KEGG   ORTHOLOGY: K13085
Entry
K13085                      KO                                     
Symbol
ipgD, sopB
Name
phosphatidylinositol-4,5-bisphosphate 4-phosphatase [EC:3.1.3.78]
Pathway
map05100  Bacterial invasion of epithelial cells
map05131  Shigellosis
map05132  Salmonella infection
Reaction
R08981  1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase
Network
nt06181  Salmonella
nt06182  Shigella
  Element
N01067  Shigella IpgD to ARNO-ARF-ACTB_G signaling pathway
N01129  Salmonella SopB to ARNO-ARF-ACTB/G signaling pathway
N01130  Salmonella SopB to RhoA signaling pathway
N01133  Salmonella SopB to RhoG signaling pathway
N01134  Salmonella SopB to CDC42 signaling pathway
N01303  Salmonella SopB to Early endosomal fusion
N01305  Salmonella SopB to ANXA2-S100A10-regulated actin cytoskeleton
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K13085  ipgD, sopB; phosphatidylinositol-4,5-bisphosphate 4-phosphatase
   05131 Shigellosis
    K13085  ipgD, sopB; phosphatidylinositol-4,5-bisphosphate 4-phosphatase
   05100 Bacterial invasion of epithelial cells
    K13085  ipgD, sopB; phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.78  phosphatidylinositol-4,5-bisphosphate 4-phosphatase
     K13085  ipgD, sopB; phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Genes
EMA: C1192_24285
STY: STY1121(sigD)
STT: t1828(sigD)
SEX: STBHUCCB_19440
SENT: TY21A_09295
STM: STM1091(sopB)
SEO: STM14_1237(sopB)
SEV: STMMW_11031
SEY: SL1344_1030(sopB)
SEM: STMDT12_C11120
SEJ: STMUK_1060(sopB)
SEB: STM474_1083(sopB)
SEF: UMN798_1133(sigD)
SETU: STU288_01790
SETC: CFSAN001921_11720(sopB)
SENR: STMDT2_10271(sigD)
SEND: DT104_10731(sopB)
SENI: CY43_05575(sopB)
SEEN: SE451236_11305(sopB)
SPT: SPA1759(sigD)
SEK: SSPA1634
SPQ: SPAB_02464
SEI: SPC_2659(sigD)
SEC: SCH_1043(sopB)
SEH: SeHA_C1201
SHB: SU5_01724
SENH: CFSAN002069_03565(sopB)
SEEH: SEEH1578_14685
SEE: SNSL254_A1187
SENN: SN31241_21590
SEW: SeSA_A1155
SEA: SeAg_B1050
SENS: Q786_04870(sopB)
SED: SeD_A1167
SEG: SG0980(sopB)
SEL: SPUL_1966(sopB)
SEGA: SPUCDC_1952(sopB)
SET: SEN0955(sopB)
SENA: AU38_04930(sopB)
SENO: AU37_04920(sopB)
SENV: AU39_04920(sopB)
SENQ: AU40_05535(sopB)
SENL: IY59_05020(sopB)
SENJ: CFSAN001992_06185
SEEC: CFSAN002050_11850(sopB)
SEEB: SEEB0189_014115(sopB)
SEEP: I137_08940(sopB)
SENB: BN855_10450
SENE: IA1_05370(sopB)
SENC: SEET0819_12115(sopB)
SES: SARI_01910
SBG: SBG_0939(sopB)
SBZ: A464_1030
SBV: N643_04465(sopB)
SALZ: EOS98_14165
SFL: CP0133(ipgD)
SFE: SFxv_4976(ipgD)
SSN: SSON_P095(ipgD)
SBC: SbBS512_A0166(ipgD)
SDY: SDY_P171(ipgD)
SDZ: Asd1617_06366
SYM: K6K13_10905
YAL: AT01_2850(sopB)
YEG: PL78_07345
FSM: CCS41_07775
