KEGG ORTHOLOGY: K12657

ORTHOLOGY: K12657

Entry

K12657                      KO

Symbol

ALDH18A1, P5CS

Name

delta-1-pyrroline-5-carboxylate synthetase [EC:2.7.2.11 1.2.1.41]

Pathway

map00330

Arginine and proline metabolism

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01230

Biosynthesis of amino acids

Module

M00015

Proline biosynthesis, glutamate => proline

Reaction

R00239

ATP:L-glutamate 5-phosphotransferase

R03313

L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)

Disease

H00266

Hereditary spastic paraplegia

H00557

Cutis laxa

H01400

Secondary hyperammonemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K12657  ALDH18A1, P5CS; delta-1-pyrroline-5-carboxylate synthetase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.41  glutamate-5-semialdehyde dehydrogenase
     K12657  ALDH18A1, P5CS; delta-1-pyrroline-5-carboxylate synthetase
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.2  Phosphotransferases with a carboxy group as acceptor
    2.7.2.11  glutamate 5-kinase
     K12657  ALDH18A1, P5CS; delta-1-pyrroline-5-carboxylate synthetase

Other DBs

GO:	0004349 0004350

Genes

HSA:	5832(ALDH18A1)

PTR:	450629(ALDH18A1)

PPS:	100969924(ALDH18A1)

GGO:	101130918(ALDH18A1)

PON:	100173488(ALDH18A1)

NLE:	100592145(ALDH18A1)

HMH:	116456943(ALDH18A1)

MCC:	703357(ALDH18A1)

MCF:	102131075(ALDH18A1)

MTHB:

126962072

MNI:	105478482(ALDH18A1)

CSAB:

103216806(ALDH18A1)

CATY:

105581757(ALDH18A1)

PANU:

101026826(ALDH18A1)

TGE:	112631251(ALDH18A1)

MLEU:

105554322(ALDH18A1)

RRO:	104664679(ALDH18A1)

RBB:	108543813(ALDH18A1)

TFN:	117069484(ALDH18A1)

PTEH:

111538731(ALDH18A1)

CANG:

105527565(ALDH18A1)

CJC:	100394646(ALDH18A1)

SBQ:	101038496(ALDH18A1)

CIMI:

108295729(ALDH18A1)

CSYR:

103262584(ALDH18A1)

MMUR:

105872690(ALDH18A1)

LCAT:

123650255(ALDH18A1)

PCOQ:

105818486(ALDH18A1)

OGA:	100966445(ALDH18A1)

MMU:	56454(Aldh18a1)

MCAL:

110286113(Aldh18a1)

MPAH:

110338028(Aldh18a1)

RNO:	361755(Aldh18a1)

MCOC:

116103815(Aldh18a1)

ANU:	117710562(Aldh18a1)

MUN:	110546305(Aldh18a1)

CGE:	100755485(Aldh18a1)

MAUA:

101828502(Aldh18a1)

PROB:

127233246(Aldh18a1)

PLEU:

114706868(Aldh18a1)

MORG:

121454581(Aldh18a1)

MFOT:

126505474

AAMP:

119813131(Aldh18a1)

NGI:	103733219(Aldh18a1)

HGL:	101713177(Aldh18a1)

CPOC:

100716882(Aldh18a1)

CCAN:

109693653(Aldh18a1)

DORD:

105986573(Aldh18a1)

DSP:	122115938(Aldh18a1)

PLOP:

125346226(Aldh18a1)

NCAR:

124985522

MMMA:

107149748(Aldh18a1)

OCU:

100352530

OPI:	101519178(ALDH18A1)

TUP:	102470903(ALDH18A1)

GVR:	103592492(ALDH18A1)

CFA:	477781(ALDH18A1)

CLUD:

112672106(ALDH18A1)

VVP:	112914101(ALDH18A1)

VLG:	121485400(ALDH18A1)

NPO:	129493928(ALDH18A1)

AML:	100469705(ALDH18A1)

UMR:	103671341(ALDH18A1)

