 | | ORTHOLOGY: K16049 | |
| Entry |
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| Symbol |
hsaC
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| Name |
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase [EC: 1.13.11.25]
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| Pathway |
| map01120 | Microbial metabolism in diverse environments |
| map01220 | Degradation of aromatic compounds |
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| Reaction |
| R04597 | 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing) |
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| Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09111 Xenobiotics biodegradation and metabolism
00984 Steroid degradation
K16049 hsaC; 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
1.13.11 With incorporation of two atoms of oxygen
1.13.11.25 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
K16049 hsaC; 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
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| Other DBs |
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| Genes |
» show all
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| Reference |
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| Authors |
Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD |
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| Title |
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. |
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| Journal |
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| Reference |
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| Authors |
Ouellet H, Johnston JB, de Montellano PR |
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| Title |
Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis. |
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| Journal |
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| Reference |
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| Authors |
Yam KC, D'Angelo I, Kalscheuer R, Zhu H, Wang JX, Snieckus V, Ly LH, Converse PJ, Jacobs WR Jr, Strynadka N, Eltis LD |
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| Title |
Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis. |
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| Journal |
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| Sequence |
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| LinkDB |
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