Acinonyx jubatus (cheetah): 106976917
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Entry
106976917 CDS
T04657
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2
KO
K02649
phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
aju
Acinonyx jubatus (cheetah)
Pathway
aju01521
EGFR tyrosine kinase inhibitor resistance
aju01522
Endocrine resistance
aju01524
Platinum drug resistance
aju04012
ErbB signaling pathway
aju04014
Ras signaling pathway
aju04015
Rap1 signaling pathway
aju04024
cAMP signaling pathway
aju04062
Chemokine signaling pathway
aju04066
HIF-1 signaling pathway
aju04068
FoxO signaling pathway
aju04070
Phosphatidylinositol signaling system
aju04071
Sphingolipid signaling pathway
aju04072
Phospholipase D signaling pathway
aju04140
Autophagy - animal
aju04150
mTOR signaling pathway
aju04151
PI3K-Akt signaling pathway
aju04152
AMPK signaling pathway
aju04210
Apoptosis
aju04211
Longevity regulating pathway
aju04213
Longevity regulating pathway - multiple species
aju04218
Cellular senescence
aju04360
Axon guidance
aju04370
VEGF signaling pathway
aju04380
Osteoclast differentiation
aju04510
Focal adhesion
aju04550
Signaling pathways regulating pluripotency of stem cells
aju04611
Platelet activation
aju04613
Neutrophil extracellular trap formation
aju04620
Toll-like receptor signaling pathway
aju04625
C-type lectin receptor signaling pathway
aju04630
JAK-STAT signaling pathway
aju04650
Natural killer cell mediated cytotoxicity
aju04660
T cell receptor signaling pathway
aju04662
B cell receptor signaling pathway
aju04664
Fc epsilon RI signaling pathway
aju04666
Fc gamma R-mediated phagocytosis
aju04668
TNF signaling pathway
aju04670
Leukocyte transendothelial migration
aju04722
Neurotrophin signaling pathway
aju04725
Cholinergic synapse
aju04750
Inflammatory mediator regulation of TRP channels
aju04810
Regulation of actin cytoskeleton
aju04910
Insulin signaling pathway
aju04914
Progesterone-mediated oocyte maturation
aju04915
Estrogen signaling pathway
aju04917
Prolactin signaling pathway
aju04919
Thyroid hormone signaling pathway
aju04923
Regulation of lipolysis in adipocytes
aju04926
Relaxin signaling pathway
aju04929
GnRH secretion
aju04930
Type II diabetes mellitus
aju04931
Insulin resistance
aju04932
Non-alcoholic fatty liver disease
aju04933
AGE-RAGE signaling pathway in diabetic complications
aju04935
Growth hormone synthesis, secretion and action
aju04960
Aldosterone-regulated sodium reabsorption
aju04973
Carbohydrate digestion and absorption
aju05010
Alzheimer disease
aju05017
Spinocerebellar ataxia
aju05020
Prion disease
aju05100
Bacterial invasion of epithelial cells
aju05135
Yersinia infection
aju05142
Chagas disease
aju05146
Amoebiasis
aju05160
Hepatitis C
aju05161
Hepatitis B
aju05162
Measles
aju05163
Human cytomegalovirus infection
aju05164
Influenza A
aju05165
Human papillomavirus infection
aju05166
Human T-cell leukemia virus 1 infection
aju05167
Kaposi sarcoma-associated herpesvirus infection
aju05168
Herpes simplex virus 1 infection
aju05169
Epstein-Barr virus infection
aju05170
Human immunodeficiency virus 1 infection
aju05171
Coronavirus disease - COVID-19
aju05200
Pathways in cancer
aju05203
Viral carcinogenesis
aju05205
Proteoglycans in cancer
aju05206
MicroRNAs in cancer
aju05207
Chemical carcinogenesis - receptor activation
aju05208
Chemical carcinogenesis - reactive oxygen species
aju05210
Colorectal cancer
aju05211
Renal cell carcinoma
aju05212
Pancreatic cancer
aju05213
Endometrial cancer
aju05214
Glioma
aju05215
Prostate cancer
aju05218
Melanoma
aju05220
Chronic myeloid leukemia
aju05221
Acute myeloid leukemia
aju05222
Small cell lung cancer
aju05223
Non-small cell lung cancer
aju05224
Breast cancer
aju05225
Hepatocellular carcinoma
aju05226
Gastric cancer
aju05230
Central carbon metabolism in cancer
aju05231
Choline metabolism in cancer
aju05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
aju05415
Diabetic cardiomyopathy
aju05417
