KEGG ORTHOLOGY: K15619

ORTHOLOGY: K15619

Entry

K15619                      KO

Symbol

SPINT1

Name

Kunitz-type protease inhibitor 1

Pathway

map05202

Transcriptional misregulation in cancer

map05215

Prostate cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K15619  SPINT1; Kunitz-type protease inhibitor 1
  09162 Cancer: specific types
   05215 Prostate cancer
    K15619  SPINT1; Kunitz-type protease inhibitor 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K15619  SPINT1; Kunitz-type protease inhibitor 1
Peptidases and inhibitors [BR:ko01002]
Peptidase inhibitors
  Family I2: Kunitz - BPTI family
   K15619  SPINT1; Kunitz-type protease inhibitor 1

Other DBs

GO:

0004867

Genes

HSA:	6692(SPINT1)

PTR:	453342(SPINT1)

PPS:	100980002(SPINT1)

GGO:	101153457(SPINT1)

PON:	100436466(SPINT1)

NLE:	100585940(SPINT1)

HMH:	116481452(SPINT1)

MCC:	704578(SPINT1)

MCF:	102122045(SPINT1)

MTHB:

126957200 126959835

MNI:	105492090(SPINT1)

CSAB:

103245811(SPINT1)

CATY:

105574182(SPINT1)

PANU:

101019993(SPINT1)

TGE:	112627932(SPINT1)

MLEU:

105546217(SPINT1)

RRO:	104682140(SPINT1)

RBB:	108523426(SPINT1)

TFN:	117070849(SPINT1)

PTEH:

111524255(SPINT1)

CANG:

105504955(SPINT1)

CJC:	100412168(SPINT1)

SBQ:	101032978(SPINT1)

CIMI:

108306158(SPINT1)

CSYR:

103275321(SPINT1)

MMUR:

105872453(SPINT1)

LCAT:

123626113(SPINT1)

PCOQ:

105814517(SPINT1)

OGA:	100957435(SPINT1)

MMU:	20732(Spint1)

MCAL:

110289694(Spint1)

MPAH:

110318999(Spint1)

RNO:	311331(Spint1)

MCOC:

116090712(Spint1)

ANU:	117702565(Spint1)

MUN:	110550615(Spint1)

CGE:	100761602(Spint1)

MAUA:

101837559(Spint1)

PROB:

127221625(Spint1)

PLEU:

114681143(Spint1)

MORG:

121465448(Spint1)

MFOT:

126495203

AAMP:

119814653(Spint1)

NGI:	103744920(Spint1)

HGL:	101720247(Spint1)

CPOC:

100731222(Spint1)

CCAN:

109694216(Spint1)

DSP:	122114621(Spint1)

PLOP:

125340821(Spint1)

NCAR:

124977392

MMMA:

107138214(Spint1)

OCU:

100345098

OPI:	101527354(SPINT1)

TUP:	102473206(SPINT1)

GVR:	103588539(SPINT1)

CFA:	487501(SPINT1)

CLUD:

112676103(SPINT1)

VVP:	112919957(SPINT1)

VLG:	121485522(SPINT1)

NPO:	129504189(SPINT1)

AML:	100473505(SPINT1)

UMR:	103673545(SPINT1)

UAH:	113242021(SPINT1)

UAR:	123775521(SPINT1)

ELK:

111161450

LLV:

125105284

MPUF:

101681232(SPINT1)

MNP:	131999639(SPINT1)

MLK:	131836122(SPINT1)

NVS:	122893162(SPINT1)

ORO:	101368336(SPINT1)

EJU:	114221474(SPINT1)

ZCA:	113910501(SPINT1)

MLX:	118003312(SPINT1)

NSU:	110585259(SPINT1)

LWW:	102737514(SPINT1)

FCA:	101085636(SPINT1)

PYU:	121041520(SPINT1)

PCOO:

112855156(SPINT1)

PBG:	122468030(SPINT1)

PVIV:

125168060(SPINT1)

LRUF:

124508252

PTG:	102961204(SPINT1)

PPAD:

109263140(SPINT1)

PUC:

125909867

AJU:

106968572

HHV:	120232283(SPINT1)

BTA:	534040(SPINT1)

BOM:	102265173(SPINT1)

BIU:	109564944(SPINT1)

BBUB:

102397807(SPINT1)

BBIS:

104994418(SPINT1)

CHX:	102172450(SPINT1)

OAS:	101111287(SPINT1)

BTAX:

128054446(SPINT1)

ODA:	120853195(SPINT1)

CCAD:

122443400(SPINT1)

MBEZ:

129562631(SPINT1)

SSC:	100157387(SPINT1)

CFR:	102504207(SPINT1)

CBAI:

105077049(SPINT1)

CDK:	105096869(SPINT1)

VPC:	102545879(SPINT1)

BACU:

103009906(SPINT1)

BMUS:

118891348(SPINT1)

LVE:	103073315(SPINT1)

OOR:	101276699(SPINT1)

DLE:	111181728(SPINT1)

PCAD:

102991946(SPINT1)

PSIU:

116748390(SPINT1)

NASI:

112391242(SPINT1)

ECB:	100071304(SPINT1)

EPZ:	103564740(SPINT1)

EAI:	106841370(SPINT1)

MYB:	102257664(SPINT1)

MYD:	102757690(SPINT1)

MMYO:

118649947(SPINT1)

MLF:	102420035(SPINT1)

PKL:	118723460(SPINT1)

EFUS:

103287323(SPINT1)

MNA:	107542962(SPINT1)

DRO:	112311875(SPINT1)

SHON:

118993571(SPINT1)

AJM:	119061299(SPINT1)

PDIC:

114492230(SPINT1)

PHAS:

123808049(SPINT1)

MMF:	118618493(SPINT1)

PPAM:

129064059(SPINT1)

HAI:	109384036(SPINT1)

RFQ:	117023794(SPINT1)

PALE:

102892287(SPINT1)

PGIG:

120587168(SPINT1)

PVP:	105288645(SPINT1)

RAY:	107514475(SPINT1)

MJV:	108384314(SPINT1)

TOD:	119239543(SPINT1)

SARA:

101554038(SPINT1)

SETR:

126020011(SPINT1)

LAV:	100671409(SPINT1)

TMU:

101350726

ETF:	101663649(SPINT1)

DNM:	101411432(SPINT1)

MDO:	100032047(SPINT1)

GAS:	123235961(SPINT1)

SHR:	100933182(SPINT1)

AFZ:

127549244

PCW:	110223715(SPINT1)

OAA:	100089180(SPINT1)

GGA:	423206(SPINT1)

PCOC:

116229189(SPINT1)

MGP:	100540482(SPINT1)

CJO:	107314832(SPINT1)

TPAI:

128086207(SPINT1)

LMUT:

125695045(SPINT1)

NMEL:

110401447(SPINT1)

APLA:

101804600(SPINT1)

ACYG:

106043273(SPINT1)

CATA:

118244736(SPINT1)

AFUL:

116489337(SPINT1)

TGU:	100226787(SPINT1)

LSR:	110472090(SPINT1)

SCAN:

103826669(SPINT1)

PMOA:

120500512(SPINT1)

OTC:	121334391(SPINT1)

PRUF:

121349559(SPINT1)

GFR:	102045453(SPINT1)

FAB:	101820871(SPINT1)

OMA:	130253579(SPINT1)

PHI:	102102872(SPINT1)

PMAJ:

107206390(SPINT1)

CCAE:

111930201(SPINT1)

CCW:	104698319(SPINT1)

CBRC:

103620757(SPINT1)

ETL:	114059297(SPINT1)

ZAB:	102062335(SPINT1)

ACHL:

103800776(SPINT1)

SVG:	106848967(SPINT1)

MMEA:

130573199(SPINT1)

HRT:	120754501(SPINT1)

FPG:	101924714(SPINT1)

FCH:	102056380(SPINT1)

CLV:	102091675(SPINT1)

EGZ:	104134090(SPINT1)

NNI:	104020363(SPINT1)

PCRI:

104036584(SPINT1)

PLET:

104626677(SPINT1)

EHS:	104516502(SPINT1)

PCAO:

104044103(SPINT1)

ACUN:

113480557(SPINT1)

TALA:

104367027(SPINT1)

PADL:

103912823(SPINT1)

AFOR:

103897498(SPINT1)

ACHC:

115352098(SPINT1)

HALD:

104313905(SPINT1)

HLE:	104839673(SPINT1)

AGEN:

126049500

GCL:

127016845

CCRI:

104157323(SPINT1)

CSTI:

104561837(SPINT1)

CMAC:

104478730(SPINT1)

MUI:	104543485(SPINT1)

BREG:

104633177(SPINT1)

FGA:	104075501(SPINT1)

GSTE:

104254775(SPINT1)

LDI:	104343770(SPINT1)

MNB:	103780340(SPINT1)

OHA:	104328105(SPINT1)

NNT:	104401794(SPINT1)

