KEGG ORTHOLOGY: K13299

ORTHOLOGY: K13299

Entry

K13299                      KO

Symbol

GSTK1

Name

glutathione S-transferase kappa 1 [EC:2.5.1.18]

Pathway

map00480

Glutathione metabolism

map00980

Metabolism of xenobiotics by cytochrome P450

map00982

Drug metabolism - cytochrome P450

map01100

Metabolic pathways

map04146

Peroxisome

map05204

Chemical carcinogenesis - DNA adducts

Reaction

R03522

RX:glutathione R-transferase

R07002

(1R)-hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene glutathione-lyase (epoxide-forming)

R07003

(1R)-glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene glutathione-lyase (epoxide-forming)

R07004

(1S)-hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene glutathione-lyase (epoxide-forming)

R07023

1-nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene glutathione-lyase (epoxide-forming)

R07024

1-nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene glutathione-lyase (epoxide-forming)

R07025

1-nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene glutathione-lyase (epoxide-forming)

R07026

1-nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene glutathione-lyase (epoxide-forming)

R07069

3,4-dihydro-3-hydroxy-4-S-glutathionyl bromobenzene glutathione-lyase (epoxide-forming)

R07070

2,3-dihydro-2-S-glutathionyl-3-hydroxy bromobenzene glutathione-lyase (epoxide-forming)

R07083

4,5-dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene glutathione-lyase (epoxide-forming)

R07084

7,8-dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene hydrolase

R07091

S-(2,2-dichloro-1-hydroxy)ethyl-glutathione 2,2-dichloroacetaldehyde-lyase (glutathione-forming)

R07092

1,1-dichloroethylene-epoxide:glutathione S-(chloroepoxyethyl)transferase [2-(S-glutathionyl)acetyl-chloride-forming]

R07093

chloroacetyl-chloride:glutathione S-chloroacetyltransferase

R07094

2-(S-glutathionyl)acetyl-chloride:glutathione 2-(S-glutathionyl)acetyltransferase

R07100

trichloroethene:glutathione S-(1,2-dichlorovinyl)transferase

R07113

1,2-dibromoethane:glutathione ethylenetransferase (episulfonium-forming)

R07116

2-bromoacetaldehyde:glutathione S-(formylmethyl)transferase

R08280

4-glutathionyl cyclophosphamide hydrolase

R09409

glutathione-S-transferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    K13299  GSTK1; glutathione S-transferase kappa 1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K13299  GSTK1; glutathione S-transferase kappa 1
   00982 Drug metabolism - cytochrome P450
    K13299  GSTK1; glutathione S-transferase kappa 1
09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    K13299  GSTK1; glutathione S-transferase kappa 1
09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K13299  GSTK1; glutathione S-transferase kappa 1
Enzymes [BR:ko01000]
2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     K13299  GSTK1; glutathione S-transferase kappa 1

Other DBs

GO:

0004364

Genes

HSA:	373156(GSTK1)

PTR:	463802(GSTK1)

PPS:	100984910(GSTK1)

GGO:	101151695(GSTK1)

PON:	100171904(GSTK1)

NLE:	100600062(GSTK1)

HMH:	116814464(GSTK1)

MCC:	704240(GSTK1)

MCF:	102127774(GSTK1)

MTHB:

126951068

MNI:	105471184(GSTK1)

CSAB:

103227127(GSTK1)

CATY:

105584644(GSTK1)

PANU:

101006611(GSTK1)

TGE:	112620448(GSTK1)

MLEU:

105546619(GSTK1)

RRO:	104674917(GSTK1)

RBB:	108544238(GSTK1)

TFN:	117072366(GSTK1)

PTEH:

111521442(GSTK1)

CANG:

105511246(GSTK1)

CJC:	100403214(GSTK1)

SBQ:	101041233(GSTK1)

CIMI:

108291114(GSTK1)

CSYR:

103271041(GSTK1)

MMUR:

105873288(GSTK1)

LCAT:

123647586(GSTK1)

PCOQ:

105815443(GSTK1)

OGA:	100963420(GSTK1)

MMU:	76263(Gstk1)

