KEGG ORTHOLOGY: K21031

ORTHOLOGY: K21031

Entry

K21031                      KO

Symbol

ISPD

Name

D-ribitol-5-phosphate cytidylyltransferase [EC:2.7.7.40]

Pathway

map00040

Pentose and glucuronate interconversions

map00515

Mannose type O-glycan biosynthesis

map01100

Metabolic pathways

Module

M00872

O-glycan biosynthesis, mannose type (core M3)

Reaction

R02921

CTP:D-ribitol-5-phosphate cytidylyltransferase

Disease

H00120

Muscular dystrophy-dystroglycanopathy type A

H00593

Limb-girdle muscular dystrophy

H01959

Muscular dystrophy-dystroglycanopathy type C

H02307

Muscular dystrophy-dystroglycanopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00040 Pentose and glucuronate interconversions
    K21031  ISPD; D-ribitol-5-phosphate cytidylyltransferase
  09107 Glycan biosynthesis and metabolism
   00515 Mannose type O-glycan biosynthesis
    K21031  ISPD; D-ribitol-5-phosphate cytidylyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.40  D-ribitol-5-phosphate cytidylyltransferase
     K21031  ISPD; D-ribitol-5-phosphate cytidylyltransferase

Other DBs

GO:

0047349

Genes

HSA:	729920(CRPPA)

PTR:	744905(ISPD)

PPS:	100989529(CRPPA)

GGO:	101141405(CRPPA)

PON:	100436260(ISPD)

NLE:	100586412(CRPPA)

HMH:	116810790(CRPPA)

MCC:	714980(CRPPA)

MCF:	102137200(CRPPA)

MTHB:

126951330

MNI:	105475621(ISPD)

CSAB:

103226446(ISPD)

CATY:

105589566(ISPD)

PANU:

101002318(CRPPA) 116274517

TGE:	112620979(ISPD)

MLEU:

105542409(ISPD)

RRO:	104657804(CRPPA)

RBB:	108540091(ISPD)

TFN:	117073177(CRPPA)

PTEH:

111545024(CRPPA)

CANG:

105525947(ISPD)

CJC:	100391839(CRPPA)

SBQ:	101028455(ISPD)

CIMI:

108303139(CRPPA)

CSYR:

103258165(ISPD)

MMUR:

105884423(ISPD)

LCAT:

123646899(CRPPA)

PCOQ:

105822436(ISPD)

OGA:	100946143(ISPD)

MMU:	75847(Crppa)

MCAL:

110306937(Crppa)

MPAH:

110324550(Ispd)

RNO:	493574(Crppa)

MCOC:

116079714(Crppa)

ANU:	117717162(Crppa)

MUN:	110558072(Crppa)

CGE:	100759830(Crppa)

MAUA:

101827509(Crppa)

PROB:

127214841(Crppa)

PLEU:

114699383(Crppa)

MORG:

121452318(Crppa)

MFOT:

126511510

AAMP:

119819036(Crppa)

NGI:	103726802 103737772(Ispd)

HGL:	101708024(Ispd)

CPOC:

100714480(Ispd)

CCAN:

109702191 109702202

DORD:

105991380(Ispd)

DSP:	122121560(Crppa)

PLOP:

125346856(Crppa)

NCAR:

124991599

MMMA:

107152644(Crppa)

OCU:	100337768(CRPPA)

OPI:	101527205(CRPPA)

TUP:	106733913(ISPD)

CFA:	100687645(CRPPA)

CLUD:

112670508(CRPPA)

VVP:	112915820(ISPD)

VLG:	121475093(CRPPA)

NPO:	129502737(CRPPA)

AML:	100477709(CRPPA)

UAH:	113260950(ISPD)

UAR:	123789210(CRPPA)

ELK:

111147336

LLV:

125081075

MPUF:

101685841(ISPD)

MNP:	132015903(CRPPA)

MLK:	131829457(CRPPA)

NVS:	122904872(CRPPA)

ORO:	101376511(ISPD)

EJU:	114219779(CRPPA)

ZCA:	113911488(CRPPA)

MLX:	118020825(CRPPA)

NSU:	110579983(CRPPA)

LWW:	102734063(CRPPA)

