KEGG ORTHOLOGY: K18384

ORTHOLOGY: K18384

Entry

K18384                      KO

Symbol

L3HYPDH

Name

trans-L-3-hydroxyproline dehydratase [EC:4.2.1.77]

Pathway

map00330

Arginine and proline metabolism

map01100

Metabolic pathways

Reaction

R04374

trans-3-hydroxy-L-proline hydro-lyase (1-pyrroline-2-carboxylate-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K18384  L3HYPDH; trans-L-3-hydroxyproline dehydratase
Enzymes [BR:ko01000]
4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.77  trans-L-3-hydroxyproline dehydratase
     K18384  L3HYPDH; trans-L-3-hydroxyproline dehydratase

Other DBs

GO:

0050346

Genes

HSA:	112849(L3HYPDH)

PTR:	112204140(L3HYPDH)

PPS:	100973980(L3HYPDH)

GGO:	101151045(L3HYPDH)

PON:	100172276(L3HYPDH)

NLE:	100585615(L3HYPDH)

HMH:	116456355(L3HYPDH)

MCC:	702076(L3HYPDH)

MCF:	102115940(L3HYPDH)

MTHB:

126959106

MNI:	105473638(L3HYPDH)

CSAB:

103229098(L3HYPDH)

CATY:

105586695(L3HYPDH)

PANU:

101020713(L3HYPDH)

TGE:	112628556(L3HYPDH)

MLEU:

105546386(L3HYPDH)

RRO:	104662157(L3HYPDH)

RBB:	108524789(L3HYPDH)

TFN:	117069548(L3HYPDH)

PTEH:

111555465(L3HYPDH)

CANG:

105526034(L3HYPDH)

CJC:	100402030(L3HYPDH)

SBQ:	101037339(L3HYPDH)

CIMI:

108308185(L3HYPDH)

CSYR:

103270543(L3HYPDH)

MMUR:

105882923(L3HYPDH)

LCAT:

123648487(L3HYPDH)

PCOQ:

105819931(L3HYPDH)

OGA:	100963751(L3HYPDH)

MMU:	67217(L3hypdh)

MCAL:

110306956(L3hypdh)

MPAH:

110324746(L3hypdh)

RNO:	314214(L3hypdh)

MCOC:

116080342(L3hypdh)

ANU:	117697297(L3hypdh)

MUN:	110553551(L3hypdh)

CGE:	100764709(L3hypdh)

MAUA:

101836204(L3hypdh)

PROB:

127230674(L3hypdh)

PLEU:

114683942(L3hypdh)

MORG:

121452501(L3hypdh)

MFOT:

126508369

AAMP:

119819615(L3hypdh)

NGI:	103739192(L3hypdh)

HGL:	101725460(L3hypdh)

CPOC:

100717752(L3hypdh)

CCAN:

109696080(L3hypdh)

DORD:

105986776(L3hypdh)

DSP:	122110094(L3hypdh)

PLOP:

125362979(L3hypdh)

NCAR:

124976845

MMMA:

107138324(L3hypdh)

OCU:	100354746 127489978

OPI:	101531052(L3HYPDH)

TUP:	102490555(L3HYPDH)

GVR:	103593017(L3HYPDH)

CFA:	490715(L3HYPDH)

CLUD:

112657791(L3HYPDH)

VVP:	112921377(L3HYPDH)

VLG:	121493177(L3HYPDH)

NPO:	129495916(L3HYPDH)

AML:	100471249(L3HYPDH)

UMR:	103672703(L3HYPDH)

UAH:	113242387(L3HYPDH)

UAR:	123800580(L3HYPDH)

ELK:	111139883 111158350

LLV:

125103979

MPUF:

101686493(L3HYPDH)

MNP:	131999996(L3HYPDH)

MLK:	131836632(L3HYPDH)

NVS:	122893840(L3HYPDH)

ORO:	101365481(L3HYPDH)

