KEGG ORTHOLOGY: K19601

ORTHOLOGY: K19601

Entry

K19601                      KO

Symbol

EYS

Name

protein eyes shut

Disease

H00527

Retinitis pigmentosa

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified
    K19601  EYS; protein eyes shut
Domain-containing proteins not elsewhere classified [BR:ko04990]
Laminin domain-containing proteins
  Laminin G domain-containing proteins
   K19601  EYS; protein eyes shut

Genes

HSA:	346007(EYS)

PTR:	100609532 472247(EYS)

GGO:	101154316(EYS) 101154628

PON:	100173479(EYS) 100442528(EYS)

NLE:	100584657(EYS)

HMH:	116469320(EYS)

MCC:	106997984 114677577 716369

MCF:	102132015(EYS)

CSAB:

103243954

CATY:

105589678(EYS)

TGE:	112622598(EYS)

RRO:	104653931(EYS)

RBB:	108526480 108526745(EYS) 108528749 108539741

TFN:	117087412(EYS)

PTEH:

111549785(EYS)

CANG:

105514334(EYS)

CJC:	100400628(EYS)

CIMI:

108301579

CSYR:

103274897

MMUR:

105862129(EYS)

LCAT:

123632980(EYS)

OGA:	100956588(EYS)

NCAR:

124989274

MMMA:

107143687(Eys)

OCU:

100339823

TUP:	102476851(EYS) 102500086

CFA:	610772(EYS)

CLUD:

112641816(EYS)

VVP:	112914100(EYS)

VLG:	121484058(EYS)

NPO:	129512973(EYS)

AML:	105240324(EYS)

UMR:	103657456(EYS)

UAH:	113261351(EYS)

UAR:	123797115(EYS)

ELK:

111152227

LLV:

125102798

MPUF:

101670523(EYS)

MNP:	132018615(EYS)

MLK:	131834646(EYS)

NVS:	122909503(EYS)

ORO:

101373689

EJU:	114204447(EYS)

ZCA:	113927933(EYS)

FCA:	101082908 109499722

PCOO:

112861989(EYS)

PVIV:

125166287(EYS)

LRUF:

124528898

PTG:	102955976 102963992(EYS)

PPAD:

109248190 109248191 109248239

PUC:

125938602

AJU:

106988920

HHV:	120224828(EYS) 120225841

SSC:	102158510(EYS)

CFR:	102509140(EYS)

CBAI:

105079138(EYS)

CDK:	105086030(EYS)

VPC:	102539517(EYS)

BACU:

102998535(EYS) 102998553

BMUS:

118905041(EYS)

LVE:	103071790 103078621(EYS) 103086974

OOR:	101275394(EYS)

DLE:	111170401 111183298

PCAD:

102989532(EYS)

PSIU:

116763769(EYS)

NASI:

112410834(EYS)

ECB:	100070526(EYS) 106782289 111769165

EPZ:	103546267 103546271 103557173(EYS)

EAI:	106833131 106842352

MYB:	102243924(EYS) 102261352

MYD:	102760403 102761090

MMYO:

118660742(EYS)

MLF:	102442586(EYS)

PKL:	118705994(EYS)

EFUS:

129150554(EYS)

MNA:	107523885 107525155

SHON:

118978730(EYS) 118978743

AJM:	119042335 119045428(EYS)

PHAS:

123821481(EYS)

MMF:	118621438(EYS)

PPAM:

129066849(EYS)

HAI:

109393324

PALE:

102889381(EYS)

RAY:	107518675(EYS)

LAV:	100669435 111749743

TMU:

101341591

MDO:	103101620 103102695 103102871(EYS) 103103248

GAS:	123246469(EYS)

SHR:	100914732 100914994(EYS)

OAA:

114811108

GGA:	100858320(EYS)

PCOC:

116240522(EYS)

MGP:	100538570 104909952 104909954

CJO:	107312079(EYS)

TPAI:

128078570 128089442(EYS) 128089450

LMUT:

125689991

NMEL:

110396399(EYS) 110396791 110396792

APLA:

101798841(EYS)

ACYG:

106030402(EYS)

CATA:

118246193(EYS)

AFUL:

116488139(EYS)

TGU:	105759112(EYS)

LSR:	110468092(EYS)

SCAN:

108962717(EYS)

PMOA:

120511947(EYS)

OTC:	121339083(EYS)

PRUF:

121358845(EYS)

GFR:	102040946 102041106(EYS)

FAB:	101809726(EYS)

OMA:	130251735(EYS)

PMAJ:

107201603(EYS)

CCAE:

111925835 111926025

CCW:	104693250(EYS)

CBRC:

103619167(EYS)

ETL:	114059280 114062842

ZAB:	102072463(EYS)

SVG:

106849527

MMEA:

130575503(EYS)

HRT:	120750043(EYS)

FCH:	114016573(EYS)

CLV:	102092117(EYS)

EGZ:	104127405(EYS)

NNI:	104020918(EYS)

ACUN:

113478024(EYS)

TALA:

104357210(EYS)

AFOR:

103893362

ACHC:

115338559(EYS)

AGEN:

126046177

GCL:

127014385

BREG:

104643088(EYS)

SHAB:

115609776(EYS)

RTD:	128907781(EYS)

AAM:	106492493 106492495

ASN:	102385954 112551503

AMJ:	102577163(EYS) 109285507

PSS:	102456584 102461967

DCC:	122459436 122459437

CPIC:

101932078 101938928(EYS)

ACS:	103279859(eys) 107983242

ASAO:

132760712(EYS)

PVT:	110073002 110073003(EYS)

PBI:	103055766 112540175

TSR:	106545657 106548035

PGUT:

117676869(EYS)

APRI:

131194949(EYS)

