KEGG ORTHOLOGY: K25166

ORTHOLOGY: K25166

Entry

K25166                      KO

Symbol

EEF1AKNMT, METTL13

Name

eEF1A lysine and N-terminal methyltransferase [EC:2.1.1.-]

Disease

H00605

Deafness, autosomal recessive

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03012 Translation factors
    K25166  EEF1AKNMT, METTL13; eEF1A lysine and N-terminal methyltransferase
Translation factors [BR:ko03012]
Eukaryotic type
  Elongation factors
   Elongation associated factors
    K25166  EEF1AKNMT, METTL13; eEF1A lysine and N-terminal methyltransferase

Genes

HSA:	51603(METTL13)

PTR:	456446(METTL13)

PPS:	100995690(EEF1AKNMT)

GGO:	101132474(EEF1AKNMT)

PON:	100432314(METTL13)

NLE:	100593722(EEF1AKNMT)

HMH:	116473238(METTL13)

MCC:	704943(EEF1AKNMT)

MCF:	102131416(METTL13)

MTHB:

126941356

MNI:	105484414(METTL13)

CSAB:

103230581(METTL13)

CATY:

105597546(METTL13)

PANU:

101024156(EEF1AKNMT)

TGE:	112624829(METTL13)

MLEU:

105554134(METTL13)

RRO:	104668540(EEF1AKNMT)

RBB:	108526251(METTL13)

TFN:	117074384(EEF1AKNMT)

PTEH:

111539336(EEF1AKNMT)

CANG:

105526344(METTL13)

CJC:	100406910(METTL13)

SBQ:	101040217(METTL13)

CIMI:

108305391(EEF1AKNMT)

CSYR:

103258582(METTL13)

MMUR:

105871679(METTL13)

LCAT:

123635311(METTL13)

PCOQ:

105821138(METTL13)

OGA:	100951643(METTL13)

MMU:	71449(Mettl13)

MCAL:

110289500(Eef1aknmt)

MPAH:

110321507(Mettl13)

RNO:	289159(Mettl13)

MCOC:

116102525(Eef1aknmt)

ANU:	117716567(Eef1aknmt)

MUN:	110561010(Mettl13)

CGE:	100771851(Eef1aknmt)

MAUA:

101822929(Eef1aknmt)

PROB:

127223486(Mettl13)

PLEU:

114689963(Eef1aknmt)

MORG:

121455002(Eef1aknmt)

MFOT:

126511253

AAMP:

119828063(Mettl13)

NGI:	103746356(Mettl13)

HGL:	101701287(Mettl13)

CPOC:

100720169(Mettl13)

CCAN:

109692612(Mettl13)

DORD:

105985009(Mettl13)

DSP:	122103687(Mettl13)

PLOP:

125360256(Mettl13)

NCAR:

124962461

MMMA:

107147379(Mettl13)

OCU:	100342720(METTL13)

OPI:	101528989(EEF1AKNMT)

TUP:	102474596(METTL13)

GVR:	103601549(METTL13)

CFA:	480074 490342(EEF1AKNMT)

CLUD:

112648613(METTL13)

VVP:	112921875(METTL13)

VLG:	121489761(METTL13)

NPO:	129506013(METTL13)

AML:	100470986(EEF1AKNMT)

UMR:	103668008(EEF1AKNMT)

UAH:

113249588

UAR:	123802948(METTL13)

ELK:

111150835

LLV:

125085873

MPUF:

101685304(METTL13)

MNP:

132025351

MLK:	131814312 131814730(METTL13)

NVS:	122918491(METTL13)

ORO:	101380870(METTL13)

EJU:

114203463

ZCA:	113932813(EEF1AKNMT)

MLX:	118014556(EEF1AKNMT)

NSU:	110574220(METTL13) 123325098

LWW:	102732885(EEF1AKNMT)

FCA:	101088296(METTL13)

