KEGG ORTHOLOGY: K19532

ORTHOLOGY: K19532

Entry

K19532                      KO

Symbol

LBR

Name

Delta14-sterol reductase (lamin-B receptor) [EC:1.3.1.70]

Pathway

map00100

Steroid biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map04820

Cytoskeleton in muscle cells

Module

M00101

Cholesterol biosynthesis, FPP => cholesterol

Reaction

R05639

4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase

Disease

H00234

Pelger-Huet anomaly

H00447

HEM skeletal dysplasia

H01133

Reynolds syndrome

H02732

Rhizomelic skeletal dysplasia with or without Pelger-Huet anomaly

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K19532  LBR; Delta14-sterol reductase (lamin-B receptor)
09140 Cellular Processes
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    K19532  LBR; Delta14-sterol reductase (lamin-B receptor)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K19532  LBR; Delta14-sterol reductase (lamin-B receptor)
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.70  Delta14-sterol reductase
     K19532  LBR; Delta14-sterol reductase (lamin-B receptor)
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    K19532  LBR; Delta14-sterol reductase (lamin-B receptor)

Other DBs

GO:	0005521 0070087 0050613

Genes

HSA:

3930(LBR)

PTR:	457776(LBR)

PPS:	100994490(LBR)

GGO:	101125385(LBR)

PON:	100174610(LBR)

NLE:	100594061(LBR)

HMH:	116457362(LBR)

MCC:	700801(LBR)

MCF:	102133452(LBR)

MTHB:

126937128

MNI:	105478369(LBR)

CSAB:

103231006(LBR)

CATY:

105576946(LBR)

PANU:

101015302(LBR)

TGE:	112625952(LBR)

MLEU:

105552325(LBR)

RRO:	104668573(LBR)

RBB:	108538748(LBR)

TFN:	117076126(LBR)

PTEH:

111537085(LBR)

CANG:

105516699(LBR)

CJC:	100415074(LBR)

SBQ:	101030744(LBR)

CIMI:

108302721(LBR)

CSYR:

103275075(LBR)

MMUR:

105863815(LBR)

LCAT:

123627516(LBR)

PCOQ:

105810144(LBR)

OGA:	100943017(LBR)

MMU:	98386(Lbr)

MCAL:

110300132(Lbr)

MPAH:

110321481(Lbr)

RNO:	89789(Lbr)

MCOC:

116067924(Lbr)

ANU:	117721844(Lbr)

MUN:	110546667(Lbr)

CGE:	100770668(Lbr)

MAUA:

101831332(Lbr)

PROB:

127223712(Lbr)

PLEU:

114684425(Lbr) 114685641

MORG:

121435914(Lbr)

MFOT:

126502191

AAMP:

119827749(Lbr)

NGI:	103726259(Lbr)

HGL:	101698844(Lbr)

CPOC:

100721369(Lbr)

CCAN:

109695262(Lbr) 109703101

DORD:

106001119(Lbr)

DSP:	122102742(Lbr)

PLOP:

125359715(Lbr)

NCAR:

124962173

MMMA:

107140504(Lbr)

OCU:

100345014

OPI:	101518604(LBR)

TUP:	102499087(LBR)

GVR:	103586688(LBR)

CFA:	490391(LBR)

CLUD:

112648830(LBR)

VVP:	112923567(LBR)

VLG:	121496000(LBR)

NPO:	129508861(LBR)

AML:	100470463(LBR)

UMR:	103669083(LBR)

UAH:	113262908(LBR)

UAR:	123791860(LBR)

ELK:

111150734

LLV:

125085971

MPUF:

101681647(LBR)

MNP:	132025525(LBR)

MLK:	131814580(LBR)

NVS:	122918692(LBR)

ORO:	101367798(LBR)

EJU:	114215496(LBR)

ZCA:	113932995(LBR)

MLX:	118013006(LBR)

NSU:	110571361(LBR)

LWW:

102739673

FCA:	101085014(LBR)

PYU:	121015010(LBR)

PCOO:

112863170(LBR)

PBG:	122476159(LBR)

PVIV:

125159601(LBR)

LRUF:

124510311

PTG:	102948976(LBR)

PPAD:

109250738(LBR)

PUC:

125925856

AJU:

106968615

HHV:	120234125(LBR)

BTA:	509348(LBR)

BOM:	102268365(LBR)

BIU:	109570576(LBR)

BBUB:

102404836(LBR)

BBIS:

104997884(LBR)

