KEGG   ORTHOLOGY: K20487
Entry
K20487                      KO                                     
Symbol
nisK, spaK
Name
two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK [EC:2.7.13.3]
Pathway
map02020  Two-component system
map02024  Quorum sensing
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    K20487  nisK, spaK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK
 09140 Cellular Processes
  09145 Cellular community - prokaryotes
   02024 Quorum sensing
    K20487  nisK, spaK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K20487  nisK, spaK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK
  09183 Protein families: signaling and cellular processes
   02022 Two-component system
    K20487  nisK, spaK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.13  Protein-histidine kinases
    2.7.13.3  histidine kinase
     K20487  nisK, spaK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK
Protein kinases [BR:ko01001]
 Histidine kinases
  OmpR family
   K20487  nisK, spaK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK
Two-component system [BR:ko02022]
 OmpR family
  NisK-NisR (lantibiotic biosynthesis)
   K20487  nisK, spaK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK
Other DBs
COG: COG0642
GO: 0000155
Genes
HAXI: HAALTHF_20940n
BSS: BSUW23_16515(spaK)
BST: GYO_3687
BIT: BIS30_06485
BLI: BL01675(spaK)
BLD: BLi00316(spaK)
BLH: BaLi_c03350(spaK)
BAY: RBAM_030970
BAQ: BACAU_3123(spaK)
BYA: BANAU_3284(spaK)
BAMP: B938_15865
BQY: MUS_3696(spaK)
BAML: BAM5036_3011(spaK)
BAMA: RBAU_3232(spaK)
BAMN: BASU_3013(spaK)
BAMB: BAPNAU_3291(spaK)
BAMT: AJ82_17500
BAMY: V529_33580(spaK)
BMP: NG74_03265(creC)
BAO: BAMF_3223(spaK)
BAZ: BAMTA208_17115(spaK)
BQL: LL3_03506(spaK)
BXH: BAXH7_03494(spaK)
BAMI: KSO_003650
BAMC: U471_32120
BAMF: U722_16635
BSIA: CWD84_03580
BVM: B9C48_15845
BSON: S101395_04831
BMOJ: HC660_32560(resE)
BAN: BA_3899
BAR: GBAA_3899
BAT: BAS3612
BAH: BAMEG_0732
BAI: BAA_3924
BAX: H9401_3713
BANT: A16_59170
BANR: A16R_39510
BANS: BAPAT_3735
BANH: HYU01_19050
BANV: DJ46_2602
BCZ: BCE33L4751(resE)
BCR: BCAH187_A3808
BAL: BACI_c37130
BNC: BCN_3589
BTF: YBT020_24970
BTHU: YBT1518_19930
BMYO: BG05_2745
BTRO: FJR70_12185
BNT: GSN03_15625
BPAC: LMD38_01700
BSM: BSM4216_3609
BGY: BGLY_0320(spaK)
BWH: A9C19_08730
BACP: SB24_13265
BACB: OY17_18795
BACO: OXB_0131
BACY: QF06_15205
BACS: AUL54_14100
BCIR: C2I06_16985
BMQ: BMQ_pBM70140
BMD: BMD_3442
BMH: BMWSH_1727
BMEG: BG04_342
BEO: BEH_10555
BCL: ABC1206 ABC3552
BON: A361_15345
CSOA: LIS82_03845
CPSS: M5V91_05825
OCN: CUC15_05080
OCB: CV093_05345
GKA: GK0307
GTE: GTCCBUS3UF5_3910
GTM: GT3921_17930
GLI: GLN3_11990
BCAL: CWI35_08680
GTN: GTNG_0270(spaK)
GWC: GWCH70_0245
GYC: GYMC61_1167
GYA: GYMC52_0289
GCT: GC56T3_0344
GMC: GY4MC1_3545
GSE: GT50_11145
GEJ: A0V43_17310
GZA: IC807_15110
GTH: Geoth_3654
PTL: AOT13_04675
