KEGG   PATHWAY: bax00260
Entry
bax00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Bacillus anthracis H9401
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bax00260  Glycine, serine and threonine metabolism
bax00260

Module
bax_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bax00260]
bax_M00621  Glycine cleavage system [PATH:bax00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bacillus anthracis H9401 [GN:bax]
Gene
H9401_1710  Aspartate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]
H9401_3750  Aspartokinase [KO:K00928] [EC:2.7.2.4]
H9401_3751  Aspartate semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
H9401_2314  Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
H9401_2485  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
H9401_1865  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
H9401_5395  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
H9401_1867  Homoserine kinase [KO:K00872] [EC:2.7.1.39]
H9401_1866  Threonine synthase [KO:K01733] [EC:4.2.3.1]
H9401_5302  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
H9401_4902  D-isomer specific 2-hydroxyacid dehydrogenase family protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
H9401_0146  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
H9401_2095  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
H9401_3692  Phosphoglycerate mutase family protein [KO:K01834] [EC:5.4.2.11]
H9401_1970  Phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
H9401_2364  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
H9401_4967  Phosphoglycerate mutase family protein [KO:K01834] [EC:5.4.2.11]
H9401_1650  Phosphoglycerate mutase family protein [KO:K01834] [EC:5.4.2.11]
H9401_5116  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
H9401_3158  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
H9401_3159  Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
H9401_0590  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
H9401_1822  Amine oxidase, flavin-containing protein [KO:K00274] [EC:1.4.3.4]
H9401_1917  Amine oxidase, flavin-containing protein [KO:K00274] [EC:1.4.3.4]
H9401_4242  glycine dehydrogenase subunit 1 [KO:K00282] [EC:1.4.4.2]
H9401_4241  glycine dehydrogenase subunit 2 [KO:K00283] [EC:1.4.4.2]
H9401_4243  Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
H9401_4181  Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
H9401_3986  Pyruvate dehydrogenase complex E3 component, dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
H9401_2643  Acetoin dehydrogenase complex, dihydrolipoamide dehydrogenase component [KO:K00382] [EC:1.8.1.4]
H9401_4990  Glycine cleavage system H protein [KO:K02437]
H9401_0909  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
H9401_1348  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
H9401_4389  Cys/Met metabolism PLP-dependent enzyme [KO:K17217] [EC:4.4.1.1 4.4.1.2]
H9401_3148  L-serine dehydratase, iron-sulfur-dependent, beta subunit [KO:K01752] [EC:4.3.1.17]
H9401_4160  L-serine dehydratase, alpha subunit [KO:K01752] [EC:4.3.1.17]
H9401_4161  L-serine dehydratase, iron-sulfur-dependent, beta subunit [KO:K01752] [EC:4.3.1.17]
H9401_3147  L-serine dehydratase, iron-sulfur-dependent, alpha subunit [KO:K01752] [EC:4.3.1.17]
H9401_1752  Threonine dehydratase [KO:K01754] [EC:4.3.1.19]
H9401_2346  Threonine ammonia-lyase, catabolic [KO:K01754] [EC:4.3.1.19]
H9401_1686  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
H9401_4783  Aspartate racemase family protein [KO:K25316] [EC:5.1.1.10]
H9401_2108  Aspartate racemase family protein [KO:K25316] [EC:5.1.1.10]
H9401_1179  Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
H9401_1178  Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
H9401_3150  Diaminobutyrate-2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bax00010  Glycolysis / Gluconeogenesis
bax00020  Citrate cycle (TCA cycle)
bax00230  Purine metabolism
bax00250  Alanine, aspartate and glutamate metabolism
bax00270  Cysteine and methionine metabolism
bax00290  Valine, leucine and isoleucine biosynthesis
bax00300  Lysine biosynthesis
bax00330  Arginine and proline metabolism
bax00460  Cyanoamino acid metabolism
bax00470  D-Amino acid metabolism
bax00564  Glycerophospholipid metabolism
bax00620  Pyruvate metabolism
bax00630  Glyoxylate and dicarboxylate metabolism
bax00640  Propanoate metabolism
bax00680  Methane metabolism
bax00860  Porphyrin metabolism
bax00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system