MCAL:

110296272(Gstk1)

MPAH:

110317036(Gstk1)

RNO:	297029(Gstk1)

MCOC:

116098079(Gstk1)

ANU:	117720334 117720353

MUN:	110557979(Gstk1)

CGE:	100750404(Gstk1) 100750691

MAUA:

101833355(Gstk1)

PROB:

127214267(Gstk1)

PLEU:

114698018(Gstk1)

MORG:

121435493 121435506 121435511

MFOT:

126515101

AAMP:

119806933(Gstk1) 119807086 119819479 119826793

NGI:	103730394(Gstk1) 103730395

HGL:	101713648(Gstk1)

CPOC:

100714509(Gstk1)

CCAN:

109697481(Gstk1)

DORD:

105989594(Gstk1)

DSP:	122105967(Gstk1)

PLOP:

125347261(Gstk1)

NCAR:

124991836

MMMA:

107148986(Gstk1)

OCU:	100349830 100350399

OPI:	101527746 101528001

TUP:	102501334(GSTK1)

GVR:	103600456(GSTK1)

CFA:	100685014 475518(GSTK1)

CLUD:

112645622 112650897(GSTK1)

VVP:	112934803(GSTK1)

VLG:	121482109 121488918(GSTK1)

NPO:	129504007 129515902(GSTK1)

AML:	100473554(GSTK1)

UMR:	103668981(GSTK1)

UAH:	113265493(GSTK1)

UAR:	123788839(GSTK1) 123797546

ELK:

111152081

LLV:

125080922

MPUF:

101687538 101694516(GSTK1)

MNP:	132015618(GSTK1)

MLK:	131829883(GSTK1)

NVS:	122905157(GSTK1)

ORO:	101383354(GSTK1)

EJU:	114211762(GSTK1)

ZCA:	113911249(GSTK1) 118356051

MLX:	118021195(GSTK1)

NSU:	110582754(GSTK1)

LWW:	102740258(GSTK1)

FCA:	101087726(GSTK1)

PYU:	121028182(GSTK1)

PCOO:

112866316(GSTK1)

PBG:	122488454(GSTK1)

PVIV:

125154578(GSTK1)

LRUF:

124524196

PTG:	102950403(GSTK1)

PPAD:

109269174(GSTK1)

PUC:

125930249

AJU:

106980762

HHV:	120238975(GSTK1)

BTA:	613498(GSTK1)

BOM:	102271847(GSTK1)

BIU:	109557745(GSTK1)

BBUB:

102409242(GSTK1)

BBIS:

104984337(GSTK1)

CHX:	102182665(GSTK1)

OAS:	101114517(GSTK1)

BTAX:

128046687(GSTK1)

ODA:	120877699(GSTK1)

CCAD:

122438766(GSTK1)

MBEZ:

129552732(GSTK1)

SSC:	100521480(GSTK1)

CFR:	102518852(GSTK1)

CBAI:

105069712(GSTK1)

CDK:	105104498(GSTK1)

VPC:	102533278(GSTK1)

BACU:

103018773(GSTK1)

BMUS:

118901126(GSTK1)

LVE:	103084267(GSTK1)

OOR:	101272261(GSTK1)

DLE:	111177335(GSTK1)

PCAD:

102984483(GSTK1) 102987330

PSIU:

116759785(GSTK1)

NASI:

112408445(GSTK1)

ECB:	100056014(GSTK1)

EPZ:	103562806(GSTK1)

EAI:	106833851(GSTK1)

MYB:	102263382(GSTK1)

MYD:	102751529(GSTK1)

MMYO:

118666313(GSTK1)

MLF:	102429821(GSTK1)

PKL:	118714166(GSTK1)

EFUS:

103297268(GSTK1)

MNA:	107523816(GSTK1)

DRO:	112316169(GSTK1)

SHON:

118997004(GSTK1)

AJM:

119038301

PDIC:

114507824(GSTK1)

PHAS:

123831005(GSTK1)

MMF:	118620436(GSTK1)

PPAM:

129063453(GSTK1)

HAI:	109376381(GSTK1)