LFU: HR49_14475
LYS: LBYS11_08640
LYB: C3943_06585 C3943_19450
LYG: C1N55_09450
LPAK: GDS87_05780 GDS87_08285 GDS87_09750
LAGR: FJQ98_06595
LMAC: I6G82_05120
LIU: OU989_05220
LLB: R6U77_03425
VIR: X953_07620
VHL: BME96_06535
VIG: BKP57_05850
VPT: KBP50_17350
APAK: AP3564_14490
BSJ: UP17_08500
PASA: BAOM_3715
BTHV: CQJ30_18215
PSYH: D0S48_14595
PCHU: QNI29_13150
BLEN: NCTC4824_00414(phoR_2)
BOU: I5818_02130
SFOR: QNH23_03830
SEP: SE_0121
SEPP: SEB_00076
SEPS: DP17_1336
SLG: SLGD_00021
SLN: SLUG_00460
SPET: CEP67_08340
SFQ: C7J90_06130
BLR: BRLA_c016240(yycG_2)
BRW: GOP56_01025
GYM: GYMC10_3455 GYMC10_4753
PPM: PPSC2_12980(eTR1)
PPO: PPM_2488(eTR1)
PPQ: PPSQR21_025740
PPOY: RE92_23815
PDU: PDUR_00535
PGM: PGRAT_04070 PGRAT_11275
POD: PODO_06765
PAEN: P40081_36880
PAEQ: R50912_33500
PAEA: R70723_32150
PAEH: H70357_18415
PAEJ: H70737_07615
PRI: PRIO_0850 PRIO_2430
PSON: JI735_20985
POW: IJ21_25900
PDH: B9T62_06000 B9T62_26905 B9T62_37125
PIB: BBD41_00585 BBD41_21605
PKB: B4V02_12030
PLW: D5F53_06335 D5F53_12990
PLEN: EIM92_00310
PLUT: EI981_01385 EI981_14345
PCHI: PC41400_01510
PTRI: KDC22_28145 KDC22_32305
PTJ: JRJ22_21010
PTHI: NDS46_03550
PKA: PQ456_01260
PDY: QJQ58_19115
PMAE: LMZ02_11915 LMZ02_31000
PAUN: MJA45_21135
PHK: SK066_01255
PPAB: KET34_19270
TCO: Theco_0448 Theco_0676
ANX: ACH33_16055
ATHE: K3F53_02825
SACA: FFV09_08930
KYR: CVV65_04160
TUM: CBW65_14760
SIV: SSIL_0471
SSIL: SOLI23_16400
SOB: CSE16_09940
SPOO: J3U78_10355
KEB: GXN75_03725
LLK: LLKF_1299(nisK)
LLT: CVCAS_0594(nisK)
LLS: lilo_0564(nisK)
LLX: NCDO2118_1266(nisK)
LLJ: LG36_0637(nisK)
LLN: LLNZ_01670
SPY: SPy_1082(srtK)
SPZ: M5005_Spy0805(srtK)
SPYM: M1GAS476_0862(srtK)
SPYA: A20_0845(srtK)
SPH: MGAS10270_Spy0918(srtK)
SPI: MGAS10750_Spy0954(srtK)
SPJ: MGAS2096_Spy0878(srtK)
SPK: MGAS9429_Spy0921(srtK)
SPB: M28_Spy0780(srtK)
SPYO: STAB901_04570
SNM: SP70585_1289
SMU: SMU_660
SMC: SmuNN2025_1331
SMUT: SMUGS5_02905
SMJ: SMULJ23_1333(spaK)
SMUA: SMUFR_0574
STC: str0902(hk04)
STL: stu0902(hk04)
STE: STER_0926
STN: STND_0875
STU: STH8232_1103(hk04)
STW: Y1U_C0972
STHE: T303_05645
STHS: AVT04_00580
SSA: SSA_0205(nisK)
SSB: SSUBM407_1000
SSU: SSU05_0906
SSV: SSU98_0911
SSS: SSUSC84_0810
SSUS: NJAUSS_0608
SUI: SSUJS14_0621
SGO: SGO_1907
SEQ: SZO_05570
SEZO: SeseC_01812
SEQU: Q426_02115
SEU: SEQ_1586
SGA: GALLO_1103
SGG: SGGBAA2069_c10890(srtK)
SGT: SGGB_1093(srtK)
SMB: smi_0309
STB: SGPB_1109(nsuK)
SCP: HMPREF0833_10630
SCF: Spaf_1097(nisK) Spaf_1119(nisK2)
SSR: SALIVB_0932(hk04)
STF: Ssal_01020
STJ: SALIVA_1179(hk04) SALIVA_2088(nisK)
STRS: SSAL8618_05780
SSAH: HSISS4_01035
SIF: Sinf_0947
SIB: SIR_0966
SIU: SII_0983
SOI: I872_00770
SIK: K710_0267
SIQ: DQ08_01285
SIO: DW64_01280
SLU: KE3_1028
SIG: N596_02970
SIP: N597_04765
STV: V470_08165
SPAT: A0O21_08950
STRA: ATM98_02945 ATM98_05520
SSOB: DK181_03900
SEQI: A6J79_08535 A6J79_10510 A6J79_10735