PYU:	121015038(EEF1AKNMT)

PCOO:

112863095(METTL13)

PBG:	122475623(METTL13)

PVIV:

125155813(METTL13)

LRUF:

124510221

PTG:	102955125(METTL13)

PPAD:

109252370(METTL13)

PUC:

125925150

AJU:	106966192(EEF1AKNMT)

HHV:	120223952(EEF1AKNMT)

BTA:	538472(METTL13)

BOM:	102278634(METTL13)

BIU:	109570671(METTL13)

BBUB:

123465796(METTL13)

BBIS:

104997370(METTL13)

CHX:	102176251(METTL13)

OAS:	101106537(METTL13)

BTAX:

128061531(METTL13)

ODA:	120880249(EEF1AKNMT)

CCAD:

122452295(METTL13)

MBEZ:

129551563(METTL13)

SSC:	100512915(METTL13)

CFR:	102522518(EEF1AKNMT)

CBAI:

105070350(METTL13)

CDK:	105092765(EEF1AKNMT)

VPC:	102534118(EEF1AKNMT)

BACU:

103020632(METTL13)

BMUS:

118885625(EEF1AKNMT)

LVE:	103075109(METTL13)

OOR:	101270941(METTL13)

DLE:	111167358(EEF1AKNMT)

PCAD:

102992713(METTL13)

PSIU:

116762722(EEF1AKNMT)

NASI:

112396212(METTL13)

ECB:	100052265(METTL13)

EPZ:	103540635(METTL13)

EAI:	106833822(METTL13)

MYB:	102259009(METTL13)

MYD:	102757622(METTL13)

MMYO:

118672839(EEF1AKNMT)

MLF:	102436147(METTL13)

PKL:	118721242(EEF1AKNMT)

EFUS:

103289960(METTL13)

MNA:	107543911(METTL13)

DRO:	112298469(METTL13)

SHON:

118979138(EEF1AKNMT)

AJM:	119065438(EEF1AKNMT)

PDIC:

114511865(EEF1AKNMT)

PHAS:

123818523(METTL13)

MMF:	118637789(EEF1AKNMT)

PPAM:

129082037(METTL13)

HAI:	109385090(METTL13)

RFQ:	117014470(EEF1AKNMT)

PALE:

102883713(METTL13)

PVP:	105299801(METTL13)

RAY:	107512048(METTL13)

MJV:	108385260(EEF1AKNMT)

TOD:	119241290(METTL13)

SARA:

101554410(METTL13)

SETR:

126013386(METTL13)

LAV:	100663629(METTL13)

TMU:

101342613

ETF:	101650355(METTL13)

DNM:	101423112(METTL13)

MDO:	100015352(METTL13)

GAS:	123243785(METTL13)

SHR:	100919256(EEF1AKNMT)

AFZ:

127562903

PCW:	110196981(METTL13)

OAA:	100084603(EEF1AKNMT)

PCOC:

116230494(EEF1AKNMT)

MGP:	100551162(EEF1AKNMT)

CJO:	107317225(EEF1AKNMT)

TPAI:

128072135(METTL13)

LMUT:

125693078(METTL13)

NMEL:

110402689(METTL13)

APLA:

101801039(EEF1AKNMT)

ACYG:

106041619(METTL13)

CATA:

118243342(METTL13)

AFUL:

116491992(EEF1AKNMT)

TGU:	100224683(EEF1AKNMT)

LSR:	110478915(EEF1AKNMT)

SCAN:

103823383(EEF1AKNMT)

PMOA:

120512239(EEF1AKNMT)

OTC:	121344338(EEF1AKNMT)

PRUF:

121359853(EEF1AKNMT)

GFR:	102031735(METTL13)

FAB:	101820942(METTL13)

OMA:	130256426(METTL13)

PHI:	102111593(METTL13)

PMAJ:

107208129(EEF1AKNMT)

CCAE:

111942430(METTL13)

