Amycolatopsis sp. AA4: CU254_01155
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Entry
CU254_01155 CDS
T05278
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
amyc
Amycolatopsis sp. AA4
Pathway
amyc00860
Porphyrin metabolism
amyc01100
Metabolic pathways
amyc01110
Biosynthesis of secondary metabolites
amyc01120
Microbial metabolism in diverse environments
amyc01240
Biosynthesis of cofactors
Module
amyc_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
amyc_M00925
Cobalamin biosynthesis, aerobic, uroporphyrinogen III => precorrin 2 => cobyrinate a,c-diamide
amyc_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
amyc00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
CU254_01155
Enzymes [BR:
amyc01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
CU254_01155
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
CU254_01155
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
ATY09236
UniProt:
A0A2K8LLD7
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Position
234292..235824
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AA seq
510 aa
AA seq
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MTPARKTAGRVAFVGSGPGDAGLLTVRAQELLAKAEVVVTDPDVPASVLAFASPDAEVRP
AVGEPSDVAKDLTAEAKAGRLALRLVSGDPLTSPAVVAEVQAVARTSAVFDVIPGVAPGT
AVPAYAGVALGGTYTEADVRGEVDWGALAAVPGPIVLHATSAHLAEAASQLTEKGLAPTT
PVAVTANGTINTQRTLDTTLASVANDAGELVGPLVVTVGQAAGQRSKLSWWESRALYGWK
VLVPRTKEQAGEMAERLRGHGATSHEVPTISVEPPRSPAQMERSVKGLVDGRYQWIVFTS
TNAVRAVWEKFEEFGLDARAFSGVKIACVGESTAAKVRSFGIIPELVPTGEQSSEGLLAE
FPPYDDVLDPVNRVLLPRADIATEILSAGLVERGWEVDDVTAYRTVRAAPPPAETREMIK
TGGFDAVCFTSSSTVRNLVGIAGKPHTRTLVACIGPKTAETAVEFGLRVDVQPEKADVPH
LVDALAEHAARLRAEGALPPPRKAKRTRRS
NT seq
1533 nt
NT seq
+upstream
nt +downstream
nt
atgacccctgctcgcaagaccgccgggcgcgtcgccttcgtgggctcgggccccggggac
gccgggctgctcaccgtccgcgcccaggaactcctggccaaggccgaggtcgtggtgacc
gacccggacgtgcccgccagcgtgctcgccttcgcctcccccgacgccgaggtccgtccc
gccgtcggcgaaccgtccgacgtcgcgaaggacctgaccgccgaggccaaggcaggccgg
ctcgcgctgcggctggtctccggcgacccgctgaccagcccggccgtcgtggccgaggtc
caggccgtcgctcgcacctcggccgtgttcgacgtcatcccgggcgtcgcgccgggcacc
gcggtgccggcgtacgcgggggtcgcgctcggcggcacctacaccgaggcggacgtccgc
ggcgaggtcgactggggcgcgctggccgcggtccccggcccgatcgtgctgcacgcgacc
tcggcgcacctggccgaggcggcgagccagctcaccgagaaggggctggctccgaccacc
ccggtcgcggtcaccgcgaacggcaccatcaacacccagcgcacgctggacaccaccctc
gcctcggtcgcgaacgacgcgggcgagctggtcggccccctggtcgtgacggtcgggcag
gccgccgggcagcggtcgaagctgtcctggtgggagtcgcgggcgctgtacggctggaag
gtcctggtgccgcgcaccaaggagcaggcgggcgagatggccgagcggctgcgcggccac
ggcgcgacctcgcacgaggtgccgaccatttcggtcgagccgccccgcagcccggcgcag
atggagcggtcggtcaagggcctggtcgacggccggtaccagtggatcgtcttcacctcc
accaacgcggtgcgcgcggtgtgggagaagttcgaggagttcggtctcgacgcgcgcgcg
ttctccggcgtgaagatcgcctgcgtcggcgaatcgacggcggcgaaggtgcggtcgttc
gggatcatcccggagctggtgccgactggcgagcagtcgtccgaggggctgctggccgag
ttcccgccgtatgacgacgttttggacccggtgaaccgggtgctgttgccgcgggcggac
atcgcgaccgagattctgtcggctggtctggtcgagcgtggttgggaagtcgacgacgtc
acggcttaccggactgtgcgggccgcgccgccgcccgcggagactcgcgagatgatcaag
accggcgggtttgacgcggtctgtttcacctcgtcgtcgaccgtgcggaacctggtcggg
atcgccgggaagccgcacacgcgcacgctggtcgcgtgcattgggccgaagaccgccgag
accgcggtggaattcggtctgcgagtggacgtccagccggagaaggccgacgtgccgcac
ctggtggacgcgctcgccgagcacgccgcccggcttcgtgcggagggcgcgttgccgccg
ccgcgcaaggccaagcgcacccggcgcagctga
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