RBAD: H2866_19305
SOD: Sant_3206(sigD) Sant_3209(sigD2)
SLIG: GTU79_05195
PAY: PAU_01919
PSI: S70_12925
PSX: DR96_586(sopB)
PSTA: BGK56_15810
PTHA: OI982_10265
PVC: G3341_17095
ANS: ArsFIN_43100(sopB)
VAN: VAA_02157
LAG: N175_09340
VAU: VANGNB10_cI1105
EMP: EZMO1_3388(ipgD)
CRZ: D1345_19490
CHAE: CH06BL_40220(sopB_sigD)
IFL: C1H71_17665(sopB)
PBON: QS306_09370
PPK: U875_18870
PPNO: DA70_11385
PPNM: LV28_19660
LIMN: HKT17_05800
BGM: CAL15_03515
CDN: BN940_04026
PVAC: HC248_01669(ipgD)
COF: FOZ74_09105
STAR: G3545_19400
HMC: HYPMC_3453
PSF: PSE_2750(ipgD)
DPG: DESPIGER_2147
OXY: HCG48_18215
PCU: PC_RS06055
PNL: PNK_0614(ipgD)
 » show all
Reference
PMID:12356723
  Authors
Niebuhr K, Giuriato S, Pedron T, Philpott DJ, Gaits F, Sable J, Sheetz MP, Parsot C, Sansonetti PJ, Payrastre B
  Title
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology.
  Journal
EMBO J 21:5069-78 (2002)
DOI:10.1093/emboj/cdf522
  Sequence
[sfl:CP0133]
LinkDB

KEGG   ORTHOLOGY: K13741
Entry
K13741                      KO                                     
Symbol
sopE
Name
guanine nucleotide exchange factor SopE
Pathway
map05100  Bacterial invasion of epithelial cells
map05132  Salmonella infection
Network
nt06181  Salmonella
nt06521  NLR signaling
  Element
N01112  Salmonella SopE/E2 to NOD-NFKB signaling pathway
N01127  Salmonella SopE to Inflammasome signaling pathway
N01128  Salmonella SopE to RAC signaling pathway
N01131  Salmonella SopE/E2 to RhoA signaling pathway
N01132  Salmonella SopE/E2 to RhoG signaling pathway
N01305  Salmonella SopB to ANXA2-S100A10-regulated actin cytoskeleton
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K13741  sopE; guanine nucleotide exchange factor SopE
   05100 Bacterial invasion of epithelial cells
    K13741  sopE; guanine nucleotide exchange factor SopE
Genes
STY: STY4609(sopE)
STT: t4303(sopE)
SEX: STBHUCCB_10950 STBHUCCB_45570
SENT: TY21A_05210 TY21A_21915
STM: STM1855(sopE2)
SEO: STM14_2244(sopE2)
SEV: STMMW_18441
SEY: SL1344_1784(sopE2) SL1344_2674(sopE)
SEM: STMDT12_C18770(sopE)
SEJ: STMUK_1829(sopE2)
SEB: STM474_1879(sopE2) STM474_2826
SEF: UMN798_1953(sopE2) UMN798_2922(sopE)
SETU: STU288_05645
SETC: CFSAN001921_07810
SENR: STMDT2_17751(sopE2)
SEND: DT104_18201(sopE2)
SENI: CY43_09470
SEEN: SE451236_15215
SPT: SPA1018(sopE2) SPA2564(sopE)
SEK: SSPA0949 SSPA2387
SPQ: SPAB_01351
SEI: SPC_1874
SEC: SCH_1852(sopE2)
SEH: SeHA_C1163 SeHA_C2059
SHB: SU5_01688 SU5_02459
SENH: CFSAN002069_03735 CFSAN002069_22565
SEEH: SEEH1578_06500 SEEH1578_14510 SEEH1578_18540
SEE: SNSL254_A1996
SENN: SN31241_29420
SEW: SeSA_A1999 SeSA_A4485
SEA: SeAg_B1274
SENS: Q786_05915
SED: SeD_A1429 SeD_A1457