SKI: D7D50_07450
SRAT: FY406_00530
SGW: D7D53_00555
SPLR: C0J00_06850
STRG: SRT_14710
SVB: NCTC12167_00898(hk04)
SMEN: SAMEA4412692_0445(srtK) SAMEA4412692_1685(creC)
SPOC: NCTC10925_00672(creC)
SLAT: J4854_05920 J4854_06310
SAUP: NCTC3168_01701(creC)
SVF: NCTC3166_01046(creC)
STOY: STYK_02720
SRUN: LPB404_06125
FPEN: KIW23_09965
LCA: LSEI_0461
LCZ: LCAZH_0491
LCS: LCBD_0525
LCE: LC2W_0527
LCW: BN194_05340
LCL: LOCK919_0553
LPQ: AF91_01555
LPI: LBPG_02645
LPAP: LBPC_0428
LCB: LCABL_05270(resE)
LCX: LCA12A_2469
LRH: LGG_00549(resE)
LRG: LRHM_0530
LRL: LC705_00539(resE)
LRA: LRHK_556
LRO: LOCK900_0511
LRC: LOCK908_0550
LANI: FAX13_09950
LMUR: CPS94_07910
LFD: QFX10_03605
LBM: DS830_03095 DS830_08510
LHB: D1010_15775
XAK: KIMC2_16790
EGV: EGCR1_14045
EAV: EH197_21375
ERAF: J9537_12255
MPS: MPTP_0097 MPTP_1503
MPX: MPD5_0087
VLC: G314FT_16060
VIE: OL234_03695
ASAN: AWM72_06090
FHM: R0V13_09300
DPM: FNV33_06680
CTC: CTC_00598 CTC_00629(spaK)
CTET: BN906_00622 BN906_00648(spaK)
CNO: NT01CX_1325 NT01CX_1433
CBO: CBO1586 CBO1925
CBA: CLB_1606(spaK) CLB_1863
CBH: CLC_1616 CLC_1870
CBY: CLM_1827 CLM_2142
CBL: CLK_1053 CLK_1381
CBK: CLL_A2206
CBB: CLD_2701 CLD_2966
CBI: CLJ_B1693 CLJ_B2128
CBN: CbC4_0482 CbC4_6019
CBT: CLH_2007
CBF: CLI_1667 CLI_1990
CBM: CBF_1973
CBJ: H04402_01655
CBE: Cbei_3321
CBZ: Cbs_3321
CBEI: LF65_03808
CKL: CKL_1290
CKR: CKR_1186
CLJ: CLJU_c07840 CLJU_c09180 CLJU_c22960 CLJU_c25670
CPAT: CLPA_c04260
CPAE: CPAST_c04260
CSB: CLSA_c24470(spaK)
CAH: CAETHG_0358 CAETHG_0636 CAETHG_2877 CAETHG_3012
CBV: U729_2422
CSQ: CSCA_1002 CSCA_1283 CSCA_1504 CSCA_1564
CLD: CLSPO_c07440 CLSPO_c16290(spaK) CLSPO_c19220(resE3)
CACE: CACET_c26640
CCK: Ccar_06850 Ccar_07175 Ccar_07910 Ccar_09220
CTYK: CTK_C13820
CEU: A7L45_02935 A7L45_03465
CARG: RSJ17_11840 RSJ17_16255
CDRK: B9W14_11455 B9W14_11745 B9W14_12415 B9W14_13675
CDY: F3K33_16885
CCOH: SAMEA4530647_0526(spaK)
CFER: D4Z93_10110
CGAS: J1C67_02070
CLOS: DMR38_03730 DMR38_04315 DMR38_11880 DMR38_13290
CCAA: KQH81_08620
CGEL: psyc5s11_06810 psyc5s11_48280
CTAG: LL095_11050 LL095_12590
CINT: HZF06_17480
CTHD: CDO33_17205
HHW: NCTC503_00467(phoR_1)
CRAS: KVH43_08750
CCL: Clocl_0773
HSC: HVS_03100(phoR1)
RUK: A4V00_01790 A4V00_13675 A4V00_18220 A4V00_18290
CSS: Cst_c00950(yycG)
CSD: Clst_0090
CCEL: CCDG5_0814
FPLA: A4U99_00920
RUM: CK1_37080
RGV: NQ502_08410
FPA: FPR_00450 FPR_05730
FPRA: CG447_10850
FDU: GXM22_13105
ACOL: K5I23_16915
CAPR: EQM14_06575
CFEM: HCR03_13765
AMUR: ADH66_07275 ADH66_10015 ADH66_10085 ADH66_14680
TFR: BR63_17030
ELM: ELI_2589
EMT: CPZ25_005190
ELIM: B2M23_19555
EVN: NQ558_04800 NQ558_13115
AWO: Awo_c01570 Awo_c34090
AWI: CHL1_000361
FMS: M1R53_00365
BPEN: NQ488_11230
BHU: bhn_I0856
RHO: RHOM_03860 RHOM_13345
RIX: RO1_29680
RIM: ROI_06070 ROI_14520 ROI_14960
RRK: H8S51_001780
CCT: CC1_02440
CCOM: I6K69_11050 I6K69_12145
