KEGG ORTHOLOGY: K13105

ORTHOLOGY: K13105

Entry

K13105                      KO

Symbol

PRCC

Name

proline-rich protein PRCC

Pathway

map05202

Transcriptional misregulation in cancer

map05211

Renal cell carcinoma

Disease

H00021

Renal cell carcinoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K13105  PRCC; proline-rich protein PRCC
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    K13105  PRCC; proline-rich protein PRCC
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03041 Spliceosome
    K13105  PRCC; proline-rich protein PRCC
Spliceosome [BR:ko03041]
Complex B
  Other components
   Prp19-related factors
    K13105  PRCC; proline-rich protein PRCC

Genes

HSA:	5546(PRCC)

PTR:	457405(PRCC)

PPS:	100967577(PRCC)

GGO:	101153885(PRCC)

PON:	100454241(PRCC)

NLE:	100583676(PRCC)

HMH:	116469259(PRCC)

MCC:	718660(PRCC)

MCF:	102122479 102131929(PRCC)

MTHB:

126947956 126962210

MNI:	105498073(PRCC)

CSAB:

103223824(PRCC)

CATY:

105594536(PRCC)

PANU:

101012065(PRCC)

TGE:	112630979(PRCC)

MLEU:

105548663(PRCC)

RRO:	104676443(PRCC)

RBB:	108515528(PRCC)

TFN:	117076790(PRCC)

PTEH:

111543807(PRCC)

CANG:

105502087(PRCC)

CJC:	100411373(PRCC)

SBQ:	101036353(PRCC)

CIMI:

108290255(PRCC)

CSYR:

103251200(PRCC)

MMUR:

105873107(PRCC)

LCAT:

123634119(PRCC)

PCOQ:

105821883(PRCC)

OGA:	100941784(PRCC)

MMU:	94315(Prcc)

MCAL:

110291859(Prcc)

MPAH:

110319994(Prcc)

RNO:	310687(Prcc)

MCOC:

116093097(Prcc)

ANU:	117707541(Prcc)

MUN:	110564396(Prcc)

CGE:	100752015(Prcc)

MAUA:

101844052(Prcc)

PROB:

127232606(Prcc)

PLEU:

114683340(Prcc)

MORG:

121451042(Prcc)

MFOT:

126516152

AAMP:

119800986(Prcc)

NGI:	103750277(Prcc)

HGL:	101723477(Prcc)

CPOC:

100716006(Prcc)

CCAN:

109686217(Prcc)

DORD:

105996534(Prcc)

DSP:	122109631(Prcc)

PLOP:

125359408(Prcc)

NCAR:

124976470

MMMA:

107156592(Prcc)

OCU:

100338827

OPI:	101527727(PRCC)

TUP:	102473846(PRCC)

GVR:	103588587(PRCC)

CFA:	610063(PRCC)

CLUD:

112648875(PRCC)

VVP:	112918967(PRCC)

VLG:	121494924(PRCC)

NPO:	129508683(PRCC)

AML:	100472890(PRCC)

UMR:	103668677(PRCC)

UAH:	113245215(PRCC)

UAR:	123783424(PRCC)

ELK:

111138928

LLV:

125085739

MPUF:

101684809(PRCC)

MNP:	132025843(PRCC)

MLK:	131814493(PRCC)

NVS:	122918314(PRCC)

ORO:	101375083(PRCC)

EJU:	114198624(PRCC)

ZCA:	113932760(PRCC)

MLX:	118013923(PRCC)

NSU:	110573456(PRCC)

LWW:	102739125(PRCC)

FCA:	101082371(PRCC)

PYU:	121015575(PRCC)

PCOO:

112851680(PRCC)

PBG:	122476443(PRCC)

PVIV:

125155218(PRCC)

LRUF:

124521735

PTG:	102962165(PRCC)

PPAD:

109256317(PRCC)

PUC:	125917691 125917692

AJU:

106988857

HHV:	120244704(PRCC)

BTA:	507189(PRCC)

BOM:	102288202(PRCC)

BIU:	109553075(PRCC)

BBUB:

102403408(PRCC)

BBIS:

104987350(PRCC)

CHX:	102172586(PRCC)

OAS:	101109505(PRCC)

BTAX:

128044433(PRCC)

ODA:	120855669(PRCC)

CCAD:

122431883(PRCC)

MBEZ:

129540967(PRCC)

SSC:	100154743(PRCC)

CFR:	102518632(PRCC)

CBAI:

105068106(PRCC)

CDK:	105105629(PRCC)

VPC:	102529893(PRCC)

BACU:

102997653(PRCC)

BMUS:

118902179(PRCC)

LVE:	103072853(PRCC)

OOR:	101274650(PRCC)

DLE:	111167185(PRCC)

PCAD:

102991390(PRCC)

PSIU:

116756868(PRCC)

NASI:

112401693(PRCC)

ECB:	100058204(PRCC)

EPZ:	103548848(PRCC)

EAI:	106828448(PRCC)

MYB:	102257610(PRCC)

MYD:	102753278(PRCC)

MMYO:

118673368(PRCC)

MLF:	102432760(PRCC)

PKL:	118721777(PRCC)

EFUS:

103298852(PRCC)

MNA:	107543880(PRCC)

DRO:	112317298(PRCC)

AJM:	119039775(PRCC)

PDIC:

114488828(PRCC)

PHAS:

123804749(PRCC)

MMF:	118637686(PRCC)

PPAM:

129062096(PRCC)

HAI:	109393447(PRCC)

RFQ:	117014770(PRCC)

PALE:

102893861(PRCC)

PGIG:

120606122(PRCC)

PVP:	105296334(PRCC)

RAY:	107521469(PRCC)

MJV:	108383320(PRCC)

TOD:	119235169(PRCC)

SARA:

101544828(PRCC)

SETR:

126020475(PRCC)

LAV:	100672452(PRCC)

TMU:

101360626

ETF:	101652348(PRCC)

DNM:	101427898(PRCC)

MDO:	100018673(PRCC)

GAS:	123244695(PRCC)

SHR:	100926230(PRCC)

AFZ:	127546402 127559761

PCW:	110209131 110211903(PRCC)

OAA:	103169137(PRCC)

GGA:	425977(PRCC)

PCOC:

116237290(PRCC)

MGP:	100540790(PRCC)

CJO:	107324418(PRCC)

TPAI:

128090574(PRCC)

LMUT:

125685704(PRCC)

NMEL:

110387930(PRCC)

APLA:

119715276(PRCC)

ACYG:

106049740(PRCC)

CATA:

118258636(PRCC)

AFUL:

116499671(PRCC)

TGU:	100231713(PRCC)

LSR:	110471502(PRCC)

SCAN:

115484473(PRCC)

PMOA:

120498902(PRCC)

OTC:	121332117(PRCC)

PRUF:

121352143(PRCC)

GFR:	102039038(PRCC)

FAB:	101810899(PRCC)

OMA:	130262598(PRCC)

PHI:	102099240(PRCC)

PMAJ:

107214588(PRCC)

CCAE:

111939542(PRCC)

CBRC:

103611293(PRCC)

ETL:	114071405(PRCC)

ZAB:	102064558(PRCC)

SVG:	106861148(PRCC)

MMEA:

130587133(PRCC)

HRT:	120766132(PRCC)

FPG:	101920819(PRCC)

FCH:	102046297(PRCC)

CLV:	102098995(PRCC)

EGZ:	104133009(PRCC)

NNI:	104012092(PRCC)

PCRI:

104032571(PRCC)

PLET:

104625873(PRCC)

EHS:	104505591(PRCC)

PCAO:

104051101(PRCC)

TALA:

104356039(PRCC)

PADL:

103920534(PRCC)

AFOR:

103899650(PRCC)

ACHC:

115345414(PRCC)

HALD:

104311258(PRCC)

HLE:	104829685(PRCC)

AGEN:

126040550

GCL:

127026949

CCRI:

104168553(PRCC)

CMAC:

104474874(PRCC)

MUI:	104542577(PRCC)

BREG:

104630022(PRCC)

GSTE:

104264320(PRCC)

LDI:	104345354(PRCC)

OHA:	104339569(PRCC)

SHAB:

115602791(PRCC)

PGUU:

104466449(PRCC)

ACAR:

104531563(PRCC)

CPEA:

104394570(PRCC)

CVF:	104287475(PRCC)

RTD:	128900988(PRCC)

CUCA:

104057101(PRCC)

TEO:	104372161(PRCC)

BRHI:

104501612(PRCC)

AAM:	106495085(PRCC)

AROW:

112969984(PRCC)

NPD:	112953546(PRCC)

TGT:	104564629(PRCC)

DNE:	112990825(PRCC)

SCAM:

104144326(PRCC)

ASN:	102368900(PRCC)

AMJ:	102572817(PRCC)

CPOO:

109323610(PRCC)

GGN:	109293392(PRCC)

PSS:	102456920(PRCC)

CMY:	102939303(PRCC)

CCAY:

125625779(PRCC)

DCC:	119847846(PRCC)

CPIC:

101952118(PRCC)

TST:	117869536(PRCC)

CABI:

116831802(PRCC)

MRV:	120390180(PRCC)

ACS:	100553675(prcc)

ASAO:

132764294(PRCC)

PVT:	110081436(PRCC)

SUND:

121916176(PRCC)

PGUT:

117670106(PRCC)

APRI:

131186441(PRCC)

PTEX:

113449249(PRCC)

NSS:	113424321(PRCC)

VKO:	123019610(PRCC)

PMUA:

114586944(PRCC)

PRAF:

128403650(PRCC)

ZVI:	118095916(PRCC)

HCG:	128337230(PRCC)

GJA:	107126048(PRCC)

STOW:

125439950(PRCC)

EMC:	129343262(PRCC)

XLA:	108700355(prcc.S) 399402(prcc.L)

XTR:	100038213(prcc)

NPR:	108803086(PRCC)

RTEM:

120921088(PRCC)

BBUF:

120981644(PRCC)

BGAR:

122921892(PRCC)

DRE:	572173(prcc)

SRX:	107716568 107753464

SANH:

107670020 107693312

SGH:	107577543 107589427

CCAR:

109052830(prcc)

CAUA:

113062199 113119968

CGIB:

127935715 127979662

PTET:

122323935(prcc)

LROH:

127182346(prcc)

OMC:	131525100(prcc)

PPRM:

120483625(prcc)

RKG:	130102344(prcc)

MAMB:

125275716(prcc)

CIDE:

127500656

MASI:

127421008 127425622

TROS:

130567388(prcc)

TDW:	130415717(prcc)

MANU:

129456061(prcc)

IPU:

108257294

IFU:	128600175(prcc)

PHYP:

113546194(prcc)

SMEO:

124376411(prcc)

TFD:	113649620(prcc)

TVC:	132863927(prcc)

AMEX:

103046585(prcc)

CMAO:

118805200(prcc)

EEE:	113582928(prcc)

CHAR:

105892046(prcc)

TRU:	101063069(prcc)

TFS:	130518594(prcc)

TNG:	GSTEN00003384G001 GSTEN00032539G001

LCO:	104927565(prcc)

NCC:

104964984

TBEN:

117478319(prcc)

CGOB:

115015460(prcc)

PGEO:

117455081(prcc)

GACU:

117542629(prcc)

EMAC:

134875059(prcc)

ELY:	117263878(prcc)

EFO:	125904970(prcc)

PLEP:

121957669(prcc)

SLUC:

116047357(prcc)

ECRA:

117956891(prcc)

ESP:	116701668(prcc)

PFLV:

114568055(prcc)

GAT:	120826565(prcc)

PPUG:

119219128(prcc)

AFB:	129097071(prcc)

CLUM:

117738679(prcc)

PSWI:

130196173(prcc)

MSAM:

119907302(prcc)

SCHU:

122864917(prcc)

CUD:	121523672(prcc)

ALAT:

119016457(prcc)

MZE:	101485161(prcc)

ONL:	100700495(prcc)

OAU:	116319992(prcc)

OLA:	101161530(prcc)

OML:	112162381(prcc)

CSAI:

133461438(prcc)

XMA:	102231229(prcc)

XCO:	114156674(prcc)

XHE:	116730582(prcc)

PRET:

103472493(prcc)

PFOR:

103146853(prcc)

PLAI:

106958719(prcc)

PMEI:

106916870(prcc)

GAF:	122843105(prcc)

PPRL:

129375017(prcc)

CVG:	107102961(prcc)

CTUL:

119779637(prcc)

GMU:	124879627(prcc)

NFU:	107394625(prcc)

KMR:	108238147(prcc)

ALIM:

106511074(prcc)

NWH:	119426161(prcc)

AOCE:

111565091(prcc)

MCEP:

125020139(prcC)

CSEM:

103394553(prcc)

POV:	109638840(prcc)

SSEN:

122786185(prcc)

HHIP:

117770638(prcc)

HSP:	118124888(prcc)

SMAU:

118292405(prcc)

LCF:

108879456

SDU:	111223181(prcc)

SLAL:

111657611(prcc)

XGL:	120786141(prcc)

HCQ:

109514589

SSCV:

125987244

SBIA:

133500268(prcc)

PEE:	133396082(prcc)

PTAO:

133471281(prcc)

BPEC:

110161125(prcc)

MALB:

109958629(prcc)

BSPL:

114865517(prcc)

SJO:	128374658(prcc)

SASA:

100195390(prcc) 106570205(PRCC)

STRU:

115173682 115175792

OTW:	112229695(prcc) 112264683

OMY:	110488235 110496344

OGO:	124012636 124043431

ONE:	115128488 115131517

OKI:	109904439 109907423

OKE:	118398084 118399426

SALP:

111955127 111955898

SNH:	120022691 120027153(prcc)

CCLU:

121585971 123491396(prcc)

ELS:	105012715(prcc)

SFM:	108930406(prcc)

PKI:	111853528(prcc)

AANG:

118233182(prcc)

LOC:	102687314(prcc)

PSPA:

121309855(prcc)

ARUT:

117395630 117965176

PSEX:

120527473(prcc)

LCM:	102366894(PRCC) 106706089

HOC:	132814448(prcc)

PMRN:

116954987(PRCC)

LRJ:	133352822(PRCC)

BFO:

BBEL:

CIN:

SCLV:

SPU:

SKO:

DME:	Dmel_CG17249(CG17249)

DER:

6545681

DSE:

6610363

DSI:	Dsimw501_GD13457(Dsim_GD13457)

DYA:	Dyak_GE20938

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI16797

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ004566

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:	108558909 108569061

APLN:

108745175

PPYR:

116168677

OTU:	111425505 111427430

BMOR:

101740866

BMAN:

114244064

MSEX:

115446591

DPL:	KGM_202220

BANY:

MJU:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105382203 105386806 105391328

PGW:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:	128996553 128997329

PHU:	Phum_PHUM317170

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_305525

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:	135209526 135209609

HAZT:

EAF:

LSM:

DSV:

RSAN:

RMP:

TUT:

DPTE:

DFR:

PTEP:

ABRU:

UDV:

LPOL:

CEL:	CELE_C39E9.11(prcc-1)

CBR:

CBG_01829

CRQ:	GCK72_014493

NAI:	NECAME_09007

BMY:	BM_BM2673(Bm2673)

LOA:	LOAG_02216

TSP:

Tsp_02448

HRO:	HELRODRAFT_159819

LGI:	LOTGIDRAFT_157968

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MMER:

OBI:

OSN:

LAK:

SMM:	Smp_134480

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

AQU:

ATH:

ALY:

CRB:

CSAT:

104701272 104747863 104767135

EUS:	EUTSA_v10022749mg

BRP:

103828332

BNA:	106357622 111199181

BOE:

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10008415mg

PVY:	116129767 116129769

MINC:

123195053 123201019

TCC:

18589407

GRA:

105782915

GHI:	107940292 121212617

GAB:

HSYR:

DZI:

EGR:

GMX:	100783897 100805518

GSJ:	114382437 114393947

PVU:	PHAVU_003G140900g

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:	131628774 131628983

LJA:	Lj4g3v2139190.1(Lj4g3v2139190.1)

ADU:

107496374

AIP:

107642804

AHF:	112697492 112723604

LANG:

109347356 109355915

PCIN:

129309675

QSA:	O6P43_002802 O6P43_022371

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PXB:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

JRE:

CILL:

CAVE:

QLO:

TWL:	119993237 119997967

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107779422 107826966

NSY:

104248333

NTO:

104117124

NAU:

109211199

INI:	109182638 109182764

ITR:

SIND:

OEU:

EGT:

SSPL:

SMIL:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:	130770723 130774437 130794248

BVG:

104883603

SOE:

110805696

CQI:	110683014 110715779

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

Os02t0175900-01(Os02g0175900)

OBR:

OGL:

BDI:

ATS:

TDC:	119316330 119323824

TAES:

123132535 123136606 123144118

TUA:

125531051

LPER:

127308026

LRD:	124686573 124691794

SBI:

8077200

ZMA:	100192621 100275702

SITA:

SVS:

PVIR:

PHAI:

PDA:	103701580 120107754

EGU:

105039318

MUS:

103980021

DCT:

110103001

PEQ:	110019127 110035022

AOF:

MSIN:

NCOL:

ATR:

SMO:	SELMODRAFT_270529 SELMODRAFT_404148

PPP:

112292575

VCN:	VOLCADRAFT_86322

CSL:	COCSUDRAFT_68037

CVR:	CHLNCDRAFT_143436

MIS:	MICPUN_113676

TVS:	TRAVEDRAFT_54142

DSQ:	DICSQDRAFT_124014

SHS:	STEHIDRAFT_166335

PSQ:	PUNSTDRAFT_136020

GTR:	GLOTRDRAFT_126767

MBR:	MONBRDRAFT_24919

SRE:	PTSG_03899

ACAN:

BBIG:

PSOJ:

Reference

PMID:12351585

Authors

Bodmer D, van den Hurk W, van Groningen JJ, Eleveld MJ, Martens GJ, Weterman MA, van Kessel AG.

Title

Understanding familial and non-familial renal cell cancer.

Journal

Hum Mol Genet 11:2489-98 (2002)
DOI:10.1093/hmg/11.20.2489

Reference

PMID:8872474

Authors

Sidhar SK, Clark J, Gill S, Hamoudi R, Crew AJ, Gwilliam R, Ross M, Linehan WM, Birdsall S, Shipley J, Cooper CS

Title

The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene.

Journal

Hum Mol Genet 5:1333-8 (1996)
DOI:10.1093/hmg/5.9.1333

Sequence

[hsa:5546]

LinkDB

DBGET integrated database retrieval system