UAH:	113251756(ALDH18A1)

UAR:	123783987(ALDH18A1)

ELK:

111144881

LLV:

125084776

MPUF:

101686538(ALDH18A1)

MNP:	132016647(ALDH18A1)

MLK:	131828615(ALDH18A1)

NVS:	122900957(ALDH18A1)

ORO:	101385981(ALDH18A1)

EJU:	114205387(ALDH18A1)

ZCA:	113923661(ALDH18A1)

MLX:	118024183(ALDH18A1)

NSU:	110589075(ALDH18A1)

LWW:

102748223

FCA:	101090803(ALDH18A1)

PYU:	121037033(ALDH18A1)

PCOO:

112854275(ALDH18A1)

PBG:	122493061(ALDH18A1)

PVIV:

125148035(ALDH18A1)

LRUF:

124507015

PTG:	102958449(ALDH18A1)

PPAD:

109264691(ALDH18A1)

PUC:

125932827

AJU:

106984803

HHV:	120230607(ALDH18A1)

BTA:	514759(ALDH18A1)

BOM:	102269374(ALDH18A1)

BIU:	109553034(ALDH18A1)

BBUB:

102389381(ALDH18A1)

BBIS:

104983536(ALDH18A1)

CHX:	102188107(ALDH18A1)

OAS:	101108974(ALDH18A1)

BTAX:

128067675(ALDH18A1)

ODA:	120873733(ALDH18A1)

CCAD:

122446088(ALDH18A1)

MBEZ:

129555514(ALDH18A1)

SSC:	100151977(ALDH18A1)

CFR:	102523778(ALDH18A1)

CBAI:

105081804(ALDH18A1)

CDK:	105084261(ALDH18A1)

VPC:	102533988(ALDH18A1)

BACU:

103016461(ALDH18A1)

BMUS:

118882847(ALDH18A1)

LVE:	103083754(ALDH18A1)

OOR:	101283575(ALDH18A1)

DLE:	111172464(ALDH18A1)

PCAD:

102987207(ALDH18A1)

PSIU:

116741381(ALDH18A1)

NASI:

112403289(ALDH18A1)

ECB:	100061213(ALDH18A1)

EPZ:	103555433(ALDH18A1)

EAI:	106842110(ALDH18A1)

MYB:	102257395(ALDH18A1)

MYD:	102753368(ALDH18A1)

MMYO:

118669927(ALDH18A1)

MLF:	102437887(ALDH18A1)

PKL:	118719326(ALDH18A1)

EFUS:

103288425(ALDH18A1)

MNA:	107542608(ALDH18A1)

DRO:	112307061(ALDH18A1)

SHON:

118990302(ALDH18A1)

AJM:	119044505(ALDH18A1) 119051362

PDIC:

114496341(ALDH18A1)

PHAS:

123828928(ALDH18A1)

MMF:	118632071(ALDH18A1)

PPAM:

129077065(ALDH18A1)

HAI:	109380966(ALDH18A1)

RFQ:	117035834(ALDH18A1)

PALE:

102891029(ALDH18A1)

PGIG:

120609270(ALDH18A1)

PVP:	105301359(ALDH18A1)

RAY:	107520442(ALDH18A1)

MJV:	108394923(ALDH18A1)

TOD:	119234598(ALDH18A1) 119242612

SARA:

101553191(ALDH18A1)

SETR:

126033815(ALDH18A1)

LAV:	100675091(ALDH18A1)

TMU:

101348140

ETF:	101652374(ALDH18A1)

DNM:	101434850(ALDH18A1)

MDO:	100023017(ALDH18A1)

GAS:	123238239(ALDH18A1)

SHR:	100933253(ALDH18A1)

AFZ:

127551726

PCW:	110215463(ALDH18A1)

OAA:	100077152(ALDH18A1)

GGA:	423976(ALDH18A1)

PCOC:

116231506(ALDH18A1)

MGP:	100547528(ALDH18A1)

CJO:	107316280(ALDH18A1)

TPAI:

128077510(ALDH18A1)