RFQ:	117018169(GSTK1)

PALE:

102896007(GSTK1)

PGIG:

120600957(GSTK1)

PVP:	105304117(GSTK1)

RAY:	107516990(GSTK1)

MJV:	108404391(GSTK1)

TOD:	119248029(GSTK1)

SARA:

101547680(GSTK1)

SETR:

126025360(GSTK1)

LAV:	100661790(GSTK1)

TMU:

101340387

ETF:	101644194(GSTK1)

DNM:	101433125(GSTK1)

MDO:	100011709(GSTK1) 103105104

GAS:	123250503(GSTK1)

SHR:	100914658(GSTK1) 100915266

AFZ:	127539283 127539284

PCW:	110216183 110216224(GSTK1) 110216226

OAA:	100075063(GSTK1)

GGA:	418302(GSTK1)

PCOC:

116240011(GSTK1)

MGP:	100550632(GSTK1)

CJO:	107319110(GSTK1)

TPAI:

128089922(GSTK1)

LMUT:

125703806(GSTK1)

NMEL:

110398092(GSTK1)

APLA:

101798670(GSTK1)

ACYG:

106048720(GSTK1)

CATA:

118247541(GSTK1)

AFUL:

116502150(GSTK1)

TGU:	100224064(GSTK1)

LSR:	110480866(GSTK1)

SCAN:

103827178(GSTK1)

PMOA:

120506369(GSTK1)

OTC:	121335933(GSTK1)

PRUF:

121354693(GSTK1)

GFR:	102042875(GSTK1)

FAB:	101821770(GSTK1)

OMA:	130259947(GSTK1)

PHI:	102107542(GSTK1)

PMAJ:

107206278(GSTK1)

CCAE:

111944340(GSTK1)

CCW:	104687150(GSTK1)

CBRC:

103617157(GSTK1)

ETL:	114065694(GSTK1)

ZAB:	102068837(GSTK1)

ACHL:

103807890(GSTK1)

SVG:	106863054(GSTK1)

MMEA:

130574822(GSTK1)

HRT:	120749646(GSTK1)

FPG:	101921280(GSTK1)

FCH:	102055020(GSTK1)

CLV:	102095701(GSTK1)

EGZ:	104126612(GSTK1)

NNI:	104009608(GSTK1)

PCRI:

104029870(GSTK1)

PLET:

104619087(GSTK1)

EHS:	104511007(GSTK1)

PCAO:

104039508(GSTK1)

ACUN:

113482233(GSTK1)

TALA:

104368929(GSTK1)

PADL:

103921847(GSTK1)

AFOR:

103905471(GSTK1)

ACHC:

115343997(GSTK1)

HALD:

104320417(GSTK1)

HLE:	104831796(GSTK1)

AGEN:

126048894

GCL:

127014235

CCRI:

104165979

CSTI:

104564059(GSTK1)

CMAC:

104474005(GSTK1)

MUI:	104534429(GSTK1)

BREG:

104630211(GSTK1)

FGA:	104070936(GSTK1)

GSTE:

104251274(GSTK1)

LDI:	104343088(GSTK1)

MNB:	103776130(GSTK1)

OHA:	104327144(GSTK1)

NNT:	104399746(GSTK1)

SHAB:

115601565(GSTK1)

DPUB:

104299513(GSTK1)

ACAR:

104528509(GSTK1)

CPEA:

104389777(GSTK1)

AVIT:

104280611(GSTK1)

CVF:	104293283(GSTK1)

RTD:	128913881(GSTK1)

CUCA:

104064388(GSTK1)

TEO:	104380641(GSTK1)

BRHI:

104498442(GSTK1)

AAM:	106497246(GSTK1)

AROW:

112972999(GSTK1)

NPD:	112951715(GSTK1)

TGT:	104564919(GSTK1)

DNE:	112990863(GSTK1)

SCAM:

104150757(GSTK1)

ASN:	102385754(GSTK1)

AMJ:	102560122(GSTK1)

PSS:	102457740(GSTK1)

CMY:	102930877(GSTK1) 102940202

DCC:	119851599(GSTK1)

CPIC:

101946179(GSTK1)

