KEGG   ORTHOLOGY: K15969
Entry
K15969            Tight     KO                                     
Symbol
tcmH
Name
tetracenomycin F1 monooxygenase [EC:1.13.12.21]
Pathway
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00783  Tetracenomycin C/8-demethyltetracenomycin C biosynthesis, tetracenomycin F2 => tetracenomycin C/8-demethyltetracenomycin C
Reaction
R06700  tetracenomycin-F1:oxygen C5-monooxygenase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15969  tcmH; tetracenomycin F1 monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15969  tcmH; tetracenomycin F1 monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.12  With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
    1.13.12.21  tetracenomycin-F1 monooxygenase
     K15969  tcmH; tetracenomycin F1 monooxygenase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Oxygenase
   K15969  tcmH; tetracenomycin F1 monooxygenase
Genes
SGU: SGLAU_26340(tcmH)
Reference
PMID:8244926
  Authors
Summers RG, Wendt-Pienkowski E, Motamedi H, Hutchinson CR
  Title
The tcmVI region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens encodes the tetracenomycin F1 monooxygenase, tetracenomycin F2 cyclase, and, most likely, a second cyclase.
  Journal
J Bacteriol 175:7571-80 (1993)
DOI:10.1128/JB.175.23.7571-7580.1993
  Sequence
[sgu:SGLAU_26340]
Reference
PMID:8329392
  Authors
Shen B, Hutchinson CR
  Title
Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.
  Journal
Biochemistry 32:6656-63 (1993)
DOI:10.1021/bi00077a019
LinkDB

DBGET integrated database retrieval system