Bison bison bison (American bison): 104984678
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Entry
104984678 CDS
T08726
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
KO
K04368
mitogen-activated protein kinase kinase 1 [EC:
2.7.12.2
]
Organism
bbis
Bison bison bison (American bison)
Pathway
bbis01521
EGFR tyrosine kinase inhibitor resistance
bbis01522
Endocrine resistance
bbis04010
MAPK signaling pathway
bbis04012
ErbB signaling pathway
bbis04014
Ras signaling pathway
bbis04015
Rap1 signaling pathway
bbis04022
cGMP-PKG signaling pathway
bbis04024
cAMP signaling pathway
bbis04062
Chemokine signaling pathway
bbis04066
HIF-1 signaling pathway
bbis04068
FoxO signaling pathway
bbis04071
Sphingolipid signaling pathway
bbis04072
Phospholipase D signaling pathway
bbis04114
Oocyte meiosis
bbis04140
Autophagy - animal
bbis04148
Efferocytosis
bbis04150
mTOR signaling pathway
bbis04151
PI3K-Akt signaling pathway
bbis04210
Apoptosis
bbis04218
Cellular senescence
bbis04270
Vascular smooth muscle contraction
bbis04370
VEGF signaling pathway
bbis04371
Apelin signaling pathway
bbis04380
Osteoclast differentiation
bbis04510
Focal adhesion
bbis04540
Gap junction
bbis04550
Signaling pathways regulating pluripotency of stem cells
bbis04613
Neutrophil extracellular trap formation
bbis04620
Toll-like receptor signaling pathway
bbis04650
Natural killer cell mediated cytotoxicity
bbis04660
T cell receptor signaling pathway
bbis04662
B cell receptor signaling pathway
bbis04664
Fc epsilon RI signaling pathway
bbis04666
Fc gamma R-mediated phagocytosis
bbis04668
TNF signaling pathway
bbis04720
Long-term potentiation
bbis04722
Neurotrophin signaling pathway
bbis04725
Cholinergic synapse
bbis04726
Serotonergic synapse
bbis04730
Long-term depression
bbis04810
Regulation of actin cytoskeleton
bbis04910
Insulin signaling pathway
bbis04912
GnRH signaling pathway
bbis04914
Progesterone-mediated oocyte maturation
bbis04915
Estrogen signaling pathway
bbis04916
Melanogenesis
bbis04917
Prolactin signaling pathway
bbis04919
Thyroid hormone signaling pathway
bbis04921
Oxytocin signaling pathway
bbis04926
Relaxin signaling pathway
bbis04928
Parathyroid hormone synthesis, secretion and action
bbis04929
GnRH secretion
bbis04934
Cushing syndrome
bbis04935
Growth hormone synthesis, secretion and action
bbis05010
Alzheimer disease
bbis05022
Pathways of neurodegeneration - multiple diseases
bbis05034
Alcoholism
bbis05132
Salmonella infection
bbis05135
Yersinia infection
bbis05160
Hepatitis C
bbis05161
Hepatitis B
bbis05163
Human cytomegalovirus infection
bbis05164
Influenza A
bbis05165
Human papillomavirus infection
bbis05166
Human T-cell leukemia virus 1 infection
bbis05167
Kaposi sarcoma-associated herpesvirus infection
bbis05170
Human immunodeficiency virus 1 infection
bbis05200
Pathways in cancer
bbis05205
Proteoglycans in cancer
bbis05206
MicroRNAs in cancer
bbis05207
Chemical carcinogenesis - receptor activation
bbis05208
Chemical carcinogenesis - reactive oxygen species
bbis05210
Colorectal cancer
bbis05211
Renal cell carcinoma
bbis05212
Pancreatic cancer
bbis05213
Endometrial cancer
bbis05214
Glioma
bbis05215
Prostate cancer
bbis05216
Thyroid cancer
bbis05218
Melanoma
bbis05219
Bladder cancer
bbis05220
Chronic myeloid leukemia
bbis05221
Acute myeloid leukemia
bbis05223
Non-small cell lung cancer
bbis05224
Breast cancer
bbis05225
Hepatocellular carcinoma
bbis05226
Gastric cancer