Lipid and atherosclerosis
aju05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
aju00001
]
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
106976917
04014 Ras signaling pathway
106976917
04015 Rap1 signaling pathway
106976917
04370 VEGF signaling pathway
106976917
04630 JAK-STAT signaling pathway
106976917
04668 TNF signaling pathway
106976917
04066 HIF-1 signaling pathway
106976917
04068 FoxO signaling pathway
106976917
04070 Phosphatidylinositol signaling system
106976917
04072 Phospholipase D signaling pathway
106976917
04071 Sphingolipid signaling pathway
106976917
04024 cAMP signaling pathway
106976917
04151 PI3K-Akt signaling pathway
106976917
04152 AMPK signaling pathway
106976917
04150 mTOR signaling pathway
106976917
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
106976917
09143 Cell growth and death
04210 Apoptosis
106976917
04218 Cellular senescence
106976917
09144 Cellular community - eukaryotes
04510 Focal adhesion
106976917
04550 Signaling pathways regulating pluripotency of stem cells
106976917
09142 Cell motility
04810 Regulation of actin cytoskeleton
106976917
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
106976917
04613 Neutrophil extracellular trap formation
106976917
04620 Toll-like receptor signaling pathway
106976917
04625 C-type lectin receptor signaling pathway
106976917
04650 Natural killer cell mediated cytotoxicity
106976917
04660 T cell receptor signaling pathway
106976917
04662 B cell receptor signaling pathway
106976917
04664 Fc epsilon RI signaling pathway
106976917
04666 Fc gamma R-mediated phagocytosis
106976917
04670 Leukocyte transendothelial migration
106976917
04062 Chemokine signaling pathway
106976917
09152 Endocrine system
04910 Insulin signaling pathway
106976917
04923 Regulation of lipolysis in adipocytes
106976917
04929 GnRH secretion
106976917
04915 Estrogen signaling pathway
106976917
04914 Progesterone-mediated oocyte maturation
106976917
04917 Prolactin signaling pathway
106976917
04926 Relaxin signaling pathway
106976917
04935 Growth hormone synthesis, secretion and action
106976917
04919 Thyroid hormone signaling pathway
106976917
09154 Digestive system
04973 Carbohydrate digestion and absorption
106976917
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
106976917
09156 Nervous system
04725 Cholinergic synapse
106976917
04722 Neurotrophin signaling pathway
106976917
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
106976917
09158 Development and regeneration
04360 Axon guidance
106976917
04380 Osteoclast differentiation
106976917
09149 Aging
04211 Longevity regulating pathway
106976917
04213 Longevity regulating pathway - multiple species
106976917
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
106976917
05206 MicroRNAs in cancer
106976917
05205 Proteoglycans in cancer
106976917
05207 Chemical carcinogenesis - receptor activation
106976917
05208 Chemical carcinogenesis - reactive oxygen species
106976917
05203 Viral carcinogenesis
106976917
05230 Central carbon metabolism in cancer
106976917
05231 Choline metabolism in cancer
106976917
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
106976917
09162 Cancer: specific types
05210 Colorectal cancer
106976917
05212 Pancreatic cancer
106976917
05225 Hepatocellular carcinoma
106976917
05226 Gastric cancer
106976917
05214 Glioma
106976917
05221 Acute myeloid leukemia
106976917
05220 Chronic myeloid leukemia
106976917
05218 Melanoma
106976917
05211 Renal cell carcinoma
106976917
05215 Prostate cancer
106976917
05213 Endometrial cancer
106976917
05224 Breast cancer
106976917
05222 Small cell lung cancer
106976917
05223 Non-small cell lung cancer
106976917
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
106976917
05170 Human immunodeficiency virus 1 infection
106976917
05161 Hepatitis B
106976917
05160 Hepatitis C
106976917
05171 Coronavirus disease - COVID-19
106976917
05164 Influenza A
106976917
05162 Measles
106976917
05168 Herpes simplex virus 1 infection
