KEGG   ORTHOLOGY: K20484
Entry
K20484                      KO                                     
Symbol
lanC, nisC, spaC, epiC
Name
class I lanthipeptide synthase [EC:3.13.2.4]
Pathway
map02020  Two-component system
map02024  Quorum sensing
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    K20484  lanC, nisC, spaC, epiC; class I lanthipeptide synthase
 09140 Cellular Processes
  09145 Cellular community - prokaryotes
   02024 Quorum sensing
    K20484  lanC, nisC, spaC, epiC; class I lanthipeptide synthase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.13  Acting on carbon-sulfur bonds
   3.13.2  Thioether and trialkylsulfonium hydrolases
    3.13.2.4  lanthipeptide synthase
     K20484  lanC, nisC, spaC, epiC; class I lanthipeptide synthase
Other DBs
COG: COG4403
Genes
VNI: VIBNI_B1813
SSEH: N7V09_15410
THAT: H3N35_11255 H3N35_20365 H3N35_22025
TACT: SG35_011860 SG35_022985
TVD: SG34_024280
PPHE: PP2015_3328
PRR: AT705_11955
PLZ: S4054249_20630
PPIS: B1L02_18305
PEA: PESP_a3854
PVB: J5X90_05215
PSAZ: PA25_32110
PFLI: CTT31_17925
PMAZ: R5H13_18940
PSRR: ELR70_24420
KIA: G8A07_03790
EHB: E7V67_017110
TOM: BWR18_06460
RID: RIdsm_01280(nisC)
MFB: MFUL124B02_22910
CCX: COCOR_03287(spaC) COCOR_03659(spaC1) COCOR_05228
CEXI: ACN6A2_36040
PPAK: JY651_26710
AGE: AA314_06591
AVM: JQX13_15445 JQX13_15465 JQX13_38755
MBD: MEBOL_005035 MEBOL_006781
CFUS: CYFUS_002183 CYFUS_005357
PBRU: LZC95_02125 LZC95_09245
PRUE: LVJ94_02250 LVJ94_13950
HOH: Hoch_3102 Hoch_4144
NANN: O0S08_10555
SBF: JCM31447_05540
PIJ: QEJ31_09940
PUV: PUV_03450(spaC)
RPOR: RHAB15C_0000325 RHAB15C_0000329
MRI: Mal4_44720
GEP: Q9293_09085
MSEA: METESE_23980
TFO: BFO_0048 BFO_0105
CPI: Cpin_1439 Cpin_3397
CBAE: COR50_19610
CHIH: GWR21_22705
COY: HF329_03480 HF329_14575 HF329_17130
CFIL: MYF79_07230
CHF: KTO58_20225 KTO58_25930
CSAC: SIO70_08490 SIO70_29495 SIO70_32925
CHIM: CK934_02840 CK934_08590
FLN: FLA_1906
PHE: Phep_0555
PCM: AY601_1455 AY601_2740 AY601_4426
PGS: CPT03_02260
PEK: FFJ24_020850
PROE: H9L23_20870
PRK: H9N25_17150
PGJ: QG516_22030
PEDO: AB3G38_06655 AB3G38_10850 AB3G38_15720 AB3G38_23450
SHT: KO02_01485
SPDR: G6053_29550
MGOT: MgSA37_03806
MUY: SNE26_07265
EMAI: KZP23_17080 KZP23_17100
SLI: Slin_4705
SMON: AWR27_15170 AWR27_15195
SOQ: LQ777_29965 LQ777_29970
EOL: Emtol_0104 Emtol_0233
DPF: ON006_13300 ON006_13305
RSI: Runsl_2465
RUP: DTQ70_28970
BER: ACE193_11305
HSW: Hsw_0197