CHX:	102187420(LBR)

OAS:	101110348(LBR)

BTAX:

128061458(LBR)

ODA:	120880355(LBR)

CCAD:

122452149(LBR)

MBEZ:

129551642(LBR)

SSC:	110255643(LBR)

CFR:	102520379(LBR)

CBAI:

105083938(LBR)

CDK:	105099770(LBR)

VPC:	102528823(LBR)

BACU:

103005659(LBR)

BMUS:

118904119(LBR)

LVE:	103074870(LBR)

OOR:	101288815(LBR)

DLE:	111177515(LBR)

PCAD:

102981747(LBR)

PSIU:

116752901(LBR)

NASI:

112404958(LBR)

ECB:	100056997(LBR)

EPZ:	103556266(LBR)

EAI:	106844724(LBR)

MYB:	102263102(LBR)

MYD:	102768045(LBR)

MMYO:

118678774(LBR)

MLF:	102424598(LBR)

PKL:	118727708(LBR)

EFUS:

103293450(LBR)

MNA:	107543637(LBR)

DRO:	112318856(LBR)

SHON:

119003171(LBR)

AJM:	119044438(LBR)

PDIC:

114512414(LBR)

PHAS:

123833114(LBR)

MMF:	118640495(LBR)

PPAM:

129073002(LBR)

HAI:	109391472(LBR)

RFQ:	117018607(LBR)

PALE:

102884834(LBR)

PGIG:

120619133(LBR)

PVP:	105292614(LBR)

RAY:	107521069(LBR)

MJV:	108403503(LBR)

TOD:	119244572(LBR)

SARA:

101536833(LBR)

SETR:

126013392(LBR)

LAV:	100674330(LBR)

TMU:

101353559

ETF:	101651543(LBR)

DNM:	101428711(LBR)

MDO:	100019067(LBR)

GAS:	123247840(LBR)

SHR:	100924570(LBR)

AFZ:

127559534

PCW:	110205526(LBR) 110208733

OAA:	100076190(LBR)

GGA:	396285(TM7SF2)

PCOC:

116230962(LBR)

MGP:	100547254(LBR)

CJO:	107311040(LBR)

TPAI:

128078318(LBR)

LMUT:

125690023(LBR)

NMEL:

110396037(LBR)

APLA:

101800362(LBR)

ACYG:

106031541(LBR)

CATA:

118253633(LBR)

AFUL:

116487634(LBR)

TGU:	100221936(LBR)

LSR:	110477501(LBR)

SCAN:

103819284(LBR)

PMOA:

120505974(LBR)

OTC:	121346926(LBR)

PRUF:

121357043(LBR)

GFR:	102041926(LBR)

FAB:	101807754(LBR)

OMA:	130251390(LBR)

PHI:	102109830(LBR)

PMAJ:

107202231(LBR)

CCAE:

111926261(LBR)

CCW:	104685563(LBR)

CBRC:

103612691(LBR)

ETL:	114073700(LBR)

ZAB:	102072016(LBR)

ACHL:

103805830(LBR)

SVG:	106853922(LBR)

MMEA:

130583043(LBR)

HRT:	120750579(LBR)

FPG:	101915288(LBR)

FCH:	102060143(LBR)

CLV:	102088345(LBR)

EGZ:	104134581(LBR)

NNI:	104019277(LBR)

PCRI:

104023809(LBR)

PLET:

104613644(LBR)

EHS:

104510345

PCAO:

104044077(LBR)

ACUN:

113478163(LBR)

TALA:

104357415(LBR)

PADL:

103925018(LBR)

AFOR:

103894455(LBR)

ACHC:

115350139(LBR)

HALD:

104311166(LBR)

HLE:	104838139(LBR)

AGEN:

126052675

GCL:

127014953

CCRI:

104159825(LBR)

CSTI:

104557513(LBR)

CMAC:

104487691(LBR)

MUI:	104541373(LBR)

BREG:

104629188(LBR)

FGA:	104075313(LBR)

GSTE:

104256491(LBR)

LDI:	104349836(LBR)

MNB:	103771789(LBR)

OHA:	104331966(LBR)

NNT:

104399273

SHAB:

115613612(LBR)

DPUB:

104300894(LBR)

PGUU:

104457557(LBR)

ACAR:

104521803(LBR)

CPEA:

104386204(LBR)

AVIT:

104273012(LBR)

CVF:	104294657(LBR)

RTD:	128906937(LBR)