bbis05230
Central carbon metabolism in cancer
bbis05231
Choline metabolism in cancer
bbis05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
bbis00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
104984678 (MAP2K1)
04012 ErbB signaling pathway
104984678 (MAP2K1)
04014 Ras signaling pathway
104984678 (MAP2K1)
04015 Rap1 signaling pathway
104984678 (MAP2K1)
04370 VEGF signaling pathway
104984678 (MAP2K1)
04371 Apelin signaling pathway
104984678 (MAP2K1)
04668 TNF signaling pathway
104984678 (MAP2K1)
04066 HIF-1 signaling pathway
104984678 (MAP2K1)
04068 FoxO signaling pathway
104984678 (MAP2K1)
04072 Phospholipase D signaling pathway
104984678 (MAP2K1)
04071 Sphingolipid signaling pathway
104984678 (MAP2K1)
04024 cAMP signaling pathway
104984678 (MAP2K1)
04022 cGMP-PKG signaling pathway
104984678 (MAP2K1)
04151 PI3K-Akt signaling pathway
104984678 (MAP2K1)
04150 mTOR signaling pathway
104984678 (MAP2K1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
104984678 (MAP2K1)
04148 Efferocytosis
104984678 (MAP2K1)
09143 Cell growth and death
04114 Oocyte meiosis
104984678 (MAP2K1)
04210 Apoptosis
104984678 (MAP2K1)
04218 Cellular senescence
104984678 (MAP2K1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
104984678 (MAP2K1)
04540 Gap junction
104984678 (MAP2K1)
04550 Signaling pathways regulating pluripotency of stem cells
104984678 (MAP2K1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
104984678 (MAP2K1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
104984678 (MAP2K1)
04620 Toll-like receptor signaling pathway
104984678 (MAP2K1)
04650 Natural killer cell mediated cytotoxicity
104984678 (MAP2K1)
04660 T cell receptor signaling pathway
104984678 (MAP2K1)
04662 B cell receptor signaling pathway
104984678 (MAP2K1)
04664 Fc epsilon RI signaling pathway
104984678 (MAP2K1)
04666 Fc gamma R-mediated phagocytosis
104984678 (MAP2K1)
04062 Chemokine signaling pathway
104984678 (MAP2K1)
09152 Endocrine system
04910 Insulin signaling pathway
104984678 (MAP2K1)
04929 GnRH secretion
104984678 (MAP2K1)
04912 GnRH signaling pathway
104984678 (MAP2K1)
04915 Estrogen signaling pathway
104984678 (MAP2K1)
04914 Progesterone-mediated oocyte maturation
104984678 (MAP2K1)
04917 Prolactin signaling pathway
104984678 (MAP2K1)
04921 Oxytocin signaling pathway
104984678 (MAP2K1)
04926 Relaxin signaling pathway
104984678 (MAP2K1)
04935 Growth hormone synthesis, secretion and action
104984678 (MAP2K1)
04919 Thyroid hormone signaling pathway
104984678 (MAP2K1)
04928 Parathyroid hormone synthesis, secretion and action
104984678 (MAP2K1)
04916 Melanogenesis
104984678 (MAP2K1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
104984678 (MAP2K1)
09156 Nervous system
04725 Cholinergic synapse
104984678 (MAP2K1)
04726 Serotonergic synapse
104984678 (MAP2K1)
04720 Long-term potentiation
104984678 (MAP2K1)
04730 Long-term depression
104984678 (MAP2K1)
04722 Neurotrophin signaling pathway
104984678 (MAP2K1)
09158 Development and regeneration
04380 Osteoclast differentiation
104984678 (MAP2K1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
104984678 (MAP2K1)
05206 MicroRNAs in cancer
104984678 (MAP2K1)
05205 Proteoglycans in cancer
104984678 (MAP2K1)
05207 Chemical carcinogenesis - receptor activation
104984678 (MAP2K1)
05208 Chemical carcinogenesis - reactive oxygen species
104984678 (MAP2K1)
05230 Central carbon metabolism in cancer
104984678 (MAP2K1)