HCW: O3303_21610
HCU: MUN79_08950
HCF: MUN80_08290 MUN80_21755
PACT: CA264_09850 CA264_09855
MARP: QYS47_05785 QYS47_05820
FLL: EI427_16385
FKA: KM029_22345
CLIT: OQ292_21255
CHRW: KA713_09875
FCR: HYN56_19785
FCS: TRV642_2119 TRV642_3917
FCU: NOX80_08675
FLAV: HAV12_004735
TJE: TJEJU_0697
TMP: F9Y86_04325 F9Y86_04345
TPLT: T19A05C_0762
AQA: D1815_17440
ARHO: ACE939_04370
FBU: UJ101_01070
EAO: BD94_0661 BD94_0662
EEN: BBD30_10495
ELB: VO54_02043(nisC)
EMG: BBD33_00730
ELIZ: JCR23_08115
CHZ: CHSO_3639
CIO: CEQ15_20035 CEQ15_20040
CHRY: CEY12_13385
CPIP: CJF12_15890
CHRS: EAG08_19630
CNK: EG343_06485
CCAU: EG346_21645
CLAC: EG342_06985 EG342_21330 EG342_21335
CRHI: KB553_22375
CDAE: MUU74_12135
CHRJ: CHRYMOREF3P_3186
CFLU: ODZ84_18125 ODZ84_18130
CCUC: JNG87_03540
CHRR: ACL0VS_20465
CIV: IMZ16_09560
BSUS: Q433_01245(subC)
BSN: BSn5_12565
BSS: BSUW23_16550(spaC)
BST: GYO_3694
BIT: BIS30_06520
BSON: S101395_04837
BMOJ: HC660_32620(sblC)
BTF: YBT020_05980
BTHT: H175_233p092
BTHU: YBT1518_19970
BMYO: BG05_2737
BBY: CY96_27565
BNT: GSN03_15665
BACY: QF06_07340 QF06_15240
BAWR: D9C22_08875 D9C22_18135
BMQ: BMQ_pBM70148
BCL: ABC3558
BGI: BGM20_16030
BTHV: CQJ30_18225
GKA: GK0304
GTE: GTCCBUS3UF5_3890
GTM: GT3921_17940
GLI: GLN3_11980
BCAL: CWI35_08695
GTN: GTNG_0268(spaC)
SAM: MW1763(bsaC)
SAS: SAS1744
SAX: USA300HOU_1813(epiC)
SAA: SAUSA300_1765(epiC)
SAO: SAOUHSC_01951
SAE: NWMN_1714(bsaC)
SUV: SAVC_08340
SUE: SAOV_1805
SUT: SAT0131_01942
SUZ: MS7_1821
SUW: SATW20_18180
SUF: SARLGA251_17040
SAUZ: SAZ172_1834(lanC)
SAUF: X998_1839
SAB: SAB1681c
SAUM: BN843_18270
SAUR: SABB_01944(epiC)
SAUI: AZ30_09225
SCAP: AYP1020_0361(nisC)
SARL: SAP2_01400
SSH: NCTC13712_01801(nisC)
SSAC: I6I31_07405
MEPI: KFV12_00380
NMY: CJ229_006840
BFM: BP422_03710
BRUM: NDK47_17220
PPY: PPE_01452(pnlC2) PPE_01453(pnlC1)
PPM: PPSC2_07475(spaC1) PPSC2_07485(spaC2)
PPO: PPM_1421(spaC1) PPM_1422(spaC2)
PPOL: X809_08145 X809_08155
PPQ: PPSQR21_015820 PPSQR21_015840 PPSQR21_045950 PPSQR21_048900
PPOY: RE92_04410 RE92_04420 RE92_14525
PLV: ERIC2_c31300
PPEO: ABE82_08720
PBV: AR543_02135
PAIH: ASL14_13580
PKA: PQ456_01225
PHK: SK066_01220
PLZH: C0638_24545
PACL: DCC85_19065
PELG: ACJ7K1_06275
PASZ: KAI36_01558 KAI36_01560(nisC)
ANX: ACH33_16065
ATHE: K3F53_02815
TUM: CBW65_02415 CBW65_23340
TAB: CIG75_06670
LLT: CVCAS_0590(nisC)
LLS: lilo_0559(nisC)
LLX: NCDO2118_1270(nisC)
LLJ: LG36_0633(nisC)
