KEGG   ORTHOLOGY: K21162
Entry
K21162                      KO                                     
Symbol
sgcE4, ncsE4, kedE4
Name
enediyne biosynthesis protein E4
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00824  9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21162  sgcE4, ncsE4, kedE4; enediyne biosynthesis protein E4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21162  sgcE4, ncsE4, kedE4; enediyne biosynthesis protein E4
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Others
   K21162  sgcE4, ncsE4, kedE4; enediyne biosynthesis protein E4
Genes
LANH: KR767_19060
XBA: C7S18_10370 C7S18_17060
PMAO: PMYSY11_0486
SWD: Swoo_1678
SPSW: Sps_03706
SMAI: EXU30_03455
SBK: SHEWBE_3492
SAES: HBH39_12035
SPSH: FM037_10050
SSEM: JYB85_11785
ASP: AOR13_475
SDE: Sde_2997
SAGA: M5M_16680
LLO: LLO_3253
TIG: THII_0010
THIP: N838_16205
TBN: TBH_C0179
HCH: HCH_01486
PHL: KKY_3572
HDI: HDIA_0904
SIL: SPO0859
DSH: Dshi_2002
PGD: Gal_03764
CID: P73_2894
MAGQ: MGMAQ_3276
SFU: Sfum_1617
MXA: MXAN_7127
BMX: BMS_1273
SGR: SGR_607(unbV)
SGB: WQO_34000
STRM: M444_38015
AMD: AMED_6871
AMN: RAM_35255
AMM: AMES_6766
AMZ: B737_6766
AOI: AORI_1834
AMYY: YIM_41015
AORI: SD37_32040
SESP: BN6_39250
ACTI: UA75_19095
ACAD: UA74_18605
ALO: CRK57502
MIL: ML5_5857
ACTN: L083_3235
CAI: Caci_6360
MAR: MAE_12730
MPK: VL20_1931
NSPH: BDGGKGIB_04550(rsxD)
RCA: Rcas_1882
MRB: Mrub_1750
RBA: RB11088
PSL: Psta_1247
LLH: I41_23630
CPI: Cpin_6727
CPRV: CYPRO_2340
SALI: L593_05865
HMU: Hmuk_1747
HALL: LC1Hm_1003
AG: AAM78014(ncsE4) AFV52141(kedE4)
 » show all
Reference
PMID:12183628 (sgcE4)
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_34000]
Reference
PMID:15797213 (ncsE4)
  Authors
Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B
  Title
The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.
  Journal
Chem Biol 12:293-302 (2005)
DOI:10.1016/j.chembiol.2004.12.013
  Sequence
Reference
PMID:23360970 (kedE4)
  Authors
Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B
  Title
Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.
  Journal
Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a
  Sequence
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