KEGG ORTHOLOGY: K14959

ORTHOLOGY: K14959

Entry

K14959                      KO

Symbol

MLL4

Name

[histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H00773

Autosomal dominant intellectual developmental disorder

H00831

Primary dystonia

H01613

Follicular lymphoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
   03036 Chromosome and associated proteins
    K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
Transcription factors [BR:ko03000]
Eukaryotic type
  Zinc finger
   CXXC CpG-binding proteins
    K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
   HMT complexes
    MLL3/MLL4 complex
     K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4

Other DBs

GO:

0042800

Genes

HSA:	9757(KMT2B)

PTR:	455959(KMT2B)

PPS:	100979249(KMT2B)

GGO:	101139923(KMT2B)

PON:	100442005(KMT2B)

NLE:	100594433(KMT2B)

HMH:	116478917(KMT2B)

MCC:	718835(KMT2B)

MCF:	102115861(KMT2B)

MTHB:

126941879

MNI:	105495504(KMT2B)

CSAB:

103234531(KMT2B)

CATY:

105578189(KMT2B)

PANU:

101011413(KMT2B)

TGE:	112613055(KMT2B)

MLEU:

105543104(KMT2B)

RRO:	104667085(KMT2B)

RBB:	108512323(KMT2B)

TFN:	117092369(KMT2B)

PTEH:

111529937(KMT2B)

CANG:

105516695(KMT2B)

CJC:	100407541(KMT2B)

SBQ:	101034359(KMT2B)

CIMI:

108286344(KMT2B)

CSYR:

103249681(KMT2B)

MMUR:

105876915(KMT2B)

LCAT:

123624459(KMT2B)

PCOQ:

105816259(KMT2B)

OGA:	100941061(KMT2B)

MMU:	75410(Kmt2b)

MCAL:

110297666(Kmt2b)

MPAH:

110338314(Kmt2b)

RNO:	102550344(Kmt2b)

MCOC:

116101986(Kmt2b)

ANU:	117709080(Kmt2b)

MUN:	110550986(Kmt2b)

CGE:	100750575(Kmt2b)

MAUA:

101835352(Kmt2b)

PROB:

127238764(Kmt2b)

PLEU:

114681635(Kmt2b)

MORG:

121449315(Kmt2b)

MFOT:

126486716

AAMP:

119820602(Kmt2b)

NGI:	103729965(Kmt2b)

HGL:	101699273(Kmt2b)

CPOC:

100735175(Kmt2b)

CCAN:

109689598(Kmt2b)

DORD:

105993122(Kmt2b)

DSP:	122097464(Kmt2b)

PLOP:

125368349(Kmt2b)

NCAR:

124966333

MMMA:

107151676(Kmt2b)

OCU:

100353483

OPI:	101535318(KMT2B)

TUP:	102477772(KMT2B)

GVR:	103583372 103592831(KMT2B)

CFA:	100688666(KMT2B)

CLUD:

112643518(KMT2B)

VVP:	112928324(KMT2B)

VLG:	121484255(KMT2B)

NPO:	129499888(KMT2B)

AML:	100469094(KMT2B)

UMR:	103682560(KMT2B)

UAH:	113244759(KMT2B)

UAR:	123793892(KMT2B)

ELK:

111161417

LLV:

125088364

MPUF:

101685930(KMT2B)

MNP:	132005509(KMT2B)

MLK:	131818658(KMT2B)

NVS:	122911561(KMT2B)

ORO:	101370290(KMT2B)

EJU:	114224359(KMT2B)

ZCA:	113935548(KMT2B)

MLX:	118022788(KMT2B)

NSU:	110590086(KMT2B)

LWW:	102730782(KMT2B)

FCA:	101098760(KMT2B)

PYU:	121011346(KMT2B)

PCOO:

112851004(KMT2B)

PBG:	122495065(KMT2B)

PVIV:

125153519(KMT2B)

LRUF:

124511218

PTG:	102964982(KMT2B)