CUCA:

104067035(LBR)

TEO:	104369668(LBR)

BRHI:

104500354(LBR)

AAM:	106482709(LBR)

AROW:

112963403(LBR)

NPD:	112942773(LBR)

TGT:	104578957(LBR)

DNE:	112980048(LBR)

SCAM:

104151590(LBR)

ASN:	102370446(LBR)

CPOO:

109319772(LBR)

PSS:	102454363(LBR)

CMY:	102935118(LBR)

CCAY:

125633686(LBR)

DCC:	119853166(LBR)

CPIC:

101937424(LBR)

TST:	117874505(LBR)

CABI:

116832688(LBR)

MRV:	120400986(LBR)

ACS:	100555974(lbr)

ASAO:

132761376(LBR)

PVT:	110075397(LBR)

SUND:

121934749(LBR)

PBI:	103062155(LBR)

PMUR:

107297430(LBR)

CTIG:

120307222(LBR)

TSR:	106548912(LBR)

PGUT:

117671758(LBR)

APRI:

131189354(LBR)

PTEX:

113433231(LBR)

NSS:	113421674(LBR)

VKO:	123025291(LBR)

PMUA:

114594621(LBR)

PRAF:

128411070(LBR)

ZVI:	118083216(LBR)

HCG:	128350113(LBR)

GJA:	107106332(LBR)

STOW:

125437412(LBR)

EMC:	129329955(LBR)

XLA:	108716485(lbr.L) 378609(lbr.S)

XTR:	100145693(lbr)

NPR:	108787063(LBR)

RTEM:

120937858(LBR)

BBUF:

120999603(LBR)

BGAR:

122933816(LBR)

MUO:	115465308(LBR)

GSH:	117356893(LBR)

DRE:	368360(lbr)

SRX:	107732420 107732539

SANH:

107690042 107698344

SGH:	107553478 107601526

CCAR:

109080244 109109386

CAUA:

113063105 113120709

CGIB:

127938434 127984246

PTET:

122325500(lbr)

LROH:

127183291(lbr)

OMC:	131527501(lbr)

PPRM:

120493906(lbr)

RKG:	130103072(lbr)

MAMB:

125278270(lbr)

CIDE:

127502536

MASI:

127410185 127415709

TROS:

130565790(lbr)

TDW:	130434846(lbr)

MANU:

129430174(lbr)

IPU:

108258129

IFU:	128600906(lbr)

PHYP:

113546867(lbr)

SMEO:

124377407(lbr)

TFD:	113647144(lbr)

TVC:	132843517(lbr)

AMEX:

103032852

CMAO:

118815284(lbr)

EEE:	113585135(lbr)

CHAR:

105892807(lbr)

TRU:	101077221(lbr)

TFS:	130515654(lbr)

LCO:	104918313(lbr)

NCC:

104949272

TBEN:

117489080(lbr)

CGOB:

115003506(lbr)

PGEO:

117440017(lbr)

GACU:

117536587(lbr)

EMAC:

134876956(lbr)

ELY:	117270923(lbr)

EFO:	125897155(lbr)

PLEP:

121955683(lbr)

SLUC:

116065556(lbr)

ECRA:

117961645(lbr)

ESP:	116705883(lbr)

PFLV:

114573571(lbr)

GAT:	120807821(lbr)

PPUG:

119194865(lbr)

AFB:	129106958(lbr)

CLUM:

117727008(lbr)

PSWI:

130202365(lbr)

MSAM:

119908875(lbr)

SCHU:

122862600(lbr)

CUD:	121521616(lbr)

ALAT:

119012471(lbr)

MZE:	101487127(lbr)

ONL:	100701576(lbr)

OAU:	116314226(lbr)

OLA:	101159885(lbr)

OML:	112140975(lbr)

XMA:	102237315(lbr)

XCO:	114158766(lbr)

XHE:	116734371(lbr)

PRET:

103458037(lbr)

GAF:	122824818(lbr)

PPRL:

129369177(lbr)

CVG:	107093275(lbr)

CTUL:

119778740(lbr)

GMU:	124882493(lbr)

NFU:	107396011(lbr)

KMR:	108246513(lbr)

ALIM:

106532953

NWH:	119418728(lbr)

AOCE:

111583488(lbr)

MCEP:

124998672(lbr)

CSEM:

103380676(lbr)

POV:	109632449(lbr)

SSEN:

122784281(lbr)

HHIP:

117758001(lbr)

