KEGG ORTHOLOGY: K22524

ORTHOLOGY: K22524

Entry

K22524                      KO

Symbol

WBP2

Name

WW domain-binding protein 2

Disease

H00605

Deafness, autosomal recessive

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified
    K22524  WBP2; WW domain-binding protein 2
Domain-containing proteins not elsewhere classified [BR:ko04990]
Other domain-containing proteins
  WW domain-containing proteins
   K22524  WBP2; WW domain-binding protein 2

Genes

HSA:	23558(WBP2)

PTR:	454892(WBP2)

PPS:	100976559 100987870(WBP2)

GGO:	101139291(WBP2)

PON:	100445039 100455965(WBP2)

NLE:	100594566(WBP2) 100598999

HMH:	116484076(WBP2)

MCC:	704545(WBP2)

MCF:	102138337(WBP2)

MTHB:

126939242

MNI:	105469179(WBP2)

CSAB:

103243029(WBP2)

CATY:

105577715(WBP2)

PANU:

101009839(WBP2)

TGE:	112609116(WBP2) 112631999

MLEU:

105540460(WBP2)

RRO:	104681294(WBP2)

RBB:	108537362(WBP2)

TFN:	117066697(WBP2)

PTEH:

111542410

CANG:

105515571(WBP2)

CJC:	100400392(WBP2)

SBQ:	101033287(WBP2)

CIMI:

108309437(WBP2)

CSYR:

103250486(WBP2)

MMUR:

105878951(WBP2)

LCAT:

123650810(WBP2)

PCOQ:

105824718(WBP2)

OGA:	100945437(WBP2)

MMU:	22378(Wbp2)

MCAL:

110305498(Wbp2)

MPAH:

110331602(Wbp2)

RNO:	192645(Wbp2)

MCOC:

116078767(Wbp2)

ANU:	117709991(Wbp2)

MUN:	110547967(Wbp2)

CGE:	100753733(Wbp2)

MAUA:

101839554(Wbp2)

PROB:

127219340(Wbp2)

PLEU:

114707053(Wbp2)

MORG:

121436327(Wbp2)

MFOT:

126500451

AAMP:

119813215(Wbp2)

NGI:	103732712(Wbp2)

HGL:	101701201(Wbp2)

CPOC:

100719917(Wbp2)

CCAN:

109695993(Wbp2)

DORD:

106001364(Wbp2)

DSP:	122128349(Wbp2)

PLOP:

125365697(Wbp2)

NCAR:

124981375

MMMA:

107156527 107157769(Wbp2)

OPI:	101528973(WBP2) 101532817

TUP:	102484269(WBP2)

GVR:	103585187(WBP2)

CFA:	608477(WBP2)

CLUD:

112672813(WBP2)

VVP:	112920807(WBP2)

VLG:	121474114(WBP2)

NPO:	129517285(WBP2)

AML:	100471107(WBP2)

UMR:	103665943(WBP2)

UAH:	113244619(WBP2)

UAR:	123803081(WBP2)

ELK:

111160370

LLV:

125087182

MPUF:

101673459(WBP2)

MNP:	132004450(WBP2)

MLK:	131816995(WBP2)

NVS:	122905974(WBP2)

ORO:	101382590(WBP2)

EJU:	114216179(WBP2)

ZCA:	113908140(WBP2) 113909593 113914722

MLX:	118024260(WBP2)

NSU:	110581689(WBP2)

LWW:	102732949(WBP2)

FCA:	101081588(WBP2)

PYU:	121017929(WBP2)

PCOO:

112863706 112864564(WBP2)

PBG:	122485914(WBP2)

PVIV:

125151843(WBP2) 125169801

LRUF:

124501192 124513407

PTG:	102950614(WBP2)

PPAD:

109276920(WBP2)

PUC:

125926354

AJU:

106987796

HHV:	120228219(WBP2)

BTA:	507060(WBP2)

