Bison bison bison (American bison): 104979781 Help Entry 104979781         CDS       T08726                                  Symbol INSR Name (RefSeq) insulin receptor isoform X1   KO K04527   insulin receptor [EC:2.7.10.1] Organism bbis  Bison bison bison (American bison) Pathway bbis04010   MAPK signaling pathway bbis04014   Ras signaling pathway bbis04015   Rap1 signaling pathway bbis04022   cGMP-PKG signaling pathway bbis04066   HIF-1 signaling pathway bbis04068   FoxO signaling pathway bbis04072   Phospholipase D signaling pathway bbis04150   mTOR signaling pathway bbis04151   PI3K-Akt signaling pathway bbis04152   AMPK signaling pathway bbis04211   Longevity regulating pathway bbis04213   Longevity regulating pathway - multiple species bbis04520   Adherens junction bbis04910   Insulin signaling pathway bbis04913   Ovarian steroidogenesis bbis04923   Regulation of lipolysis in adipocytes bbis04930   Type II diabetes mellitus bbis04931   Insulin resistance bbis04932   Non-alcoholic fatty liver disease bbis04960   Aldosterone-regulated sodium reabsorption bbis05010   Alzheimer disease bbis05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:bbis00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     104979781 (INSR)    04014 Ras signaling pathway     104979781 (INSR)    04015 Rap1 signaling pathway     104979781 (INSR)    04066 HIF-1 signaling pathway     104979781 (INSR)    04068 FoxO signaling pathway     104979781 (INSR)    04072 Phospholipase D signaling pathway     104979781 (INSR)    04022 cGMP-PKG signaling pathway     104979781 (INSR)    04151 PI3K-Akt signaling pathway     104979781 (INSR)    04152 AMPK signaling pathway     104979781 (INSR)    04150 mTOR signaling pathway     104979781 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     104979781 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     104979781 (INSR)    04923 Regulation of lipolysis in adipocytes     104979781 (INSR)    04913 Ovarian steroidogenesis     104979781 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     104979781 (INSR)   09149 Aging    04211 Longevity regulating pathway     104979781 (INSR)    04213 Longevity regulating pathway - multiple species     104979781 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     104979781 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     104979781 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     104979781 (INSR)    04932 Non-alcoholic fatty liver disease     104979781 (INSR)    04931 Insulin resistance     104979781 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:bbis01001]     104979781 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:bbis04090]     104979781 (INSR) Enzymes [BR:bbis01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      104979781 (INSR) Protein kinases [BR:bbis01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    104979781 (INSR) CD molecules [BR:bbis04090]  Proteins   104979781 (INSR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like DUF4476 B2 Motif Other DBs NCBI-GeneID:  104979781 NCBI-ProteinID:  XP_010826605 Ensembl:  ENSBBBG00000018333 UniProt:  A0A6P3GJE4 LinkDB All DBs Position Unknown AA seq 1382 aa AA seqDB search MGAGGGRGAAAVLLMVVVAALLVGAAGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHL QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTSEGLCCHSECL GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHNKCKNSRRQG CHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC TIINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE RNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQ NVTEFDGQDACGSNSWTVVDIDPPTRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE RQAEDSELYELDYCLKGLKLPSRTWSPPFESEGSQKHNQSEYEESAGECCSCPKTDSQIL KELEESSFRKTFEDYLHNVVFIPRKSSSGPVAEDARPSRKRRALGDVGNVTAAVPTVLGF PNTSSTSTPMSSEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPEERCSVAAYV SARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGEEELHLCV SRRHYALERGCRLRGLLPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDVPSNIAKIIIG PLIFVFLFSVVIGSICLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPR EKITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKTVNESASLRERIEFLNEASVMKG FTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMA AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV RWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDN CPERVTDLMRMCWQFNPKMRPTFLEIVDLLKDDLHPSFPEVSFFHSEENKAPESEELEME