

OGA:	100944322(AP2B1)

MMU:	71770(Ap2b1)

MCAL:

110305972(Ap2b1)

MPAH:

110331191(Ap2b1)

RNO:	140670(Ap2b1)

MCOC:

116078714(Ap2b1)

ANU:	117694055 117711451(Ap2b1)

MUN:	110555673(Ap2b1)

CGE:	100750609(Ap2b1)

MAUA:

101833520(Ap2b1)

PROB:

127218639(Ap2b1)

PLEU:

114707711(Ap2b1)

MORG:

121456888(Ap2b1) 121466494

MFOT:

126494811

AAMP:

119811183(Ap2b1)

NGI:	103746052(Ap2b1)

HGL:	101709272(Ap2b1)

CPOC:

100713559(Ap2b1)

CCAN:

109693485(Ap2b1)

DORD:

105983457(Ap2b1)

DSP:	122119749(Ap2b1)

PLOP:

125366451(Ap2b1)

NCAR:

124964474 124978862

MMMA:

107150332(Ap2b1)

OCU:

100347007

OPI:	101536700(AP2B1)

TUP:	102484774(AP2B1)

CFA:	480605(AP2B1)

CLUD:

112655334(AP2B1)

VVP:	112917984(AP2B1)

VLG:	121472909(AP2B1)

NPO:	129506823(AP2B1)

AML:	100484452(AP2B1)

UMR:	103667291(AP2B1)

UAH:	113268957(AP2B1)

UAR:	123777178(AP2B1)

ELK:

111151383

LLV:

125086635

MPUF:

101670408(AP2B1)

MNP:	132004283(AP2B1) 132016125

MLK:	131815547(AP2B1)

NVS:	122906465(AP2B1)

ORO:	101378810(AP2B1)

EJU:	114213739(AP2B1)

ZCA:	113939217(AP2B1)

MLX:	118024628(AP2B1)

NSU:	110593269(AP2B1)

LWW:	102726492 102743007(AP2B1)

FCA:	101084752(AP2B1)

PYU:	121017109(AP2B1)

PCOO:

112854727(AP2B1)

PBG:	122485237(AP2B1)

PVIV:

125151370(AP2B1)

LRUF:

124513093

PTG:	102961642(AP2B1)

PPAD:

109251948(AP2B1)

PUC:

125926788

AJU:

106980428

HHV:	120219720 120224387(AP2B1)

BTA:	282183(AP2B1)

BOM:	102266291(AP2B1)

BIU:	109573850(AP2B1)

BBUB:

102395101(AP2B1)

BBIS:

105004013(AP2B1)

CHX:	102172093(AP2B1)

OAS:	101115974(AP2B1)

BTAX:

128064373(AP2B1)

ODA:	120866371(AP2B1)

CCAD:

122449473(AP2B1)

MBEZ:

129539881(AP2B1)

SSC:	100620457(AP2B1)

CFR:	102521438(AP2B1)

CBAI:

105064283(AP2B1)

CDK:	105097873(AP2B1)

VPC:	102530436(AP2B1)

BACU:

102998474(AP2B1)

BMUS:

118886305(AP2B1)

LVE:

103070590

OOR:	101281493 101287369(AP2B1)

DLE:	111171050(AP2B1)

PCAD:

102978548(AP2B1)

PSIU:

116745244 116745671(AP2B1)

NASI:

112408044(AP2B1)

ECB:	100058050(AP2B1)

EPZ:	103554501(AP2B1)

EAI:	106844649(AP2B1)

MYB:	102248889(AP2B1)

MYD:	102767830(AP2B1)

MMYO:

118671325(AP2B1) 118675589

MLF:	102441155(AP2B1)

PKL:	118726238(AP2B1)

EFUS:

103289707 103297155(AP2B1)

MNA:	107530830 107532602(AP2B1)

DRO:	112298620(AP2B1)

SHON:

119001391(AP2B1)

AJM:	119065271(AP2B1)

PDIC:

114502875(AP2B1)

PHAS:

123817000(AP2B1)

MMF:	118635047(AP2B1)

PPAM:

129065184 129066957 129070826 129086551(AP2B1)

HAI:	109373170(AP2B1)

RFQ:	117012896(AP2B1)

PALE:

102879381(AP2B1)

PGIG:

120620891(AP2B1)

PVP:	105304972(AP2B1)

RAY:	107499680(AP2B1)

TOD:	119232184(AP2B1)

SARA:

101545746(AP2B1)

SETR:

126006112(AP2B1)

LAV:	100671481(AP2B1)

TMU:

101351101

ETF:	101643724(AP2B1)

DNM:	101434362(AP2B1)

MDO:	100017800(AP2B1)

GAS:	123244331(AP2B1)

SHR:	100913959(AP2B1)

AFZ:

127559002

PCW:	110221387(AP2B1)

OAA:	100092691(AP2B1)

GGA:	417525(AP2B1)

PCOC:

116228138(AP2B1)

MGP:	100544831(AP2B1)

CJO:	107322521(AP2B1)

TPAI:

128083381(AP2B1)

LMUT:

125702808(AP2B1)

NMEL:

110407560(AP2B1)

APLA:

101805247(AP2B1)

ACYG:

106041400(AP2B1)

CATA:

118254090(AP2B1)

AFUL:

116497150(AP2B1)

TGU:	100229073(AP2B1)

LSR:	110482057(AP2B1)

SCAN:

103820082(AP2B1)

PMOA:

120507874(AP2B1)

OTC:	121345759(AP2B1)

PRUF:

121361611(AP2B1)

GFR:	102036430(AP2B1)

FAB:	101806840(AP2B1)

OMA:	130260745(AP2B1)

PHI:	102107304(AP2B1)

PMAJ:

107212857(AP2B1)

CCAE:

111937712(AP2B1)

CCW:	104691099(AP2B1)

CBRC:

103621535(AP2B1)

ETL:	114065017(AP2B1)

ZAB:	102060589(AP2B1)

ACHL:

103801083(AP2B1)

SVG:	106853343(AP2B1)

MMEA:

130577756(AP2B1)

HRT:	120761197(AP2B1)

FPG:	101921864(AP2B1)

FCH:	102056609(AP2B1)

CLV:	102097636(AP2B1)

EGZ:	104131809(AP2B1)

NNI:	104016096(AP2B1)

PCRI:

104035929(AP2B1)

PLET:

104623291

EHS:

104512815

PCAO:

104046598

ACUN:

113487237(AP2B1)

TALA:

104357829(AP2B1)

PADL:

103918689(AP2B1)

AFOR:

103905307(AP2B1)

ACHC:

115346898(AP2B1)

HALD:

104314437(AP2B1)

HLE:	104835528(AP2B1)

AGEN:

GCL:

CSTI:

CMAC:

MUI:

BREG:

104643300(AP2B1)

FGA:	104080876(AP2B1)

GSTE:

104264382

LDI:

104353710

MNB:

103780909

OHA:	104329391(AP2B1)

NNT:	104400040(AP2B1)

SHAB:

115601807(AP2B1)

DPUB:

104301886

PGUU:

104463549

ACAR:

104527938

CPEA:

104394261(AP2B1)

AVIT:

104278280

CVF:	104286528(AP2B1)

RTD:	128912433(AP2B1)

CUCA:

104058665(AP2B1)

BRHI:

104499680

AAM:	106497342(AP2B1)

AROW:

112964973(AP2B1)

NPD:	112945414(AP2B1)

TGT:	104576592(AP2B1)

DNE:	112987360(AP2B1)

SCAM:

104151214(AP2B1)

CPOO:

109316989(AP2B1)

GGN:	109293517(AP2B1)

PSS:	102450399(AP2B1)

CMY:	102946352(AP2B1)

CCAY:

125623747(AP2B1)

DCC:	119844722(AP2B1)

CPIC:

101937682(AP2B1)

TST:	117867652(AP2B1)

CABI:

116830255(AP2B1)