FCA:	101092257(CRPPA)

PYU:	121028671(CRPPA)

PCOO:

112866350(ISPD)

PBG:	122487954(CRPPA)

PVIV:

125161114(CRPPA)

LRUF:

124524548

PTG:	102962555(ISPD)

PPAD:

109263775(ISPD)

PUC:

125929969

AJU:	106984142(CRPPA)

HHV:

120221991

BTA:	104968457(CRPPA)

BOM:	102267591(ISPD)

BIU:	109557272(ISPD)

BBUB:

102408185(CRPPA)

BBIS:

105004525(ISPD)

CHX:	102187829(ISPD)

OAS:	101117925(CRPPA)

BTAX:

128046583(CRPPA)

ODA:	120878037(CRPPA)

CCAD:

122438160(CRPPA)

MBEZ:

129552272(CRPPA)

SSC:	100623666(ISPD)

CFR:	102513861(CRPPA)

CBAI:

105078608(ISPD)

CDK:	105092905(CRPPA)

VPC:	102545143(CRPPA)

BACU:

103006306(ISPD)

BMUS:

118900802(CRPPA)

LVE:	103089501(ISPD)

OOR:	101269182(CRPPA)

DLE:	111181747(CRPPA)

PCAD:

102973887(CRPPA)

PSIU:

116759842(CRPPA)

NASI:

112414560(ISPD)

ECB:	100065851(ISPD)

EPZ:	103561908(ISPD)

EAI:	106824377(CRPPA)

MYB:	102251618(ISPD)

MYD:	102758358(ISPD)

MMYO:

118666164(CRPPA)

MLF:	102417983(ISPD)

PKL:	118714234(CRPPA)

EFUS:

103292306(CRPPA)

MNA:	107541632(ISPD)

DRO:	112319864(ISPD)

SHON:

118993761(CRPPA)

AJM:	119062851(CRPPA)

PDIC:

114507840(CRPPA)

PHAS:

123812140(CRPPA)

MMF:	118619906(CRPPA)

PPAM:

129063117(CRPPA)

HAI:	109391915(ISPD)

RFQ:	117012507(CRPPA)

PALE:

102889402(ISPD)

PGIG:

120602300(CRPPA)

PVP:	105293957(ISPD)

RAY:	107507974(ISPD)

MJV:	108397403(CRPPA)

TOD:	119242959(CRPPA)

SARA:

101555867(ISPD)

SETR:

126025989(CRPPA)

LAV:	100658658(ISPD)

TMU:

101349627

ETF:	101659829(CRPPA)

DNM:	101447485(ISPD)

MDO:	100021926(ISPD)

GAS:	123248875(CRPPA)

SHR:	100933596(CRPPA)

AFZ:

127564192

PCW:	110217591(ISPD)

OAA:	103171116(CRPPA)

GGA:	420591(ISPD)

PCOC:

116227012(CRPPA)

MGP:	100546755(CRPPA)

CJO:	107309227(CRPPA)

TPAI:

128086188(CRPPA)

LMUT:

125695969(CRPPA)

NMEL:

110393665(ISPD)

APLA:

101798432(CRPPA)

ACYG:

106037529(CRPPA)

CATA:

118255895(CRPPA)

AFUL:

116485531(CRPPA)

TGU:	100224476(CRPPA)

LSR:	110474698(CRPPA)

SCAN:

103812855(CRPPA)

PMOA:

120502995(CRPPA)

OTC:	121343284(CRPPA)

PRUF:

121353156(CRPPA)

GFR:	102043726(ISPD)

FAB:	101808459(ISPD)

OMA:	130249498(CRPPA)

PHI:	102106665(ISPD)

PMAJ:

107199782(CRPPA)

CCAE:

111924281(ISPD)

CCW:	104689133(CRPPA)

CBRC:

103612318(ISPD)

ETL:	114054598(CRPPA)

ZAB:	102062820(ISPD)

ACHL:

103800986(ISPD)

SVG:	106864756(ISPD)

MMEA:

130577618(CRPPA)

HRT:	120761220(CRPPA)

FPG:	101918624(ISPD)

FCH:	102045764(CRPPA)

CLV:	102091684 102099043(ISPD)