SHAB:

115606614(SPINT1)

DPUB:

104309433(SPINT1)

PGUU:

104464984(SPINT1)

ACAR:

104522332(SPINT1)

CPEA:

104390427(SPINT1)

AVIT:

104279645(SPINT1)

CVF:	104295873(SPINT1)

RTD:	128909424(SPINT1)

CUCA:

104067283(SPINT1)

TEO:	104380723(SPINT1)

BRHI:

104490257(SPINT1)

AAM:	106498361(SPINT1)

AROW:

112966114(SPINT1)

NPD:	112942486(SPINT1)

TGT:	104568980(SPINT1)

DNE:	112987575(SPINT1)

SCAM:

104150385(SPINT1)

ASN:	102385030(SPINT1)

AMJ:	102574141(SPINT1)

CPOO:

109321449(SPINT1)

GGN:	109298756(SPINT1)

PSS:	102452161(SPINT1)

CMY:	102932118(SPINT1)

CCAY:

125638830(SPINT1)

DCC:	119858106(SPINT1)

CPIC:

101946553(SPINT1)

TST:	117876840(SPINT1)

CABI:

116818279(SPINT1)

MRV:	120405283(SPINT1)

ACS:	100556267(spint1)

ASAO:

132766118(SPINT1)

PVT:	110080117(SPINT1)

SUND:

121926830(SPINT1)

PBI:	103061939(SPINT1)

PMUR:

107291012(SPINT1)

CTIG:

120299231(SPINT1)

TSR:	106545015(SPINT1)

PGUT:

117665676(SPINT1)

APRI:

131187627(SPINT1)

PTEX:

113442464(SPINT1)

NSS:	113410139(SPINT1)

VKO:	123026298(SPINT1)

PMUA:

114593957(SPINT1) 114603440

PRAF:

128410952(SPINT1)

ZVI:	118083204(SPINT1)

HCG:	128340442(SPINT1)

GJA:	107113928(SPINT1)

STOW:

125427290(SPINT1)

EMC:	129323872(SPINT1)

XLA:	108699269(spint1.L) 108700587

XTR:	100488118(spint1)

NPR:	108794335(SPINT1)

RTEM:

120920680(SPINT1)

BBUF:

120981916(SPINT1)

BGAR:

122921915(SPINT1)

MUO:	115477390(SPINT1)

GSH:	117363506(SPINT1)

DRE:	406426(spint1a) 797346(spint1b)

SRX:	107715686(spint1) 107716057 107726576

SANH:

107663135 107670253(spint1) 107678770

SGH:	107552882 107560182 107565447(spint1)

CCAR:

109060089 109093882

CAUA:

113079037 113117742 113121270

CGIB:

127933225 127976366 127984562

PTET:

122325214(spint1b) 122334442(spint1a)

LROH:

127151864(spint1b) 127179939(spint1a)

OMC:	131522896(spint1a) 131526532(spint1b)

PPRM:

120473266(spint1a) 120476175

RKG:	130085685(spint1a) 130086707(spint1b)

MAMB:

125269267(spint1a) 125278138(spint1b)

CIDE:

127498860 127502732

MASI:

127410180 127410710 127455186

TROS:

130560834(spint1a) 130566367(spint1b)

TDW:	130434895(spint1b) 130437235(spint1a)

MANU:

129418049(spint1a)

IPU:	108257674(spint1b) 108269617(spint1a)

IFU:	128601259(spint1b) 128612746

PHYP:

113525046 113538656(spint1)

SMEO:

124376741(spint1b) 124390236(spint1a)

TFD:	113638750(spint1b) 113659667(spint1a)

TVC:	132842965(spint1b) 132852769(spint1a)

AMEX:

103024868 103032340(spint1)

CMAO:

118815948(spint1b) 118823678(spint1a)

EEE:	113571328(spint1) 113574350

CHAR:

105907258 105908259(spint1a)

TRU:	101073645 101079502(spint1)

TFS:	130513168(spint1a) 130516462

TNG:	GSTEN00008413G001

LCO:	104924798(spint1) 104933381

NCC:	104953743(spint1)

TBEN:

117480560(spint1a) 117483609

CGOB:

115004627 115027336(spint1)

PGEO:

117468140(spint1a)

GACU:

117549891(spint1a)

EMAC:

134877243 134881432(spint1a)

ELY:	117267605(spint1a) 117270500

EFO:	125897324 125900472(spint1a)

PLEP:

121953783(spint1a)

SLUC:

116035520(spint1a) 116061384

ECRA:

117935565(spint1a)

ESP:	116669871(spint1)

PFLV:

114546476(spint1)

GAT:	120814762 120832545(spint1a)

PPUG:

119195242 119228002(spint1a)

AFB:	129103481(spint1a) 129107523

CLUM:

117727129 117751467(spint1a)

PSWI:

130201980(spint1a) 130202438

MSAM:

119909402 119910593(spint1a)

SCHU:

122861340(spint1a) 122862655

CUD:	121521261 121526799(spint1a)

ALAT:

119004904(spint1a) 119012770

MZE:	101464875 101473873(spint1)

ONL:	100695926 109194167(spint1)

OAU:	116322330(spint1a) 116335145

OLA:	101157585 101173105(spint1) 101175207

OML:	112141147 112141279 112157655

CSAI:

133418382 133462551(spint1a)

XMA:	102223662 102231699(spint1)

XCO:	114134284(spint1) 114158159

XHE:	116709156(spint1) 116733914

PRET:

103457124 103458554(spint1)

PFOR:

103136087(spint1) 103153707

PLAI:

106953624(spint1) 106961533

PMEI:

106913922(spint1) 106914502

GAF:	122825611 122845591(spint1a)

PPRL:

129353682 129365123(spint1a)

CVG:	107094384(spint1) 107104114

CTUL:

119777608 119789553(spint1a)

GMU:	124856047(spint1a) 124881492

NFU:	107377908 107392477(spint1)

KMR:	108237189(spint1a) 108242575

ALIM:

106519872(spint1) 106528670

NWH:	119418400(spint1b) 119427798(spint1a)

AOCE:

111577929(spint1) 111582617

MCEP:

124998885 125023997(spint1a)

CSEM:

103381353 103389490(spint1)

POV:	109628210(spint1) 109646404

SSEN:

122760308 122763494 122765520(spint1a)

HHIP:

117756620(spint1a) 117758726

HSP:	118104001 118116937(spint1a)

SMAU:

118286392(spint1a) 118290670

LCF:	108892602(spint1a)

SDU:	111225957(spint1) 111231748

SLAL:

111652481(spint1) 111656893

XGL:	120788627 120795258(spint1a)

HCQ:	109515991 109516021 109524883

SSCV:

125981430 125990494

SBIA:

133513640(spint1a)

PEE:	133412620(spint1a) 133416665

PTAO:

133468392 133488364(spint1a)

BPEC:

110155331(spint1) 110164255

MALB:

109968309(spint1) 109974449

BSPL:

114848900(spint1a) 114849989

SJO:	128375415(spint1a) 128377446

SASA:

106571141(SPIT1) 106610865(SPIT1)

STRU:

115162392 115172673 115175076

OTW:	112249910(spint1b) 112256634 112261848(spint1a)

OMY:	100136686 110505477 110529352(spint1b)

OGO:	123990537(spint1b) 124002250(spint1a) 124046405

ONE:	115107542 115138447 115146270

OKI:	109894548 109900526 109903991

OKE:	118362425 118368368 118398864

SALP:

111954427 112068197 112079463

SNH:	120023463 120024436(spint1b) 120060252

CCLU:

121539226 121544965 121552506(spint1b)

ELS:	105015646(spint1) 105021702

SFM:	108919608(spint1)

PKI:	111838886(spint1) 111861017

AANG:

118212512(spint1a) 118230881

LOC:	102691807(spint1)

PSPA:

121324366 121329967

ARUT:

117420791 117973948

PSEX:

120518550(spint1a)

LCM:	102351733(SPINT1)

CMK:

RTP:

CPLA:

HOC:

LERI:

ATEN:

Reference

PMID:9045658

Authors

Shimomura T, Denda K, Kitamura A, Kawaguchi T, Kito M, Kondo J, Kagaya S, Qin L, Takata H, Miyazawa K, Kitamura N

Title

Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor.

Journal

J Biol Chem 272:6370-6 (1997)
DOI:10.1074/jbc.272.10.6370

Sequence

[hsa:6692]

Reference

PMID:18832587

Authors

Nagaike K, Kawaguchi M, Takeda N, Fukushima T, Sawaguchi A, Kohama K, Setoyama M, Kataoka H

Title

Defect of hepatocyte growth factor activator inhibitor type 1/serine protease inhibitor, Kunitz type 1 (Hai-1/Spint1) leads to ichthyosis-like condition and abnormal hair development in mice.

Journal

Am J Pathol 173:1464-75 (2008)
DOI:10.2353/ajpath.2008.071142

LinkDB

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