KEGG ORTHOLOGY: K17256

ORTHOLOGY: K17256

Entry

K17256                      KO

Symbol

IGFALS, ALS

Name

insulin-like growth factor-binding protein complex acid labile subunit

Pathway

map04935

Growth hormone synthesis, secretion and action

Disease

H01907

Acid-labile subunit deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    K17256  IGFALS, ALS; insulin-like growth factor-binding protein complex acid labile subunit
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K17256  IGFALS, ALS; insulin-like growth factor-binding protein complex acid labile subunit
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K17256  IGFALS, ALS; insulin-like growth factor-binding protein complex acid labile subunit

Other DBs

GO:

0005520

Genes

HSA:	3483(IGFALS)

PTR:	467869(IGFALS)

PPS:	100983691(IGFALS)

GGO:	101124823(IGFALS)

PON:	100437823(IGFALS)

NLE:	100587629(IGFALS)

HMH:	116462517(IGFALS)

MCC:	722493(IGFALS)

MCF:	102128549(IGFALS)

MTHB:

126944624

MNI:	105485836(IGFALS)

CSAB:

103226344(IGFALS)

CATY:

105573693(IGFALS)

PANU:

101016557(IGFALS)

TGE:	112613709(IGFALS)

MLEU:

105529787(IGFALS)

RBB:	108519389(IGFALS)

TFN:	117097839(IGFALS)

PTEH:

111524083(IGFALS)

CANG:

105522863(IGFALS)

SBQ:	101048750(IGFALS)

CIMI:

108291004(IGFALS)

CSYR:

103272852(IGFALS)

MMUR:

105859593(IGFALS)

LCAT:

123631457(IGFALS)

PCOQ:

105813095(IGFALS)

OGA:	100953043(IGFALS)

MMU:	16005(Igfals)

MCAL:

110312664(Igfals)

MPAH:

110338369(Igfals)

RNO:	79438(Igfals)

MCOC:

116078620(Igfals)

ANU:	117711052(Igfals)

MUN:	110548697(Igfals)

CGE:	100753202(Igfals)

MAUA:

101824991(Igfals)

PROB:

127219537(Igfals)

PLEU:

114681231(Igfals)

MORG:

121463936(Igfals)

MFOT:

126498356

AAMP:

119812603(Igfals)

NGI:	103752435(Igfals)

HGL:	101726656(Igfals)

CPOC:

100728190(Igfals)

CCAN:

109690176(Igfals)

DORD:

105981954(Igfals)

DSP:	122123767(Igfals)

PLOP:

125340404 125340405(Igfals)

NCAR:

124970517

MMMA:

107146737(Igfals)

OCU:

127486403

OPI:	101520944(IGFALS)

TUP:	102483603(IGFALS)

GVR:	103597667(IGFALS)

CFA:	490069(IGFALS)

CLUD:

112640565(IGFALS)

VVP:	112909075(IGFALS)

VLG:	121486519(IGFALS)

NPO:	129519451(IGFALS)

AML:	100468838(IGFALS)

UMR:	121103628(IGFALS)

UAH:	113245094(IGFALS)

UAR:	123783744(IGFALS)

ELK:

111156079

LLV:

125090183

MPUF:

101685966(IGFALS)

MNP:	132027037(IGFALS)

MLK:	131819957(IGFALS)

NVS:	122895819(IGFALS)

ORO:	101366100(IGFALS)

EJU:	114215687(IGFALS)

ZCA:	113933412(IGFALS)

MLX:	118021702(IGFALS)

NSU:	110587943(IGFALS)

LWW:	102733009(IGFALS)

FCA:	101085262(HAGH)

PYU:	121019705(IGFALS)

PCOO:

112853346(IGFALS)

PBG:	122471847(IGFALS)

PVIV:

125154359(IGFALS)

LRUF:

124525535

PPAD:

109278111(IGFALS)

PUC:

125927151

AJU:

106982756

HHV:	120241550(IGFALS)

BTA:	532494(IGFALS)

BOM:	102272323(IGFALS)

BIU:	109578229(IGFALS)

BBUB:

102397296(IGFALS)

CHX:	108633905(IGFALS)