EJU:	114216648(L3HYPDH)

ZCA:	113909791(L3HYPDH)

MLX:	118002357(L3HYPDH)

NSU:	110590657(L3HYPDH)

LWW:	102741642(L3HYPDH)

FCA:	101098960(L3HYPDH)

PYU:	121031841(L3HYPDH)

PCOO:

112856244(L3HYPDH)

PBG:	122469162(L3HYPDH)

PVIV:

125168942(L3HYPDH)

LRUF:

124512147

PTG:	102955955(L3HYPDH)

PPAD:

109268398(L3HYPDH)

PUC:

125909456

AJU:

106974568

HHV:	120237472(L3HYPDH)

BTA:	510525(L3HYPDH)

BOM:	102267712(L3HYPDH)

BIU:	109565207(L3HYPDH)

BBUB:

102410346(L3HYPDH)

BBIS:

104994185(L3HYPDH)

CHX:	102170980(L3HYPDH)

OAS:	101102239(L3HYPDH)

BTAX:

128053837(L3HYPDH)

ODA:	120852876(L3HYPDH)

CCAD:

122443710(L3HYPDH)

MBEZ:

129563006(L3HYPDH)

SSC:	110262303(L3HYPDH)

CFR:	102510698(L3HYPDH)

CBAI:

105074630(L3HYPDH)

CDK:	105086230(L3HYPDH)

VPC:	102545772(L3HYPDH)

BACU:

103001798(L3HYPDH)

BMUS:

118890219(L3HYPDH)

LVE:	103089729(L3HYPDH)

OOR:	101288505(L3HYPDH)

DLE:	111173103(L3HYPDH)

PCAD:

102982447(L3HYPDH)

PSIU:

116749971(L3HYPDH)

NASI:

112390509(L3HYPDH)

ECB:	100059502(L3HYPDH)

EPZ:	103560585(L3HYPDH)

EAI:	106846079(L3HYPDH)

MYB:	102251331(L3HYPDH)

MYD:	102751344(L3HYPDH)

MMYO:

118656113(L3HYPDH)

MLF:	102417956(L3HYPDH)

PKL:	118717232(L3HYPDH)

EFUS:

103283688(L3HYPDH)

MNA:	107525912(L3HYPDH)

DRO:	112311822(L3HYPDH)

SHON:

118992457(L3HYPDH)

AJM:	119045233(L3HYPDH)

PDIC:

114492810(L3HYPDH)

PHAS:

123808412(L3HYPDH)

MMF:	118615926(L3HYPDH)

PPAM:

129065768(L3HYPDH)

HAI:	109383857(L3HYPDH)

RFQ:	117023350(L3HYPDH)

PALE:

102892379(L3HYPDH)

PGIG:

120603566(L3HYPDH)

PVP:	105308841(L3HYPDH)

RAY:	107519593(L3HYPDH)

MJV:	108399464(L3HYPDH)

TOD:	119239143(L3HYPDH) 119242889 119242891

SARA:

101548981(L3HYPDH)

SETR:

126003918(L3HYPDH)

LAV:	100671364(L3HYPDH)

TMU:

101343227

ETF:	101662195(L3HYPDH)

DNM:	101430455(L3HYPDH)

MDO:	100026616(L3HYPDH)

GAS:	123237762(L3HYPDH)

SHR:	100916958(L3HYPDH)

AFZ:

127549583

PCW:	110208425(L3HYPDH)

OAA:	100086994(L3HYPDH)

GGA:	423531(L3HYPDH)

PCOC:

116236621(L3HYPDH)

MGP:	104911286(L3HYPDH)

CJO:	107315418(L3HYPDH)

TPAI:

128086846(L3HYPDH)

LMUT:

125694661(L3HYPDH)

NMEL:

110401546(L3HYPDH)

APLA:

119717200(L3HYPDH)

ACYG:

106037183(L3HYPDH)

CATA:

118250293(L3HYPDH)

AFUL:

116489961(L3HYPDH)

TGU:	100232596(L3HYPDH)

LSR:	110484108(L3HYPDH)

SCAN:

103826352(L3HYPDH)

PMOA:

120513519(L3HYPDH)

OTC:	121332936(L3HYPDH)

PRUF:

121349189(L3HYPDH)

GFR:	102042007(L3HYPDH)

FAB:	101810740(L3HYPDH)

OMA:	130254005(L3HYPDH)

PHI:	102107944(L3HYPDH)

PMAJ:

107206387(L3HYPDH)

CCAE:

111929702(L3HYPDH)

CCW:	104684550(L3HYPDH)

CBRC:

103618879(L3HYPDH)

ETL:	114069015(L3HYPDH)

ZAB:	102060997(L3HYPDH)

ACHL:

103805467(L3HYPDH)

SVG:	106850278(L3HYPDH)

MMEA:

130582508(L3HYPDH)

HRT:	120754326(L3HYPDH)

FPG:	101918943(L3HYPDH)

FCH:	102059456(L3HYPDH)

CLV:	102096316(L3HYPDH)

EGZ:	104135281(L3HYPDH)

NNI:	104009686(L3HYPDH)

PCRI:

104033273(L3HYPDH)

PLET:

104613909(L3HYPDH)

PCAO:

104053604(L3HYPDH)

ACUN:

113480427(L3HYPDH)

TALA:

104365648(L3HYPDH)

PADL:

103924269(L3HYPDH)

AFOR:

103903299(L3HYPDH)

ACHC:

115338590(L3HYPDH)

HLE:	104842095(L3HYPDH)

AGEN:

126050593

GCL:

127016613

CCRI:

104168108(L3HYPDH)

CSTI:

104556921(L3HYPDH)

BREG:

104640823(L3HYPDH)

FGA:	104069441(L3HYPDH)

GSTE:

104250558(L3HYPDH)

LDI:	104340058(L3HYPDH)

OHA:	104331475(L3HYPDH)

NNT:	104400429(L3HYPDH)

SHAB:

115606537(L3HYPDH)

DPUB:

104303369(L3HYPDH)

PGUU:

104457827(L3HYPDH)

ACAR:

104521154(L3HYPDH)

CPEA:

104392897(L3HYPDH)

AVIT:

104267399(L3HYPDH)

CVF:	104286951(L3HYPDH)

RTD:	128909230(L3HYPDH)

CUCA:

104062353(L3HYPDH)

TEO:	104369834(L3HYPDH)

BRHI:

104488119(L3HYPDH)

AAM:	106495231(L3HYPDH)

AROW:

112976272(L3HYPDH)

NPD:	112959680(L3HYPDH)

TGT:	104568158(L3HYPDH)

DNE:	112992064(L3HYPDH)

SCAM:

104141431(L3HYPDH)

ASN:	102369998(L3HYPDH)

AMJ:	102565530(L3HYPDH)

CPOO:

109320683(L3HYPDH)

GGN:	109299284(L3HYPDH)

PSS:	102462476(L3HYPDH)

CMY:	102947990(L3HYPDH)

CCAY:

125637519(L3HYPDH)

DCC:	119857882(L3HYPDH)

CPIC:

101931630(L3HYPDH)

TST:	117876845(L3HYPDH)

CABI:

116825945(L3HYPDH)

MRV:	120404156(L3HYPDH)

ACS:	100559609(l3hypdh)

ASAO:

132761213(L3HYPDH)

PVT:	110083781(L3HYPDH)

SUND:

121931884(L3HYPDH)

PBI:	103049310(L3HYPDH)

PMUR:

107294579(L3HYPDH)

CTIG:

120297162(L3HYPDH)

TSR:	106554612(L3HYPDH)

PGUT:

117675140(L3HYPDH)

APRI:

131188030(L3HYPDH)

PTEX:

113435089(L3HYPDH)

NSS:	113413706(L3HYPDH)

VKO:	123026717(L3HYPDH)

PMUA:

114600110(L3HYPDH)

PRAF:

128418660(L3HYPDH)

ZVI:	118079650(L3HYPDH)

HCG:	128337325(L3HYPDH)

GJA:	107120397(L3HYPDH)

STOW:

125427362(L3HYPDH)

EMC:	129324256(L3HYPDH)

XLA:	108698829(l3hypdh.L)

XTR:	493490(l3hypdh)

NPR:	108791712(L3HYPDH)

RTEM:

120920367(L3HYPDH)

BBUF:

120981724(L3HYPDH)

BGAR:

122921506(L3HYPDH)

MUO:	115477220(L3HYPDH)

GSH:	117363677(L3HYPDH)

DRE:	565785(l3hypdh)

SRX:

107755210

SANH:

107684001

SGH:	107601901(l3hypdh)

CCAR:

109058095(l3hypdh)

CAUA:

113120994(l3hypdh)

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

MASI:

TROS:

TDW:

MANU:

IPU:

IFU:

PHYP:

113545195(l3hypdh)

SMEO:

124376736

TFD:

113644260

TVC:

132843307

AMEX:

103042342(l3hypdh)

CMAO:

118816162

EEE:	113568740(l3hypdh)

CHAR:

105897774

TRU:	101066682(l3hypdh)

TFS:

130516620

TNG:	GSTEN00023082G001

LCO:	104930547(l3hypdh)

NCC:	104951072(l3hypdh)

TBEN:

117493077

CGOB:

115028812(l3hypdh)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116706546(l3hypdh)

PFLV:

114573751(l3hypdh)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:	101483912(l3hypdh)

ONL:	100711126(l3hypdh)

OAU:

116310790

OLA:	101166521(l3hypdh)

OML:	112140416 112157886

CSAI:

133464721

XMA:	102217165(l3hypdh)

XCO:	114158489(l3hypdh)

XHE:	116734076(l3hypdh)

PRET:

103457582(l3hypdh)

PFOR:

103138615(l3hypdh)

PLAI:

106949069(l3hypdh)

PMEI:

106919669(l3hypdh)

GAF:

122825837

PPRL:

129351220

CVG:	107083634(l3hypdh)

CTUL:

119785061

GMU:

124881893

NFU:	107377581(l3hypdh)

KMR:

108240087

ALIM:

106516924(l3hypdh)

NWH:

119418192

AOCE:

111566664(l3hypdh)

MCEP:

124998832

LCF:

108895649

SDU:	111216353(l3hypdh)

SLAL:

111652661(l3hypdh)

XGL:

120788715

HCQ:	109524865(l3hypdh)

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110155871(l3hypdh)

MALB:

109953913(l3hypdh)

BSPL:

114850092

SJO:

128377037

SASA:

106571502(l3hypdh)

STRU:

115174671(l3hypdh)

OTW:

112250415

OMY:

110529713

OGO:

123990851

ONE:	115107855(l3hypdh)

OKI:	109900837(l3hypdh)

OKE:

118398558

SALP:

111954005(l3hypdh)

SNH:

120024397

CCLU:

121552883

ELS:	105017645(l3hypdh)

SFM:	108930829(l3hypdh)

PKI:	111844408(l3hypdh)

AANG:

118229933

LOC:	102698417(l3hypdh)

PSPA:

121324778

ARUT:

117405268 117421952

PSEX:

120518842

LCM:	102352794(L3HYPDH)

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

116948451(L3HYPDH)

LRJ:	133352711(L3HYPDH)

BFO:	118406711 118406712 118406713 118407066 118407067 118419782

BBEL:

109467419 109467423

CIN:	100178125 100178684 113474013

SCLV:

120327094 120327095 120327099 120327100 120331895

SPU:	582891 585737

LPIC:

129253852 129260219 129260490 129262393

APLC:

110978363

AJC:

117107388

SKO:	100374014(l3hypdh) 100375070 100375215 100376940

PPOI:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

HRO:	HELRODRAFT_110204

LGI:	LOTGIDRAFT_118524 LOTGIDRAFT_118892

PVUL:

126821804 126830603 130010457

PCAN:

112570601

BGT:

106069189

GAE:	121366440 121371867 121390587

HRF:

124151491

HRJ:

124260739

CRG:	105344406 105346271 105346272

CVN:

111111541

CANU:

128175281 128176576 128179101

OED:	125650802 125652335 125652432

MYI:	110457033 110457034 110457035 110457044

PMAX:

117322638 117323495 117323496 117323497

MCAF:

127737123 127738825 127738826

MMER:

123536541 123536542 123545553

RPHI:

DPOL:

OBI:

OSN:

LAK:	106170700 106170725

NVE:	5495736 5501579 5507229

EPA:

110254897

ATEN:

116300698

ADF:	107329603 107343685 107343686

AMIL:

114976260 114976269

PDAM:

113665581

SPIS:

111328850

DGT:	114533622 114533660 114533661

XEN:

HMG:

HSY:

AQU:

MTM:	MYCTH_2307630

FGR:	FGSG_07885

FPU:	FPSE_11038

FPOA:

FPOAC1_011675

FVN:	FVRRES_12729

FVR:	FVEG_12059

FOX:	FOXG_03798

NHE:	NECHADRAFT_29955 NECHADRAFT_48195 NECHADRAFT_83096 NECHADRAFT_85483 NECHADRAFT_86269 NECHADRAFT_97182

FFC:	NCS54_00971900 NCS54_01110300 NCS54_01223000 NCS54_01296800

FKR:	NCS57_00021800 NCS57_00494300 NCS57_01210500

FMU:	J7337_007244

MAW:

MAC_07874

MAJ:

MAA_06218

PLJ:	VFPFJ_01628

PTKZ:

JDV02_003310

CFJ:	CFIO01_04717 CFIO01_08980

CLUP:

CLUP02_02444

CHIG:

CH63R_12526

SAPO:

SAPIO_CDS4802

PFY:	PFICI_09227 PFICI_13991

PSCO:

LY89DRAFT_595446 LY89DRAFT_688136

ANI:	ANIA_02121

AFM:	AFUA_5G02000

NFI:	NFIA_040120

ANG:	An05g02210 An08g04750

AFV:	AFLA_000360

ALUC:

AKAW2_30571A AKAW2_81362A

ACHE:

ACHE_51054S

APUU:

APUU_20930S

PCS:	N7525_002421

PDP:	PDIP_88540

TMF:	EYB26_007279

PNO:	SNOG_02266

ARAB:

EKO05_0006771

PFJ:	MYCFIDRAFT_214964

FFU:	CLAFUR5_06126

CBET:

CB0940_08787

NPA:	UCRNP2_5499

CCAC:

CcaHIS019_0312460(CcaverHIS019_0312460)

TVS:	TRAVEDRAFT_84985

DSQ:	DICSQDRAFT_166099

PSQ:	PUNSTDRAFT_62142

MRR:	Moror_4294 Moror_5541

E1B28_000033

HAXI:

HAALTHF_25520n

HTQ:	FRZ44_49700

HADH:

FRZ61_48240

PFLA:

Pflav_031310

GOG:	C1280_19355

» show all

Reference

PMID:22528483

Authors

Visser WF, Verhoeven-Duif NM, de Koning TJ

Title

Identification of a human trans-3-hydroxy-L-proline dehydratase, the first characterized member of a novel family of proline racemase-like enzymes.

Journal

J Biol Chem 287:21654-62 (2012)
DOI:10.1074/jbc.M112.363218

Sequence

[hsa:112849]

LinkDB

DBGET integrated database retrieval system