KEGG   Addendum: AAG13917
Entry
AAG13917          CDS       T10000                                 
Symbol
megAI
Name
(KEGG) megalomicin 6-deoxyerythronolide B synthase 1
  KO
K10817  6-deoxyerythronolide-B synthase EryAI [EC:2.3.1.94]
Taxonomy
TAX:47868
  Lineage
Bacteria; Actinomycetota; Actinomycetes; Micromonosporales; Micromonosporaceae; Micromonospora
Organism
Micromonospora megalomicea
SSDB
Motif
Pfam: Acyl_transf_1 ketoacyl-synt KR Ketoacyl-synt_C PP-binding adh_short KAsynt_C_assoc Epimerase adh_short_C2 Thiolase_N Polysacc_synt_2 GDP_Man_Dehyd RmlD_sub_bind 3Beta_HSD Sacchrp_dh_NADP YAcAr NmrA
Other DBs
NCBI-ProteinID: AAG13917
GB: AF263245
UniProt: Q9F830
LinkDB
AA seq 3546 aa
MVDVPDLLGTRTPHPGPLPFPWPLCGHNEPELRARARQLHAYLEGISEDDVVAVGAALAR
ETRAQDGPHRAVVVASSVTELTAALAALAQGRPHPSVVRGVARPTAPVVFVLPGQGAQWP
GMATRLLAESPVFAAAMRACERAFDEVTDWSLTEVLDSPEHLRRVEVVQPALFAVQTSLA
ALWRSFGVRPDAVLGHSIGELAAAEVCGAVDVEAAARAAALWSREMVPLVGRGDMAAVAL
SPAELAARVERWDDDVVPAGVNGPRSVLLTGAPEPIARRVAELAAQGVRAQVVNVSMAAH
SAQVDAVAEGMRSALTWFAPGDSDVPYYAGLTGGRLDTRELGADHWPRSFRLPVRFDEAT
RAVLELQPGTFIESSPHPVLAASLQQTLDEVGSPAAIVPTLQRDQGGLRRFLLAVAQAYT
GGVTVDWTAAYPGVTPGHLPSAVAVETDEGPSTEFDWAAPDHVLRARLLEIVGAETAALA
GREVDARATFRELGLDSVLAVQLRTRLATATGRDLHIAMLYDHPTPHALTEALLRGPQEE
PGRGEETAHPTEAEPDEPVAVVAMACRLPGGVTSPEEFWELLAEGRDAVGGLPTDRGWDL
DSLFHPDPTRSGTAHQRAGGFLTGATSFDAAFFGLSPREALAVEPQQRITLELSWEVLER
AGIPPTSLRTSRTGVFVGLIPQEYGPRLAEGGEGVEGYLMTGTTTSVASGRVAYTLGLEG
PAISVDTACSSSLVAVHLACQSLRRGESTMALAGGVTVMPTPGMLVDFSRMNSLAPDGRS
KAFSAAADGFGMAEGAGMLLLERLSDARRHGHPVLAVIRGTAVNSDGASNGLSAPNGRAQ
VRVIRQALAESGLTPHTVDVVETHGTGTRLGDPIEARALSDAYGGDREHPLRIGSVKSNI
GHTQAAAGVAGLIKLVLAMQAGVLPRTLHADEPSPEIDWSSGAISLLQEPAAWPAGERPR
RAGVSSFGISGTNAHAIIEEAPPTGDDTRPDRMGPVVPWVLSASTGEALRARAARLAGHL
REHPDQDLDDVAYSLATGRAALAYRSGFVPADASTALRILDELAAGGSGDAVTGTARAPQ
RVVFVFPGQGWQWAGMAVDLLDGDPVFASVLRECADALEPYLDFEIVPFLRAEAQRRTPD
HTLSTDRVDVVQPVLFAVMVSLAARWRAYGVEPAAVIGHSQGEIAAACVAGALSLDDAAR
AVALRSRVIATMPGNGAMASIAASVDEVAARIDGRVEIAAVNGPRAVVVSGDRDDLDRLV
ASCTVEGVRAKRLPVDYASHSSHVEAVRDALHAELGEFRPLPGFVPFYSTVTGRWVEPAE
LDAGYWFRNLRHRVRFADAVRSLADQGYTTFLEVSAHPVLTTAIEEIGEDRGGDLVAVHS
LRRGAGGPVDFGSALARAFVAGVAVDWESAYQGAGARRVPLPTYPFQRERFWLEPNPARR
VADSDDVSSLRYRIEWHPTDPGEPGRLDGTWLLATYPGRADDRVEAARQALESAGARVED
LVVEPRTGRVDLVRRLDAVGPVAGVLCLFAVAEPAAEHSPLAVTSLSDTLDLTQAVAGSG