PPAD:

109251503(KMT2B)

PUC:	125918291 125918297

AJU:

106974745

HHV:	120243477(KMT2B)

BTA:	785776(KMT2B)

BOM:	102269320(KMT2B)

BIU:	109572325(KMT2B)

BBIS:

104995419(KMT2B)

CHX:	102172292(KMT2B)

OAS:	101104086(KMT2B)

BTAX:

128062799(KMT2B)

ODA:	120872497(KMT2B)

CCAD:

122421375(KMT2B)

MBEZ:

129546059(KMT2B)

SSC:	100520742(KMT2B)

CFR:	102520520(KMT2B)

CBAI:

105065102(KMT2B)

CDK:

105088051

VPC:	102538562(KMT2B)

BACU:

103015601(KMT2B)

BMUS:

118884797(KMT2B)

LVE:	103073652(KMT2B)

OOR:	101276223(KMT2B)

DLE:	111181136(KMT2B)

PCAD:

102987727(KMT2B)

PSIU:

116744553(KMT2B)

NASI:

112392388(KMT2B)

ECB:	100059802(KMT2B)

EPZ:	103566091(KMT2B)

EAI:	106829152(KMT2B)

MYB:	102259087(KMT2B)

MYD:	102771251(KMT2B)

MMYO:

118674717(KMT2B)

MLF:	102433699(KMT2B)

PKL:	118720655(KMT2B)

EFUS:

103284776(KMT2B)

MNA:	107543372(KMT2B)

DRO:	112320053(KMT2B)

SHON:

118982549(KMT2B)

AJM:	119044204(KMT2B)

PDIC:

114511083(KMT2B)

PHAS:

123823661(KMT2B)

MMF:	118638673(KMT2B)

PPAM:

129083195(KMT2B)

HAI:	109372008(KMT2B)

RFQ:	117034916(KMT2B)

PALE:

102881431(KMT2B)

PGIG:

120592489(KMT2B)

PVP:	105306647(KMT2B)

RAY:	107497624(KMT2B)

MJV:	108401519(KMT2B)

TOD:	119250148(KMT2B)

SARA:

101537418(KMT2B)

SETR:

126027579(KMT2B)

LAV:	100669611(KMT2B)

TMU:

101345928

ETF:	101656752(KMT2B)

DNM:	101413650(KMT2B)

MDO:	100617561(KMT2B)

GAS:

123256611

SHR:	100927672(KMT2B)

AFZ:

127556061

PCW:	110201341(KMT2B)

OAA:	103165316(KMT2B)

ASN:	102382195(KMT2B)

CMY:	102931937(KMT2B)

CCAY:

125625630(KMT2B)

DCC:	119847681(KMT2B)

CPIC:

101950574(KMT2B)

TST:	117869515(KMT2B)

CABI:

116839067(KMT2B)

MRV:	120390254(KMT2B)

ACS:	100556600(kmt2b)

ASAO:

132780295(KMT2B)

PVT:	110089900(KMT2B)

SUND:

121915298(KMT2B)

PBI:	103058696(KMT2B)

PMUR:

107287999(KMT2B)

CTIG:

120300040(KMT2B)

TSR:	106550780(KMT2B)

PGUT:

117669309(KMT2B)

APRI:

131204277(KMT2B)

PTEX:

113437418(KMT2B)

NSS:	113419887(KMT2B)

VKO:	123025799(KMT2B)

PMUA:

114603572(KMT2B)

PRAF:

128418584(KMT2B)

ZVI:	118085945(KMT2B)

HCG:	128332572(KMT2B)

GJA:	107108169(KMT2B)

STOW:

125434769(KMT2B)

EMC:	129343103(KMT2B)

XLA:	108696880 108697287

XTR:	100144721(kmt2b)

NPR:	108799776(KMT2B)

RTEM:

120916238(KMT2B)

BBUF:

120993856(KMT2B)

BGAR:

122929120(KMT2B)

MUO:	115476211(KMT2B)