LMUT:

125692868(ALDH18A1)

NMEL:

110399696(ALDH18A1)

APLA:

101804818(ALDH18A1)

ACYG:

106047319

CATA:

118248722(ALDH18A1)

AFUL:

116491371(ALDH18A1)

TGU:	100229739(ALDH18A1)

LSR:	110477045(ALDH18A1)

SCAN:

103813749(ALDH18A1)

PMOA:

120512729(ALDH18A1)

OTC:	121333635(ALDH18A1)

PRUF:

121353472(ALDH18A1)

GFR:	102035419(ALDH18A1)

FAB:	101810669(ALDH18A1)

OMA:	130254587(ALDH18A1)

PHI:	102099899(ALDH18A1)

PMAJ:

107206749(ALDH18A1)

CCAE:

111931670(ALDH18A1)

CCW:	104694923(ALDH18A1)

CBRC:

103615301(ALDH18A1)

ETL:	114067419(ALDH18A1)

ZAB:	102071980(ALDH18A1)

ACHL:

103811419(ALDH18A1)

SVG:	106861937(ALDH18A1)

MMEA:

130584247(ALDH18A1)

HRT:	120755545(ALDH18A1)

FPG:	101922420(ALDH18A1)

FCH:	102053636(ALDH18A1)

CLV:	102091714(ALDH18A1)

EGZ:	104128271(ALDH18A1)

NNI:	104013873(ALDH18A1)

PCRI:

104025074

PLET:

104616688(ALDH18A1)

EHS:	104503432(ALDH18A1)

PCAO:

104040136

ACUN:

113481799(ALDH18A1)

TALA:

104355993(ALDH18A1)

PADL:

103918618(ALDH18A1)

AFOR:

103897800(ALDH18A1)

ACHC:

115348217(ALDH18A1)

HALD:

104322754(ALDH18A1)

HLE:	104840748(ALDH18A1)

AGEN:

126043250

GCL:

127017817

CCRI:

104164425(ALDH18A1)

CSTI:

104554495(ALDH18A1)

CMAC:

104485815(ALDH18A1)

MUI:	104543182(ALDH18A1)

BREG:

104639962(ALDH18A1)

FGA:

104078863

GSTE:

104251383(ALDH18A1)

LDI:	104348427(ALDH18A1)

MNB:	103778291(ALDH18A1)

OHA:	104326828(ALDH18A1)

SHAB:

115608117(ALDH18A1)

DPUB:

104309137(ALDH18A1)

PGUU:

104458377(ALDH18A1)

ACAR:

104518588(ALDH18A1)

CPEA:

104388649(ALDH18A1)

CVF:	104293242(ALDH18A1)

RTD:	128911231(ALDH18A1)

CUCA:

104063114(ALDH18A1)

TEO:	104375512(ALDH18A1)

BRHI:

104498951(ALDH18A1)

AAM:	106485813(ALDH18A1)

AROW:

112966010(ALDH18A1)

NPD:	112944710(ALDH18A1)

TGT:	104580850(ALDH18A1)

DNE:	112992661(ALDH18A1)

SCAM:

104141315(ALDH18A1)

ASN:	102372617(ALDH18A1)

PSS:	102455081(ALDH18A1)

CMY:	102938224(ALDH18A1)

CCAY:

125640268(ALDH18A1)

DCC:	119858693(ALDH18A1)

CPIC:

101948019(ALDH18A1)

TST:	117879910(ALDH18A1)

CABI:

116823132(ALDH18A1)

MRV:	120368670(ALDH18A1)

ACS:	100563206(aldh18a1)

ASAO:

132770829(ALDH18A1)

PVT:	110084044(ALDH18A1)

SUND:

121925301(ALDH18A1)

PBI:	103052669(ALDH18A1)

PMUR:

107287724(ALDH18A1)

CTIG:

120314179(ALDH18A1)

TSR:	106537852(ALDH18A1)

PGUT:

117678565(ALDH18A1)

APRI:

131201029(ALDH18A1)