PTEX:

NSS:

PMUA:

PRAF:

ZVI:	118082767 118082770

HCG:	128337879 128337958 128340819

GJA:

107116028

EMC:

129324203

DRE:	557044(si:ch211-69e5.1)

SRX:	107736852 107747288

SANH:

107664247 107683858

SGH:

107553185

CCAR:

109047660 109101270

CAUA:

113068813 113068815 113112286 113112457 113113229

CGIB:

128025995

PTET:

122356922(eys)

LROH:

127175456(eys)

OMC:	131552196(eys)

PPRM:

120463063(eys)

RKG:	130088226(eys)

MAMB:

125276353(eys)

CIDE:

127525331

MASI:

127414057

TROS:

130558780(eys)

TDW:	130431434(eys)

MANU:

129415704(eys)

PHYP:

113544265 113544266

SMEO:

124381282(eys)

TFD:	113660698(eys)

TVC:	132858284(eys)

AMEX:

103043642(eys)

CMAO:

118816849(eys)

CHAR:

105890845(eys)

TRU:	105416389(eys)

TFS:	130533644(eys)

TNG:	GSTEN00030699G001

LCO:	104940198(eys)

NCC:	104941244 104941246

TBEN:

117499661(eys)

CGOB:

115019792(eys)

PGEO:

117459314(eys)

GACU:

117536827(eys)

EMAC:

134858831(eys)

ELY:	117248352(eys)

EFO:	125903399(eys)

PLEP:

121954735(eys)

SLUC:

116052515(eys)

ECRA:

117959959(eys)

ESP:	116704924(eys)

PFLV:

114571939(eys)

GAT:	120820317(eys)

PPUG:

119214057(eys)

AFB:	129092210(eys)

CLUM:

117743611(eys)

PSWI:

130207416(eys)

MSAM:

119917130(eys)

SCHU:

122884413(eys)

CUD:	121510785(eys)

ALAT:

119034145(eys)

MZE:	101464800(eys)

ONL:	102078134(eys)

OAU:	116322750(eys)

OLA:	105355817(eys)

OML:	118599715(eys)

CSAI:

133463203(eys)

XMA:	102228644(eys)

XCO:	114138452(eys)

XHE:	116713129(eys)

PRET:

103477020(eys)

PFOR:

103134183(eys)

PLAI:

106957971

GAF:	122842366(eys)

PPRL:

129359659(eys)

CVG:	107084577(eys)

CTUL:

119790633(eys)

GMU:	124859556(eys)

NFU:	107375584 107375733(eys)

KMR:	108234035(eys)

ALIM:

106519287(eys)

AOCE:

111582338

MCEP:

125018339(eys)

CSEM:

103387287 107989322

POV:	109633094(eys)

SSEN:

122781681(eys)

HHIP:

117775623(eys)

HSP:	118118690(eys)

SMAU:

118283473(eys)

LCF:

108894545

SDU:	111234291(eys)

SLAL:

111658936(eys)

XGL:	120796328(eys)

HCQ:	109516117(eys)

SSCV:

125978659

SBIA:

133509656(eys)

PEE:	133409820(eys)

PTAO:

133485990(eys)

BPEC:

110156870(eys)

MALB:

109961902(eys)

BSPL:

114870508(eys)

SJO:	128372468(eys)

SASA:

106560780 106566431 106577289 106577473

OTW:	112239872(eys) 112253580

OMY:	110516873 110518258 118943928 118966042

OKE:

127922911

ELS:	105008903(eys)

SFM:

108932739

PKI:	111860749 111860751

AANG:

118218359(eys)

LOC:	102689342(eys)

PSPA:

121316380(eys)

ARUT:

117403189

LCM:

106706194

CMK:	103179035(eys)

PMRN:

116946553(EYS)

LRJ:	133352973(EYS)

BFO:

118404893

BBEL:

109476379

SPU:

593680

DME:	Dmel_CG33955(eys)

DER:

6542857

DSE:

6613084

DSI:	Dsimw501_GD23147(Dsim_GD23147)

DYA:	Dyak_GE18127

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI14162

DAZ:	108609473 108620386

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

AOQ:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AAG:

AALB:

CQU:	CpipJ_CPIJ001497

CPII:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:	114882967 114883024

OLG:

MGEN:

NMEA:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

MJU:

PMAC:

PPOT:

PXU:

PRAP:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105394934 105395111

PGW:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

HVI:	124373355 124373626

MQU:

128999531

PHU:	Phum_PHUM150870

FOC:

TPAL:

ZNE:

CSEC:

BROR:

FCD:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

HAZT:

EAF:

LSM:

TCF:

TUT:

DPTE:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LGI:	LOTGIDRAFT_111382

LAK:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

DGT:

XEN:

HMG:

HSY:

Reference

PMID:18836446

Authors

Abd El-Aziz MM, Barragan I, O'Driscoll CA, Goodstadt L, Prigmore E, Borrego S, Mena M, Pieras JI, El-Ashry MF, Safieh LA, Shah A, Cheetham ME, Carter NP, Chakarova C, Ponting CP, Bhattacharya SS, Antinolo G

Title

EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa.

Journal

Nat Genet 40:1285-7 (2008)
DOI:10.1038/ng.241

Sequence

[hsa:346007]

Reference

PMID:17011488

Authors

Husain N, Pellikka M, Hong H, Klimentova T, Choe KM, Clandinin TR, Tepass U

Title

The agrin/perlecan-related protein eyes shut is essential for epithelial lumen formation in the Drosophila retina.

Journal

Dev Cell 11:483-93 (2006)
DOI:10.1016/j.devcel.2006.08.012

Sequence

[dme:Dmel_CG33955]

LinkDB

DBGET integrated database retrieval system