SPH: MGAS10270_Spy0921
SPI: MGAS10750_Spy0957
SPJ: MGAS2096_Spy0880
SPK: MGAS9429_Spy0924
SPB: M28_Spy0783
SPYO: STAB901_04585
SPW: SPCG_0146
SNV: SPNINV200_01410
STC: str0099(labC)
STL: stu0099(labC)
STN: STND_0103
STW: Y1U_C0092
STHE: T303_01765
STHS: AVT04_04365
SSUS: NJAUSS_0614
SUI: SSUJS14_0627
SDS: SDEG_0295(labC)
SDG: SDE12394_01395
SDQ: SDSE167_0326(labC)
STB: SGPB_1101(nsuC)
STRS: SSAL8618_00830
SIB: SIR_0589
SIU: SII_0987
SEQI: A6J79_10720
SMEN: SAMEA4412692_0448(nisC)
SPOC: NCTC10925_00696(nsuC)
LAW: LACWKB8_1291
LHS: DLD54_06220
LROS: LROSL1_2320
CKL: CKL_3505
CKR: CKR_3092
CCB: Clocel_4256 Clocel_4262
CRW: CROST_000280
CFB: CLFE_002720
CAUN: CLAUR_029670
CRAS: KVH43_13015
ROB: CK5_35940
BYL: A4V09_08140
VGU: HYG85_07145
VPY: HZI73_04970
TIZ: RBU61_03635
MPHU: MPHO_39010
CFG: CFREI_02815(nisC)
NBR: O3I_005640 O3I_014610 O3I_014615
NTP: CRH09_17645 CRH09_19305
NOZ: DMB37_01805
NIE: KV110_21885 KV110_21890
NSPU: IFM12276_53030
NVU: V7968_13025 V7968_22380 V7968_22385
SCO: SCO0270(SCF1.12) SCO6929(SC1G8.01c)
SGR: SGR_3846 SGR_6574
SGB: WQO_02250
SFI: SFUL_5860
SGRF: SGFS_020110 SGFS_064350
SCYE: R2B67_03810 R2B67_23910
SCB: SCAB_32041
SVL: Strvi_1315 Strvi_3083 Strvi_5422
SHY: SHJG_7924
SRC: M271_10115
SMAL: SMALA_2711
SAUO: BV401_15610
SSOI: I1A49_15465
SANT: QR300_08460
SBH: SBI_06950
SDV: BN159_7741
SALS: SLNWT_1143 SLNWT_1182
SLV: SLIV_36565
STRE: GZL_05720 GZL_07087
SLD: T261_01807 T261_8499
SXI: SXIM_01810 SXIM_36760
STRM: M444_15205 M444_18495 M444_22365
STRC: AA958_15645
SAMB: SAM23877_7259
SRW: TUE45_pSRc_0584(TUE45_pSRTUE45c_0584)
STRF: ASR50_00540 ASR50_02325 ASR50_34895
SRN: A4G23_00518
STRT: A8713_00055 A8713_30520
SCLF: BB341_06930 BB341_16120
SGS: AVL59_25165
SGM: GCM10017557_34390
SCAD: DN051_07250
SNR: SNOUR_26770 SNOUR_32460
SALU: DC74_2052 DC74_6285 DC74_773
SALL: SAZ_04400 SAZ_33100
STRD: NI25_06435
SSIA: A7J05_06855
SVU: B1H20_01765 B1H20_18180
SPUN: BFF78_08040
SGV: B1H19_05670 B1H19_06505
SALJ: SMD11_6442
SFK: KY5_0110c KY5_0270 KY5_1224c KY5_7244c
SRJ: SRO_3846
SVQ: N6Q81_33440
SDX: C4B68_00390 C4B68_07055
SQZ: FQU76_02530 FQU76_24370
SNQ: CP978_26360
STIR: DDW44_30830
SKA: CP970_20030 CP970_41510 CP970_42350
SGZ: C0216_09875 C0216_32280 C0216_32640
SNK: CP967_19710
SHAW: CEB94_33760
SFIC: EIZ62_30345
SSPO: DDQ41_08200 DDQ41_25210
SPAD: DVK44_04645 DVK44_21615
SAQU: EJC51_17965
SGF: HEP81_01489
SRIM: CP984_09030
SSUB: CP968_31985