106976917
05163 Human cytomegalovirus infection
106976917
05167 Kaposi sarcoma-associated herpesvirus infection
106976917
05169 Epstein-Barr virus infection
106976917
05165 Human papillomavirus infection
106976917
09171 Infectious disease: bacterial
05135 Yersinia infection
106976917
05100 Bacterial invasion of epithelial cells
106976917
09174 Infectious disease: parasitic
05146 Amoebiasis
106976917
05142 Chagas disease
106976917
09164 Neurodegenerative disease
05010 Alzheimer disease
106976917
05017 Spinocerebellar ataxia
106976917
05020 Prion disease
106976917
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
106976917
05418 Fluid shear stress and atherosclerosis
106976917
05415 Diabetic cardiomyopathy
106976917
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
106976917
04932 Non-alcoholic fatty liver disease
106976917
04931 Insulin resistance
106976917
04933 AGE-RAGE signaling pathway in diabetic complications
106976917
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
106976917
01524 Platinum drug resistance
106976917
01522 Endocrine resistance
106976917
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
aju04131
]
106976917
Membrane trafficking [BR:
aju04131
]
Endocytosis
Rab GTPases and associated proteins
Rab associated proteins
106976917
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PI3K_P85_iSH2
SH2
AAA_13
DUF4201
Laminin_I
PI_PP_I
Legum_prodom
Exonuc_VII_L
Motif
Other DBs
NCBI-GeneID:
106976917
NCBI-ProteinID:
XP_026896475
UniProt:
A0A6J1XVU4
LinkDB
All DBs
Position
A1:133009700..133375034
Genome browser
AA seq
554 aa
AA seq
DB search
MTTLTLTWAPLPHPKSLAQQIFEPAQVNHEAVIFICETCERRGFLPPAYGTTGSQWLCPW
GAGGERRCCGGPVPTSVSRRASPRVPRRRRPCARRAGALPRSGRHRGGGGESRGRRSHCR
RPAWPRETADMHNLQTLPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDT
ADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRN
ESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDY
TRTSQEIQMKRTAIEAFNETIKIFEEQCQSQERYSKEYIEKFKREGNEKEIQRIMHNYEK
LKSRISEIVDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVR
QKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRE
SSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSL
NVTLAYPVYAQQRR
NT seq
1665 nt
NT seq
+upstream
nt +downstream
nt
atgacaactttgactttgacttgggctcccctcccccacccgaaatccctagctcagcaa
atatttgaacctgcccaagttaatcatgaagccgtgatctttatctgcgagacgtgcgag
cgccggggctttctccctcccgcgtacggcaccaccggcagccagtggctgtgtccatgg
ggagcgggcggtgagcggcgctgctgcggcggtcccgtcccgacgtccgtgtcgcgccgc
gcgagcccgagggtcccgcgccgccgccgcccctgcgctcggcgggcgggagcgctgccg
cggagtgggcgccaccgtgggggcggcggggagagccgggggcggcgttcgcattgtcgg
agaccggcctggccgcgggaaactgcagacatgcataacctgcaaacattgcctcctaaa
ccacccaaacccactactgtagccaacaacggtatgaataacaatatgtccttacaagat
gctgaatggtactggggagatatctcaagggaagaagtgaatgaaaaacttcgagataca
gctgatgggacctttttggtacgagacgcatctactaaaatgcacggtgattatactctt
acactaaggaaaggaggaaataacaagttaatcaaaatatttcaccgagatgggaaatat
ggcttctctgacccactaaccttcaactctgtggttgaactaataaaccactaccggaat
gagtccctagctcagtacaatcccaaactggacgtgaaattactttatccagtatccaaa
taccaacaggatcaagttgtcaaagaagataatattgaagctgtagggaaaaaattacat
gaatataacactcaatttcaagaaaaaagtcgggaatatgatagattatatgaagattat
acccgtacttcccaggaaatccagatgaaaagaacagctattgaagcatttaatgaaacc
ataaaaatatttgaagagcagtgccaaagccaagaacggtacagcaaagaatacatagaa
aaatttaaacgggaaggcaatgagaaagaaatacaaaggattatgcataattatgaaaag
ttgaagtctcgcatcagcgaaattgtggacagtagaagacgactggaggaggacttgaag
aaacaggcagctgagtatcgggagattgacaagcgcatgaacagcattaaaccagacctc
attcagctgagaaagacaagagaccaatacttgatgtggttgactcagaaaggtgttcgg
cagaagaagctgaacgagtggctgggcaatgagaacactgaagaccaatactcgctggtg
gaggatgatgaggatttgccgcaccacgacgagaagacatggaatgtcggcagcagcaac
agaaacaaggctgaaaacctactccgggggaagcgagatggcaccttcctggtccgggaa
agcagtaaacagggctgctatgcctgctcggtagtggtggatggcgaagtgaagcactgt
gtcatcaacaaaacggcaactggctacggctttgccgagccctataacctgtacagctcc
ctgaaagagctggtgctacattaccaacacacctccctcgtgcagcacaacgactccctc
aacgtcacactagcctacccggtatatgcacagcagaggcgatga
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