KEGG   Bison bison bison (American bison): 104984678
Entry
104984678         CDS       T08726                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
bbis  Bison bison bison (American bison)
Pathway
bbis01521  EGFR tyrosine kinase inhibitor resistance
bbis01522  Endocrine resistance
bbis04010  MAPK signaling pathway
bbis04012  ErbB signaling pathway
bbis04014  Ras signaling pathway
bbis04015  Rap1 signaling pathway
bbis04022  cGMP-PKG signaling pathway
bbis04024  cAMP signaling pathway
bbis04062  Chemokine signaling pathway
bbis04066  HIF-1 signaling pathway
bbis04068  FoxO signaling pathway
bbis04071  Sphingolipid signaling pathway
bbis04072  Phospholipase D signaling pathway
bbis04114  Oocyte meiosis
bbis04140  Autophagy - animal
bbis04148  Efferocytosis
bbis04150  mTOR signaling pathway
bbis04151  PI3K-Akt signaling pathway
bbis04210  Apoptosis
bbis04218  Cellular senescence
bbis04270  Vascular smooth muscle contraction
bbis04370  VEGF signaling pathway
bbis04371  Apelin signaling pathway
bbis04380  Osteoclast differentiation
bbis04510  Focal adhesion
bbis04540  Gap junction
bbis04550  Signaling pathways regulating pluripotency of stem cells
bbis04613  Neutrophil extracellular trap formation
bbis04620  Toll-like receptor signaling pathway
bbis04650  Natural killer cell mediated cytotoxicity
bbis04660  T cell receptor signaling pathway
bbis04662  B cell receptor signaling pathway
bbis04664  Fc epsilon RI signaling pathway
bbis04666  Fc gamma R-mediated phagocytosis
bbis04668  TNF signaling pathway
bbis04720  Long-term potentiation
bbis04722  Neurotrophin signaling pathway
bbis04725  Cholinergic synapse
bbis04726  Serotonergic synapse
bbis04730  Long-term depression
bbis04810  Regulation of actin cytoskeleton
bbis04910  Insulin signaling pathway
bbis04912  GnRH signaling pathway
bbis04914  Progesterone-mediated oocyte maturation
bbis04915  Estrogen signaling pathway
bbis04916  Melanogenesis
bbis04917  Prolactin signaling pathway
bbis04919  Thyroid hormone signaling pathway
bbis04921  Oxytocin signaling pathway
bbis04926  Relaxin signaling pathway
bbis04928  Parathyroid hormone synthesis, secretion and action
bbis04929  GnRH secretion
bbis04934  Cushing syndrome
bbis04935  Growth hormone synthesis, secretion and action
bbis05010  Alzheimer disease
bbis05022  Pathways of neurodegeneration - multiple diseases
bbis05034  Alcoholism
bbis05132  Salmonella infection
bbis05135  Yersinia infection
bbis05160  Hepatitis C
bbis05161  Hepatitis B
bbis05163  Human cytomegalovirus infection
bbis05164  Influenza A
bbis05165  Human papillomavirus infection
bbis05166  Human T-cell leukemia virus 1 infection
bbis05167  Kaposi sarcoma-associated herpesvirus infection
bbis05170  Human immunodeficiency virus 1 infection
bbis05200  Pathways in cancer
bbis05205  Proteoglycans in cancer
bbis05206  MicroRNAs in cancer
bbis05207  Chemical carcinogenesis - receptor activation
bbis05208  Chemical carcinogenesis - reactive oxygen species
bbis05210  Colorectal cancer
bbis05211  Renal cell carcinoma
bbis05212  Pancreatic cancer
bbis05213  Endometrial cancer
bbis05214  Glioma
bbis05215  Prostate cancer
bbis05216  Thyroid cancer
bbis05218  Melanoma
bbis05219  Bladder cancer
bbis05220  Chronic myeloid leukemia
bbis05221  Acute myeloid leukemia
bbis05223  Non-small cell lung cancer
bbis05224  Breast cancer
bbis05225  Hepatocellular carcinoma
bbis05226  Gastric cancer
bbis05230  Central carbon metabolism in cancer
bbis05231  Choline metabolism in cancer
bbis05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:bbis00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    104984678 (MAP2K1)
   04012 ErbB signaling pathway
    104984678 (MAP2K1)
   04014 Ras signaling pathway
    104984678 (MAP2K1)
   04015 Rap1 signaling pathway
    104984678 (MAP2K1)
   04370 VEGF signaling pathway
    104984678 (MAP2K1)
   04371 Apelin signaling pathway
    104984678 (MAP2K1)
   04668 TNF signaling pathway
    104984678 (MAP2K1)
   04066 HIF-1 signaling pathway
    104984678 (MAP2K1)
   04068 FoxO signaling pathway
    104984678 (MAP2K1)
   04072 Phospholipase D signaling pathway
    104984678 (MAP2K1)
   04071 Sphingolipid signaling pathway
    104984678 (MAP2K1)
   04024 cAMP signaling pathway
    104984678 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    104984678 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    104984678 (MAP2K1)
   04150 mTOR signaling pathway
    104984678 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    104984678 (MAP2K1)
   04148 Efferocytosis
    104984678 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    104984678 (MAP2K1)
   04210 Apoptosis
    104984678 (MAP2K1)
   04218 Cellular senescence
    104984678 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    104984678 (MAP2K1)
   04540 Gap junction
    104984678 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    104984678 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    104984678 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    104984678 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    104984678 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    104984678 (MAP2K1)
   04660 T cell receptor signaling pathway
