KEGG ORTHOLOGY: K21421

ORTHOLOGY: K21421

Entry

K21421                      KO

Symbol

NOX2, GP91, CYBB

Name

NADPH oxidase 2 [EC:1.-.-.-]

Pathway

map04066

HIF-1 signaling pathway

map04145

Phagosome

map04216

Ferroptosis

map04217

Necroptosis

map04613

Neutrophil extracellular trap formation

map04621

NOD-like receptor signaling pathway

map04670

Leukocyte transendothelial migration

map04933

AGE-RAGE signaling pathway in diabetic complications

map05010

Alzheimer disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05140

Leishmaniasis

map05171

Coronavirus disease - COVID-19

map05415

Diabetic cardiomyopathy

map05417

Lipid and atherosclerosis

Disease

H00089

IFN-gamma/IL-12 axis

H00098

Chronic granulomatous disease

H01167

Granulibacter infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
  09143 Cell growth and death
   04216 Ferroptosis
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
   04217 Necroptosis
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
   04621 NOD-like receptor signaling pathway
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
   04670 Leukocyte transendothelial migration
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
   05020 Prion disease
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
   05022 Pathways of neurodegeneration - multiple diseases
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
   05415 Diabetic cardiomyopathy
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2
Membrane trafficking [BR:ko04131]
Others
  NADPH oxidases (Nox) and associated proteins
   NADPH oxidases
    K21421  NOX2, GP91, CYBB; NADPH oxidase 2

Other DBs

GO:

0016175

TC:

5.B.1.1.1

Genes

HSA:	1536(CYBB)

PTR:	465566(CYBB)

PPS:

GGO:

PON:

NLE:

HMH:

MCC:	696542(CYBB)

MCF:

102122418

MTHB:

126946357

MNI:

105463247

CSAB:

103247465(CYBB)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100415466(CYBB)

SBQ:

CIMI:

CSYR:

MMUR:

PCOQ:

OGA:

MMU:	13058(Cybb)

MCAL:

110286646

MPAH:

110313555

RNO:	66021(Cybb)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

OCU:	100008801(CYBB)

OPI:

101520179

TUP:

102468293

GVR:

103593579

CFA:	491825(CYBB)

CLUD:

VVP:

VLG:

NPO:

AML:	100468223 109490984

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101086207(CYBB)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	281112(CYBB)

BOM:

BBUB:

BBIS:

CHX:

OAS:	100036757(CYBB)

BTAX:

ODA:

CCAD:

MBEZ:

SSC:	397108(GP91-PHOX)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100050132(CYBB)

EPZ:

EAI:

MYB:

MYD:

MMYO:

MLF:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

OAA:

GGA:	418581(CYBB)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ETL:

ZAB:

ACHL:

SVG:

MMEA:

HRT:

FPG:

FCH:

CLV:

EGZ:

NNI:

PCRI:

PLET:

EHS:

PCAO:

ACUN:

TALA:

PADL:

AFOR:

ACHC:

HALD:

HLE:

AGEN:

GCL:

CCRI:

CSTI:

CMAC:

MUI:

BREG:

FGA:

GSTE:

LDI:

MNB:

OHA:

NNT:

SHAB:

DPUB:

PGUU:

ACAR:

CPEA:

AVIT:

CVF:

RTD:

CUCA:

TEO:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	444353(cybb.L)

XTR:	595081(cybb)

NPR:

RTEM:

BBUF:

BGAR:

MUO:

GSH:

DRE:	393386(cybb)

SRX:	107737212 107751141

SANH:

107691306 107695080

SGH:	107569247 107576937

CCAR:

CAUA:

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

MASI:

TROS:

TDW:

MANU:

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

AMEX:

CMAO:

EEE:

CHAR:

TRU:	445888(gp91phox)

TFS:

130522039

TNG:	GSTEN00019431G001

LCO:

TBEN:

CGOB:

PGEO:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

ALAT:

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

MCEP:

CSEM:

POV:

SSEN:

HHIP:

HSP:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

MALB:

BSPL:

SJO:

SASA:

100270807(cybb) 106575674

STRU:

115179597 115196370

OTW:	112253649 112266313

OMY:	100329199(gp91phox) 118936247

OGO:	124021056 124021674

ONE:

115119078

OKI:	109875970 116354027

OKE:

118376411

SALP:

112077474

SNH:	120033766 120042644

CCLU:

ELS:

SFM:

PKI:

AANG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:

RTP:

CPLA:

HOC:	132820484 132820754

LERI:

129702683

BFO:

118423236

BBEL:

109466371

CIN:	100169685(nox2)

SCLV:

120332919 120333101 120345115

SPU:	115928144 594258 757329

LPIC:

129258921 129258928

APLC:

110974417

AJC:	117105238 117105256

SKO:	100377887 102809132

NVL:

108567087

DPX:	DAPPUDRAFT_263961

PVM:

113829916

HRO:	HELRODRAFT_66368

LGI:	LOTGIDRAFT_180688

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:	106150924 106156566

NVE:	5509919 5510197

EPA:	110233982 110235063 110248433 110249082

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:	114538306 114538330

XEN:	124440965 124442591

HMG:	100202604 101236489

HSY:

130645757

TAD:	TRIADDRAFT_25818

AQU:

100639820

MNT:	112093711 21394110 21410725

NCR:	NCU10775(nox-2)

NTE:	NEUTE1DRAFT148131(NEUTE1DRAFT_148131)

SMP:	SMAC_08741(putative_nox2)

PAN:	PODANSg1798

PBEL:

PPSD:

PPSP:

PPSA:

TTT:	THITE_2117168

MTM:	MYCTH_2066622

CTHR:

MGR:

PPEI:

PGRI:

TMN:	UCRPA7_1472

SSCK:

SPSK_07252

FGR:	FGSG_10807

FPU:	FPSE_08853

FPOA:

FPOAC1_009529

FVN:	FVRRES_10170

FVR:	FVEG_11478

NHE:	NECHADRAFT_93345

FMU:	J7337_009877 J7337_012453

TRE:	TRIREDRAFT_81646

TRR:	M419DRAFT_89254

MAW:

MAC_01488

MAJ:

MAA_04914

PCHM:

VFPPC_03673 VFPPC_07750

CMT:

CCM_01357

AMUS:

LMH87_003961

PLJ:	VFPFJ_01978

PTKZ:

JDV02_003973

VAL:	VDBG_03457

VDA:	VDAG_09930

CFJ:	CFIO01_08793

CLUP:

CLUP02_12949

CHIG:

CH63R_12188

SAPO:

SAPIO_CDS3817

ELA:	UCREL1_9117

PFY:	PFICI_14637

SSL:	SS1G_11172

BFU:	BCIN_02g04930(BcnoxB)

MBE:

MBM_02981

PSCO:

LY89DRAFT_649551

GLZ:	GLAREA_05336

TMF:	EYB26_009015

TRG:	TRUGW13939_11236

CIM:	CIMG_00491

CPW:	CPC735_057350

URE:	UREG_00528

PBL:	PAAG_05966

PBN:	PADG_06026

ABE:

ARB_07242

TVE:

TRV_03949

AJE:	HCAG_01252

BGH:	BDBG_06745

PNO:	SNOG_12260

PTE:

PTT_13443

BZE:	COCCADRAFT_35195

BSC:	COCSADRAFT_109835

BOR:	COCMIDRAFT_107502

AALT:

CC77DRAFT_927857

ARAB:

EKO05_0009771

NPA:	UCRNP2_5073

TML:	GSTUM_00003774001

TMS:	TREMEDRAFT_32037

TVS:	TRAVEDRAFT_154726

DSQ:	DICSQDRAFT_169781

PCO:	PHACADRAFT_253883

SHS:	STEHIDRAFT_156361 STEHIDRAFT_94006

HIR:	HETIRDRAFT_147877

PSQ:	PUNSTDRAFT_58473

ADL:	AURDEDRAFT_117067

FME:	FOMMEDRAFT_111964

GTR:	GLOTRDRAFT_65323

LBC:	LACBIDRAFT_173015(LbNoxB)

CCI:	CC1G_09830

ABP:	AGABI1DRAFT60718(AGABI1DRAFT_60718)

ABV:	AGABI2DRAFT194938(AGABI2DRAFT_194938)

PCUB:

JR316_0013107

MPR:	MPER_01688

MRR:	Moror_4662 Moror_9356

E1B28_002890 E1B28_006306

SCM:	SCHCO_01038608(SCHCODRAFT_01038608)

CPUT:

CONPUDRAFT_83020

SLA:	SERLADRAFT_386004

WSE:	WALSEDRAFT_31540

WIC:	J056_002411

PGR:	PGTG_04320

PTRC:

PtA15_5A381

PSTR:

Pst134EA_009315

MLR:	MELLADRAFT_43541 MELLADRAFT_70910

MBR:	MONBRDRAFT_33523

SRE:	PTSG_07396

DDI:	DDB_G0289653(noxA)

DPP:	DICPUDRAFT_32111

DFA:	DFA_11184(noxA)

ACAN:

ACA1_370180

TET:	TTHERM_00510191

PIF:	PITG_04250 PITG_15645

PSOJ:

PHYSODRAFT_526416

NGR:	NAEGRDRAFT_80514

» show all

Reference

PMID:2425263

Authors

Royer-Pokora B, Kunkel LM, Monaco AP, Goff SC, Newburger PE, Baehner RL, Cole FS, Curnutte JT, Orkin SH

Title

Cloning the gene for an inherited human disorder--chronic granulomatous disease--on the basis of its chromosomal location.

Journal

Nature 322:32-8 (1986)
DOI:10.1038/322032a0

Sequence

[hsa:1536]

LinkDB

DBGET integrated database retrieval system