KEGG ORTHOLOGY: K18419

ORTHOLOGY: K18419

Entry

K18419                      KO

Symbol

DCGR8

Name

microprocessor complex subunit DGCR8

Disease

H01004

Velocardiofacial syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K18419  DCGR8; microprocessor complex subunit DGCR8
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Gene silencing
   microRNA pathway
    Microprocessor complex
     K18419  DCGR8; microprocessor complex subunit DGCR8

Genes

HSA:	54487(DGCR8)

PPS:	100985198(DGCR8)

PON:	100457566(DGCR8)

NLE:	100586696(DGCR8)

HMH:	116459257(DGCR8)

MCC:	100425351(DGCR8)

MCF:	102142445(DGCR8)

MTHB:

126929609

MNI:	105480708(DGCR8)

CSAB:

103222984(DGCR8)

CATY:

105601265(DGCR8)

PANU:

101024599(DGCR8)

TGE:	112632560(DGCR8)

MLEU:

105543872(DGCR8)

RRO:	104681979(DGCR8)

RBB:	108518385(DGCR8)

TFN:	117096019(DGCR8)

PTEH:

111526739(DGCR8)

CANG:

105524055(DGCR8)

CJC:	100414093(DGCR8)

SBQ:	101036513(DGCR8)

CIMI:

108291619(DGCR8)

CSYR:

103262087(DGCR8)

MMUR:

105877719(DGCR8)

LCAT:

123626163(DGCR8)

PCOQ:

105818852(DGCR8)

OGA:	100961070(DGCR8)

MMU:	94223(Dgcr8)

MCAL:

110311762(Dgcr8)

MPAH:

110329631(Dgcr8)

RNO:	287954(Dgcr8)

MCOC:

116085685(Dgcr8)

ANU:	117717977(Dgcr8)

MUN:	110553334(Dgcr8)

MAUA:

101836377(Dgcr8)

PROB:

127226902(Dgcr8)

PLEU:

114681012(Dgcr8)

MORG:

121465181(Dgcr8)

MFOT:

126489049

AAMP:

119824609(Dgcr8)

NGI:	103742055(Dgcr8)

HGL:	101725234(Dgcr8)

CPOC:

100731338(Dgcr8)

CCAN:

109684339(Dgcr8)

DORD:

105997234(Dgcr8)

DSP:	122095907(Dgcr8)

PLOP:

125349384(Dgcr8)

NCAR:

124990311

MMMA:

107154731(Dgcr8)

OCU:

100351620

OPI:	101522652(DGCR8)

GVR:	103600300(DGCR8)

CLUD:

112676964(DGCR8)

VVP:	112907463(DGCR8)

VLG:	121475365(DGCR8)

NPO:	129508415(DGCR8)

AML:	100464916(DGCR8)

UMR:	103669261(DGCR8)

UAH:	113245915(DGCR8)

UAR:	123803543(DGCR8)

ELK:

111142423

LLV:

125082106

MPUF:

101670991(DGCR8)

MNP:	132023439(DGCR8)

MLK:	131810823(DGCR8)

NVS:	122903154(DGCR8)

ORO:	101378899(DGCR8)

EJU:	114201851(DGCR8)

ZCA:	113913093(DGCR8)

MLX:	117999786(DGCR8)

NSU:	110581108(DGCR8)

LWW:

102730709

FCA:	101096112(DGCR8)

PYU:	121023296(DGCR8)

PCOO:

112870225(DGCR8)

PBG:	122471016(DGCR8)

PVIV:

125148820(DGCR8)

LRUF:

124525684

PTG:	102962566(DGCR8)

PPAD:

109258628(DGCR8)

PUC:

125914914

AJU:

106983620

HHV:	120238842(DGCR8)

BTA:	540254(DGCR8)

BOM:	102270215(DGCR8)

BIU:	109571220(DGCR8)

BBIS:

104981997(DGCR8)

OAS:	101122137(DGCR8)

BTAX:

128062297(DGCR8)

ODA:	120871357(DGCR8)

CCAD:

122454604(DGCR8)

MBEZ:

129542201(DGCR8)

SSC:	100616094(DGCR8)

CFR:	102521678(DGCR8)

CBAI:

105070534(DGCR8)

CDK:	105106450(DGCR8)

VPC:	102526103(DGCR8)

BACU:

103008630(DGCR8)

BMUS:

118906702(DGCR8)

LVE:	103082507(DGCR8)

OOR:	101283603(DGCR8)

DLE:	111162884(DGCR8)

PCAD:

102993813(DGCR8) 114483866

PSIU:

116765124(DGCR8)