    104984678 (MAP2K1)
   04662 B cell receptor signaling pathway
    104984678 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    104984678 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    104984678 (MAP2K1)
   04062 Chemokine signaling pathway
    104984678 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    104984678 (MAP2K1)
   04929 GnRH secretion
    104984678 (MAP2K1)
   04912 GnRH signaling pathway
    104984678 (MAP2K1)
   04915 Estrogen signaling pathway
    104984678 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    104984678 (MAP2K1)
   04917 Prolactin signaling pathway
    104984678 (MAP2K1)
   04921 Oxytocin signaling pathway
    104984678 (MAP2K1)
   04926 Relaxin signaling pathway
    104984678 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    104984678 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    104984678 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    104984678 (MAP2K1)
   04916 Melanogenesis
    104984678 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    104984678 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    104984678 (MAP2K1)
   04726 Serotonergic synapse
    104984678 (MAP2K1)
   04720 Long-term potentiation
    104984678 (MAP2K1)
   04730 Long-term depression
    104984678 (MAP2K1)
   04722 Neurotrophin signaling pathway
    104984678 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    104984678 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    104984678 (MAP2K1)
   05206 MicroRNAs in cancer
    104984678 (MAP2K1)
   05205 Proteoglycans in cancer
    104984678 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    104984678 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    104984678 (MAP2K1)
   05230 Central carbon metabolism in cancer
    104984678 (MAP2K1)
   05231 Choline metabolism in cancer
    104984678 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    104984678 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    104984678 (MAP2K1)
   05212 Pancreatic cancer
    104984678 (MAP2K1)
   05225 Hepatocellular carcinoma
    104984678 (MAP2K1)
   05226 Gastric cancer
    104984678 (MAP2K1)
   05214 Glioma
    104984678 (MAP2K1)
   05216 Thyroid cancer
    104984678 (MAP2K1)
   05221 Acute myeloid leukemia
    104984678 (MAP2K1)
   05220 Chronic myeloid leukemia
    104984678 (MAP2K1)
   05218 Melanoma
    104984678 (MAP2K1)
   05211 Renal cell carcinoma
    104984678 (MAP2K1)
   05219 Bladder cancer
    104984678 (MAP2K1)
   05215 Prostate cancer
    104984678 (MAP2K1)
   05213 Endometrial cancer
    104984678 (MAP2K1)
   05224 Breast cancer
    104984678 (MAP2K1)
   05223 Non-small cell lung cancer
    104984678 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    104984678 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    104984678 (MAP2K1)
   05161 Hepatitis B
    104984678 (MAP2K1)
   05160 Hepatitis C
    104984678 (MAP2K1)
   05164 Influenza A
    104984678 (MAP2K1)
   05163 Human cytomegalovirus infection
    104984678 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    104984678 (MAP2K1)
   05165 Human papillomavirus infection
    104984678 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    104984678 (MAP2K1)
   05135 Yersinia infection
    104984678 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    104984678 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    104984678 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    104984678 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    104984678 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    104984678 (MAP2K1)
   01522 Endocrine resistance
    104984678 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bbis01001]
    104984678 (MAP2K1)
Enzymes [BR:bbis01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     104984678 (MAP2K1)
Protein kinases [BR:bbis01001]
 Serine/threonine kinases: STE group
  STE7 family
   104984678 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Seadorna_VP7 Haspin_kinase
Other DBs
NCBI-GeneID: 104984678
NCBI-ProteinID: XP_010832837
Ensembl: ENSBBBG00000009402
UniProt: A0A6P3H1F9
LinkDB
Position
Unknown
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggccccggacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagctcgatgaacagcagcggaagcgcctcgaggcctttctgacccagaagcagaaggtg
ggggaactgaaggatgatgactttgagaagatcagtgagctgggtgccggcaatggaggt
gtggtgttcaaggtctcccacaagccgtccggacttgttatggccagaaagctaattcac
ctggagatcaaacctgccatccggaaccagatcataagggagctgcaggttctccatgag
tgcaactcgccttatatcgtgggcttctacggggcgttctacagcgacggcgagatcagc
atctgcatggagcacatggatgggggttccttggatcaagttctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccgtccaacatcctagtgaacagc
cgtggagagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcaccaggtcctacatgtcgccagagcgactccaggggacccattac
tccgtgcagtcggacatctggagcatggggctctctctggttgagatggctgtcgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagaccccgcccaggccaaggacccccgggaggcccctcagctcttat
ggaatggacagccgacctccaatggcaatttttgagttgttggattacatagtcaatgag
cctcctccaaaactgcccagtggagtattcagtctggaatttcaggattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacacccacccatgcggctggcgtctaa

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