BOM:	102266129(WBP2)

BIU:	109573670(WBP2)

BBUB:

102401345(WBP2)

BBIS:

105000355(WBP2)

CHX:	102171819(WBP2)

OAS:	101108404(WBP2)

BTAX:

128064615(WBP2)

ODA:	120866761(WBP2)

CCAD:

122436891(WBP2)

MBEZ:

129544709(WBP2)

SSC:	100521149(WBP2)

CFR:	102504053(WBP2)

CBAI:

105065638(WBP2)

CDK:	105105534(WBP2)

VPC:	102536138(WBP2)

BACU:

103018610(WBP2)

BMUS:

118887062(WBP2)

LVE:	103075633(WBP2)

OOR:	101274681(WBP2)

DLE:	111182815(WBP2)

PCAD:

102987625(WBP2)

PSIU:

116745929(WBP2)

NASI:

112410387(WBP2)

ECB:	100059379(WBP2)

EPZ:	103546593(WBP2)

EAI:	106830310(WBP2)

MYB:	102261753(WBP2)

MYD:	102751890(WBP2)

MMYO:

118671911(WBP2)

MLF:	106694493(WBP2)

PKL:	118704647(WBP2)

EFUS:

103298276(WBP2)

MNA:	107536633(WBP2)

DRO:	112298658(WBP2)

SHON:

119000406(WBP2)

AJM:	119058655(WBP2)

PDIC:

114502957(WBP2)

PHAS:

123817743(WBP2)

MMF:	118634397(WBP2)

PPAM:

129086484(WBP2)

HAI:	109383767(WBP2)

RFQ:	117013280(WBP2)

PALE:

102896866(WBP2)

PGIG:

120600026(WBP2)

PVP:	105293365(WBP2)

RAY:	107501572(WBP2)

MJV:	108406208(WBP2)

TOD:	119232014(WBP2)

SARA:

101543235(WBP2)

SETR:

126004211(WBP2)

LAV:	100677767(WBP2)

TMU:

101356539

ETF:	101659448(WBP2)

DNM:	101420897(WBP2) 101426539

MDO:	100022561(WBP2)

GAS:	123243563 123243882(WBP2) 123248086

SHR:	100926402(WBP2)

AFZ:

127560460

PCW:	110219380(WBP2)

OAA:	103165833(WBP2)

GGA:	417368(WBP2)

PCOC:

116232595(WBP2)

MGP:	100541574(WBP2)

CJO:	107322025(WBP2)

TPAI:

128082944(WBP2)

LMUT:

125702168(WBP2)

NMEL:

110407466(WBP2)

APLA:

101797690(WBP2)

ACYG:

106034793(WBP2)

CATA:

118253890(WBP2)

AFUL:

116496528(WBP2)

TGU:	100230329(WBP2)

LSR:	110476584(WBP2)

SCAN:

103819857(WBP2)

PMOA:

120505607(WBP2)

OTC:	121338361(WBP2)

PRUF:

121363868(WBP2)

GFR:	102036939(WBP2)

FAB:	101806378(WBP2)

OMA:	130260428(WBP2)

PHI:	102103381(WBP2)

PMAJ:

107212416(WBP2)

CCAE:

111937293(WBP2)

CCW:	104694322(WBP2)

CBRC:

103621726(WBP2)

ETL:	114063389(WBP2)

ZAB:	102062196(WBP2)

ACHL:

103803136(WBP2)

SVG:	106860979(WBP2)

MMEA:

130581065(WBP2)

HRT:	120761147(WBP2)

FPG:	101912944(WBP2)

FCH:	102058117(WBP2)

CLV:	102097146(WBP2)

EGZ:	104125390(WBP2)

NNI:	104022850(WBP2)

PCRI:

104030648(WBP2)

PLET:

104628273(WBP2)

EHS:	104504593(WBP2)

PCAO:

104053375(WBP2)

ACUN:

113486826(WBP2)

TALA:

104367602(WBP2)

PADL:

103917429(WBP2)

AFOR:

103899009(WBP2)

ACHC:

115341084(WBP2)

HALD:

104312296(WBP2)

HLE:	104839183(WBP2)

AGEN:

126043785

GCL:

127024158

CCRI:

104158495(WBP2)

CSTI:

104556323(WBP2)

CMAC:

104474293(WBP2)

MUI:	104537920(WBP2)

BREG:

104636145(WBP2)

FGA:	104080853(WBP2)

GSTE:

104259375(WBP2)

LDI:	104352142(WBP2)

MNB:	103774852(WBP2)

OHA:	104337264(WBP2)

NNT:	104404904(WBP2)

SHAB:

115616539(WBP2)

DPUB:

104297916(WBP2)

PGUU:

104471325(WBP2)

ACAR:

104532231(WBP2)

CPEA:

104393171(WBP2)

AVIT:

104280218(WBP2)

CVF:	104295987(WBP2)

RTD:	128917996(WBP2)

CUCA:

104061960(WBP2)

TEO:	104378655(WBP2)

BRHI:

104500394(WBP2)

AAM:	106483846(WBP2) 106499994

AROW:

112977710(WBP2)

NPD:	112953662(WBP2)

TGT:	104571837(WBP2)

DNE:	112982439(WBP2)

SCAM:

104138577(WBP2)

ASN:	102370202 102380476(WBP2)

AMJ:	102561944(WBP2) 102569772

CPOO:

109313374 109315086(WBP2)

GGN:	109287976(WBP2) 109290822

PSS:	102444399 102447972(WBP2)

CMY:	102935532 102943092(WBP2)

CCAY:

125621284(WBP2) 125643314

DCC:	119843165(WBP2) 119862231

CPIC:

101941021 101943111(WBP2)

TST:	117887233(WBP2)

CABI:

116816470 116832249(WBP2)

MRV:	120372900 120383369(WBP2)

ACS:	100563202(wbp2)

ASAO:

132768601(WBP2)

PVT:	110085178(WBP2) 110086702

SUND:

121923349(WBP2)

PBI:	103059114(WBP2) 107326082

PMUR:

107290259(WBP2) 114923055 114923731

CTIG:

120301181(WBP2) 120315870

TSR:	106537452(WBP2)

PGUT:

117660495(WBP2) 117673103

APRI:

131192255(WBP2)

PTEX:

113437155(WBP2)

NSS:	113412081(WBP2)

VKO:	123025176 123035543(WBP2)

PMUA:

114590629(WBP2)

PRAF:

128407517(WBP2)

ZVI:	118079848(WBP2)

HCG:	128342986(WBP2)

GJA:	107113174(WBP2)

STOW:

125430240(WBP2) 125431722

EMC:	129328567(WBP2)

XLA:	398767(wbp2.L) 733432(wbp2.S)

XTR:	496980(wbp2)

NPR:	108786363 108796852(WBP2)

RTEM:

120918481(WBP2)

BBUF:

121005955(WBP2)

BGAR:

122940699(WBP2)

MUO:	115473356(WBP2)

GSH:	117367904(WBP2)

DRE:	553565(wbp2)

SRX:	107711317 107740862

SANH:

107666818 107667802

SGH:	107549326 107567801 107578800

CCAR:

109077228 109112429 109112433

CAUA:

113056473 113081093 113111368 113111452

CGIB:

127968824 128025522

PTET:

122333506(wbp2)

LROH:

127174440(wbp2)

OMC:	131550729(wbp2)

PPRM:

120462737(wbp2)

RKG:	130104185(wbp2)

MAMB:

125255468(wbp2)

CIDE:

127523270

MASI:

127423611 127427351

TROS:

130569456(wbp2)

TDW:	130438812(wbp2)

MANU:

129420450(wbp2)

IPU:

108273821

IFU:	128616607(wbp2)

PHYP:

113527308(wbp2)

SMEO:

124389162 124389361

TFD:	113634046(wbp2)

TVC:	132862936(wbp2)

AMEX:

103041232(wbp2)

CMAO:

118809108(wbp2)

EEE:	113581976(wbp2)

CHAR:

105896472(wbp2)

TRU:	101071015(wbp2)

TFS:	130539221(wbp2)

TNG:	GSTEN00021720G001

LCO:	104924900(wbp2)

TBEN:

117497636(wbp2)

CGOB:

115024989(wbp2)

PGEO:

117464635(wbp2)

GACU:

117551484(wbp2)

EMAC:

134870798(wbp2)

ELY:	117247394(wbp2)

EFO:	125880358(wbp2)

PLEP:

121959337(wbp2)

SLUC:

116044094(wbp2)

ECRA:

117937422(wbp2)

ESP:	116671133(wbp2)

PFLV:

114547759(wbp2)

GAT:	120819834(wbp2)

PPUG:

119212728(wbp2)

AFB:	129091598(wbp2)

CLUM:

117748453(wbp2) 117748465

PSWI:

130203595(wbp2)

MSAM:

119915735(wbp2)

SCHU:

122867915(wbp2)

CUD:	121528462(wbp2)

ALAT:

119010387(wbp2)

MZE:	101467913(wbp2)

ONL:	100692044(wbp2)

OAU:	116330873(wbp2)

OML:	112141357(wbp2)

CSAI:

133418779(wbp2)

XMA:	102229523(wbp2)

XCO:	114151784(wbp2)

XHE:	116726884(wbp2)

PRET:

103481951(wbp2)

PFOR:

103144075(wbp2)

PLAI:

106935296(wbp2)

PMEI:

106927041(wbp2)

GAF:	122822977(wbp2)

PPRL:

129377584(wbp2)

CVG:	107098400(wbp2)

CTUL:

119792598(wbp2)

GMU:	124875176(wbp2)

NFU:	107396712(wbp2)

KMR:	108235876(wbp2)

ALIM:

106512242 106535694

NWH:	119423782(wbp2)

AOCE:

111570560(wbp2)

MCEP:

125022200(wbp2)

CSEM:

103382151(wbp2)

POV:	109627004(wbp2)

SSEN:

122761453(wbp2)

HHIP:

117753172(wbp2)

HSP:	118100594(wbp2)

SMAU:

118287431(wbp2)

LCF:

108872603

SDU:	111219927(wbp2)

SLAL:

111656402(wbp2)

XGL:	120794074(wbp2)

HCQ:	109513302(wbp2)

SSCV:

125991684

SBIA:

133495304(wbp2)

PEE:	133418267(wbp2)

PTAO:

133469095(wbp2)

BPEC:

110155169 110155183

MALB:

109974906(wbp2)

BSPL:

114845313(wbp2)

SJO:	128381559(wbp2)

SASA:

106578876 106589470

STRU:

115156317 115201252

OTW:	112224342(wbp2) 112237620

OMY:	110491320 110498914(wbp2)

OGO:	124040100(wbp2) 124048104

ONE:	115124023 115144119

OKI:	109865337 109870334

OKE:	118357411(wbp2) 118368662

SALP:

111967847 111977687(wbp2)

SNH:	120029316 120046097

CCLU:

121547407 121567582

ELS:	105023031(wbp2)

SFM:	108939926(wbp2)

PKI:	111856710(wbp2)

AANG:

118220789(wbp2)

LOC:	102697371(wbp2)

PSPA:

121295405(wbp2) 121296424 121306074(wbp2nl)

ARUT:

117423297 117424799

LCM:	102364351(WBP2) 106703855

CMK:

103175637

CPLA:

122561962

HOC:	132825574 132827698 132827718

LERI:

129707004 129708338

PMRN:

116946154

LRJ:	133353479(WBP2)

BFO:

BBEL:

CIN:

SPU:

APLC:

SKO:

DME:	Dmel_CG11009(Wbp2)

DER:

6545381

DSE:

6605499

DSI:	Dsimw501_GD14410(Dsim_GD14410)

DYA:	Dyak_GE21928

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI11667

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:	110680967 5575321

AALB:

109403396 115257472

CQU:	CpipJ_CPIJ017787

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_207263

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:	129002609 129003798

PHU:	Phum_PHUM521450

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_305547

DMK:

116926250

DPZ:

124315083

PVM:	113801937 113805399

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:	119441202 119454608 119462274

RSAN:

119376978 119397368 119399281

RMP:	119162991 119173738

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_C18B2.4(C18B2.4) CELE_D2013.6(wbp-2)

CBR:	CBG_14242 CBG_20227

CRQ:	GCK72_004724 GCK72_024131

NAI:	NECAME_06121

BMY:	BM_BM18192(Bm18192)

LOA:	LOAG_18082

TSP:	Tsp_09194 Tsp_09209 Tsp_09210

HRO:	HELRODRAFT_182232 HELRODRAFT_90408

LGI:	LOTGIDRAFT_216116

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_038210

SHX:	MS3_00010293(WBP2)

OVI:	T265_10376

EGL:	EGR_04708 EGR_04712

NVE:	116614261 5509629

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_63698

CRE:	CHLRE_03g189100v5

MNG:	MNEG_12238

CSL:	COCSUDRAFT_45836

CVR:	CHLNCDRAFT_134845

TTT:	THITE_2109975

MTM:	MYCTH_2306615

CTHR:

CTHT_0040760

MGR:

MGG_01306

VAL:	VDBG_08053

VDA:	VDAG_01549

SSL:	SS1G_00137

BFU:	BCIN_03g06590

MBE:

MBM_01103

PSCO:

LY89DRAFT_550248

GLZ:	GLAREA_06045

ACT:	ACLA_050460

NFI:	NFIA_104810

PDP:	PDIP_34110

TRG:	TRUGW13939_02841

CIM:	CIMG_01560

URE:	UREG_05273

PBL:	PAAG_02698

PBN:	PADG_01726

ABE:

ARB_02335

TVE:

TRV_04687

AJE:	HCAG_01570

BGH:	BDBG_07204

PNO:	SNOG_06130

PTE:

PTT_19079

BZE:	COCCADRAFT_85321

BSC:	COCSADRAFT_32980

BOR:	COCMIDRAFT_36474

AALT:

CC77DRAFT_1024609

PFJ:	MYCFIDRAFT_211038

BCOM:

BAUCODRAFT_32235

NPA:	UCRNP2_3075

PCO:	PHACADRAFT_250827

HIR:	HETIRDRAFT_146807

GTR:	GLOTRDRAFT_109461

LBC:	LACBIDRAFT_192514

CCI:	CC1G_08835

WSE:	WALSEDRAFT_60820

TAN:

TA04330

TOT:	TOT_030000455

BEQ:	BEWA_014130

BBO:	BBOV_IV002540

TET:	TTHERM_00502170

PTM:	GSPATT00037881001

PIF:	PITG_08699

PSOJ:

PHYSODRAFT_520806

» show all

Reference

PMID:9202023

Authors

Chen HI, Einbond A, Kwak SJ, Linn H, Koepf E, Peterson S, Kelly JW, Sudol M

Title

Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands.

Journal

J Biol Chem 272:17070-7 (1997)
DOI:10.1074/jbc.272.27.17070

Sequence

[hsa:23558]

Reference

PMID:16772533

Authors

Dhananjayan SC, Ramamoorthy S, Khan OY, Ismail A, Sun J, Slingerland J, O'Malley BW, Nawaz Z

Title

WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors.

Journal

Mol Endocrinol 20:2343-54 (2006)
DOI:10.1210/me.2005-0533

LinkDB

DBGET integrated database retrieval system