KEGG   ORTHOLOGY: K22517
Entry
K22517                      KO                                     
Symbol
CBLB
Name
E3 ubiquitin-protein ligase CBL-B [EC:2.3.2.27]
Pathway
map04012  ErbB signaling pathway
map04120  Ubiquitin mediated proteolysis
map04144  Endocytosis
map04625  C-type lectin receptor signaling pathway
map04660  T cell receptor signaling pathway
map04910  Insulin signaling pathway
map05162  Measles
Disease
H02540  Infantile-onset multisystem autoimmune disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
   04660 T cell receptor signaling pathway
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
  09152 Endocrine system
   04910 Insulin signaling pathway
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
 09160 Human Diseases
  09172 Infectious disease: viral
   05162 Measles
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
   04121 Ubiquitin system
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   CBL proteins
    K22517  CBLB; E3 ubiquitin-protein ligase CBL-B
Genes
HSA: 868(CBLB)
PTR: 460566(CBLB)
PPS: 100984607(CBLB)
GGO: 101124684(CBLB)
PON: 100452289(CBLB)
NLE: 100588040(CBLB)
HMH: 116466990(CBLB)
MCC: 703879(CBLB)
MCF: 102114949(CBLB)
MTHB: 126947841
MNI: 105477589(CBLB)
CSAB: 103228406(CBLB)
CATY: 105599650(CBLB)
PANU: 101011142(CBLB)
TGE: 112618546(CBLB)
MLEU: 105550372(CBLB)
RRO: 104674409(CBLB)
RBB: 108544485(CBLB)
TFN: 117083570(CBLB)
PTEH: 111542832(CBLB)
CANG: 105519581(CBLB)
CJC: 100409801(CBLB)
SBQ: 101035841(CBLB)
CIMI: 108305841(CBLB)
CSYR: 103261288(CBLB)
MMUR: 105878030(CBLB)
LCAT: 123630580(CBLB)
OGA: 100942227(CBLB)
MMU: 208650(Cblb)
MCAL: 110311127(Cblb)
MPAH: 110330092(Cblb)
RNO: 171136(Cblb)
MCOC: 116085981(Cblb)
ANU: 117717744(Cblb)
MUN: 110540535(Cblb)
CGE: 100774600(Cblb)
MAUA: 101826106(Cblb)
PROB: 127227249(Cblb)
PLEU: 114691911(Cblb)
MORG: 121461747(Cblb)
MFOT: 126514504
AAMP: 119824571(Cblb)
NGI: 103747585(Cblb)
HGL: 101719173(Cblb)
CPOC: 100718857(Cblb)
CCAN: 109699003(Cblb)
DORD: 105994912(Cblb)
DSP: 122105546(Cblb)
PLOP: 125351651(Cblb)
NCAR: 124992598
MMMA: 107136344(Cblb)
OCU: 100355469
OPI: 101527411(CBLB)
TUP: 102485272(CBLB)
GVR: 103597898(CBLB)
CFA: 487965(CBLB)
CLUD: 112679007(CBLB)
VVP: 112913407(CBLB)
VLG: 121488606(CBLB)
NPO: 129503860(CBLB)
AML: 100473515(CBLB)
UMR: 103677350(CBLB)
UAH: 113250824(CBLB)
UAR: 123784092(CBLB)
ELK: 111149136
LLV: 125096644
MPUF: 101676377(CBLB)
MNP: 132012251(CBLB)
MLK: 131825173(CBLB)
NVS: 122908475(CBLB)
ORO: 101374044(CBLB)
EJU: 114221055(CBLB)
ZCA: 113917547(CBLB)
MLX: 118007136(CBLB)
NSU: 110582330(CBLB)
LWW: 102725755
FCA: 101101498(CBLB)
PYU: 121036187(CBLB)
PCOO: 112850503(CBLB)
PBG: 122491397(CBLB)
PVIV: 125174915(CBLB)
LRUF: 124526752
PTG: 102962133(CBLB)
PPAD: 109266341(CBLB)
PUC: 125920912
AJU: 106972259
HHV: 120239104(CBLB)
BTA: 525906(CBLB)
BOM: 102287221(CBLB)
BIU: 109568926(CBLB)
BBUB: 102389208(CBLB)
BBIS: 104987544(CBLB)
CHX: 102186998(CBLB)
OAS: 101114404(CBLB)
BTAX: 128053306(CBLB)
ODA: 120852099(CBLB)
CCAD: 122428853(CBLB)
MBEZ: 129550267(CBLB)
SSC: 100621690(CBLB)
CFR: 102515465(CBLB)