SPHV: F9278_14765 F9278_23700
SFUG: CNQ36_16665
SPAC: B1H29_07990 B1H29_19675
STSU: B7R87_02620 B7R87_18355 B7R87_20570 B7R87_24105 B7R87_26915
SGX: H4W23_12990
SCOE: CP976_26350
SBAT: G4Z16_00530 G4Z16_06550
SSPB: CP982_02295
SPLA: CP981_33920
SBRO: GQF42_40705
SCYG: S1361_32730(nisC)
SDW: K7C20_32405
SVD: CP969_17280
SCAL: I6J39_01875
SFB: CP974_02680
SMOB: J7W19_20925 J7W19_29380 J7W19_31925
SPRA: CP972_03635
SPEU: CGZ69_14835
SROI: IAG44_39820 IAG44_39825 IAG44_42290
SHK: J2N69_32530
SDD: D9753_20305
SMAO: CAG99_14135 CAG99_18985
SINE: KI385_28605
SYAN: NRK68_00280
SAKB: K1J60_22730
STAA: LDH80_14670
SNIG: HEK616_10030
SCAE: IHE65_15005
STUB: MMF93_08015 MMF93_21480
SSPN: LXH13_21440
STUD: STRTU_000638
STEE: F3L20_18410
SGK: PET44_14035 PET44_17255 PET44_34195
SYUN: MOV08_26980 MOV08_32545
SOV: QZH56_33865
SHAU: K9S39_23700 K9S39_31055
SFP: QUY26_27290
STTN: BSL84_27515
SCAY: PYS65_06000
SARM: DVA86_32185
SPRF: K4G22_17890
STPB: QR97_02040 QR97_39630
SRPA: HEP86_10660 HEP86_35455 HEP86_36795
SMIB: SMIR_04435
STRW: QHG49_16805
SCHE: QRN89_16925
SGLY: P8A20_24945 P8A20_30165
STAC: ABII15_14900 ABII15_35870
STYI: C9F11_01930(nisC1) C9F11_21035(nisC2) C9F11_36430(nisC3)
STRJ: H7827_09550
SEXP: SLV14_000942 SLV14_001742
SFLU: ACKTSN_21465
SSTO: ACE1OC_06330 ACE1OC_09100 ACE1OC_40160
SLUA: AB8735_03340 AB8735_03350 AB8735_38540
STGO: KBP30_00915 KBP30_03490
STCM: SCMC78_62350
STID: G7Z12_04175
STHU: M1P56_14160
STRQ: CGL27_01200 CGL27_16465 CGL27_38730
SHUG: ABVG11_26655
STHC: AY578_00390
SCT: SCAT_0533 SCAT_2820
SCY: SCATT_05430 SCATT_28060
KSK: KSE_04770 KSE_58830
KAB: B7C62_17035
KIT: CFP65_1559
KIS: HUT16_27265
KCM: ABWK59_33215
KNB: ACF9IK_09465 ACF9IK_13950 ACF9IK_30065
KIC: KCMC57_up61600
KPUR: ACFCLZ_18920
STRI: C7M71_008485 C7M71_017730 C7M71_022640
YIA: LO772_08175 LO772_16250 LO772_27140
ABRY: NYE86_08210
AREV: RVR_2395 RVR_5508
CMS: pCSL0018
CCAP: AES38_14930
AIG: QDX25_06070 QDX25_08175
PROU: AB1046_03105
PROZ: ACO229_06825 ACO229_06890
OEK: FFI11_016970
PSOI: PCC79_16965
NOY: EXE57_10145
KQI: F1D05_10850
THAO: NI17_009795
TALX: FOF52_10230 FOF52_15440
NDA: Ndas_4693
NAL: B005_2168 B005_4397
NGV: CDO52_03825 CDO52_26065
NEX: NE857_03335 NE857_22010 NE857_26285
NAKE: KGD83_01685
NCG: KGD84_18995
STRR: EKD16_21870
SAIU: J4H86_06475
TCU: Tcur_4648
ACTW: F7P10_18940
AGRA: AGRA3207_002566 AGRA3207_003486 AGRA3207_004965
AMAZ: LUW76_20865 LUW76_25215