MRV:	120387139(AP2B1)

ASAO:

132770935

PVT:	110084545(AP2B1)

SUND:

121917030(AP2B1)

PBI:

103054037

PMUR:

107288934(AP2B1)

CTIG:

120304247(AP2B1)

TSR:	106544130(AP2B1)

PGUT:

117667518(AP2B1)

APRI:

131188849(AP2B1)

PTEX:

113441597(AP2B1)

NSS:	113415166(AP2B1)

VKO:	123036678(AP2B1)

PMUA:

114585072(AP2B1)

PRAF:

128402650(AP2B1)

ZVI:	118096866(AP2B1)

HCG:	128335922 128336024

GJA:	107107726(AP2B1)

STOW:

125445597

EMC:	129344542(AP2B1)

XLA:	108709616(ap2b1.S) 380165(ap2b1.L)

XTR:	394814(ap2b1)

NPR:	108791086(AP2B1)

RTEM:

120926690

BBUF:

120995471(AP2B1)

BGAR:

122932006 122932012

MUO:	115482529(AP2B1)

GSH:

117349121

DRE:	334632(ap2b1)

SRX:	107710711 107712150(ap2b1)

SANH:

107681897 107685655

SGH:	107587683(ap2b1) 107595508

CCAR:

109060218

CAUA:

113049745

CGIB:

127957774

PTET:

122345269(ap2b1)

LROH:

127165152(ap2b1)

OMC:	131540669(ap2b1)

PPRM:

120471826(ap2b1)

RKG:	130082460(ap2b1)

MAMB:

125267717(ap2b1)

CIDE:

127512787

MASI:

127421317 127434931

TROS:

130567698(ap2b1)

TDW:	130419145(ap2b1)

MANU:

129440891(ap2b1)

IPU:

108259891

IFU:	128603394(ap2b1)

PHYP:

113531610(ap2b1)

SMEO:

124378877(ap2b1)

TFD:	113663364(ap2b1)

TVC:	132840625(ap2b1)

AMEX:

103025660(ap2b1)

CMAO:

118814326(ap2b1)

EEE:	113573713(ap2b1)

CHAR:

105895351(ap2b1)

TRU:

101066950

TFS:	130537633(ap2b1)

TNG:	GSTEN00014639G001

LCO:

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:	117267632(ap2b1)

EFO:	125898955(ap2b1)

PLEP:

121952161(ap2b1)

SLUC:

116055933(ap2b1)

ECRA:

117955422(ap2b1)

ESP:

116700222

PFLV:

114566580

GAT:	120821222(ap2b1)

PPUG:

119215468(ap2b1)

AFB:	129113099(ap2b1)

MSAM:

119895332(ap2b1)

SCHU:

122887970(ap2b1)

CUD:	121518480(ap2b1)

ALAT:

119031238(ap2b1)

MZE:

ONL:

OAU:

OLA:

OML:	112142550(ap2b1)

CSAI:

133460068(ap2b1)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122845353(ap2b1)

PPRL:

129354006(ap2b1)

CVG:

107090293

CTUL:

119798132(ap2b1)

GMU:	124876622(ap2b1)

NFU:	107387063(ap2b1)

KMR:	108238077(ap2b1)

ALIM:

106528049

NWH:	119419905(ap2b1)

AOCE:

111586269

MCEP:

125021071(ap2b1)

CSEM:

POV:

SSEN:

HHIP:

HSP:

SMAU:

LCF:	108893602(ap2b1)

SDU:

111234269

SLAL:

111666192

XGL:	120802563(ap2b1)

HCQ:

109517967

SSCV:

125981882

SBIA:

133491475(ap2b1)

PEE:	133415737(ap2b1)

PTAO:

133467116(ap2b1)

BPEC:

110153891

MALB:

109959315

BSPL:

114869082(ap2b1)

SJO:	128370996(ap2b1)

SASA:

100380745(ap2b1) 106603458

STRU:

115148788 115154253

OTW:	112228515(ap2b1) 112257929

OMY:	110533577(ap2b1) 110537549

OGO:	123998901 124011287(ap2b1)

