Entry Symbol DHKTD1
Name 2-oxoadipate dehydrogenase E1 component [EC:1.2.4.-]
Pathway map01110 Biosynthesis of secondary metabolites
map01210 2-Oxocarboxylic acid metabolism
Module M00032 Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
Reaction R01933 2-oxoadipate dehydrogenase complex
R01940 2-oxoadipate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating)
Disease H00264 Charcot-Marie-Tooth disease
H02644 Alpha-aminoadipic and alpha-ketoadipic aciduria
Brite KEGG Orthology (KO) [BR:ko00001 ]ko03029 ] BRITE hierarchy Genes » show all Taxonomy UniProt Reference Authors Xu W, Zhu H, Gu M, Luo Q, Ding J, Yao Y, Chen F, Wang Z
Title DHTKD1 is essential for mitochondrial biogenesis and function maintenance.
Journal Reference Authors Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O
Title Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
Journal Reference Authors Nemeria NS, Gerfen G, Nareddy PR, Yang L, Zhang X, Szostak M, Jordan F
Title The mitochondrial 2-oxoadipate and 2-oxoglutarate dehydrogenase complexes share their E2 and E3 components for their function and both generate reactive oxygen species.
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