HSP:	118099152(lbr)

SMAU:

118289802(lbr)

LCF:

108901765

SDU:	111216371(lbr)

SLAL:

111661334(lbr)

XGL:	120788738(lbr)

HCQ:	109524925(lbr)

SSCV:

125990178

SBIA:

133496382(lbr)

PEE:	133416641(lbr)

PTAO:

133468418(lbr)

BPEC:

110175403(lbr)

MALB:

109968075

BSPL:

114849607(lbr)

SJO:	128377228(lbr)

SASA:

106571452 106607865

STRU:

115174736 115192120

OTW:	112217644 112250363(lbr)

OMY:	110522282 110529660(lbr)

OGO:	123990803(lbr) 123995138

ONE:	115107809 115139361

OKI:	109866178 109900791

OKE:	118386957 118398607(lbr)

SALP:

111954352 111972907

SNH:	120019008 120024390(lbr)

CCLU:

121548865 121552282(lbr)

ELS:	105017775(lbr)

SFM:	108925158(lbr)

PKI:	111854033(lbr)

AANG:

118230081(lbr)

LOC:	102683290(lbr)

PSPA:

121317139(lbr)

ARUT:

117411599(lbr)

PSEX:

120526124(lbr)

LCM:	102358779(LBR)

CMK:	103181605(lbr)

CPLA:

122548562(lbr)

HOC:	132830341(lbr)

LERI:

129697587(lbr)

PMRN:

116939578 116947160(TM7SF2)

LRJ:	133347208 133347373 133359394

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:	100374928 100376417

DME:	Dmel_CG17952(LBR)

DER:

6548282

DSE:

6615434

DSI:	Dsimw501_GD11624(Dsim_GD11624)

DYA:	Dyak_GE12220

DAN:

DSR:

DPO:

DPE:

DMN:	108159763 117192342

DWI:

6641057

DGR:

116805138

DMO:	Dmoj_GI18730

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108354984 108359437

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AAG:

AALB:

CQU:	CpipJ_CPIJ012350

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

TCA:	103312575 103312760 103312761 103315078

SOY:

115879795

AGRG:

126747623

ATD:

109596614

CSET:

123314816 123314925 123318759

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_212278

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105389055 105396026

PGW:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM517050

FOC:

ZNE:

CSEC:

BROR:

IEL:

DMK:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:	121122417 121123599

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

HRO:	HELRODRAFT_187232

LGI:	LOTGIDRAFT_118629

PVUL:

126821244

PCAN:

112562689

BGT:

106065041

GAE:	121371501 121371502 121371503

HRF:

124111959

HRJ:

124285962

CRG:	105317853 105341250

CVN:

111128051

OED:	125649088 130051729

MYI:	110442449 110442461 110454663

PMAX:

117321823 117321824 117323876

MCAF:

127698659

MMER:

123534372 123540808 128559279

RPHI:

132720075

DPOL:

127873422

OBI:	106880238 106880897

OSN:	115217064 115217706

LAK:	106157959 106157960 106169637

SMM:	Smp_124300

SHX:	MS3_00002182

EGL:

EGR_06785

NVE:

5502522

EPA:	110252825 110252829

ATEN:

116292115

ADF:	107327637 107357912

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:	130657323 130657325

TAD:	TRIADDRAFT_32223 TRIADDRAFT_32264

AQU:

100640520

MBR:	MONBRDRAFT_38824

» show all

Reference

PMID:23100253

Authors

Hirano Y, Hizume K, Kimura H, Takeyasu K, Haraguchi T, Hiraoka Y

Title

Lamin B receptor recognizes specific modifications of histone H4 in heterochromatin formation.

Journal

J Biol Chem 287:42654-63 (2012)
DOI:10.1074/jbc.M112.397950

Reference

PMID:20576617

Authors

Lu X, Shi Y, Lu Q, Ma Y, Luo J, Wang Q, Ji J, Jiang Q, Zhang C

Title

Requirement for lamin B receptor and its regulation by importin {beta} and phosphorylation in nuclear envelope assembly during mitotic exit.

Journal

J Biol Chem 285:33281-93 (2010)
DOI:10.1074/jbc.M110.102368

Sequence

[hsa:3930]

Reference

PMID:27336722

Authors

Tsai PL, Zhao C, Turner E, Schlieker C

Title

The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations.

Journal

Elife 5:e16011 (2016)
DOI:10.7554/eLife.16011

Sequence

[hsa:3930]

LinkDB

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