OAS:	101111599(IGFALS)

BTAX:

128060152(IGFALS)

ODA:	120873059(IGFALS)

CCAD:

122432933(IGFALS)

MBEZ:

129545234(IGFALS)

SSC:	397322(IGFALS)

CFR:	102508475(IGFALS)

CBAI:

105064871(IGFALS)

CDK:	105099734(IGFALS)

VPC:	102534341(IGFALS)

BACU:

103003212(IGFALS)

BMUS:

118880883(IGFALS)

LVE:	103069456(IGFALS)

OOR:	101281079(IGFALS)

DLE:	111185149(IGFALS)

PCAD:

102991142(IGFALS)

PSIU:

116740453(IGFALS)

NASI:

112409454(IGFALS)

ECB:	111767589(IGFALS)

EPZ:	103540033(IGFALS)

EAI:	106836216(IGFALS)

MYB:	102257089(IGFALS)

MYD:	102762067(IGFALS)

MMYO:

118656291(IGFALS)

MLF:	102418180(IGFALS)

PKL:	118703873(IGFALS)

EFUS:

103290487(IGFALS)

MNA:	107533393(IGFALS)

DRO:	112298290(IGFALS)

SHON:

118978771(IGFALS)

AJM:	119058165(IGFALS)

PDIC:

114512218(IGFALS)

PHAS:

123807172(IGFALS)

MMF:	118642745(IGFALS)

PPAM:

129083572(IGFALS)

HAI:	109385793(IGFALS)

RFQ:	117019423(IGFALS)

PALE:

102885090(IGFALS)

PGIG:

120620228(IGFALS)

PVP:	105303317(IGFALS)

RAY:	107506073(IGFALS)

MJV:	108384448(IGFALS)

TOD:	119242386(IGFALS)

SARA:

101542659(IGFALS)

SETR:

126000903(IGFALS)

LAV:	100666000(IGFALS)

TMU:

101347655

ETF:	101657104(IGFALS)

DNM:	101417280(IGFALS)

MDO:	100011409(IGFALS)

GAS:	123230912(IGFALS)

SHR:	100924106(IGFALS)

AFZ:

127543391

PCW:	110221855(IGFALS)

OAA:	100091187(IGFALS)

GGA:	427649(IGFALS)

PCOC:

116230272(IGFALS)

MGP:	100547647(IGFALS)

CJO:	107320889(IGFALS)

TPAI:

128079092(IGFALS)

LMUT:

125700825(IGFALS)

NMEL:

110405933(IGFALS)

APLA:

101800279(IGFALS)

ACYG:

106033341(IGFALS)

CATA:

118249322(IGFALS)

AFUL:

116495133(IGFALS)

TGU:	100220636(IGFALS)

LSR:	110470195(IGFALS)

SCAN:

103817949(IGFALS)

PMOA:

120512910(IGFALS)

OTC:	121336168(IGFALS)

PRUF:

121350647(IGFALS)

GFR:	102039609(IGFALS)

FAB:	101813183(IGFALS)

OMA:	130259104(IGFALS)

PHI:	102111708(IGFALS)

PMAJ:

107211078(IGFALS)

CCAE:

111936237(IGFALS)

CCW:	104684931(IGFALS)

CBRC:

103620465(IGFALS)

ETL:	114060238(IGFALS)

ZAB:	102061295(IGFALS)

ACHL:

103798667

SVG:	106860595(IGFALS)

MMEA:

130582109(IGFALS)

HRT:	120759785(IGFALS)

FPG:	101920790(IGFALS)

FCH:	102057682(IGFALS)

CLV:	102097403(IGFALS)

EGZ:	104127367(IGFALS)

NNI:	104023529(IGFALS)

PCRI:

104038494(IGFALS)

PLET:

104621402(IGFALS)

EHS:	104506140(IGFALS)

PCAO:

104042683(IGFALS)

ACUN:

113485527(IGFALS)

TALA:

104368841(IGFALS)

PADL:

103917197(IGFALS)

AFOR:

103898152(IGFALS)

ACHC:

115335716(IGFALS)

HALD:

104320790

HLE:	104831465(IGFALS)

AGEN:

126034294

GCL:

127022467

CCRI:

104169213

CSTI:

104557299(IGFALS)

CMAC:

104479281

MUI:	104542260(IGFALS)

BREG:

104641308(IGFALS)

FGA:	104074269(IGFALS)

GSTE:

104255590(IGFALS)

LDI:	104353120(IGFALS)

MNB:	103772884(IGFALS)

OHA:	104336102(IGFALS)

NNT:

104410077

SHAB:

115606342(IGFALS)

DPUB:

104304824(IGFALS)

PGUU:

104464450(IGFALS)

ACAR:

104528366(IGFALS)

CPEA:

104389479(IGFALS)

AVIT:

104279612

CVF:	104292223(IGFALS)

RTD:	128913455(IGFALS)

CUCA:

104068192(IGFALS)

TEO:	104379337(IGFALS)

BRHI:

104499031(IGFALS)

AAM:	106500008(IGFALS)

AROW:

112965134(IGFALS)

NPD:	112955664(IGFALS)

TGT:	104567114(IGFALS)

DNE:	112981035(IGFALS)

SCAM:

104147551(IGFALS)

ASN:	102378098(IGFALS)

AMJ:	102575291(IGFALS)

CPOO:

109313376(IGFALS)

GGN:	109290824(IGFALS)

PSS:	106732496(IGFALS)

CMY:	102929900(IGFALS)

CCAY:

125643793(IGFALS)

DCC:	119862781(IGFALS)

CPIC:

101942471(IGFALS)

TST:	117884347(IGFALS)

CABI:

116816469(IGFALS)

MRV:	120372870(IGFALS)

ACS:	100567817(igfals)

ASAO:

132781852(IGFALS)

PVT:	110086694(IGFALS)

SUND:

121914412(IGFALS)

PBI:	103064923(IGFALS)

PMUR:

107293799(IGFALS)

CTIG:

120315803(IGFALS)

TSR:	106550187(IGFALS)

PGUT:

117673102(IGFALS)

APRI:

131185389(IGFALS)

PTEX:

113438716(IGFALS)

NSS:	113421875(IGFALS)

VKO:	123025049(IGFALS)

PMUA:

114584667(IGFALS)

PRAF:

128401805(IGFALS)

ZVI:	118093214(IGFALS)

HCG:	128336336(IGFALS)

GJA:	107105454(IGFALS)

STOW:

125431735(IGFALS)

EMC:	129340076(IGFALS)

XLA:	100101314(igfals.L)

XTR:	100489984(igfals)

NPR:	108801901(IGFALS)

RTEM:

120943155(IGFALS)

BBUF:

121008131(IGFALS)

BGAR:

122944850(IGFALS)

MUO:	115476572(IGFALS)

GSH:	117345539(IGFALS)

DRE:	570758(igfals)

SRX:	107710645 107719182

SANH:

107674637 107703367

SGH:	107550298 107550300 107565761

CCAR:

109049421 109049507

CAUA:

113083275(igfals)

CGIB:

127951986

PTET:

122342103(igfals)

LROH:

127155879(igfals)

OMC:	131535994(igfals)

PPRM:

120490259(igfals)

RKG:	130087096(igfals)

MAMB:

125270300(igfals)

CIDE:

127508381

MASI:

127452098

TROS:

130562080(igfals)

TDW:	130426956(igfals)

MANU:

129431669(igfals)

IPU:	108257360(igfals)

IFU:	128600281(igfals)

PHYP:

113535927(igfals)

SMEO:

124375749(igfals)

TFD:	113634877(igfals)

TVC:	132837418(igfals)

AMEX:

103036545(igfals)

CMAO:

118805770(igfals)

EEE:	113574968(igfals)

CHAR:

105899290(igfals)

TRU:	101063421(igfals)

TFS:	130514598(igfals)

LCO:	104918706(igfals) 104935596

NCC:	104966895(igfals)

TBEN:

117493504(igfals)

CGOB:

115011635(igfals)

PGEO:

117451250(igfals)

GACU:

117548803(igfals)

EMAC:

134878759(igfals)

ELY:	117267981(igfals)

EFO:	125880022(igfals)

PLEP:

121943506(si:dkey-182i3.11) 121956042(igfals)

