KEGG   Actinomyces howellii: NCTC11636_00092
Entry
NCTC11636_00092   CDS       T06068                                 
Symbol
leuC
Name
(GenBank) 3-isopropylmalate dehydratase large subunit
  KO
K01703  3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35]
Organism
ahw  Actinomyces howellii
Pathway
ahw00290  Valine, leucine and isoleucine biosynthesis
ahw00660  C5-Branched dibasic acid metabolism
ahw01100  Metabolic pathways
ahw01110  Biosynthesis of secondary metabolites
ahw01210  2-Oxocarboxylic acid metabolism
ahw01230  Biosynthesis of amino acids
Module
ahw_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:ahw00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00660 C5-Branched dibasic acid metabolism
    NCTC11636_00092 (leuC)
  09105 Amino acid metabolism
   00290 Valine, leucine and isoleucine biosynthesis
    NCTC11636_00092 (leuC)
Enzymes [BR:ahw01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.33  3-isopropylmalate dehydratase
     NCTC11636_00092 (leuC)
    4.2.1.35  (R)-2-methylmalate dehydratase
     NCTC11636_00092 (leuC)
SSDB
Motif
Pfam: Aconitase AcnX
Other DBs
NCBI-ProteinID: VEG25551
UniProt: A0A448HCS5
LinkDB
Position
1:100351..101757
AA seq 468 aa
MGMTLAQKVWRDHVVAQGADGAPDLLYIDLHLVHEVTSPQAFEGLRLAGRRVRRPDLTLA
TEDHNTPTLDIDLPIADLTSRTQIDTLRANCAEFGVRLHSLGDADQGIVHAVGPQLGLTQ
PGMTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPIAPFKTMSVRIDGELPEGSG
AKDIILAIIAKIGTNGAQGHVIEYRGRAIEQLSMEARMTICNMSIEAGARAGMIAPDQTT
FDYLAGRPHAPVAEDWDEAVAYWSSLRTDDDAVFDTEVVLAAADIEPYVTWGTNPGQGLP
ISASVPVPEEIADATERRAAERAIEYMDLTPGTPLRDIRVDAVFLGSCTNGRIEDLRAAA
EVLRGRRKAPGVRMLVVPASARIRIQAEAEGLDQVFTDFGAEWRNAGCSMCLAMNPDKLA
PGERAASTSNRNFEGRQGKGGRTHLVSPVVAAATAVRGTLSTPADLGA
NT seq 1407 nt   +upstreamnt  +downstreamnt
atgggaatgaccctcgcgcagaaggtgtggcgcgaccacgtcgtcgcccagggtgccgac
ggggcccccgacctgctctacatcgacctccacctcgtccacgaggtgacgagcccccag
gccttcgagggcctgcgcctggcgggtcgccgcgtccgccgccccgacctgacgctggcc
accgaggaccacaacaccccgaccctcgacatcgacctgccgatcgccgacctgaccagc
cgcacccagatcgacaccctgcgggccaactgcgccgagttcggggtgcgtctgcactcc
ctgggcgacgccgaccagggtatcgtccacgccgtcggcccccagctcggcctgacccag
ccgggcatgacggtcgtgtgcggggactcccacacctcgacccacggcgccttcggcgcg
ctggccttcggcatcggcacgagccaggtcgagcacgtcctggccacccagaccctgccc
atcgcgccgttcaagacgatgagcgtgcgcatcgacggcgagctgcccgagggaagcggt
gccaaggacatcatcctggcgatcatcgccaagatcggcaccaacggcgcccagggccac
gtcatcgagtaccgcggccgggccatcgagcagctctcgatggaggcgcgcatgacgatc
tgcaacatgagcatcgaggccggcgcacgggccggcatgatcgcccccgaccagaccacc
ttcgactaccttgccgggcgtccccacgccccggtggccgaggactgggacgaggcggtc
gcctactggagctccctgcgcaccgacgacgacgcggtcttcgacaccgaggtcgtcctg
gcggcggccgacatcgagccctacgtcacctgggggaccaaccccggccagggcctgccg
atctcggcgagcgtgccggttcccgaggagatcgccgacgccaccgagcgtcgcgcggcc
gagcgggccatcgagtacatggacctgactcccggcacgccgctgcgcgacatccgggtc
gacgccgtcttcctgggcagctgcaccaacggccgcatcgaggacctgcgcgccgcggcc
gaggtcctgcgagggcgcaggaaggccccgggggtgcgcatgctcgtcgtgcccgcctcg
gcgcgcatccgcatccaggccgaggccgagggcctcgaccaggtcttcacggacttcggt
gccgagtggcgcaacgccggctgctcgatgtgcctggcgatgaaccccgacaagctcgcc
ccgggggagcgcgccgcctcgacctccaaccgcaacttcgaggggcgtcagggcaagggc
gggcgcacccacctcgtgtccccggtcgtcgccgccgccaccgccgttcgcggcacgctg
tccacccccgccgacctgggcgcctga

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