TST:	117885554(GSTK1)

MRV:	120405660(GSTK1)

ACS:	100563685(gstk1)

ASAO:

132767559(GSTK1) 132780565

PVT:	110070144 110070151 110071484

SUND:

121921706(GSTK1)

PBI:	103055353(GSTK1)

PMUR:

107289971 107289973

CTIG:

120306076 120306077

PGUT:

117656600(GSTK1)

APRI:

131190161(GSTK1)

PTEX:

113455000 113455001

VKO:	123028062(GSTK1)

PMUA:

114587839 114587866

PRAF:

128405167(GSTK1)

ZVI:	118075262(GSTK1)

HCG:	128344319 128346771(GSTK1)

GJA:	107115534(GSTK1)

STOW:

125425160 125425191(GSTK1)

EMC:	129345741(GSTK1)

XLA:	379895(gstk1.L) 734753(gstk1.S)

XTR:	496688(gstk1)

NPR:	108795392 108803212

RTEM:

120947039 120947040

BBUF:

121005862 121005863

BGAR:

122939968 122939969 122942429

MUO:	115457962(GSTK1)

GSH:	117350840(GSTK1)

DRE:	436833(gstk1) 678541(gstk4)

SRX:	107716830 107716832 107727779

SANH:

107672055 107672119 107682987 107704859 107704924

SGH:	107552844 107587784 107587785

CCAR:

109074798 109074799 109083277 109083278

CAUA:

113079776 113099623 113116052 113116053 113116054

CGIB:

127975161 127975162 127975247 128030575

PTET:

122354615 122359881 122359973

LROH:

127178681 127179158(gstk1)

OMC:

PPRM:

RKG:

MAMB:

CIDE:

MASI:

TROS:

130557711(gstk1)

TDW:	130432618(gstk1)

MANU:

129448217(gstk1)

IPU:	100528083(gstk1) 108264329 124629198

IFU:	128602978 128603064

PHYP:

113533953 113533954

SMEO:

124384095(gstk1)

TFD:	113659063(gstk1)

TVC:	132846396(gstk1)

AMEX:

103043665 103044355

CMAO:

118820409(gstk1)

EEE:	113573080(gstk1)

CHAR:

105901641 105901652(gstk1)

TRU:	101072145(gstk1)

TFS:

130533032

NCC:	104960396 104960399

TBEN:

117480727 117480728

CGOB:

115021860(gstk1)

PGEO:

117460910 117461037

GACU:

117543225 117543226 117543227 117543230

EMAC:

134861494(gstk1) 134861495

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116674609 116691305

PFLV:

114557530(gstk1)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

130213485(gstk1)

MSAM:

119897462

SCHU:

122882090(gstk1)

CUD:

121513408

ALAT:

119006383

MZE:	101469374(gstk1)

ONL:	100709083(gstk1)

OAU:

116323812

OLA:	101171358(gstk1)

OML:	112143718(gstk1)

CSAI:

133441052

XMA:	102217916(gstk1)

XCO:	114142372(gstk1)

XHE:	116717859(gstk1)

PRET:

103478023(gstk1)

PFOR:

103136716(gstk1)

PLAI:

106952583(gstk1)

PMEI:

106916575(gstk1)

GAF:

122831033

PPRL:

129371232(gstk1)

CVG:	107082175(gstk1)

CTUL:

119782959

GMU:

124865810

NFU:	107379432(gstk1)

KMR:

108235447

ALIM:

106511373(gstk1)

NWH:

119409359

AOCE:

111576829 111576831 111582043

MCEP:

125016372

CSEM:

103387930(gstk1)

POV:	109633329(gstk1)

SSEN:

122774917(gstk1)

HHIP:

HSP:

SMAU:

LCF:

SDU:	111230099(gstk1)

SLAL:

111669838(gstk1)

XGL:

120784126

HCQ:	109515316(gstk1)

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110163056(gstk1)

MALB:

109966149(gstk1)

BSPL:

114842966 114842967

SJO:

128365870

SASA:

100196661 106576751

OTW:	112225920 112253768

OMY:	100305229(gstk1) 110509171

OGO:	123996575 124004740

ONE:	115101231 115140807

OKI:	109868238 109879286

OKE:	118367909 118371233

SALP:

111964845(gstk1)

SNH:	120030874 120048702

CCLU:

121542994 121586226

ELS:	105019054(gstk1)

SFM:	108924726(gstk1)

PKI:	111833969(gstk1)

AANG:

118229068

PSPA:

121325379

ARUT:

117425255

PMRN:

116957808(GSTK1)

LRJ:	133340802(GSTK1)

BFO:	118430882 118431037

BBEL:

109472689 109472691

CIN:

100186348

SCLV:

120330727 120332535 120332536

AJC:

117110349

SKO:	100372161 100378230 102808613

DPX:	DAPPUDRAFT_193187 DAPPUDRAFT_308406

DMK:	116935971 123466752 123469363 123469364

DPZ:	124327293 124327296

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123749859 123768064 123768304

CQD:

PTRU:

MNZ:

EAF:

LSM:

TCF:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

113790261 113790271 113791148 113791149

DFR:	124494426 124498595 124498596

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

CEL:	CELE_D2024.7(gstk-2) CELE_ZK1320.1(gstk-1)

CBR:	CBG_05816 CBG_10410

CRQ:	GCK72_003658 GCK72_013895

NAI:	NECAME_05549 NECAME_10302

HRO:	HELRODRAFT_87059

LGI:	LOTGIDRAFT_108316

PVUL:

126810437

PCAN:

112557420

BGT:

106057713

GAE:	121390212 121390366

HRF:

124144917

HRJ:

124260908

CRG:

105325336

CVN:	111136538 111136662

CANU:

OED:

MYI:

PMAX:

MCAF:

127700191 127703953 127720318

MMER:

123526324 128548357

RPHI:

132721786

DPOL:

127832115 127842373 127881506

OBI:

106876882

OSN:

115213158

LAK:	106159077 106174835

OVI:	T265_05510

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

AQU:

PPP:

FGR:	FGSG_07224

FPU:	FPSE_03156

FVR:	FVEG_05362

FOX:	FOXG_02193

TRE:	TRIREDRAFT_57965

TRR:	M419DRAFT_72237

MAJ:

MAA_06002

CMT:

CCM_01814

PLJ:	VFPFJ_05700

PTKZ:

JDV02_000787

SSL:	SS1G_12640

BFU:	BCIN_10g02820

MBE:

MBM_04889

PSCO:

LY89DRAFT_687779

GLZ:	GLAREA_11124

TRG:	TRUGW13939_01155

BGH:	BDBG_04296

PNO:	SNOG_01009

BZE:	COCCADRAFT_92661

BSC:	COCSADRAFT_35747

BOR:	COCMIDRAFT_93712

NPA:	UCRNP2_7724

TML:	GSTUM_00001646001

SHS:	STEHIDRAFT_165278

ADL:	AURDEDRAFT_113593 AURDEDRAFT_183093

RSX:	RhiXN_04110

UMA:	UMAG_05678

PFP:	PFL1_04845

SGRA:

EX895_002708

PGR:	PGTG_14747 PGTG_17111

MLR:	MELLADRAFT_94402

SRE:	PTSG_07561

ACAN:

ACA1_263920

GTT:	GUITHDRAFT_110084

» show all

Reference

PMID:21428694

Authors

Morel F, Aninat C

Title

The glutathione transferase kappa family.

Journal

Drug Metab Rev 43:281-91 (2011)
DOI:10.3109/03602532.2011.556122

Reference

PMID:19663909

Authors

Petit E, Michelet X, Rauch C, Bertrand-Michel J, Terce F, Legouis R, Morel F

Title

Glutathione transferases kappa 1 and kappa 2 localize in peroxisomes and mitochondria, respectively, and are involved in lipid metabolism and respiration in Caenorhabditis elegans.

Journal

FEBS J 276:5030-40 (2009)
DOI:10.1111/j.1742-4658.2009.07200.x

Sequence

[cel:CELE_ZK1320.1 CELE_D2024.7]

LinkDB

DBGET integrated database retrieval system