EGZ:	104133024(ISPD)

NNI:	104009208(ISPD)

PCRI:

104027633(ISPD)

PLET:

104617788

EHS:

104506607

PCAO:

104046572(ISPD)

ACUN:

113476565(ISPD)

TALA:

104359311(CRPPA)

PADL:

103918707(ISPD)

AFOR:

103901217(ISPD)

ACHC:

115339050(CRPPA)

HALD:

104321190(ISPD)

HLE:	104838094(ISPD)

AGEN:

126037898

GCL:

127012692

CCRI:

104158283(ISPD)

MUI:

104539921

LDI:	104350734(ISPD)

OHA:	104326552(ISPD)

SHAB:

115616037(CRPPA)

DPUB:

104299906(ISPD)

PGUU:

104469222(ISPD)

CPEA:

104386348(ISPD)

CVF:	104288882(ISPD)

RTD:	128905425(CRPPA)

CUCA:

104068007(ISPD)

TEO:	104384085(ISPD)

BRHI:

104493896(ISPD)

AAM:	106483424(ISPD)

AROW:

112971554(ISPD)

NPD:	112952261(ISPD)

TGT:	104576125(ISPD)

DNE:	112986040(ISPD)

SCAM:

104147892(ISPD)

ASN:	102378278(ISPD)

AMJ:	102565024(ISPD)

CPOO:

109309368(ISPD)

GGN:	109291460(ISPD)

PSS:	102443797(ISPD)

CMY:	102938794(CRPPA)

CCAY:

125631495(CRPPA)

DCC:	119852079(CRPPA)

CPIC:

101946437(CRPPA)

TST:	117872271(CRPPA)

CABI:

116837205(CRPPA)

MRV:	120397859(CRPPA)

ACS:	100564525(ispd)

ASAO:

132778802(CRPPA)

PVT:	110073107(ISPD)

SUND:

121935146(CRPPA)

PBI:	103059035(ISPD)

PMUR:

107282972(CRPPA)

CTIG:

120303362(CRPPA)

TSR:	106557097(ISPD)

PGUT:

117654899(CRPPA)

APRI:

131196979(CRPPA)

PTEX:

113440056(ISPD)

NSS:	113418900(ISPD)

VKO:	123023175(CRPPA)

PMUA:

114607101(CRPPA)

PRAF:

128424148(CRPPA)

ZVI:	118091723(CRPPA)

HCG:	128330300(CRPPA)

GJA:	107119139(ISPD)

STOW:

125441224(CRPPA)

EMC:	129337805(CRPPA)

XLA:	108718486(crppa.L)

XTR:	548994(crppa)

NPR:	108788012(ISPD)

RTEM:

120939853(CRPPA)

BBUF:

121000699(CRPPA)

BGAR:

122938478(CRPPA)

MUO:	115469051(CRPPA)

GSH:	117354102(CRPPA)

DRE:	798716(crppa)

SRX:	107730867 107752635

SANH:

107683245 107704765

SGH:	107582240 107587840

CCAR:

109079886

CAUA:

113114985(ispd)

CGIB:

127972749

PTET:

122358986(crppa)

LROH:

127176715(crppa)

OMC:	131554292(crppa)

PPRM:

120477887(crppa)

RKG:	130104317(crppa)

MAMB:

125248966(crppa)

CIDE:

127495691

MASI:

127421871

TROS:

130564667(crppa)

TDW:	130428112(crppa)

MANU:

129438310(crppa)

IPU:	108277411(crppa)

IFU:	128621324(crppa)

PHYP:

113539387(ispd)

SMEO:

124394611(crppa)

TFD:	113643646(crppa)

TVC:	132858168(crppa)

AMEX:

103023727(ispd)

CMAO:

118803454(crppa)

EEE:	113570823(ispd)

CHAR:

105894068(crppa)

TRU:	101062396(crppa)

TFS:	130532664(crppa)

LCO:

104935585

NCC:	104960397 104960472(ispd)

TBEN:

117480076(crppa)

CGOB:

115021021(crppa)

PGEO:

117461297(crppa)

GACU:

117543303(crppa)

EMAC:

134861378(crppa)

ELY:	117265933(crppa)

