Entry Symbol K12928, ACS
Name aphidicolan-16beta-ol synthase/syn-copalyl-diphosphate synthase [EC:
4.2.3.42 5.5.1.14 ]
Pathway map01110 Biosynthesis of secondary metabolites
Reaction R06312 9alpha-copalyl-diphosphate lyase (decyclizing)
R06313 9alpha-copalyl-diphosphate diphosphate-lyase (aphidicolan-16beta-ol-forming)
Brite KEGG Orthology (KO) [BR:ko00001 ]ko01000 ] BRITE hierarchy Other DBs Genes Taxonomy UniProt Reference Authors Oikawa H, Toyomasu T, Toshima H, Ohashi S, Kawaide H, Kamiya Y, Ohtsuka M, Shinoda S, Mitsuhashi W, Sassa T
Title Cloning and functional expression of cDNA encoding aphidicolan-16 beta-ol synthase: a key enzyme responsible for formation of an unusual diterpene skeleton in biosynthesis of aphidicolin.
Journal Sequence Reference Authors Toyomasu T, Nakaminami K, Toshima H, Mie T, Watanabe K, Ito H, Matsui H, Mitsuhashi W, Sassa T, Oikawa H
Title Cloning of a gene cluster responsible for the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha.
Journal Sequence LinkDB All DBs
