Achromobacter aegrifaciens: RA224_25875
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Entry
RA224_25875 CDS
T09343
Name
(GenBank) thiamine pyrophosphate-dependent enzyme
KO
K11381
2-oxoisovalerate dehydrogenase E1 component [EC:
1.2.4.4
]
Organism
aaeg
Achromobacter aegrifaciens
Pathway
aaeg00280
Valine, leucine and isoleucine degradation
aaeg00640
Propanoate metabolism
aaeg00785
Lipoic acid metabolism
aaeg01100
Metabolic pathways
aaeg01110
Biosynthesis of secondary metabolites
aaeg01210
2-Oxocarboxylic acid metabolism
Module
aaeg_M00036
Leucine degradation, leucine => acetoacetate + acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
aaeg00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00640 Propanoate metabolism
RA224_25875
09105 Amino acid metabolism
00280 Valine, leucine and isoleucine degradation
RA224_25875
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
RA224_25875
Enzymes [BR:
aaeg01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
RA224_25875
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GFIT
Motif
Pfam:
E1_dh
Transket_pyr
Transketolase_C
DXP_synthase_N
Transketolase_N
TPP_enzyme_C
Motif
Other DBs
NCBI-ProteinID:
WLW60627
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Position
complement(5556318..5558546)
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AA seq
742 aa
AA seq
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MKHINEGAAPAAKPSRLAALHTDTPWWRLTATAADAGAIAPREMVRMLEQLILIRRFEEK
LLKLSVAGILHGPAHSSIGQDGAAVGAMSVLESADKINGTHRMHHQFLAKALNHATPADY
SPLDSETLDSHREVVYRTYAEILGLTPGYCGGRGGSMHLRYPEAGIYGSNAIVGGNPSHA
VGYAFADKLRGRDHVSVAFFGDGAMQSGAAYEAMNLAALYNAPTIFFVENNLYAVSTHVS
EQTRETRLSARGLSLGVPAIEFDGMDVVAARLAMQEARAIIRRDGGPVLLEAQTYRYLHQ
SGALKGSAFRYRDKDEEEAWGARDPMSIFPAQLKSLGLIDDAGFTRLERRADELIDGALG
RLLEHYGDEAAQRIRPELWPDPASVDSGIRGNLGELAGQRAIELEEQTPASLADAKFQDV
ISRAMLLNMQRDDGIFILGEDVHRLKGGTAGATKDIGDHFPERLIGTPICENGFTGLALG
AALNGMRPVVEIMYPDFALVAADQLFNQIAKVRHMFGGKFAVPVLVRSRVTAGTGYGSQH
SMDASGLFAQYPGWRILAPSRPYDYIGLLNAALRCDDPVLMVEYNDLFKTVGKVPAEDWD
YIVPIGRARVAREGARCTILTYGVMVEVCCQAAERTGIDAQVIDLRTLDPLGIDWDTIAA
GVKRTQALMIVEQTTRGTSIGSRVASEAQSRLFDWLDHEIVHVTGANSSPVVSKVLERAA
LADAQAVEMALKSMDSRRGGAR
NT seq
2229 nt
NT seq
+upstream
nt +downstream
nt
atgaagcacatcaatgaaggcgcggcgcctgccgcgaaaccctcgcggcttgccgccctg
cacaccgacacgccgtggtggcggcttaccgccaccgccgcggatgcgggggccatcgcg
ccgcgcgagatggtccgcatgctggagcagttgatactgatccggcgcttcgaagagaag
ctgctgaagctgagcgtggccggcatcctgcatggtccggcgcattccagcatcggccag
gacggcgccgccgtgggcgccatgtcggtgctggagtcggccgacaagatcaacggcacc
caccgcatgcaccaccagtttcttgccaaggcgctgaaccacgccacaccggcggactat
tcgccgttggactcggaaacgctggattcgcaccgcgaggtggtctaccggacttatgcc
gagatcctgggcctgacgccgggttattgcggcggccgcggcggttccatgcatctgcgc
tatcccgaggccggcatctatggatccaacgccatcgtgggcggcaatccgtcgcatgcg
gtgggttacgcctttgccgacaagctgcgcgggcgcgatcatgtgtcggtggccttcttc
ggcgacggcgccatgcagagcggggcggcgtacgaggccatgaaccttgcggcgctctac
aacgctcccaccattttcttcgtggaaaacaacctgtacgccgtgtccacccacgtgtcg
gaacagacgcgcgaaacccgcttgtcggcgcgcggcctgtccctgggcgtgccggcgatc
gagttcgacggcatggacgtggtggctgcgcgcctggccatgcaggaagctcgggccatc
atccgccgcgacggcgggccggtgctgctggaagcgcagacctaccgctacctgcaccag
tcgggcgcgctcaagggcagcgcgttccgctaccgcgacaaggacgaggaagaggcttgg
ggcgcgcgcgatcccatgtcgatatttcccgcgcagctgaaatcgctgggcctgatcgac
gatgccggcttcacccgcctggagcgccgtgcggacgaactgatagacggcgccctaggg
cggctgttggagcactacggcgacgaggcagcgcaacgcatccggcccgaactgtggccg
gacccggccagcgtggacagcggtatccgcggcaacctgggcgaactcgcgggccaacgc
gccatcgagctggaggagcagacgccagcgagcctggcggacgccaagttccaggacgtg
atttcgcgcgccatgctgctgaacatgcagcgcgacgacggcatcttcatcctgggcgag
gatgtgcatcgcctgaaaggcggcacggccggcgctaccaaggacataggcgatcacttt
ccggaacgcctcatcggcacgcccatctgcgagaatggtttcactggcctggccttgggc
gcggcgttgaacggcatgcggcccgtggtggagatcatgtatcccgacttcgcgctggtg
gccgcggaccagctgttcaaccagatcgccaaggtgcgccacatgttcggcggcaagttc
gcagtgccggtgctggtgcgcagccgggtcacggcgggcaccggctatggctcgcagcat
tccatggacgccagcggcctgtttgcccagtatccagggtggcggatcctggcgccatcg
cgtccctatgactatatcggcctgctcaacgccgcgctgcgctgcgacgatccggtcctg
atggtggaatacaacgacctgttcaagacggtgggcaaggtgcccgccgaggactgggac
tacatcgtgccgatcggccgggcccgggtcgcgcgcgagggcgcacgctgcaccatcctg
acctacggcgtcatggtcgaggtctgctgccaggcggcggaacgtacgggcatcgacgcc
caggtgatagacctgcgcacgctggatccgctgggcatcgattgggacaccatcgcggcc
ggcgtcaagcgcacgcaggcgctgatgatcgtggagcagactacccgcggcacctcgatc
ggctcgcgggtggcgagcgaggcgcagtcaaggctgtttgactggctggaccacgagatc
gtgcacgttacgggcgccaattcctcgcccgtggtctccaaggtgctggagcgcgccgca
ttggcggacgcgcaggccgtggagatggccctgaaatccatggacagccgccgcggcggc
gcccgctga
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