EFO:	125892957(crppa)

PLEP:

121945842(crppa)

SLUC:

116036085(crppa)

ECRA:

117945838(crppa)

ESP:	116691371(crppa)

PFLV:

114557749(crppa)

GAT:	120810732(crppa)

PPUG:

119198001(crppa)

AFB:	129109696(crppa)

CLUM:

117745388(crppa)

PSWI:

130212704(crppa)

MSAM:

119897047(crppa)

SCHU:

122882319(crppa)

CUD:	121513847(crppa)

ALAT:

119006828(crppa)

MZE:	101469765(ispd)

ONL:	100701655(ispd)

OAU:	116334991(crppa)

OLA:	101160346(ispd)

OML:	112136728(crppa)

CSAI:

133441163(crppa)

XMA:	102222855(ispd)

XCO:	114142187(crppa)

XHE:	116716756(crppa)

PRET:

103477675(ispd)

PFOR:

103150305(ispd)

PLAI:

106936596 106958115(ispd)

PMEI:

106907744 106926471(ispd)

GAF:	122830706(crppa)

PPRL:

129371024(crppa)

CVG:	107100909(ispd)

CTUL:

119779768(crppa)

GMU:	124866284(crppa)

NFU:	107379196(ispd)

KMR:	108243278(crppa)

ALIM:

106524966(ispd)

NWH:	119409224(crppa)

AOCE:

111589041(ispd)

MCEP:

125016878(crppa)

CSEM:

103388979(ispd)

POV:	109639763(ispd)

SSEN:

122762809(crppa)

HHIP:

117776475(crppa)

HSP:	118114268(crppa)

SMAU:

118284963(crppa)

LCF:	108883206(crppa)

SDU:	111222460(ispd)

SLAL:

111644498(ispd)

XGL:	120784832(crppa)

HCQ:	109521068(ispd)

SSCV:

125974823

SBIA:

133500629(crppa)

PEE:	133401612(crppa)

PTAO:

133479891(crppa)

BPEC:

110159160(ispd)

MALB:

109968970(ispd)

BSPL:

114843280(crppa)

SASA:

106582287 106605211(ispd)

STRU:

115177010 115177763

OTW:	112230104(crppa)

OMY:	110488227(crppa)

OGO:

123997666

ONE:

115141141

OKI:	109902091(crppa)

OKE:	118364365(crppa) 118367417

SALP:

111958553 111965154

SNH:

120047145

CCLU:

121553358 123487229

ELS:	105021901(crppa)

SFM:	108927328(crppa)

PKI:	111839071(ispd)

AANG:

118224157(crppa)

LOC:	102693365(ispd)

PSPA:

121313587(crppa)

ARUT:

117399487(crppa)

PSEX:

120515603

LCM:

102351162

CMK:	103182656(crppa)

CPLA:

122549790(crppa)

HOC:	132816022(crppa)

LERI:

129712992(crppa)

PMRN:

116948320(CRPPA)

LRJ:	133345189(CRPPA)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:	100373121 100374023

BTAB:

109033928

CLEC:

106664849

HHAL:

106680924

NLU:	111044975 120348942 120352829

HVI:

124369735

MQU:	128999166 129005884

PHU:	Phum_PHUM391000

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

MNZ:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

HRO:	HELRODRAFT_63060

LGI:	LOTGIDRAFT_111165

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:	124279640 124281372

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

127855009 127859526 127859527 127859746

OBI:	106878830 106881934

OSN:	115210345 115210488

LAK:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_21810

MBR:	MONBRDRAFT_2255

SRE:	PTSG_07710

» show all

Reference

PMID:26923585

Authors

Kanagawa M, Kobayashi K, Tajiri M, Manya H, Kuga A, Yamaguchi Y, Akasaka-Manya K, Furukawa J, Mizuno M, Kawakami H, Shinohara Y, Wada Y, Endo T, Toda T

Title

Identification of a Post-translational Modification with Ribitol-Phosphate and Its Defect in Muscular Dystrophy.

Journal

Cell Rep 14:2209-23 (2016)
DOI:10.1016/j.celrep.2016.02.017

Sequence

[hsa:729920]

LinkDB

DBGET integrated database retrieval system