SEG: SG1233 SG1261(sopE2)
SEL: SPUL_1675(sopE2) SPUL_1705
SEGA: SPUCDC_1675(sopE2)
SET: SEN1155 SEN1182(sopE2)
SENA: AU38_05950 AU38_06085
SENO: AU37_05940 AU37_06075
SENV: AU39_05940 AU39_06075
SENQ: AU40_06690 AU40_06845
SENL: IY59_06085 IY59_06235
SENJ: CFSAN001992_02195 CFSAN001992_09525
SEEC: CFSAN002050_11645 CFSAN002050_15750
SEEB: SEEB0189_010220
SEEP: I137_07570 I137_07690
SENB: BN855_19150
SENE: IA1_09210
SENC: SEET0819_16020
SES: SARI_01086
SBG: SBG_1707(sopE2)
SBZ: A464_1954
SBV: N643_08310
SALZ: EOS98_09945
HDE: HDEF_2312
SYM: K6K13_18245
YEL: LC20_07430
YHI: D5F51_10705
PSTW: DSJ_23980
PVW: HU752_005450
CVI: CV_0296
CHRO: CXB49_21250
IFL: C1H71_11710
BMA: BMAA1523(bopE)
BML: BMA10229_2078(bopE)
BMN: BMA10247_A0761(bopE)
BMAL: DM55_4856(bopE)
BMAE: DM78_4102(bopE)
BMAQ: DM76_3809(bopE)
BMAI: DM57_08330
BMAF: DM51_3229(bopE)
BMAZ: BM44_4985(bopE)
BMAB: BM45_3886(bopE)
BPS: BPSS1525(bopE)
BPM: BURPS1710b_A0564(bopE)
BPL: BURPS1106A_A2067(sopE)
BPD: BURPS668_A2155(sopE)
BPSE: BDL_4834(bopE)
BPSM: BBQ_4625(bopE)
BPSU: BBN_4968(bopE)
BPSD: BBX_3996(bopE)
BPZ: BP1026B_II1621(bopE)
BPQ: BPC006_II2049
BPK: BBK_4134(bopE)
BPSH: DR55_3751(bopE)
BPSA: BBU_4510(bopE)
BPSO: X996_3537(bopE)
BUT: X994_5592(bopE)
BTE: BTH_II0848
BTQ: BTQ_4135(bopE)
BTJ: BTJ_5167(bopE)
BTZ: BTL_3638(bopE)
BTD: BTI_4004(bopE)
BTV: BTHA_4250(bopE)
BTHE: BTN_5621(bopE)
BTHM: BTRA_3629(bopE)
BTHA: DR62_3387
BTHL: BG87_3591(bopE)
BOK: DM82_5832(bopE)
BOC: BG90_4799(bopE)
BHG: I6G56_20445
BUD: AQ610_23220
BUL: BW21_5998(bopE)
 » show all
Reference
PMID:10449782
  Authors
Mirold S, Rabsch W, Rohde M, Stender S, Tschape H, Russmann H, Igwe E, Hardt WD
  Title
Isolation of a temperate bacteriophage encoding the type III effector protein SopE from an epidemic Salmonella typhimurium strain.
  Journal
Proc Natl Acad Sci U S A 96:9845-50 (1999)
DOI:10.1073/pnas.96.17.9452
  Sequence
[sty:STY4609]
Reference
PMID:10931274
  Authors
Stender S, Friebel A, Linder S, Rohde M, Mirold S, Hardt WD
  Title
Identification of SopE2 from Salmonella typhimurium, a conserved guanine nucleotide exchange factor for Cdc42 of the host cell.
  Journal
Mol Microbiol 36:1206-21 (2000)
DOI:10.1046/j.1365-2958.2000.01933.x
  Sequence
[stm:STM1855]
Reference
PMID:15321998
  Authors
Huang FC, Werne A, Li Q, Galyov EE, Walker WA, Cherayil BJ
  Title
Cooperative interactions between flagellin and SopE2 in the epithelial interleukin-8 response to Salmonella enterica serovar typhimurium infection.
  Journal
Infect Immun 72:5052-62 (2004)
DOI:10.1128/IAI.72.9.5052-5062.2004
  Sequence
[stm:STM1855]
LinkDB

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