Actinoplanes sp. SE50/110: ACPL_7861
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Entry
ACPL_7861 CDS
T02044
Symbol
hemD
Name
(GenBank) uroporphyrinogen III methyltransferase / synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
ase
Actinoplanes sp. SE50/110
Pathway
ase00860
Porphyrin metabolism
ase01100
Metabolic pathways
ase01110
Biosynthesis of secondary metabolites
ase01120
Microbial metabolism in diverse environments
ase01240
Biosynthesis of cofactors
Module
ase_M00121
Heme biosynthesis, plants and bacteria, glutamate => heme
ase_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
ase_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
ase00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
ACPL_7861 (hemD)
Enzymes [BR:
ase01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
ACPL_7861 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
ACPL_7861 (hemD)
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GFIT
Motif
Pfam:
HEM4
TP_methylase
B12-binding
Motif
Other DBs
NCBI-ProteinID:
AEV88739
UniProt:
G8S656
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Position
complement(8674274..8675860)
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AA seq
528 aa
AA seq
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MTTRTARKPAGRIAFIGAGPGDPELLTRRAYAALTDADQVVHDRGVPESLLAAVRADAKP
DAQFSPAEGAPGDVAKVLLSAAKSGLSAVHLVAGDPFGHESVVKEVQAVARTAVHFEVIP
GIGQAEGVAAYAGVPLPGVRIAADVDDVTSLDFDALAGAAQKGSFAVAVDAGDLAAVRDG
LLAAGVEPGVPVAVTGDGTGETQYTTTSTVDSFVAAALGFTGRVVLTVGAEVAERDAMSW
WENRPLYGWKVLVPRTKEQAGAMSARLRAYGAIPCEVPTIAVEPPRTPAQMERAVKGLVD
GRYAWVVFTSVNAVRAVWEKFAEHGLDARHFGGVKIACIGEATAEAVRDFGIQPELIPAG
EQSSEGLLAEFSPHDEILDPVGRVLLPRADIATETLAAGLIERGWEVDDVTAYRTVRAAP
PPAEIRDAIKSGGFDAVLFTSSSTVRNLVGIAGKPHARTVVAVIGPKTAETAVEFGLRVD
TQPQNASVPDLVEALAEYALELREKLAAMPAKQRRGSKVQGPTALRFR
NT seq
1587 nt
NT seq
+upstream
nt +downstream
nt
atgaccacccgcaccgcccgtaagccagccggacgcatcgcgttcatcggcgccggaccc
ggcgacccggagctgcttacccgccgcgcgtacgccgcgttgaccgatgccgaccaggtg
gtccacgaccggggcgtacccgagtcgctgctggccgcggtccgcgcggacgccaaaccc
gacgcgcagttcagcccggccgagggcgcccccggcgacgtggccaaggtgctgctctcc
gccgccaagtccgggctgtccgccgtccacctggtggccggcgacccgttcggccacgag
tcggtggtcaaggaggtgcaggcggtcgcccggaccgcggtgcacttcgaggtgatcccg
ggcatcgggcaggccgagggtgtcgccgcgtacgccggcgtgccgctgcccggcgtgcgg
atcgccgccgacgtcgacgacgtcacctcgctcgacttcgacgcgctggccggcgcggcc
cagaagggctcgttcgcggtcgccgtggacgccggcgacctcgccgcggtccgcgacggg
ctgctcgcggccggcgtcgaaccgggtgtcccggtcgcggtgaccggcgacggcaccggc
gagacgcagtacaccaccacctcgacggtggacagcttcgtggccgccgcgctcggcttc
accggccgggtggtgctcaccgtcggggccgaggtcgccgagcgggacgcgatgagctgg
tgggagaaccgcccgctgtacggctggaaggtcctggtcccgcggaccaaggagcaggcc
ggcgcgatgagcgcgcggctgcgggcgtacggcgccatcccgtgcgaggtgccgaccatc
gcggtcgagccgccgcgcaccccggcgcagatggagcgcgcggtcaagggcctggtcgac
ggccgctacgcctgggtggtgttcacctcggtgaacgccgtccgcgcggtctgggagaaa
ttcgccgagcacggcctcgacgcccgtcacttcggcggtgtgaagatcgcctgcatcggg
gaggccaccgccgaggcggtccgcgacttcggcatccagcccgagctgatcccggccggc
gagcagtccagcgagggcctgctggccgagttctcgccgcacgacgagatcctcgacccg
gtcggccgggtgctgctgccgcgcgccgacatcgccaccgagaccctggccgccggcctg
atcgagcggggctgggaggtggacgacgtgaccgcgtaccggacggtgcgggccgcgccg
ccgccggccgagatccgcgacgcgatcaagtccgggggcttcgacgcggtgctgttcacc
tcgtcctccacggtccgcaacctggtcggcatcgccggcaagccgcacgcccgcacggtc
gtcgcggtgatcgggccgaaaaccgcggagaccgcggtcgagttcggcctgcgggtcgac
acccagccgcagaacgcctcggtgccggacctggtcgaggcgctcgccgaatacgccctg
gagctgcgcgagaaactggcggcgatgcccgccaagcagcgccgcggctcgaaggtgcag
ggcccgacggccctccgattccgctga
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