ACTQ: OG417_25080 OG417_33025 OG417_33040 OG417_34375 OG417_45320
NOW: GBF35_16230 GBF35_37460 GBF35_40650
NGN: LCN96_15935 LCN96_25335 LCN96_32105
FRA: Francci3_0205 Francci3_1126 Francci3_1822 Francci3_2032 Francci3_3314 Francci3_3531 Francci3_3997
FAL: FRAAL2700 FRAAL6343
FRE: Franean1_0055 Franean1_1333 Franean1_2800 Franean1_6754
FRI: FraEuI1c_0879 FraEuI1c_6945
SEN: SACE_4959
SACG: FDZ84_24635 FDZ84_24715
AMQ: AMETH_1231
AMYC: CU254_41390
AAB: A4R43_24690
AACD: LWP59_37690
ATHM: L1857_05355
AMOG: QRX60_17700
AMYZ: HUW46_04506(nisC) HUW46_05907
ANW: QP939_03980
ABAR: AMYBAR_005260
PHH: AFB00_04970
SSYI: EKG83_09695 EKG83_24900 EKG83_25595 EKG83_26675
SACX: IOD16_27115
KAL: KALB_5942 KALB_6955 KALB_7175
KUT: JJ691_56010
KPHY: AOZ06_04935 AOZ06_15795 AOZ06_16520 AOZ06_40715
LXR: ACRSBM_22765 ACRSBM_34690
ACTA: C1701_26070
ACAU: ACOJVX_10495 ACOJVX_12515 ACOJVX_19320
ALO: CRK57672 CRK59226 CRK59310
ACTU: Actkin_04237(nisC)
CROS: N8J89_17970 N8J89_24310
UME: RM788_18740 RM788_33250(fxlM) RM788_37910 RM788_44000
SAQ: Sare_0603
MAU: Micau_4117 Micau_6128
MICB: MicB006_5566
MTUA: CSH63_04330 CSH63_21335
MICH: FJK98_32130
MCAB: HXZ27_03815 HXZ27_15440
MSAG: GCM10017556_24530
MCRA: ID554_13010
VER: HUT12_05015
MENO: Jiend_16210
MCHL: PVK74_10560 PVK74_24330 PVK74_30040
MFEU: H1D33_24725
MPRN: Q3V37_17425
MICF: QQG74_21535
MICN: WHN02_22635
AIH: Aiant_48020
ACTL: L3i22_023810
ASIC: Q0Z83_089720
PSUU: Psuf_023030 Psuf_023050
PRY: Prubr_74640
DVC: Dvina_51900
DACT: KZZ52_25380
NHY: JQS43_14325 JQS43_21955
CAI: Caci_3937
SNA: Snas_3603 Snas_5418
NAV: JQS30_06005
BLN: Blon_0521
BLON: BLIJ_0524
AEY: CDG81_13590 CDG81_17730
KBS: EPA93_00945 EPA93_02565 EPA93_05225 EPA93_12370 EPA93_12625 EPA93_15460 EPA93_44280 EPA93_45690 EPA93_45915 EPA93_45925
 » show all
Reference
PMID:7689965
  Authors
Kuipers OP, Beerthuyzen MM, Siezen RJ, De Vos WM
  Title
Characterization of the nisin gene cluster nisABTCIPR of Lactococcus lactis. Requirement of expression of the nisA and nisI genes for development of immunity.
  Journal
Eur J Biochem 216:281-91 (1993)
DOI:10.1111/j.1432-1033.1993.tb18143.x
  Sequence
[llt:CVCAS_0590]
Reference
PMID:23071302
  Authors
Zhang Q, Yu Y, Velasquez JE, van der Donk WA.
  Title
Evolution of lanthipeptide synthetases.
  Journal
Proc Natl Acad Sci U S A 109:18361-6 (2012)
DOI:10.1073/pnas.1210393109
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