GSH:	117369214(KMT2B)

DRE:	560856(kmt2ba) 566825(kmt2bb)

SRX:	107724085 107739503 107745205 107747652

SANH:

107665484 107675870 107693264 107701550

SGH:	107571391(kmt2b) 107585719 107589473 107599517

CCAR:

109085861 109103645 109112389

CAUA:

113061939 113061940 113062164 113069211 113077794 113099189 113099201 113114935 113120015

CGIB:

127935245 127973165 127979018 128028980

PTET:

122323526(kmt2ba) 122358939(kmt2bb)

LROH:

127157412(kmt2bb) 127182023(kmt2ba)

OMC:	131520426(kmt2bb) 131525286(kmt2ba)

PPRM:

120478822(kmt2bb) 120483374(kmt2ba)

RKG:	130070691(kmt2bb) 130070833(kmt2ba)

MAMB:

125248738 125275959(kmt2ba)

CIDE:

127495955 127501701

MASI:

127421184 127422178 127425593 127429839

TROS:

130564368(kmt2bb) 130566892(kmt2ba)

TDW:	130415530(kmt2ba) 130428110(kmt2bb)

MANU:

129438380(kmt2bb) 129454902(kmt2ba)

IPU:	108272954(kmt2ba) 108277672(kmt2bb)

IFU:	128615464(kmt2ba) 128621843(kmt2bb)

PHYP:

113535181 113539221(kmt2b)

SMEO:

124381839(kmt2ba) 124394710(kmt2bb)

TFD:	113641273(kmt2ba) 113642372(kmt2bb)

TVC:	132842880(kmt2ba) 132858299(kmt2bb)

AMEX:

103022217(kmt2b) 103024771

CMAO:

118803799(kmt2bb) 118805983(kmt2ba)

EEE:	113572597 113586392(kmt2b)

CHAR:

105901266(kmt2bb) 105902047(kmt2ba)

TRU:	101064190 101073293(kmt2b) 115251849

TFS:	130518561(kmt2ba) 130532714(kmt2bb)

TNG:	GSTEN00032527G001

LCO:	104927558 104932361(kmt2b)

NCC:	104960690 104961389(kmt2b)

TBEN:

117477555(kmt2ba) 117480290(kmt2bb)

CGOB:

115016046 115021110(kmt2b)

PGEO:

117455559(kmt2ba) 117460876(kmt2bb)

GACU:

117542674(kmt2ba) 117553899(kmt2bb)

EMAC:

134861535(kmt2bb) 134874859

ELY:	117263326(kmt2ba) 117266030(kmt2bb)

EFO:	125893714(kmt2bb) 125904405(kmt2ba)

PLEP:

121946079(kmt2bb) 121957413(kmt2ba)

SLUC:

116047504(kmt2ba) 116049332(kmt2bb)

ECRA:

117946883(kmt2bb) 117956541(kmt2ba)

ESP:	116690992(kmt2b) 116701633

PFLV:

114556540(kmt2b) 114567833

GAT:	120811149(kmt2bb) 120826849(kmt2ba)

PPUG:

119197459(kmt2bb) 119218734(kmt2ba)

AFB:	129097316 129110093(kmt2bb)

CLUM:

117739150(kmt2ba) 117745348(kmt2bb)

PSWI:

130193257 130213312(kmt2bb)

MSAM:

119898296(kmt2bb) 119907919(kmt2ba)

SCHU:

122864889(kmt2ba) 122881423(kmt2bb)

CUD:	121512979(kmt2bb) 121524572(kmt2ba)

ALAT:

119005807(kmt2bb) 119016569(kmt2ba)

MZE:	101467874 101481309(kmt2b)

ONL:	100689867 100700132(kmt2b)

OAU:	116319815(kmt2bb) 116320047(kmt2ba)

OLA:	101157226 101174945(kmt2b)

OML:	112143279(kmt2bb) 112162480(kmt2ba)

CSAI:

133428222(kmt2bb) 133461414(kmt2ba)

XMA:	102222844 102229737(kmt2b)

XCO:	114142152(kmt2b) 114156616

XHE:	116713912(kmt2b) 116730674

PRET:

103472504 103478519(kmt2b)

PFOR:

103143107(kmt2b) 103146865

PLAI:

106945874(kmt2b) 106960535

PMEI:

106919951 106928418(kmt2b)

GAF:	122831339(kmt2bb) 122843072(kmt2ba)

PPRL:

129371385(kmt2bb) 129374949

CVG:	107086122(kmt2b) 107101115

CTUL:

119775533(kmt2bb) 119779627

GMU:	124864459(kmt2bb) 124879104

NFU:	107372442(kmt2b) 107394636

KMR:	108240680(kmt2ba) 108241999(kmt2bb)

ALIM:

106517704(kmt2b) 106537143

NWH:	119409464(kmt2bb) 119425834(kmt2ba)

AOCE:

111571387 111577070(kmt2b)

MCEP:

125015742(kmt2bb) 125020556

CSEM:

103388508(kmt2b) 103394161

POV:	109633105(kmt2b) 109638782

SSEN:

122774538(kmt2bb) 122786593(kmt2ba)

HHIP:

117770576 117776549(kmt2bb)

HSP:	118113601(kmt2bb) 118124314(kmt2ba)

SMAU:

118291930(kmt2ba) 118300255(kmt2bb)

LCF:	108888836 108890658(kmt2bb)

SDU:	111223127 111234049(kmt2b)

SLAL:

111657578 111664979(kmt2b)

XGL:	120783762(kmt2bb) 120786435(kmt2ba)

HCQ:	109514546 109525616(kmt2b)

SSCV:

125975503 125987183

SBIA:

133499114(kmt2ba) 133500576(kmt2bb)

PEE:	133396134 133401744(kmt2bb)

PTAO:

133471228(kmt2ba) 133479257(kmt2bb)

BPEC:

110161138 110171497(kmt2b)

MALB:

109971699(kmt2b) 109973928

BSPL:

114843364(kmt2bb) 114866253(kmt2ba)

SJO:	128366747(kmt2bb) 128374749(kmt2ba)

SASA:

106570121 106577926 106588247 106594944 106605615

STRU:

115164151 115173397 115176084 115177337

OTW:	112226731 112230014 112246968 112264909

OMY:	110487656 110496098 110510370 110538034

OGO:	123998007 124005299 124012097 124043698

ONE:	115101452 115128277 115131800 115140822

OKI:	109900891 109901820 109903796 109907621

OKE:	118367807 118373824 118398340 118399190

SALP:

111955007 111955466 111958933 111964605

SNH:	120022385 120026748 120030911 120047222

CCLU:

121556964 121571388 121585346 121586284

ELS:	105007527 105019114(kmt2b)

SFM:	108930328(kmt2b)

PKI:	111833696(kmt2b) 111839650

AANG:

118212590(kmt2bb) 118233860

LOC:	102692171(kmt2b)

PSPA:

121299031(kmt2bb) 121304193

ARUT:

117434041(kmt2bb) 117971976 117971978

HOC:

CGLO:

CSET:

AGB:

FCD:

DMK:

PJA:

PCLA:

EAF:

PPOI:

EGL:

NVE:	5501691 5502141

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

AQU:

Reference

PMID:17707229

Authors

Demers C, Chaturvedi CP, Ranish JA, Juban G, Lai P, Morle F, Aebersold R, Dilworth FJ, Groudine M, Brand M

Title

Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.

Journal

Mol Cell 27:573-84 (2007)
DOI:10.1016/j.molcel.2007.06.022

Sequence

[hsa:9757]

Reference

PMID:17500065

Authors

Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K

Title

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

Journal

J Biol Chem 282:20395-406 (2007)
DOI:10.1074/jbc.M701574200

Sequence

[hsa:9757]

LinkDB

DBGET integrated database retrieval system