FEDMESVPLDRASHAQREEAGGRDGGSALGLKRNYDEHIPYTHMNGGKKNGRILTLPRSN PS NT seq 4149 nt NT seq  +upstreamnt  +downstreamnt atgggcgccgggggcgggaggggggcggcagccgtgctgctgatggtggtcgtcgccgcg ctgctggtgggcgccgcgggccacctgtaccctggagaagtgtgccccggtatggatatc cggaataatctcacccggctgcatgagctggccaactgctcagtcatcgaaggacatttg cagattctgttgatgttcaaaacgagacctgaggacttccgagacctcagtttccccaaa ctcatcatgatcactgattacttgctgctcttccgggtctatgggctggagagcctgaag gacttgttccccaacctcacggttatccgaggctcacgcctcttctttaattatgcgctg gtcatctttgagatggttcacctgaaggagcttggcctctacaacctgatgaacatcacc cgggggtctgtccgcattgagaagaacaatgaactctgctacctggccaccatcgactgg tctcgcatcctggattccgtggaggataattatatcgtgctgaacaaagacgacaatgag gagtgtggggacatttgtccaggcaccgccaagggcaagaccaactgccctgccactgtc atcaacgggcaatttgtggagcggtgctggacacacagccactgccagaaagtgtgtccg accatctgcaagtcacatggctgcacctctgagggtctctgctgccacagcgagtgcttg ggcaactgctcagagcccgacgaccccaccaagtgtgtggcctgtcgcaacttctacctg gacggcaggtgtgtggagacctgcccgcccccttactaccacttccaagactggcgctgc gtgaacttcagcttctgccaggacctgcacaacaaatgcaagaactctcggaggcaaggc tgccaccagtatgtcattcacaataacaagtgcatccccgagtgcccctctggctacacg atgaattccagcaacttgatgtgtaccccttgcctgggcccctgtcccaaggtatgccac ctcctggaaggcgagaagaccatcgattcggtgacatctgcccaggagctccgaggctgc accatcatcaacggaagcttaatcatcaacattcgagggggcaacaacctggcagctgag ctagaggccaaccttggactcattgaagaaatttcaggatatctgaaaatccgccggtcc tatgccctggtgtcactttccttcttccggaagttacgtctgattcgaggggagaccttg gaaattgggaactactctttctacgccttggacaaccagaacctaaggcagctgtgggac tggagcaaacacaacctcaccatcactcaggggaaactcttcttccactataaccccaaa ctctgcctgtcggaaattcacaagatggaggaagtttcaggaaccaaggggcgccaggag agaaatgacattgctctaaagaccaatggggaccaggcatcctgtgaaaatgaattactt aaattttcttacattcggacatcttacgacaagatcttgctgaaatgggagccgtattgg cctcctgacttccgagacctcctggggttcatgttgttctacaaagaggccccttaccag aacgtgacagaattcgatgggcaggatgcgtgcggctccaacagctggacagtggtggat attgacccgcctacgaggtccaacgaccccaagtcacagaaccaccctgggtggctgatg cgtggtctcaagccctggacccagtatgccatctttgtcaagaccctggtcaccttttct gatgaacgccgtacatacggggccaagagtgacatcatctatgtccagacagacgccact aatccttccgtgcccctggatcccatctcagtttctaattcctcgtcccagattattctg aagtggaagcctccctccgaccccaatggcaatatcacacactacttggtgttctgggag agacaggcggaagacagtgagctgtatgaactggattattgcctcaaagggttgaagctg ccctcccggacctggtctccaccattcgagtcggagggctcccagaagcacaaccagagt gagtatgaggagtctgctggcgaatgctgctcctgcccaaagaccgactcgcagatcctc aaggagctggaggagtcctcgttcaggaaaacgtttgaagattacctgcacaacgtggtt ttcatccccagaaaatcatcttcaggccctgttgccgaggacgctaggccttcgaggaaa cgcagagcccttggtgacgtggggaatgtgacagcagccgtgcccactgttctggggttc cccaatacctcctccaccagcacgcccatgagctcggaggagcacagacccttcgagaaa gtggtgaacaaggagtcgctggtcatctccggcctgcgtcactttactggctatcgcatc gagcttcaggcttgcaaccaagattcccccgaggagaggtgtagcgtggctgcctatgtc agtgccaggaccatgcctgaagccaaggcagatgatattgtcggccccgtgacccatgaa atcttcgagaacaacgttgttcacttgatgtggcaggagcccaaggaacccaacggtctg attgtgctgtatgaagtgagttaccgacgatacggcgaggaggagctgcacctctgcgtc tcccgccgacattatgctctggagcgtggctgccggctgcgtgggctgctgcctgggaat tacagtgtgcgagttcgggccacctccctggcaggcaatgggtcttggacggaagccacc tatttctacgtgacagactatttagacgtgccatcaaatattgcaaaaatcatcatcggt cccctcatctttgtctttctcttcagtgttgtgattggaagtatttgtctattcctgaga aagaggcagccagatgggccattgggaccactgtatgcttcttcaaacccagagtacctc agtgccagcgatgtgtttccatgctctgtgtatgtgccggacgagtgggaggtgcctcga gagaagatcacactcctgcgagaattggggcaaggctcctttggcatggtgtatgagggc aacgccagggacattgtcaagggtgaggcggagacgcgcgtggcagtgaagacggtcaac gagtcagccagcctgcgagagcggatcgagtttctcaacgaggcttcggtcatgaagggc ttcacctgccaccatgtggtccgcctcctgggggtggtgtccaaaggccagccaacgctg gtggtgatggagttgatggctcacggagacctgaagagttacctccgttccctgcggcct gaggctgagaataaccccggccgccctccgcctaccctgcaagaaatgattcagatggcg gcagagatcgccgatgggatggcatacctgaacgctaagaagttcgtgcaccgggatctt gcagcccggaactgcatggttgcccacgactttacagtcaaaattggagactttggaatg acaagagacatctatgaaacggattactaccggaaagggggcaaaggtctgctccctgtg cggtggatggcacctgaatccctgaaggacggagtcttcaccacctcttcagacatgtgg tcttttggtgtggtcctttgggaaattaccagcttggcagaacagccttaccaaggtcta tcaaatgagcaggtgctgaaatttgtcatggatggagggtacctggatcaacctgacaat tgtccagagagagtcaccgacctgatgcggatgtgctggcagttcaaccccaagatgcgt ccaaccttcctggagatcgtggacctgctcaaggacgacctgcaccccagctttcccgaa gtgtccttcttccacagcgaggagaacaaggcgcccgagagcgaggagctggaaatggag tttgaggacatggagagcgtgcccctggaccgggcctcgcacgcgcagagagaggaggcc gggggccgggatggagggtcggcgctggggctaaagcgaaactatgacgagcacatcccc tacacccacatgaacgggggcaagaaaaacggacggattctgactttgccccggtcaaat ccttcctaa

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