SLUC:

116059410(igfals)

ECRA:

117942488(si:dkey-182i3.11) 117958659(igfals)

ESP:	116703483(igfals)

PFLV:

114569020(igfals)

GAT:	120828093(igfals)

PPUG:

119220032(igfals)

CLUM:

117735295(igfals)

PSWI:

130189323(igfals)

MSAM:

119882837(si:dkey-182i3.11) 119891689(igfals)

SCHU:

122868527(igfals)

CUD:	121529298(igfals)

ALAT:

119014647(igfals)

MZE:	101482232(igfals)

ONL:	100700353(igfals)

OAU:	116318398(igfals)

OLA:	101172904(igfals)

OML:	112146544(igfals)

CSAI:

133421825(igfals)

XMA:	102228015(igfals) 102229118

XCO:	114133498 114159954(igfals)

XHE:	116734865(igfals)

PRET:

103468697(igfals) 103475163

PFOR:

103138306 103143780(igfals)

PLAI:

106947961 106964054(igfals)

PMEI:

106921478 106934035(igfals)

GAF:	122821510(igfals) 122832876(si:dkey-182i3.11)

PPRL:

129352547(igfals)

CVG:	107083049(igfals)

CTUL:

119785250(igfals)

GMU:	124863194 124864300 124884321(si:dkey-182i3.11)

NFU:	107378394(igfals)

KMR:	108243687(igfals) 108247896(si:dkey-182i3.11)

ALIM:

106528700(igfals)

NWH:	119421776(igfals)

AOCE:

111567924(igfals)

MCEP:

124997510(igfals)

CSEM:

103392769(igfals)

POV:	109634210(igfals)

SSEN:

122763922(igfals)

HHIP:

117766155(igfals)

HSP:	118123473(igfals)

SMAU:

118289425(igfals)

LCF:

108902991

SDU:	111217774(igfals)

SLAL:

111660452(igfals)

XGL:	120806605(igfals)

HCQ:	109519357(igfals)

SSCV:

125983841

SBIA:

133515098(igfals)

PEE:	133414995(igfals)

PTAO:

133466542(igfals)

BPEC:

110166809(igfals)

MALB:

109965996(igfals)

BSPL:

114859861(igfals)

SJO:	128378432(igfals)

SASA:

106601095 106607361 106612733

STRU:

115171199 115198816

OTW:	112226063(igfals) 112246034 112266891

OMY:	110486336(igfals) 110503725 110538281

OGO:	123999957 124006084 124015075(igfals)

ONE:	115104203 115110343 115141674

OKI:	109893392 109898478

OKE:	118365353(igfals) 118384528

SALP:

111980779 111981408

SNH:	120034120 120036724

CCLU:

121550799 121569114

ELS:	105013389(igfals)

SFM:	108932957(igfals)

PKI:	111846421(igfals)

AANG:

118209232(si:dkey-182i3.11) 118216058 118221917 118222656

LOC:	102689280(igfals)

PSPA:

121301507(igfals) 121330080

ARUT:

117418182 117434536 117973769

PSEX:

120519978(igfals)

LCM:	102351238(IGFALS) 102363207

CMK:	103173273 103188261(igfals)

RTP:	109913531(si:dkey-182i3.11) 109918426

CPLA:

122560834

HOC:

132825573

LERI:

129696397 129707005(igfals)

BFO:	118403584 118406765 118410952 118415709 118415711 118420367 118420965 118424476 118425046 118425139 118425164 118426357 118431624 118431644 118431981 118432489

BBEL:

109463175 109465463 109465867 109466154 109466810 109472874 109474445 109474447 109474570 109476044 109476519 109484900 109484992 109485511 109485973 109486030 109486747 109487321

CIN:

100181603

SCLV:

120339889

SPU:	100892941 100893380 105446402 115923197

LPIC:

129257730 129260608 129261407 129262260 129262377 129267373

APLC:

110989538

DPO:	4813372 4813861

DPE:	6600262 6602776

DMN:	108152640 108152971

DWI:

6645289

DMO:	Dmoj_GI12285

DAZ:

DNV:

DHE:

BDR:

AGA:

ACOZ:

AARA:

ASTE:

AAG:

CQU:	CpipJ_CPIJ010495

CPII:

BCOO:

AME:

BIM:

BTER:

CCAL:

OBB:	114882176 114882647

MGEN:

117218088

NMEA:

116432174

CGIG:

122398206 122398769

SOC:	105196344 105203740

MPHA:

105831685 105837428

AEC:	105145090 105146337

ACEP:

105623997 105627838

PBAR:

105428918 105430586 105433373

VEM:	105562102 105569972

HST:	105181353 105187749 105190398

DQU:	106746551 106748174 106749233

CFO:	105250597 105254862 105257565

FEX:	115234741 115245510

LHU:	105667681 105678764

PGC:	109859211 109863839

OBO:	105278239 105286559

PCF:

PFUC:

VVE:

NVI:

CSOL:

TPRE:

LBD:	127277235 127289618

FAS:	105265269 105267956 105269404 105269406 105271691

DAM:	107039086 107041849 107042996 107045660 114841465 114841617

AGIF:

122849347 122850566 122852082 122856555 122859289

VCAN:

DSM:

NFB:

NLO:

NVG:

AROA:

105688150 105691039 105692580 105693817 125501473

TCA:	100142410 103312368 103314309 656369

DPA:	109536965 109536977 109544871

SOY:	115878138 115883073 115887514

CSET:

123314229 123319749

AGB:	108908840 108910285 108912267

LDC:

111506985

NVL:	108557378 108557815 108566668

APLN:

108733531 108741824 108744179 108744236

PPYR:

116161309 116161717 116162196 116162197 116167328 116180032 116180033 116181110

OTU:	111413500 111425949 111425950 111427787

BANY:

112045402

CCRN:

123291682 123294846

API:

100572794

RMD:	113556738 113557118 113557517

ACOO:

BTAB:

DCI:

CLEC:

NLU:	111045886 111056945

PHU:	Phum_PHUM020080

TPAL:

117652381

ZNE:	110827927 110830105 110830661

CSEC:

111862471 111866706 111872366 111874985 111875788

IEL:

124153882

PTEP:

107457364

ABRU:

129963339

UDV:	129219782 129226026 129231814 129232663

SDM:

118189667

LPOL:

106474890

HRO:	HELRODRAFT_86512

PVUL:

126807946 126818532

PCAN:

112554317 112568656

BGT:	106063965 106075337 106078093

GAE:	121378545 121386951

HRF:	124139314 124146553

HRJ:	124256910 124269470 124275047 124277851 124280193

CRG:	105319673 105336100 105339008 105342288 105345180

CVN:	111099898 111104516 111108518 111124569 111130311 111130318

CANU:

128158279 128163614 128182540 128186273 128189155 128190803 128191506

OED:	125661187 125680176 125683624

MYI:	110449269 110452314 110453874 110463651

PMAX:

117329055 117335441 117341789

MMER:

123536140

RPHI:

132719284 132726790 132735289 132753281

DPOL:

127864471

OBI:	106878200 106878584 106878986

OSN:	115212306 115213960 115216740 115226435 115231044

ADF:

107329579

HSY:	130614258 130614673

» show all

Reference

PMID:24423360

Authors

Hogler W, Martin DD, Crabtree N, Nightingale P, Tomlinson J, Metherell L, Rosenfeld R, Hwa V, Rose S, Walker J, Shaw N, Barrett T, Frystyk J

Title

IGFALS gene dosage effects on serum IGF-I and glucose metabolism, body composition, bone growth in length and width, and the pharmacokinetics of recombinant human IGF-I administration.

Journal

J Clin Endocrinol Metab 99:E703-12 (2014)
DOI:10.1210/jc.2013-3718

Sequence

[hsa:3483]

Reference

PMID:1379671

Authors

Leong SR, Baxter RC, Camerato T, Dai J, Wood WI

Title

Structure and functional expression of the acid-labile subunit of the insulin-like growth factor-binding protein complex.

Journal

Mol Endocrinol 6:870-6 (1992)
DOI:10.1210/mend.6.6.1379671

Sequence

[hsa:3483]

LinkDB

DBGET integrated database retrieval system