05231 Choline metabolism in cancer
104984678 (MAP2K1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
104984678 (MAP2K1)
09162 Cancer: specific types
05210 Colorectal cancer
104984678 (MAP2K1)
05212 Pancreatic cancer
104984678 (MAP2K1)
05225 Hepatocellular carcinoma
104984678 (MAP2K1)
05226 Gastric cancer
104984678 (MAP2K1)
05214 Glioma
104984678 (MAP2K1)
05216 Thyroid cancer
104984678 (MAP2K1)
05221 Acute myeloid leukemia
104984678 (MAP2K1)
05220 Chronic myeloid leukemia
104984678 (MAP2K1)
05218 Melanoma
104984678 (MAP2K1)
05211 Renal cell carcinoma
104984678 (MAP2K1)
05219 Bladder cancer
104984678 (MAP2K1)
05215 Prostate cancer
104984678 (MAP2K1)
05213 Endometrial cancer
104984678 (MAP2K1)
05224 Breast cancer
104984678 (MAP2K1)
05223 Non-small cell lung cancer
104984678 (MAP2K1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
104984678 (MAP2K1)
05170 Human immunodeficiency virus 1 infection
104984678 (MAP2K1)
05161 Hepatitis B
104984678 (MAP2K1)
05160 Hepatitis C
104984678 (MAP2K1)
05164 Influenza A
104984678 (MAP2K1)
05163 Human cytomegalovirus infection
104984678 (MAP2K1)
05167 Kaposi sarcoma-associated herpesvirus infection
104984678 (MAP2K1)
05165 Human papillomavirus infection
104984678 (MAP2K1)
09171 Infectious disease: bacterial
05132 Salmonella infection
104984678 (MAP2K1)
05135 Yersinia infection
104984678 (MAP2K1)
09164 Neurodegenerative disease
05010 Alzheimer disease
104984678 (MAP2K1)
05022 Pathways of neurodegeneration - multiple diseases
104984678 (MAP2K1)
09165 Substance dependence
05034 Alcoholism
104984678 (MAP2K1)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
104984678 (MAP2K1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
104984678 (MAP2K1)
01522 Endocrine resistance
104984678 (MAP2K1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
bbis01001
]
104984678 (MAP2K1)
Enzymes [BR:
bbis01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
104984678 (MAP2K1)
Protein kinases [BR:
bbis01001
]
Serine/threonine kinases: STE group
STE7 family
104984678 (MAP2K1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Seadorna_VP7
Haspin_kinase
Motif
Other DBs
NCBI-GeneID:
104984678
NCBI-ProteinID:
XP_010832837
Ensembl:
ENSBBBG00000009402
UniProt:
A0A6P3H1F9
LinkDB
All DBs
Position
Unknown
AA seq
393 aa
AA seq
DB search
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq
1182 nt
NT seq
+upstream
nt +downstream
nt
atgcccaagaagaagccgacgcccatccagctgaacccggccccggacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagctcgatgaacagcagcggaagcgcctcgaggcctttctgacccagaagcagaaggtg
ggggaactgaaggatgatgactttgagaagatcagtgagctgggtgccggcaatggaggt
gtggtgttcaaggtctcccacaagccgtccggacttgttatggccagaaagctaattcac
ctggagatcaaacctgccatccggaaccagatcataagggagctgcaggttctccatgag
tgcaactcgccttatatcgtgggcttctacggggcgttctacagcgacggcgagatcagc
atctgcatggagcacatggatgggggttccttggatcaagttctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccgtccaacatcctagtgaacagc
cgtggagagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcaccaggtcctacatgtcgccagagcgactccaggggacccattac
tccgtgcagtcggacatctggagcatggggctctctctggttgagatggctgtcgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagaccccgcccaggccaaggacccccgggaggcccctcagctcttat
ggaatggacagccgacctccaatggcaatttttgagttgttggattacatagtcaatgag
cctcctccaaaactgcccagtggagtattcagtctggaatttcaggattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacacccacccatgcggctggcgtctaa
DBGET
integrated database retrieval system