Actinoplanes sp. L3-i22: L3i22_101920
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Entry
L3i22_101920 CDS
T08939
Symbol
hemD
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
actl
Actinoplanes sp. L3-i22
Pathway
actl00860
Porphyrin metabolism
actl01100
Metabolic pathways
actl01110
Biosynthesis of secondary metabolites
actl01120
Microbial metabolism in diverse environments
actl01240
Biosynthesis of cofactors
Module
actl_M00121
Heme biosynthesis, plants and bacteria, glutamate => heme
actl_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
actl_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
actl00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
L3i22_101920 (hemD)
Enzymes [BR:
actl01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
L3i22_101920 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
L3i22_101920 (hemD)
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
B12-binding
Motif
Other DBs
NCBI-ProteinID:
BCY15104
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Position
complement(11391732..11393318)
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AA seq
528 aa
AA seq
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MTTRTARKPAGRIAFIGAGPGDPELLTRRAYAALTEADQVVYDRGVPDSLLSAVRADAKA
DAQFSPAEGAPGDVAKVLLSAAKSGLSAVHLVAGDPFGHESVVKEVQAVARTAVHFEVIP
GIGQAEGVAAYAGVPLPGVRIAADVDDVTTLDFDALAGAAQKGSFAVAVDAGDLAAVRDG
LLAAGVEPGVPVGVTGDGTGETQYTTTSTVDSFVAAALGFTGRVVLTVGAEVGERDALSW
WENRPLYGWKVLVPRTKEQAGAMSARLRAYGAIPCEVPTIAVEPPRTPAQMERAVKGLVD
GRYAWVVFTSVNAVRAVWEKFAEHGLDARHFGGVKIACIGEATAEAVRAFGIQPEMIPAG
EQSSEGLLAEFSPHDEILDPVGRVLLPRADIATETLAAGLIERGWEVDDVTAYRTVRAAP
PPAEIRDAIKSGGFDAVLFTSSSTVRNLVGIAGKPHARTVVAVIGPKTAETAIEFGLRVD
SQPQNASVPDLVEALAEYALELREKLAAMPAKQRRGSKVQGPTALRFR
NT seq
1587 nt
NT seq
+upstream
nt +downstream
nt
atgaccacccgcaccgcccgtaagccagccggacgcatcgcgttcatcggcgccggaccc
ggcgacccggagctgctgacccgccgcgcgtatgccgcgctgaccgaggccgaccaggtg
gtctacgaccggggcgtgcccgactcgctgctgtccgcggtccgcgccgacgccaaggcg
gacgcccagttcagcccggccgaaggcgcccccggtgacgtggccaaggtgctgctctcc
gcggccaagtccggcctgtccgccgtgcacctggtggccggcgacccgttcggccacgag
tccgtggtcaaggaggtgcaggcggtcgcgcgtaccgccgtgcacttcgaggtgatcccg
ggcatcggccaggccgagggcgtcgccgcctacgccggggtgccgctgcccggcgtccgg
atcgccgccgacgtcgacgacgtcaccacgctcgacttcgacgcgctggccggcgcggcc
cagaagggctcgttcgccgtcgcggtggacgccggtgacctggccgcggtccgcgacggg
ctgctcgccgccggcgtcgagccgggtgtcccggtcggcgtgaccggcgacggcaccggc
gagacgcagtacaccaccacctcgacggtggacagcttcgtcgccgccgcgctcggcttc
accggccgggtcgtgctgaccgtcggcgccgaggtcggcgagcgggacgcgctcagctgg
tgggagaaccgcccgctgtacggctggaaggtcctggtcccgcggaccaaggagcaggcc
ggggcgatgagcgcgcgcctgcgggcgtacggcgccatcccgtgcgaggtgccgaccatc
gcggtcgagccgccgcgcaccccggcgcagatggagcgcgcggtcaagggcctggtcgac
ggccggtacgcctgggtcgtcttcacctcggtgaacgcggtccgcgcggtctgggagaag
ttcgccgagcacggcctggacgcccgccacttcggcggcgtgaagatcgcctgcatcggt
gaggccaccgccgaggcggtccgcgcgttcggcatccagcccgagatgatcccggccggc
gagcagtccagcgagggcctgctggccgagttctcgccgcacgacgagatcctcgacccg
gtcggccgggtgctgctgccgcgcgccgacatcgccaccgagaccctcgcggccggcctg
atcgagcggggctgggaggtggacgacgtgaccgcgtaccggacggtgcgggccgcgccg
ccgccggccgagatccgcgacgcgatcaagtcgggtggcttcgacgcggtgctcttcacc
tcgtcctcgaccgttcgcaacctggtcggcatcgccggcaagccgcacgcccgtacggtc
gtcgcggtgatcggcccgaagaccgcggagaccgcgatcgagttcggcctgcgggtggac
agccagccgcagaacgcctcggtgccggacctggtcgaggccctcgccgagtacgccctg
gaactgcgcgagaagctggcggcgatgcccgccaagcagcgtcgcggctccaaggtgcag
gggccgacggcgctccgcttccgctga
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