NASI:

112412189(DGCR8)

ECB:	100050636(DGCR8)

EPZ:	103561788(DGCR8)

EAI:	106827529(DGCR8)

MYB:	102257526(DGCR8)

MYD:	102752107(DGCR8)

MMYO:

118678614(DGCR8)

MLF:	102432202(DGCR8)

PKL:	118725642(DGCR8)

EFUS:

103286964(DGCR8)

MNA:	107530570(DGCR8)

DRO:	112301803(DGCR8)

SHON:

119001793(DGCR8)

AJM:	119046300(DGCR8)

PDIC:

114509068(DGCR8)

PHAS:

123806587(DGCR8)

MMF:	118639753(DGCR8)

PPAM:

129086340(DGCR8)

HAI:	109373209(DGCR8)

RFQ:	117017575(DGCR8)

PALE:

102889580(DGCR8)

PGIG:

120610497(DGCR8)

PVP:	105296841(DGCR8)

RAY:	107521853(DGCR8)

MJV:	108406871(DGCR8)

TOD:	119234455(DGCR8)

SARA:

101554391(DGCR8)

SETR:

125995059(DGCR8)

LAV:	100670176(DGCR8)

TMU:

101347316

ETF:	101652062(DGCR8)

DNM:	101444713(DGCR8)

MDO:	100026180(DGCR8)

GAS:	123230431(DGCR8)

SHR:	100925248(DGCR8)

AFZ:

127545753

PCW:	110215133(DGCR8)

OAA:	100680880(DGCR8)

PCOC:

116228702(DGCR8)

MGP:	100546160(DGCR8)

CJO:	107321067(DGCR8)

TPAI:

128084650(DGCR8)

LMUT:

125701636(DGCR8)

NMEL:

110406165(DGCR8)

APLA:

101803497(DGCR8)

ACYG:

106031236(DGCR8)

CATA:

118252854(DGCR8)

AFUL:

116496094(DGCR8)

TGU:	100227274(DGCR8)

LSR:	110478090(DGCR8)

SCAN:

103818090(DGCR8)

PMOA:

120509756(DGCR8)

OTC:	121338945(DGCR8)

PRUF:

121364986(DGCR8)

GFR:	102041104(DGCR8)

FAB:	101821208(DGCR8)

OMA:	130259528(DGCR8)

PHI:	102114550(DGCR8)

PMAJ:

107211556(DGCR8)

CCAE:

111936508(DGCR8)

CCW:	104688621(DGCR8)

CBRC:

103615971(DGCR8)

ETL:	114061835(DGCR8)

ZAB:	102070246(DGCR8)

ACHL:

103806837(DGCR8)

SVG:	106864833(DGCR8)

MMEA:

130575283(DGCR8)

HRT:	120760445(DGCR8)

FPG:	101916917(DGCR8)

FCH:	102046281(DGCR8)

CLV:	102089419(DGCR8)

EGZ:	104127200(DGCR8)

NNI:	104019980(DGCR8)

PCRI:

104034120(DGCR8)

PLET:

104622873(DGCR8)

EHS:	104502449(DGCR8)

PCAO:

104045651(DGCR8)

ACUN:

113486164(DGCR8)

TALA:

104368465(DGCR8)

PADL:

103912225(DGCR8)

AFOR:

103894874(DGCR8)

ACHC:

115346009(DGCR8)

HALD:

104319286(DGCR8)

HLE:	104840621(DGCR8)

AGEN:

126041392

GCL:

127022771

CCRI:

104162962(DGCR8)

CSTI:

104552718(DGCR8)

CMAC:

104480327(DGCR8)

MUI:	104544879(DGCR8)

BREG:

104633554(DGCR8)

FGA:	104081748(DGCR8)

GSTE:

104260884(DGCR8)

LDI:	104354692(DGCR8)

MNB:	103771685(DGCR8)

OHA:	104327548(DGCR8)

NNT:	104412757(DGCR8)

SHAB:

115614180(DGCR8)

DPUB:

104309660(DGCR8)

PGUU:

104471902(DGCR8)

ACAR:

104524028(DGCR8)

CPEA:

104388734(DGCR8)

AVIT:

104272010(DGCR8)

CVF:	104289201(DGCR8)

RTD:	128917040(DGCR8)

CUCA:

104054693(DGCR8)

TEO:	104381355(DGCR8)

BRHI:

104491900(DGCR8)

AAM:	106486852(DGCR8)

AROW:

112978417(DGCR8)

NPD:	112946029(DGCR8)

TGT:

104576814

DNE:	112987140(DGCR8)

SCAM:

104138854(DGCR8)

ASN:	102385050(DGCR8)

AMJ:	102574458(DGCR8)

CPOO:

109312759(DGCR8)

GGN:	109290464(DGCR8)

PSS:	102445971 102454620 102458239(DGCR8) 102459831

CMY:	102946522(DGCR8)

CCAY:

125623110(DGCR8)

DCC:	119843601(DGCR8)

CPIC:

101945739(DGCR8)

TST:	117887889(DGCR8)

CABI:

116819451(DGCR8)

MRV:	120386035(DGCR8)

ASAO:

132781437(DGCR8)

PVT:	110087923(DGCR8)

SUND:

121916717(DGCR8)

PBI:	103054649(DGCR8)

PMUR:

107295454(DGCR8)

CTIG:

120303130(DGCR8)

TSR:	106537633(DGCR8)

PGUT:

117676381(DGCR8)

APRI:

131185670(DGCR8)

PTEX:

113446502(DGCR8)

NSS:	113423493(DGCR8)

VKO:	123028545(DGCR8)

PMUA:

114586658(DGCR8)

PRAF:

128404126(DGCR8)

ZVI:	118076603(DGCR8)

HCG:	128338207(DGCR8)

GJA:	107120990(DGCR8)

STOW:

125442576(DGCR8)

EMC:	129341119(DGCR8)

XLA:	108716057 432110(dgcr8.L)

XTR:	100144670(dgcr8)

NPR:	108787921(DGCR8)

RTEM:

120935798(DGCR8)

BBUF:

120988675(DGCR8)

BGAR:

122934506(DGCR8)

MUO:	115479504(DGCR8)

GSH:	117365876(DGCR8)

DRE:	563963(dgcr8)

SRX:	107726381 107744441

SANH:

107672729 107687688

SGH:	107592303 107599932

CCAR:

109090295 109090815

CAUA:

113048930 113091439

CGIB:

127957477 128011198

PTET:

122345017(dgcr8)

LROH:

127166132(dgcr8)

OMC:	131541354(dgcr8)

PPRM:

120470155(dgcr8)

RKG:	130078503(dgcr8)

MAMB:

125266642(dgcr8)

CIDE:

127513453

MASI:

127417165 127439959

TROS:

130546966(dgcr8)

TDW:	130419418(dgcr8)

MANU:

129440013(dgcr8)

IPU:

108255709

IFU:	128598908(dgcr8)

PHYP:

113536839(dgcr8)

SMEO:

124380391(dgcr8)

TFD:	113657331(dgcr8)

TVC:	132854951(dgcr8)

AMEX:

103025771(dgcr8)

CMAO:

118827110(dgcr8)

EEE:	113590896(dgcr8)

CHAR:

105889971(dgcr8)

TRU:	101069862(dgcr8)

TFS:	130526215(dgcr8)

TNG:	GSTEN00031078G001

LCO:	104920952(dgcr8)

NCC:

104947663

TBEN:

117498722(dgcr8)

CGOB:

115013339(dgcr8)

PGEO:

117443351(dgcr8)

GACU:

117535590(dgcr8)

EMAC:

134872964(dgcr8)

ELY:	117252509(dgcr8)

EFO:	125889859(dgcr8)

PLEP:

121943938(dgcr8)

SLUC:

116050469(dgcr8)

ECRA:

117945389(dgcr8)

ESP:	116689696(dgcr8)

PFLV:

114556000(dgcr8)

GAT:	120831253(dgcr8)

PPUG:

119224409(dgcr8)

AFB:	129101060(dgcr8)

CLUM:

117736152(dgcr8)

PSWI:

130197402(dgcr8)

MSAM:

119891337(dgcr8)

SCHU:

122876382(dgcr8)

CUD:	121509624(dgcr8)

ALAT:

119019200(dgcr8)

MZE:	101486142(dgcr8)

ONL:	100700191(dgcr8)

OAU:	116323338(dgcr8)

OML:	112148137(dgcr8)

CSAI:

133451373(dgcr8)

XMA:	102218623(dgcr8)

XCO:	114154230(dgcr8)

XHE:	116729576(dgcr8)

PRET:

103469739(dgcr8)

PFOR:

103141341(dgcr8)

PLAI:

106947314(dgcr8)

PMEI:

106922425(dgcr8)

GAF:	122828354(dgcr8)

PPRL:

129373115(dgcr8)

CVG:	107089942(dgcr8)

CTUL:

119775574(dgcr8)

GMU:	124877184(dgcr8)

NFU:	107393542(dgcr8)

KMR:	108234947(dgcr8)

