Amycolatopsis methanolica: AMETH_0451
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Entry
AMETH_0451 CDS
T03230
Symbol
hemD
Name
(GenBank) uroporphyrinogen III synthase/methyltransferase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
amq
Amycolatopsis methanolica
Pathway
amq00860
Porphyrin metabolism
amq01100
Metabolic pathways
amq01110
Biosynthesis of secondary metabolites
amq01120
Microbial metabolism in diverse environments
amq01240
Biosynthesis of cofactors
Module
amq_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
amq_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
amq00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
AMETH_0451 (hemD)
Enzymes [BR:
amq01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
AMETH_0451 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
AMETH_0451 (hemD)
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GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
AIJ20543
UniProt:
A0A076MI46
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Position
435053..436588
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AA seq
511 aa
AA seq
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MTPARTTAGRVAFVGSGPGDAGLLTVRAQELLAKAEVVVTDPDVPAGVLAGASADAEVRP
AVGEPAEVAKDLANEAKGGRLVLRLSSGDPLTSAAAVAEVQAVAKTSAVFEVVPGITPGS
AVPAYAGIALGGSYTDVDVRGDVDWAKVAAAPGPIVLHATSGQLAEAAGALTEHGLAGTT
PVAVTANGTINTQRTVDTTLASLSQDAGELVGPLVVTVGEQAGQRSKLSWWESRALYGWK
VLVPRTKEQAGEMAERLRIHGATSHEVPTISVEPPRSPAQMERAVKGLVDGRYQWIVFTS
ANAVKAVWEKFEEFGLDARAFSGVKIACVGEATAARVRAFGINPEMIPQGEQSSEGLLAE
FPPYDDVLDPVNRVLLPRADIATETLSAGLVDRGWEVDDVTAYRTVRAAPPPAETREMIK
TGGFDAVCFTSSSTVRNLVGIAGKPHTRTLVACIGPKTAETAVEFGLRVDVQPEVADVPH
LVDALAAHAAKLRAEGALPPPRKAKRTRRSS
NT seq
1536 nt
NT seq
+upstream
nt +downstream
nt
atgacccccgcgcggacaaccgctgggcgcgtcgccttcgtgggctccggccccggcgac
gccggactgctgaccgtacgtgcccaggagctcctggcgaaggccgaggtcgtggtgacc
gacccggacgtgcccgccggcgtgctcgcgggcgccagcgcggacgccgaggtcaggccc
gccgtcggcgagcccgccgaggtcgcgaaggacctcgccaacgaggccaagggcggacgg
ctcgtgctgcgcctgtccagcggcgacccgctgaccagcgccgccgccgtcgccgaggtg
caggccgtcgcgaagaccagcgcggtcttcgaggtcgtgccgggcatcacgccgggttcg
gccgtgcccgcctacgccggcatcgcgctcggcggcagctacaccgacgtcgacgtccgc
ggcgacgtcgactgggcgaaggtggccgccgcccccggcccgatcgtgctgcacgcgact
tccggccagctggccgaggccgccggcgcgctgaccgaacacggcctggcaggcaccacc
ccggtcgccgtcaccgccaacggcacgatcaacacccagcgcacggtcgacaccacgctg
gcgagcctgtcgcaggacgccggtgaactggtcggcccgctcgtggtgaccgtcggcgag
caggccgggcagcggtcgaagctgtcctggtgggagtcgcgcgccctctacggctggaag
gtcctggtgccccgcaccaaggagcaggccggcgagatggccgagcggctgcgcatccac
ggcgccacgtcgcacgaggtcccgaccatctcggtcgagccgccgcgcagccccgcccag
atggagcgcgcggtcaagggcctggtcgacggccgctaccagtggatcgtgttcacctcg
gccaacgcggtgaaggcggtgtgggagaagttcgaggagttcggcctcgacgcccgcgcc
ttctccggtgtgaagatcgcctgcgtcggcgaggccaccgcggcccgcgtgcgcgcgttc
ggcatcaacccggagatgatcccgcagggcgagcagtccagcgagggtctgctggccgag
ttcccgccgtacgacgacgtgctggacccggtgaaccgcgtgctgctgccgcgggccgac
atcgccaccgagaccctgtccgccggcctggtcgaccgcggctgggaggtcgacgacgtg
acggcctaccggaccgtccgcgccgcgccgccgcctgccgagacccgcgagatgatcaag
accggcgggttcgacgcggtgtgcttcacctcgtcgtcgaccgtgcggaacctggtcggc
atcgcgggcaagccgcacacacgcacgctggtcgcgtgcatcgggccgaagaccgcggag
accgcggtcgagttcggcctgcgggtggacgtgcagccggaggtggccgacgtgccgcac
ctggtcgacgcgctcgccgcgcacgccgccaagctgcgcgcggagggcgccctgccgccg
ccgcggaaggcgaagcgcacccggcgttcttcctga
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