CCW:	104695608(EEF1AKNMT)

CBRC:

103612525(METTL13)

ETL:	114063542(EEF1AKNMT)

ZAB:	102061850(EEF1AKNMT)

ACHL:

103811145

SVG:	106852212(METTL13)

MMEA:

130577424(METTL13)

HRT:	120756459(METTL13)

FPG:	101921582(METTL13)

FCH:	102056708(EEF1AKNMT)

CLV:	102098206(METTL13)

EGZ:	104132068(METTL13)

NNI:	104010398(METTL13)

PCRI:

104028887(METTL13)

PLET:

104622826(METTL13)

EHS:	104516252(METTL13)

PCAO:

104050215(METTL13)

TALA:

104365477(METTL13)

PADL:

103914008(METTL13)

AFOR:

103893996(METTL13)

ACHC:

115349072(EEF1AKNMT)

HALD:

104316460(METTL13)

HLE:	104840409(METTL13)

AGEN:

126042337

GCL:

127018990

CCRI:

104167990(METTL13)

CSTI:

104563060(METTL13)

CMAC:

104481182(METTL13)

MUI:	104533475(METTL13)

BREG:

104643238(METTL13)

FGA:	104072707(METTL13)

LDI:	104343197(METTL13)

MNB:

103781104

OHA:	104333718(METTL13)

NNT:	104411504(METTL13)

SHAB:

115611466(EEF1AKNMT)

DPUB:

104298202(METTL13)

PGUU:

104465701(METTL13)

ACAR:

104526294(EEF1AKNMT)

CPEA:

104390679(METTL13)

AVIT:

104267099(METTL13)

CVF:	104293398(METTL13)

RTD:	128913838(METTL13)

CUCA:

104058364(METTL13)

TEO:	104376167(METTL13)

AAM:	106499695(METTL13)

AROW:

112976423(METTL13)

NPD:	112951194(METTL13)

TGT:	104569973(METTL13)

DNE:	112997429(METTL13)

SCAM:

104142694(METTL13)

ASN:	102385883(METTL13)

AMJ:	102558216(METTL13)

CPOO:

109307105(METTL13)

GGN:	109287022(METTL13)

PSS:	102456801(METTL13)

CMY:	102936892(METTL13)

CCAY:

125641211(METTL13)

CPIC:

101950280(METTL13)

TST:	117881673(EEF1AKNMT)

CABI:

116816305(EEF1AKNMT)

MRV:	120370742(EEF1AKNMT)

ACS:	100559546(mettl13)

ASAO:

132774338(METTL13)

PVT:	110081639(METTL13)

SUND:

121928183(METTL13)

PBI:	103067472(METTL13)

PMUR:

107302860(EEF1AKNMT)

CTIG:

120310520(EEF1AKNMT)

TSR:

106553731

PGUT:

117661214(EEF1AKNMT)

APRI:

131195671(METTL13)

PTEX:

113438137(EEF1AKNMT)

NSS:	113424965(EEF1AKNMT)

VKO:	123027934(METTL13)

PMUA:

114598522(EEF1AKNMT)

PRAF:

128415217(METTL13)

ZVI:	118088570(EEF1AKNMT)

HCG:	128322753(METTL13)

GJA:	107121040(METTL13)

STOW:

125433130(METTL13)

EMC:	129329655(METTL13)

XLA:	414682(eef1aknmt.S)

XTR:	733963(eef1aknmt)

NPR:	108795560(METTL13)

RTEM:

120945752(EEF1AKNMT)

BBUF:

120979149(EEF1AKNMT)

BGAR:

122943949(METTL13)

MUO:	115472881(EEF1AKNMT)

GSH:	117367918(EEF1AKNMT)

DRE:	557908(mettl13)

SRX:	107712871 107733805

SANH:

107669158(mettl13)

SGH:	107581472(mettl13)

CCAR:

109083979

CAUA:

113063056 113071264

CGIB:

127938938

PTET:

122325270(mettl13)

LROH:

127151856(mettl13)

OMC:	131526513(mettl13)

PPRM:

120493709(mettl13)

RKG:	130096118(mettl13)

MAMB:

125279087(mettl13)

CIDE:

127502671

MASI:

127416094

TROS:

130566192(mettl13)

TDW:	130434074(mettl13)

MANU:

129429303(mettl13)

IPU:	108257793(mettl13)

IFU:	128601416(mettl13)

PHYP:

113545167(eef1aknmt)

SMEO:

124376721(mettl13)

TFD:	113658705(mettl13)

TVC:	132843415(mettl13)

AMEX:

103031783(mettl13)

CMAO:

118815445(mettl13)

EEE:	113587375(eef1aknmt)

CHAR:

122131154(mettl13)

TRU:	101061521(eef1aknmt)

TFS:	130529125(mettl13)

TNG:	GSTEN00003705G001

LCO:	104919136(eef1aknmt)

NCC:	104943265(mettl13)

TBEN:

117495576(mettl13)

CGOB:

115007096(eef1aknmt)

PGEO:

117445188(mettl13)

GACU:

117555052(mettl13)

EMAC:

134869413(mettl13)

ELY:	117254457(mettl13)

EFO:	125895924(mettl13)

PLEP:

121941205(mettl13) 121965081

SLUC:

116058897(mettl13)

ECRA:

117949966(mettl13)

ESP:	116695421(eef1aknmt)

PFLV:

114561211(eef1aknmt)

GAT:	120824152(mettl13)

PPUG:

119217080(mettl13)

AFB:	129094775(mettl13)

CLUM:

117729962(mettl13)

PSWI:

130194454(mettl13)

MSAM:

119901019(mettl13)

SCHU:

122877141(mettl13)

CUD:	121512367(mettl13)

ALAT:

119028278(mettl13)

MZE:	101467605(mettl13)

ONL:	100708771(mettl13)

OAU:	116331311(mettl13)

OLA:	110014767(mettl13)

OML:	112142342(mettl13)

CSAI:

133457769(mettl13)

XMA:	102221443(mettl13)

XCO:	114150977(eef1aknmt)

XHE:	116726395(eef1aknmt)

PRET:

103463774(mettl13)

PFOR:

103137057(mettl13)

PLAI:

106963719(mettl13)

PMEI:

106921003(mettl13)

GAF:	122839197(mettl13)

PPRL:

129369140(mettl13)

CVG:	107099737(mettl13)

CTUL:

119797722(mettl13)

GMU:	124873401(mettl13)

NFU:	107393449(mettl13)

KMR:	108243378(mettl13)

ALIM:

106533576(mettl13)

NWH:	119408016(mettl13)

AOCE:

111577514(mettl13)

MCEP:

125009381(mettl13)

CSEM:

103376663(mettl13)

POV:	109625745(mettl13)

SSEN:

122780352(mettl13)

HHIP:

117760230(mettl13)

HSP:	118121314(mettl13)

SMAU:

118318592(mettl13)

LCF:	108879083(mettl13)

SDU:	111236194(mettl13)

SLAL:

111668239(mettl13)

XGL:	120791284(mettl13)

HCQ:	109531986(mettl13)

SSCV:

125976140

SBIA:

133503870(mettl13)

PEE:	133406686(mettl13)

PTAO:

133480660(mettl13)

BPEC:

110154867(mettl13)

MALB:

109962039(mettl13)

BSPL:

114853425(mettl13)

SJO:	128361631(mettl13)

SASA:

106613973

STRU:

115158471(eef1aknmt)

OTW:	112251083(eef1aknmt)

OMY:	110524505(mettl13)

OGO:

123996865

ONE:	115108491(eef1aknmt)

OKI:	109902683(eef1aknmt)

OKE:

118391972

SALP:

111975799(mettl13)

SNH:	120054522(mettl13)

CCLU:

121533340(mettl13)

ELS:	105011723(eef1aknmt)

SFM:

114911299

PKI:	111834956(mettl13)

AANG:

118225912(mettl13)

LOC:	102682243(mettl13)

PSPA:

121327179(mettl13)

ARUT:

117412513(mettl13)

PSEX:

120515136(mettl13)

LCM:	102362594(METTL13)

CMK:	103180020(mettl13)

RTP:	109919030(mettl13)

CPLA:

122554596(mettl13)

HOC:	132818666(mettl13)

LERI:

129701184(mettl13)

PMRN:

116938852(EEF1AKNMT)

LRJ:	133345812(METTL13)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG2614(CG2614)

DER:

6548889

DSE:

6618178

DSI:	Dsimw501_GD24273(Dsim_GD24273)

DYA:	Dyak_GE13319

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI18249

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ003499

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_201566

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

125050779 125053086 125059046

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:	100160277 100161863

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

MQU:	129001696 129004633

PHU:	Phum_PHUM248170

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_304751

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

119105603 119105698 119114494

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_C01B10.8(metl-13)

CBR:

CBG_05389

CRQ:	GCK72_013739

BMY:	BM_BM1866(Bm1866)

LOA:	LOAG_11489

TSP:

Tsp_05984

HRO:	HELRODRAFT_186734

LGI:	LOTGIDRAFT_129263

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111123308 111127215

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HSY:

TAD:	TRIADDRAFT_49728

AQU:

ATH:

ALY:

CRB:

CSAT:

104700291 104753350 104786443

EUS:	EUTSA_v10016302mg

BRP:

103867700

BNA:	106430040 106451343

BOE:

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10004378mg

PVY:	116121605 116123612

MINC:

123221676

TCC:

18602678

GRA:

105796503

GHI:	107934484 107935986

GAB:

HSYR:

DZI:

EGR:

GMX:	100776393 100793111

GSJ:	114412892 114421669

VRA:

VAR:

VUN:

VUM:

CCAJ:

MTR:

TPRA:

CAM:

PSAT:

VVO:

LJA:	Lj4g3v2603640.2(Lj4g3v2603640.2)

ADU:

AIP:

AHF:

LANG:

PCIN:

QSA:	O6P43_009668

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103443442 114824042

MSYL:

ZJU:

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QLO:

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VVI:

VRI:

SLY:

SPEN:

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SDUL:

CANN:

LBB:

NTA:	107785081 107798152

NSY:

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LSV:

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SOE:

CQI:	110711485 110714724

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

Os04t0379300-01(Os04g0379300)

OBR:

OGL:

BDI:

ATS:

TDC:	119354934 119364072

TAES:

123045281 123053118 123189024

TUA:	125537739 125537743

LPER:

127334331

LRD:	124674258 124675667

SBI:

ZMA:

SITA:

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PVIR:

PHAI:

PDA:

EGU:

MUS:

ZOF:	121970199 121975283

DCT:

PEQ:

AOF:

MSIN:

NCOL:

ATR:

PPP:

CSL:	COCSUDRAFT_45160

TET:	TTHERM_00118620

PTM:	GSPATT00016618001

» show all

Reference

PMID:30612740

Authors

Liu S, Hausmann S, Carlson SM, Fuentes ME, Francis JW, Pillai R, Lofgren SM, Hulea L, Tandoc K, Lu J, Li A, Nguyen ND, Caporicci M, Kim MP, Maitra A, Wang H, Wistuba II, Porco JA Jr, Bassik MC, Elias JE, Song J, Topisirovic I, Van Rechem C, Mazur PK, Gozani O

Title

METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis.

Journal

Cell 176:491-504.e21 (2019)
DOI:10.1016/j.cell.2018.11.038

Sequence

[hsa:51603]

LinkDB

DBGET integrated database retrieval system