ALIM:

106524336(dgcr8)

NWH:	119414117(dgcr8)

AOCE:

111569425(dgcr8)

MCEP:

125012886(dgcr8)

CSEM:

103398078(dgcr8)

POV:	109633783(dgcr8)

SSEN:

122766776 122769365(dgcr8)

HHIP:

117767970(dgcr8)

HSP:	118114933(dgcr8)

SMAU:

118313516(dgcr8)

LCF:

108878112

SDU:	111228533(dgcr8)

SLAL:

111647941(dgcr8)

XGL:	120805818(dgcr8)

HCQ:	109524995(dgcr8)

SSCV:

125993893

SBIA:

133500053(dgcr8)

PEE:	133400385(dgcr8)

PTAO:

133474670(dgcr8)

BPEC:

110163316(dgcr8)

MALB:

109954809(dgcr8)

BSPL:

114862975(dgcr8)

SJO:	128364495(dgcr8)

SASA:

106580468 106585092(dgcr8)

STRU:

115164309(dgcr8) 115200343

OTW:	112248637 112262708

OMY:	110525849 110536232(dgcr8)

OGO:	124034178 124036467

ONE:	115111759 115140225

OKI:	109881807 109896067

OKE:	118358459(dgcr8) 118393376

SALP:

111957846(dgcr8) 111973882

SNH:	120036338 120063261

CCLU:

121530639 121585010

ELS:	105014343(dgcr8)

SFM:	108940381(dgcr8)

PKI:	111844154(dgcr8)

AANG:

118206497(dgcr8)

LOC:	102686171(dgcr8)

PSPA:

121297481 121299443

ARUT:

117426576 117427952

PSEX:

120540598(dgcr8)

LCM:	102364685(DGCR8)

CMK:	103183991(dgcr8)

RTP:

109917108

CPLA:

122562527(dgcr8)

HOC:	132827024(dgcr8)

LERI:

129709224(dgcr8)

BBEL:

109477612

CIN:

100181045

SCLV:

120342636

SPU:	100890524 762970

LPIC:

129255043

APLC:

110976582

SKO:

102809108

DME:	Dmel_CG1800(pasha)

DER:

6554298

DSE:

6621959

DSI:	Dsimw501_GD21592(Dsim_GD21592)

DYA:	Dyak_GE10954

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI23404

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119680039 119683048

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:	110681018 5574820

AALB:

109399310

CQU:	CpipJ_CPIJ017023 CpipJ_CPIJ019585

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:	105286765 113562616

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_212752

BANY:

112050431 112056282

MJU:

123871099

NIQ:

126775614

VCD:	124533187 124543345

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105385273 105388373

PGW:

126375864

CFEL:

113372615

CCRN:

123302623

API:	100162002 100168027 100168637 103308416

DNX:	107164803 107167272 107170612 107172166

AGS:	114123098 114125962 114130298 114130633 114132799

RMD:	113554415 113557080 113557995 113558077

ACOO:

126834325 126834574

DVT:	126896310 126904648

BTAB:

109037609

DCI:	103505735 103510676

CLEC:

106662882

HHAL:

106684812

NLU:	111050555 111060328 120350591 120354787

HVI:

124369756

MQU:	128992182 128992206 128993126 128993129 128998521 128998643

PHU:	Phum_PHUM574170

FOC:	113212351 113216272

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_211957

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:	107369954 107370020

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_T22A3.5(pash-1)

CBR:	CBG_24339(Cbr-pash-1)

CRQ:	GCK72_002420

NAI:	NECAME_05922

BMY:	BM_BM5906(Bma-pash-1)

LOA:	LOAG_18183

TSP:

Tsp_01393

HRO:	HELRODRAFT_99418

LGI:	LOTGIDRAFT_141857

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MMER:

RPHI:

OBI:

OSN:

LAK:

SMM:	Smp_087220

SHX:	MS3_00007435(DGCR8_1)

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

AQU:

Reference

PMID:15574589

Authors

Han J, Lee Y, Yeom KH, Kim YK, Jin H, Kim VN

Title

The Drosha-DGCR8 complex in primary microRNA processing.

Journal

Genes Dev 18:3016-27 (2004)
DOI:10.1101/gad.1262504

Sequence

[hsa:54487]

Reference

PMID:17159994

Authors

Faller M, Matsunaga M, Yin S, Loo JA, Guo F

Title

Heme is involved in microRNA processing.

Journal

Nat Struct Mol Biol 14:23-9 (2007)
DOI:10.1038/nsmb1182

Sequence

[hsa:54487]

LinkDB

DBGET integrated database retrieval system