PTEX:

113436710(ALDH18A1)

NSS:	113419526(ALDH18A1)

VKO:	123026446(ALDH18A1)

PMUA:

114597621(ALDH18A1)

PRAF:

128414379(ALDH18A1)

ZVI:	118079181 118093735(ALDH18A1)

HCG:	128349423(ALDH18A1)

GJA:	107107574(ALDH18A1)

STOW:

125438224(ALDH18A1)

EMC:	129332286(ALDH18A1)

XLA:	444469(aldh18a1.L)

XTR:	550060(aldh18a1)

NPR:	108791339(ALDH18A1)

RTEM:

120946763(ALDH18A1)

BBUF:

121003836(ALDH18A1)

BGAR:

122941248(ALDH18A1)

MUO:	115470050(ALDH18A1)

GSH:	117359526(ALDH18A1)

DRE:	557186(aldh18a1)

SRX:	107707764 107755531

SANH:

107684039 107702454

SGH:	107566204(aldh18a1) 107581629

CCAR:

109056660(aldh18a1) 109056685

CAUA:

113076923 113111588

CGIB:

127969450 128025371

PTET:

122355334(aldh18a1)

LROH:

127174264(aldh18a1)

OMC:	131551369(aldh18a1)

PPRM:

120474608(aldh18a1)

RKG:	130102766(aldh18a1)

MAMB:

125255477(aldh18a1)

CIDE:

127523750

MASI:

127423346 127426880

TROS:

130569561(aldh18a1)

TDW:	130439460(aldh18a1)

MANU:

129421003(aldh18a1)

IPU:

108274232

IFU:	128617121(aldh18a1)

PHYP:

113527399(aldh18a1)

SMEO:

124389301(aldh18a1)

TFD:	113638985(aldh18a1)

TVC:	132837849(aldh18a1)

AMEX:

103029980(aldh18a1)

CMAO:

118809393(aldh18a1)

EEE:	113577671(aldh18a1)

CHAR:

105912596 116224115

TRU:	101062378 101073205

TFS:	130533707(aldh18a1) 130533927

TNG:	GSTEN00006945G001 GSTEN00025100G001

LCO:	104925653 104933327

NCC:	104943465 104948536

TBEN:

117473867(aldh18a1) 117499547

CGOB:

115019754 115025093

PGEO:

117460014 117464940(aldh18a1)

GACU:

117543129(aldh18a1) 117562661

EMAC:

134858789 134870628(aldh18a1)

ELY:	117247027(aldh18a1) 117248823

EFO:	125880556(aldh18a1) 125903725

PLEP:

121942869 121942952 121942953 121958788(aldh18a1)

SLUC:

116039455 116061370(aldh18a1)

ECRA:

117936955(aldh18a1) 117960282

ESP:	116671184 116693915

PFLV:

114548124 114572513

GAT:	120819717(aldh18a1) 120820818

PPUG:

119213008(aldh18a1) 119214436

AFB:	129091488(aldh18a1) 129092216

CLUM:

117744181 117748656(aldh18a1)

PSWI:

130198351 130203467(aldh18a1)

MSAM:

119916248(aldh18a1) 119917720

SCHU:

122867794(aldh18a1) 122884466

CUD:	121511551 121527944(aldh18a1)

ALAT:

119010131(aldh18a1) 119033345

MZE:	101466829 101478244

ONL:	100697766 100705401

OAU:	116318572 116327496(aldh18a1)

OLA:	101169240 101173087

OML:	112153893(aldh18a1) 112162152

CSAI:

133419723(aldh18a1) 133463318

XMA:	102218924 102235369

XCO:	114137644 114151758

XHE:	116713655 116726709

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122823380(aldh18a1) 122842706

PPRL:

129360110 129368107(aldh18a1)

CVG:	107081732 107089987

CTUL:

119774904(aldh18a1) 119789670

GMU:	124858627 124875459(aldh18a1)

NFU:	107375402 107387577

KMR:	108240682 108247683(aldh18a1)

ALIM:

106516993 106526533

NWH:	119411094 119423677(aldh18a1)

AOCE:

111571793 111579056

MCEP:

125018486 125021986(aldh18a1)

CSEM:

103387586(aldh18a1)

POV:	109626590 109636006

SSEN:

122759234(aldh18a1) 122782278

HHIP:

117753433(aldh18a1) 117775526

HSP:	118100869(aldh18a1) 118119332

SMAU:

118284043 118287918(aldh18a1)

LCF:	108885764 108901695(aldh18a1)

SDU:	111220059 111220592

SLAL:

111657077 111659006

XGL:	120794750(aldh18a1) 120796856

HCQ:	109513386 109523114(aldh18a1)

SSCV:

125978710

SBIA:

133495831(aldh18a1) 133509854

PEE:	133409612(aldh18a1)

PTAO:

133485986(aldh18a1)

BPEC:

110154286 110168122

MALB:

109962616(aldh18a1)

BSPL:

114845667(aldh18a1) 114870706

SJO:	128373152 128381355(aldh18a1)

SASA:

100380546(p5cs) 106579029 106589322

STRU:

115158195 115162848 115201079

OTW:	112223534 112223892 112224182

OMY:	110491465 110491809 110499060

OGO:	124039972 124047764 124048230

ONE:	115106436 115106753 115143986

OKI:	109865178 109865908 109869967

OKE:	118357548 118363618 118367313

SALP:

111967694 111978098 111978158

SNH:	120029760 120045780 120046431

CCLU:

121568065 121586398

ELS:	105007677 105010633(aldh18a1)

SFM:	108932698 108940430

PKI:	111860130(aldh18a1)

AANG:

118221265(aldh18a1)

LOC:	102688777(aldh18a1)

PSPA:

121322257 121325708

ARUT:

117416224 117418283(aldh18a1)

PSEX:

120543207(aldh18a1)

LCM:	102361605(ALDH18A1)

CMK:	103189972(aldh18a1)

CPLA:

122561252(aldh18a1)

HOC:	132826320(aldh18a1)

LERI:

129704205(aldh18a1)

PMRN:

116944698(ALDH18A1)

LRJ:	133340234(ALDH18A1)

BFO:

BBEL:

CIN:

SCLV:

SPU:	115924090 576086

LPIC:

129273518

APLC:

110983345

AJC:

117102981

SKO:	100375273(ALDH18A1)

DME:	Dmel_CG7470(P5CS)

DER:

6544029

DSE:

6616530

DSI:	Dsimw501_GD15014(Dsim_GD15014)

DYA:	Dyak_GE22600 Dyak_GE23278

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI13568

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108361789 108371955

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ013217

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:	109543170 109543202

SOY:	115882014 115882037

AGRG:

126741035 126741284

ATD:

109594875

CSET:

123314688

AGB:	108907168 108914096

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_205264

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM237750

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_41805

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

VDE:

VJA:

TUT:	107360722 107370251

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

LPOL:

CEL:	CELE_T22H6.2(alh-13)

CBR:	CBG_00074(Cbr-alh-13)

CRQ:	GCK72_024952

NAI:	NECAME_01073

TSP:

Tsp_08147

LGI:	LOTGIDRAFT_225803

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111132445 111132779 111132780 111136221

CANU:

OED:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:	106168445 106175733

SMM:	Smp_145020

SHX:	MS3_00007390

OVI:	T265_05909

NVE:	116606932 5510521

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:	114525860 114540224

XEN:

HMG:

HSY:

AQU:

ATH:	AT2G39800(P5CS1) AT3G55610(P5CS2)

ALY:	9312384 9315890

CRB:	17887352 17888155

CSAT:

104712202 104781445 104782439 104785446 104791850 104792812

EUS:	EUTSA_v10010150mg EUTSA_v10016322mg

BRP:	103841472 103857883 103863147 103865746 103867010

BNA:	106360784 106391557 106395965 106415918 106420560 106438070 106445364 106450268 106451021 111205300

BOE:	106312526 106328310 106337409 106342005 106342200

RSZ:	108838998 108843963 108849439 108855262 108863281 130510012

THJ:	104810068 104824302

CPAP:

110822736

CIT:	102609124 102619471

CIC:	CICLE_v10011176mg CICLE_v10030839mg

PVY:	116111949 116132462 116132514

MINC:

123201597 123221474 123227551

TCC:	18586020 18597690

GRA:	105761839 105776210 105779419 105786488

GHI:	107898839 107899340 107935332 107940896 107957998 121209556 121222614

GAB:	108460513 108463517 108464374 108472424

HSYR:

120137376 120142428 120151122 120170121 120188149 120208767 120209492 120213324

DZI:	111296119 111310174 111311098

EGR:

104454339

GMX:	100791063 100797414(ALDH18B3) 100798598(ALDH18B1) 100800143 100809989(ALDH18B2) 100816150(ALDH18B4) 548058(P5CS)

GSJ:	114384414 114394645 114395792 114398618 114406181 114414889 114418968

PVU:	PHAVU_001G236900g PHAVU_008G115100g PHAVU_008G230300g PHAVU_010G0154000

VRA:	106757860 106764975 106774140 106778700

VAR:	108327695 108327781 108338195 108347704

VUN:	114165791 114173365 114184094 114194530

VUM:	124825710 124831886 124842585 124848573

CCAJ:

109788034 109793193 109798886 109800085

APRC:

113850349 113851444 113860934

MTR:	11410328 25491556 25498588

TPRA:

123889273 123918204 123919541

CAM:	101490622 101499756 101512568(P5CS)

PSAT:

127083871 127107852 127127575

VVO:	131601404 131605216 131609291 131656108

LJA:	Lj0g3v0092639.1(Lj0g3v0092639.1) Lj0g3v0092639.2(Lj0g3v0092639.2) Lj0g3v0115579.1(Lj0g3v0115579.1) Lj1g3v3443810.1(Lj1g3v3443810.1)

ADU:	107475037 107480874 107484570

AIP:	107625609 107631303 107639408

AHF:	112727811 112733624 112743520 112748454 112791578 112796906

LANG:

109325791 109329791 109351532 109352704 109359479 109363092

PCIN:

129287802 129302913

QSA:	O6P43_014371 O6P43_016724 O6P43_020653 O6P43_026470

FVE:	101303287 101307714 101308126

RCN:	112182840 112193882

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103433459 103435445 103450277 114824457

MSYL:

126594184 126618554 126620637 126629391

PXB:	103935868 103937226 103942882 103949392

ZJU:	107413210 107430799

MNT:	21393693 21399994

CSAV:

115697703 115705168

CSV:	101210588 101222070

CMO:	103485529 103486360

BHJ:	120076770 120091604

MCHA:

111006663 111015124

CMAX:

111481470 111487661 111489663

CMOS:

111442049 111445327 111457038

CPEP:

111791841 111805552 111808864

RCU:

8287478

JCU:

105647140

HBR:	110644032 110645217

MESC:

110619320 110625066

POP:	18101402 7490371

PEU:	105133158 105133674

PALZ:

118052256 118059673

JRE:	108982231 108990701 109004862

CILL:

122275845 122279400 122301437

CAVE:

132186766 132191363

QSU:	112001264 112024108

QLO:	115953117 115957815

TWL:	119981744 119985286 120004194

VVI:	100232881(P5CS) 100266504

VRI:	117919926 117927906

SLY:	101244293 544281(PRO2)

SPEN:

107023644 107028540

SOT:	102582423 102594541

SSTN:

125841314 125872147

SDUL:

129889131 129898721

CANN:

107838979 107873263

LBB:	132606142 132608787

NTA:	107773204 107776743 107797411 107819560(P5CS)

NSY:	104212556 104222627

NTO:	104086409 104108074

NAU:	109212426 109233261

INI:

109186502

ITR:

116013328

SIND:

105160941 105161590 105167125

OEU:	111396861 111405478 111407413

EGT:	105960416 105970178 105977744

SSPL:

121744009 121775080 121777350 121789804 121790879

SMIL:

131019536

SHIS:

125223260 125224115

APAN:

127244915 127245771

HAN:	110865391 110868870 110872627 118486761 118491214

ECAD:

122591091 122601104 122603212

LSV:	111912284 111912426 111917053 111919756

CCAV:

112504383 112521641 112524092

DCR:	108198666 108199525 108214662

CSIN:

114268389 114297402

RVL:	131300117 131323269

AEW:	130793365 130794160

BVG:

104904817

SOE:

110785480

CQI:	110722294 110733340

ATRI:

130802959 130803582

MOF:	131159859 131165824

NNU:

104601951

MING:

122058224 122087312

TSS:	122644140 122652005

PSOM:

113308039 113309744 113310343 113320821 113344699

OSA:	4324853 4338979

DOSA:

Os01t0848200-01(Os01g0848200) Os05t0455500-01(Os05g0455500)

OBR:	102710073 102710124

OGL:	127772899 127775818

BDI:	100822226 100823447

ATS:	109751184 109784000

TDC:	119269583 119277593 119281916 119346982

TAES:

123062592 123071410 123079750 123135734 123182224 606368

TUA:	125520402 125545280

LPER:

127322339 127344457

LRD:	124665207 124665562 124707576 124707585

SBI:	110430201 110433516

ZMA:	100280719 103630430 778431

SITA:

101765114 101775420

SVS:	117848437 117857150

PVIR:

120665284 120673121 120698485 120708657

PHAI:

112884356 112892130

PDA:	103697558 103704121 120112739

EGU:	105046387 105052168

MUS:	103994027 103999638

ZOF:	121971456 121976196 122021784 122025715

DCT:

110102720

PEQ:

110022935

AOF:	109829830 109843699 109847764

MSIN:

131243831 131252776 131252790

NCOL:

116256258

ATR:

18436293

SMO:	SELMODRAFT_410685 SELMODRAFT_444883

PPP:

112279186

CRE:	CHLRE_03g146527v5

MNG:

MNEG_5123

CSL:	COCSUDRAFT_37765

CVR:	CHLNCDRAFT_30278

APRO:

F751_4834 F751_4835

OLU:	OSTLU_1184

OTA:	OT_ostta10g02570

BPG:	Bathy11g02660

MIS:	MICPUN_59938

MPP:	MICPUCDRAFT_30966(JGI:MicpuC2_30966)

MBR:	MONBRDRAFT_19302

SRE:	PTSG_08123

ACAN:

ACA1_109790

PTI:	PHATRDRAFT_18027 PHATRDRAFT_55086(P5CS)

FCY:	FRACYDRAFT_211069

TPS:	THAPSDRAFT_41038(P5CS)

AAF:	AURANDRAFT_54959

PIF:	PITG_12161

PSOJ:

PHYSODRAFT_555969

SPAR:

SPRG_01557

GTT:	GUITHDRAFT_87452

» show all

Reference

PMID:11092761

Authors

Baumgartner MR, Hu CA, Almashanu S, Steel G, Obie C, Aral B, Rabier D, Kamoun P, Saudubray JM, Valle D

Title

Hyperammonemia with reduced ornithine, citrulline, arginine and proline: a new inborn error caused by a mutation in the gene encoding delta(1)-pyrroline-5-carboxylate synthase.

Journal

Hum Mol Genet 9:2853-8 (2000)
DOI:10.1093/hmg/9.19.2853

Sequence

[hsa:5832]

Reference

PMID:10037775

Authors

Hu CA, Lin WW, Obie C, Valle D

Title

Molecular enzymology of mammalian Delta1-pyrroline-5-carboxylate synthase. Alternative splice donor utilization generates isoforms with different sensitivity to ornithine inhibition.

Journal

J Biol Chem 274:6754-62 (1999)
DOI:10.1074/jbc.274.10.6754

Sequence

[hsa:5832]

LinkDB

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