CBAI: 105080142(CBLB)
CDK: 105087708(CBLB)
VPC: 102527933(CBLB)
BACU: 103002776(CBLB)
BMUS: 118894212(CBLB)
LVE: 103083966(CBLB)
OOR: 101280577(CBLB)
DLE: 111185062(CBLB)
PCAD: 102980192(CBLB)
PSIU: 116753251(CBLB)
NASI: 112393232(CBLB)
ECB: 100061819(CBLB)
EPZ: 103549198(CBLB)
EAI: 106838872(CBLB)
MYB: 102245653(CBLB)
MYD: 102759944(CBLB)
MMYO: 118676386(CBLB)
MLF: 102432845(CBLB)
PKL: 118724944(CBLB)
EFUS: 103301562(CBLB)
MNA: 107523964(CBLB)
DRO: 112320522(CBLB)
SHON: 118999006(CBLB)
AJM: 119058052(CBLB)
PDIC: 114489417(CBLB)
PHAS: 123827009(CBLB)
MMF: 118617083(CBLB)
PPAM: 129073692(CBLB)
HAI: 109395019(CBLB)
RFQ: 117036582(CBLB)
PALE: 102890283(CBLB)
PGIG: 120598144(CBLB)
PVP: 105309876(CBLB)
RAY: 107514119(CBLB)
MJV: 108396704(CBLB)
TOD: 119257555(CBLB)
SARA: 101546966(CBLB)
SETR: 126025968(CBLB)
LAV: 100669603(CBLB)
TMU: 101345632
ETF: 101641844(CBLB)
DNM: 101418752(CBLB)
MDO: 100011932(CBLB)
GAS: 123242395(CBLB)
SHR: 100913401(CBLB)
AFZ: 127554025
PCW: 110217499(CBLB)
OAA: 100089052(CBLB)
GGA: 418406(CBLB)
PCOC: 116242368(CBLB)
MGP: 100546892(CBLB)
CJO: 107321076(CBLB)
TPAI: 128090366(CBLB)
LMUT: 125702435(CBLB)
NMEL: 110400575(CBLB)
APLA: 101799051(CBLB)
ACYG: 106038875(CBLB)
CATA: 118244975(CBLB)
AFUL: 116500897(CBLB)
TGU: 100226776(CBLB)
LSR: 110472839(CBLB)
SCAN: 103820721(CBLB)
PMOA: 120513390(CBLB)
OTC: 121345473(CBLB)
PRUF: 121351645(CBLB)
GFR: 102033221(CBLB)
FAB: 101810847(CBLB)
OMA: 130253930(CBLB)
PHI: 102103800(CBLB)
PMAJ: 107208416(CBLB)
CCAE: 111940265 111940281
CCW: 104687176(CBLB)
CBRC: 103613861(CBLB)
ETL: 114057223(CBLB)
ZAB: 102071711(CBLB)
ACHL: 103807793
SVG: 106861371(CBLB)
MMEA: 130578085(CBLB)
HRT: 120748876(CBLB)
FPG: 101912806(CBLB)
FCH: 102053933(CBLB)
CLV: 102097605
EGZ: 104129286(CBLB)
NNI: 104014116(CBLB)
PCRI: 104033521(CBLB)
PLET: 104623234
EHS: 104506930(CBLB)
PCAO: 104051186(CBLB)
ACUN: 113482374(CBLB)
TALA: 104361189(CBLB)
PADL: 103914685(CBLB)
AFOR: 103893620(CBLB)
ACHC: 115343815(CBLB)
HALD: 104313430(CBLB)
HLE: 104831628(CBLB)
AGEN: 126049020
GCL: 127016886
CCRI: 104157926(CBLB)
CSTI: 104549328(CBLB)
CMAC: 104481542(CBLB)
MUI: 104539755
BREG: 104637746(CBLB)
FGA: 104080082
LDI: 104344126(CBLB)
MNB: 103771012
OHA: 104333904(CBLB)
NNT: 104411578(CBLB)
SHAB: 115601587(CBLB)
DPUB: 104297087(CBLB)
PGUU: 104460843
CPEA: 104384962(CBLB)
AVIT: 104277309(CBLB)
CVF: 104285285(CBLB)
RTD: 128904349(CBLB)
CUCA: 104056174(CBLB)
TEO: 104383220
BRHI: 104495439(CBLB)
AAM: 106490686(CBLB)
AROW: 112965109(CBLB)
NPD: 112949479(CBLB)
TGT: 104566991(CBLB)
DNE: 112990518(CBLB)
SCAM: 104144225(CBLB)
ASN: 102384451(CBLB)
AMJ: 102563760(CBLB)
CPOO: 109324954(CBLB)
GGN: 109303562(CBLB)
PSS: 102454526(CBLB)
CMY: 102943844(CBLB)
CCAY: 125620527(CBLB)
DCC: 119858421(CBLB)
CPIC: 101947986(CBLB)
TST: 117887769(CBLB)
CABI: 116816526(CBLB)
MRV: 120371363(CBLB)
ACS: 100561034(cblb)
ASAO: 132772009(CBLB)
PVT: 110087890(CBLB)
SUND: 121917208 121917254
PBI: 103059707(CBLB)
PMUR: 107287381(CBLB)
CTIG: 120317929(CBLB)
TSR: 106548782(CBLB)
PGUT: 117663011(CBLB)
APRI: 131199344(CBLB)
PTEX: 113436387(CBLB)
NSS: 113409774(CBLB)