ONE:	115105476 115135969

OKI:	109873239 109892801

OKE:	118390024(ap2b1) 118391100

SALP:

111950989 111980305

SNH:	120030785 120057018(ap2b1)

CCLU:

121551480 121579374(ap2b1)

ELS:	105011096(ap2b1)

SFM:	108928227(ap2b1)

PKI:	111847861(ap2b1)

AANG:

118235709(ap2b1)

LOC:	102688936(ap2b1)

PSPA:

121308468(ap2b1)

ARUT:

117429256(ap2b1)

PSEX:

120531384(ap2b1)

LCM:	102348314(AP2B1)

CMK:

103180611

CPLA:

122564151

HOC:	132830532(ap2b1)

LERI:

129710699(ap2b1)

LPIC:

APLC:

AJC:

BROR:

VDE:

VJA:

TUT:

PMEO:

CEL:	CELE_Y71H2B.10(apb-1)

CBR:	CBG_09822(Cbr-apb-1)

CRQ:	GCK72_009632

LOA:	LOAG_16454

TSP:

Tsp_08913

HRO:	HELRODRAFT_187670

BGT:

EGL:

HMG:

HSY:

CME:	CYME_CMR021C

SCE:	YJR005W(APL1)

SEUB:

DI49_3020

SPAO:

SPAR_J01940

AGO:	AGOS_ADR342C

ERC:

Ecym_5078

KLA:	KLLA0_E09527g

KMX:	KLMA_80077(APL1)

LTH:	KLTH0B02706g

VPO:	Kpol_344p2

ZRO:	ZYRO0A11440g

CGR:	CAGL0G04103g

NCS:	NCAS_0D02830(NCAS0D02830)

NDI:	NDAI_0I02070(NDAI0I02070)

TPF:	TPHA_0E02950(TPHA0E02950)

TBL:	TBLA_0D03160(TBLA0D03160) TBLA_0H00410(TBLA0H00410)

TGB:	HG536_0E04130

TDL:	TDEL_0E04020(TDEL0E04020)

KAF:	KAFR_0C06290(KAFR0C06290)

KNG:	KNAG_0H02390(KNAG0H02390)

ZMK:	HG535_0A05170

PPA:	PAS_chr3_0079

DHA:	DEHA2F24816g

PIC:	PICST_84899

PGU:	PGUG_00489

SPAA:

SPAPADRAFT_139198

LEL:	PVL30_003132

CAL:	CAALFM_C114040WA(CaO19.7212)

CTP:	CTRG_03680

COT:	CORT_0G00440

CDU:	CD36_13020

CTEN:

CANTEDRAFT_111853

YLI:	YALI0E15598g

CLU:	CLUG_04127

CLUS:

A9F13_04g04059

CAUR:

CJI96_0000426

SLB:	AWJ20_3081(APL1)

BNN:	FOA43_002125

BBRX:

BRETT_003879

OPA:	HPODL_04561

NCR:

NCU05232

NTE:	NEUTE1DRAFT129184(NEUTE1DRAFT_129184)

SMP:	SMAC_07169

PAN:	PODANSg3782

PBEL:

PPSD:

PPSP:

PPSA:

TTT:	THITE_2122857

MTM:	MYCTH_2309758

CTHR:

MGR:

PPEI:

PGRI:

TMN:	UCRPA7_619

SSCK:

SPSK_07056

FGR:	FGSG_09735

FPU:	FPSE_01049

FPOA:

FPOAC1_011909

FVN:	FVRRES_12976

FVR:	FVEG_15844

FOX:	FOXG_08330

NHE:	NECHADRAFT_58172

FFC:	NCS54_00257400

FKR:	NCS57_00252900

FMU:	J7337_004445

TRE:	TRIREDRAFT_74731

TRR:	M419DRAFT_127053

MAW:

MAJ:

PCHM:

CMT:

AMUS:

PLJ:	VFPFJ_01024

PTKZ:

JDV02_007637

VDA:	VDAG_10176

CFJ:	CFIO01_08156

CLUP:

CLUP02_15366

CHIG:

CH63R_04921

SAPO:

SAPIO_CDS9765

ELA:	UCREL1_1219

PFY:	PFICI_05218

SSL:	SS1G_08464

BFU:	BCIN_12g02640(Bcapl1)

MBE:

MBM_01978

PSCO:

LY89DRAFT_82815

GLZ:	GLAREA_09512

ANI:	ANIA_05950

AFM:	AFUA_2G10340

ACT:	ACLA_069370

NFI:	NFIA_085740

AOR:	AO090011000604

ANG:	An16g04650

AFV:	AFLA_008005

ALUC:

AKAW2_70395S

ACHE:

ACHE_40127A

APUU:

APUU_10987A

PCS:	N7525_004309

PDP:	PDIP_64230

POU:	POX_f07927

TMF:	EYB26_003484

TRG:	TRUGW13939_07835

CIM:	CIMG_04360

CPW:	CPC735_073720

URE:	UREG_01604

PBL:	PAAG_01418

PBN:	PADG_00350

ABE:

ARB_05793

TVE:

TRV_04555

AJE:	HCAG_08087

BGH:	BDBG_07081

PNO:	SNOG_13536

PTE:

PTT_15407

BZE:	COCCADRAFT_106819

BSC:	COCSADRAFT_25679

BOR:	COCMIDRAFT_107423

AALT:

CC77DRAFT_1017016

ARAB:

EKO05_0010902

ZTR:	MYCGRDRAFT_42849

PFJ:	MYCFIDRAFT_34110

FFU:	CLAFUR5_08550

CBET:

CB0940_04483

BCOM:

BAUCODRAFT_37199

NPA:	UCRNP2_10123

TML:	GSTUM_00009031001

CNE:

CNB04170

CNB:

CNBB1570

CNG:	CNAG_03928

CGI:	CGB_A1820C

CDEU:

CNBG_5539

TMS:	TREMEDRAFT_38658

CCAC:

CcaHIS019_0404760(CcaverHIS019_0404760)

TVS:	TRAVEDRAFT_145845

DSQ:	DICSQDRAFT_97274

PCO:	PHACADRAFT_256011

SHS:	STEHIDRAFT_74255

HIR:	HETIRDRAFT_380250

PSQ:	PUNSTDRAFT_89675

ADL:	AURDEDRAFT_81239

FME:	FOMMEDRAFT_104422

GTR:	GLOTRDRAFT_114642

RSX:	RhiXN_02134

LBC:	LACBIDRAFT_187666

CCI:	CC1G_04284

ABP:	AGABI1DRAFT68597(AGABI1DRAFT_68597)

ABV:	AGABI2DRAFT148659(AGABI2DRAFT_148659)

PCUB:

JR316_0003775

MRR:	Moror_6512

E1B28_008776

SCM:	SCHCO_02683209(SCHCODRAFT_02683209)

CPUT:

CONPUDRAFT_47528

SLA:	SERLADRAFT_418809

WSE:	WALSEDRAFT_40545

UMA:	UMAG_04249

PFP:	PFL1_01378

SGRA:

EX895_001997

PGR:	PGTG_14472

PTRC:

PtA15_8A6

PSTR:

Pst134EA_014929

MLR:	MELLADRAFT_42759

EIV:	EIN_284520

PTM:	GSPATT00012069001 GSPATT00015502001 GSPATT00017058001

» show all

Reference

PMID:1969413

Authors

Ponnambalam S, Robinson MS, Jackson AP, Peiperl L, Parham P

Title

Conservation and diversity in families of coated vesicle adaptins.

Journal

J Biol Chem 265:4814-20 (1990)

Sequence

[hsa:163]

Reference

PMID:19033387

Authors

Lau AW, Chou MM

Title

The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway.

Journal

J Cell Sci 121:4008-17 (2008)
DOI:10.1242/jcs.033522

Sequence

[hsa:163]

LinkDB

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