CEV: LK421_08300 LK421_09205
ROB: CK5_04050 CK5_05680 CK5_35890
BYL: A4V09_01465 A4V09_06545 A4V09_08155 A4V09_08185 A4V09_08930 A4V09_10485 A4V09_12175
BHAN: CGC63_13315
BLAU: DQQ01_06435 DQQ01_06880 DQQ01_07055
BPRO: PMF13cell1_02798(baeS_4) PMF13cell1_03984(cssS) PMF13cell1_05185(resE_13)
BLAB: EYS05_02565 EYS05_15875
BWX: NQ550_12625 NQ550_19690 NQ550_21765
BMAS: LK422_01145 LK422_04055 LK422_06895
BLAR: LC508_00230 LC508_04175 LC508_04475 LC508_06405 LC508_08110 LC508_08990 LC508_09905 LC508_25650
BLUI: Blut17040_16210 Blut17040_31460
BCOC: BLCOC_18710(sasA_15) BLCOC_29340(sasA_27) BLCOC_38610(sasA_34) BLCOC_42700(sasA_36)
BHV: BLHYD_02150(rcsC_1)
CSCI: HDCHBGLK_02145(cssS_1) HDCHBGLK_02895(creC)
CHYL: CE91St63_08900 CE91St63_27150
BPRL: CL2_28900
ARF: AR1Y2_0608
ACAC: EYQ97_16495
LUA: D4A81_09620
EHL: EHLA_0766
ACEL: acsn021_22190(spaK) acsn021_40900 acsn021_44000
ACHT: bsdcttw_05560 bsdcttw_40850
EEL: EUBELI_01658
RTO: RTO_31550
RGN: RGna_06960 RGna_16680
RLR: NQ541_11655
DLO: K5I24_11630 K5I24_16565
DFM: NQ560_12950 NQ560_13855 NQ560_15095
SINT: K5I26_09105 K5I26_14665
WCP: H9Q76_13690
SSUN: H9Q77_02895
QDO: H9Q78_04715
AHB: bsdtb5_10160
ERE: EUBREC_0091
ERT: EUR_30220
ERA: ERE_02710
KIB: RBB56_14040
CBIL: EUBC25_06940
CPRO: CPRO_14580(czcS)
CLE: Clole_0118
CEW: EKH84_03710
AMIC: Ami3637_07390
ETM: CE91St48_00180
AMT: Amet_3868
PSOR: RSJ16_09140
CDF: CD630_04820(spaK) CD630_04850 CD630_13520(cprK)
PDC: CDIF630_00610(spaK) CDIF630_00613 CDIF630_01508(cprK)
CDC: CD196_0438(spaK) CD196_0442 CD196_1216
CDL: CDR20291_0424(spaK) CDR20291_0428 CDR20291_1194
PDF: CD630DERM_04820(spaK) CD630DERM_04850 CD630DERM_13520(cprK)
PHX: KGNDJEFE_01375(walK_2)
TTM: Tthe_1882
TTO: Thethe_01870
TXY: Thexy_0989
TSH: Tsac_2263
AAUT: ACETAC_00460
TEP: TepRe1_0902
TAE: TepiRe1_0978
PHAR: NCTC13077_00014(yycG_1)
AMEI: LV469_00810
MHAP: JFY71_04000
CAD: Curi_c22930
SPOA: EQM13_07485
TIZ: RBU61_14585
AARG: Aargi30884_01000
ABSI: A9CBEGH2_02110
ERB: A4V01_10480
EHN: H9Q80_13430
TUR: AT726_08005
TSG: HLK68_07325
ERM: EYR00_03580
OLO: ADJ70_04930
PCAT: Pcatena_14550(srtK)
TIO: INP52_02950
CAER: CSV91_03080
CSTC: LK434_06025 LK434_09215
CCU: Ccur_04110
ELE: Elen_1171 Elen_3010
EYY: EGYY_22070
EGD: GS424_005995 GS424_017330
GPA: GPA_27680
CBAC: JI75_04580
RTS: CE91St31_14750 CE91St31_25440
BLN: Blon_1004
BLON: BLIJ_1024
BAST: BAST_1585
BCOR: BCOR_0499
BII: BINDI_0438
BANG: BBAG_0989
PSUB: Pelsub_P1130
KBS: EPA93_02555 EPA93_10650
SMR: Smar_1100
SHC: Shell_1368
 » show all
Reference
PMID:8161176
  Authors
Engelke G, Gutowski-Eckel Z, Kiesau P, Siegers K, Hammelmann M, Entian KD
  Title
Regulation of nisin biosynthesis and immunity in Lactococcus lactis 6F3.
  Journal
Appl Environ Microbiol 60:814-25 (1994)
DOI:10.1128/AEM.60.3.814-825.1994
  Sequence
[llt:CVCAS_0594]
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