RECPIWVVTENAVAVGPFERLRDPAHGALWALGRVVALENPAVWGGLVDVPSGSVAELSR
HLGTTLSGAGEDQVALRPDGTYARRWCRAGAGGTGRWQPRGTVLVTGGTGGVGRHVARWL
ARQGTPCLVLASRRGPDADGVEELLTELADLGTRATVTACDVTDREQLRALLATVDDEHP
LSAVFHVAATLDDGTVETLTGDRIERANRAKVLGARNLHELTRDADLDAFVLFSSSTAAF
GAPGLGGYVPGNAYLDGLAQQRRSEGLPATSVAWGTWAGSGMAEGPVADRFRRHGVMEMH
PDQAVEGLRVALVQGEVAPIVVDIRWDRFLLAYTAQRPTRLFDTLDEARRAAPGPDAGPG
VAALAGLPVGEREKAVLDLVRTHAAAVLGHASAEQVPVDRAFAELGVDSLSALELRNRLT
TATGVRLATTTVFDHPDVRTLAGHLAAELGGGSGRERPGGEAPTVAPTDEPIAIVGMACR
LPGGVDSPEQLWELIVSGRDTASAAPGDRSWDPAELMVSDTTGTRTAFGNFMPGAGEFDA
AFFGISPREALAMDPQQRHALETTWEALENAGIRPESLRGTDTGVFVGMSHQGYATGRPK
PEDEVDGYLLTGNTASVASGRIAYVLGLEGPAITVDTACSSSLVALHVAAGSLRSGDCGL
AVAGGVSVMAGPEVFREFSRQGALAPDGRCKPFSDEADGFGLGEGSAFVVLQRLSVAVRE
GRRVLGVVVGSAVNQDGASNGLAAPSGVAQQRVIRRAWGRAGVSGGDVGVVEAHGTGTRL
GDPVELGALLGTYGVGRGGVGPVVVGSVKANVGHVQAAAGVVGVIKVVLGLGRGLVGPMV
CRGGLSGLVDWSSGGLVVADGVRGWPVGVDGVRRGGVSAFGVSGTNAHVVVAEAPGSVVG
AERPVEGSSRGLVGVVGGVVPVVLSAKTETALHAQARRLADHLETHPDVPMTDVVWTLTQ
ARQRFDRRAVLLAADRTQAVERLRGLAGGEPGTGVVSGVASGGGVVFVFPGQGGQWVGMA
RGLLSVPVFVESVVECDAVVSSVVGFSVLGVLEGRSGAPSLDRVDVVQPVLFVVMVSLAR
LWRWCGVVPAAVVGHSQGEIAAAVVAGVLSVGDGARVVALRARALRALAGHGGMASVRRG
RDDVQKLLDSGPWTGKLEIAAVNGPDAVVVSGDPRAVTELVEHCDGIGVRARTIPVDYAS
HSAQVESLREELLSVLAGIEGRPATVPFYSTLTGGFVDGTELDADYWYRNLRHPVRFHAA
VEALAARDLTTFVEVSPHPVLSMAVGETLADVESAVTVGTLERDTDDVERFLTSLAEAHV
HGVPVDWAAVLGSGTLVDLPTYPFQGRRFWLHPDRGPRDDVADWFHRVDWTATATDGSAR
LDGRWLVVVPEGYTDDGWVVEVRAALAAGGAEPVVTTVEEVTDRVGDSDAVVSMLGLADD
GAAETLALLRRLDAQASTTPLWVVTVGAVAPAGPVQRPEQATVWGLALVASLERGHRWTG
LLDLPQTPDPQLRPRLVEALAGAEDQVAVRADAVHARRIVPTPVTGAGPYTAPGGTILVT
GGTAGLGAVTARWLAERGAEHLALVSRRGPGTAGVDEVVRDLTGLGVRVSVHSCDVGDRE
SVGALVQELTAAGDVVRGVVHAAGLPQQVPLTDMDPADLADVVAVKVDGAVHLADLCPEA
ELFLLFSSGAGVWGSARQGAYAAGNAFLDAFARHRRDRGLPATSVAWGLWAAGGMTGDQE
AVSFLRERGVRPMSVPRALEALERVLTAGETAVVVADVDWAAFAESYTSARPRPLLHRLV
TPAAAVGERDEPREQTLRDRLAALPRAERSAELVRLVRRDAAAVLGSDAKAVPATTPFKD
LGFDSLAAVRFRNRLAAHTGLRLPATLVFEHPNAAAVADLLHDRLGEAGEPTPVRSVGAG
LAALEQALPDASDTERVELVERLERMLAGLRPEAGAGADAPTAGDDLGEAGVDELLDALE
RELDAR
Reference
PMID:10972798
  Authors
Volchegursky Y, Hu Z, Katz L, McDaniel R
  Title
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.
  Journal
Mol Microbiol 37:752-62 (2000)
DOI:10.1046/j.1365-2958.2000.02059.x

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