VKO: 123026067(CBLC) 123028975(CBLB)
PMUA: 114595893(CBLB)
PRAF: 128412830(CBLB)
ZVI: 118084650(CBLB)
HCG: 128333041(CBLC) 128350878(CBLB)
GJA: 107121592(CBLB)
STOW: 125431059(CBLB) 125435516(CBLC) 125444894
EMC: 129325718(CBLB)
XLA: 431829(cblb.S) 443854(cblb.L)
XTR: 448509(cblb)
NPR: 108789887(CBLB)
RTEM: 120926561(CBLB)
BBUF: 120995610(CBLB)
BGAR: 122931241(CBLB)
MUO: 115470707(CBLB)
GSH: 117359477(CBLB)
DRE: 556277(cblb)
SRX: 107744616 107747038
SANH: 107693962 107699267
SGH: 107548831 107576804
CAUA: 113054363(cblb) 113109881
CGIB: 127965827 128021131
PTET: 122353180(cblb)
LROH: 127171620(cblb)
OMC: 131548382(cblb)
PPRM: 120481818(cblb)
RKG: 130075555(cblb)
MAMB: 125261588(cblb)
CIDE: 127520732
MASI: 127432511 127433787
TROS: 130545654(cblb)
TDW: 130411801(cblb)
IPU: 108276857
IFU: 128620290(cblb)
PHYP: 113543494(cblb)
SMEO: 124393193(cblb)
TFD: 113645586(cblb)
TVC: 132862947(cblb)
AMEX: 103034711(cblb)
CMAO: 118825147(cblb)
EEE: 113571604(cblb)
CHAR: 105902079(cblb)
TRU: 101063765(cblb)
TFS: 130537306(cblb)
TNG: GSTEN00016328G001
LCO: 104935532(cblb)
TBEN: 117472132(cblb)
CGOB: 115018518(cblb)
PGEO: 117458294(cblb)
GACU: 117544317(cblb)
EMAC: 134872063(cblb)
ELY: 117270623(cblb)
EFO: 125898591(cblb)
PLEP: 121952400(cblb)
SLUC: 116058320(cblb)
ECRA: 117955044(cblb)
ESP: 116700422(cblb)
PFLV: 114566515(cblb)
GAT: 120821431(cblb)
AFB: 129113321(cblb)
CLUM: 117742422(cblb)
PSWI: 130191922(cblb)
MSAM: 119895784(cblb)
SCHU: 122888420(cblb)
CUD: 121518771(cblb)
ALAT: 119031754(cblb)
MZE: 101484242(cblb)
ONL: 100704398
OAU: 116313917(cblb)
OLA: 101157475(cblb)
OML: 112140505(cblb)
AOCE: 111567948
CSEM: 103395038(cblb)
POV: 109628744(cblb)
SSEN: 122779985(cblb)
HHIP: 117774511(cblb)
HSP: 118122658(cblb)
SMAU: 118300153(cblb)
LCF: 108900056
SDU: 111222177(cblb)
SLAL: 111653975(cblb)
XGL: 120802074(cblb)
BPEC: 110169053(cblb)
MALB: 109972711(cblb)
BSPL: 114869214(cblb)
SJO: 128371668(cblb)
SASA: 106602828(cblb)
STRU: 115155003(cblb)
OTW: 112216734(cblb)
OMY: 110490114(cblb)
OGO: 123994761(cblb)
ONE: 115106824(cblb)
OKI: 109864425(cblb)
OKE: 118366066(cblb)
SALP: 111950986(cblb)
SNH: 120057410(cblb)
CCLU: 121579738(cblb)
ELS: 105028781(cblb)
SFM: 108936157(cblb)
PKI: 111855703(cblb)
AANG: 118209933 118236245(cblb)
LOC: 102691528(cblb)
PSPA: 121298777 121302581
ARUT: 117405466 117407470
PSEX: 120523261(cblb)
LCM: 102346401(CBLB)
CMK: 103180132(cblb)
CPLA: 122555260(cblb)
HOC: 132821102(cblb)
LERI: 129702578(cblb)
PMRN: 116948063 116957834
LRJ: 133341985 133358470 133358472
SCLV: 120326326
 » show all
Reference
PMID:10086340
  Authors
Ettenberg SA, Keane MM, Nau MM, Frankel M, Wang LM, Pierce JH, Lipkowitz S
  Title
cbl-b inhibits epidermal growth factor receptor signaling.
  Journal
Oncogene 18:1855-66 (1999)
DOI:10.1038/sj.onc.1202499
  Sequence
[hsa:868]
Reference
PMID:7784085
  Authors
Keane MM, Rivero-Lezcano OM, Mitchell JA, Robbins KC, Lipkowitz S
  Title
Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene.
  Journal
Oncogene 10:2367-77 (1995)
  Sequence
[hsa:868]
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