Bubalus bubalis (water buffalo): 102400234
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Entry
102400234 CDS
T05912
Symbol
PDE8A
Name
(RefSeq) high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X5
KO
K18437
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:
3.1.4.53
]
Organism
bbub
Bubalus bubalis (water buffalo)
Pathway
bbub00230
Purine metabolism
bbub01100
Metabolic pathways
bbub04927
Cortisol synthesis and secretion
bbub04934
Cushing syndrome
bbub05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
bbub00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
102400234 (PDE8A)
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
102400234 (PDE8A)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
102400234 (PDE8A)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
102400234 (PDE8A)
Enzymes [BR:
bbub01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
102400234 (PDE8A)
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Gene cluster
GFIT
Motif
Pfam:
PDEase_I
PAS_9
PAS
PAS_3
PAS_4
DUF5894
PAS_8
PAS_12
SPO22
DUF5055
Motif
Other DBs
NCBI-GeneID:
102400234
NCBI-ProteinID:
XP_025127470
EnsemblRapid:
ENSBBUG00015021895
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Position
20:complement(47274522..47418151)
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AA seq
767 aa
AA seq
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MRPWVAIADVQFGPMRFHPDQLQVLLVFTKEDNQCNGFCRACEKAGFMCTVTKEAQTALA
CFLDKHHDIIIIDHRNSRHLDAEALCRSIRSSKLSENTVIIGVVRRVDREESCVMSLIAA
GFTRRYIENPSPMACYNELLQLEFGEVRSQLKLRACNSMFAALEKSQEAIEITSEDHIIQ
YANPAFETTMGYQSGELIGKEIAEVPINEKKADLLDTINSCKEWQGIYSVRKKNGDNVQQ
NVKIIPVIGQGGKIRHYVSIIRVCNGNNKAETIAECVQTDSYADNQSGKHKDRRKSSLDV
KTVASRTNEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLEIL
RTTELYSPQFGAKDDDPHANDLVGGLVSDGLRRLSGNEYVLTTKNLQQAPSSSIVPISLH
DVPSQITRAMEKEEYWDFNIFELEAATHKRPLIYLGLKVFARFGVCEFLKCPEATLRSWL
QVIEANYHASNPYHNSTHSADVLHATAYFLCKERIKQTLDPLDEVAALIAATIHDVDHPG
RTNSFLCNAGSELAILYNDMAVLEHHHAALAFQLTTGDDKCNIFKNMERNDYQTLRQGII
DMVLATEMTKHFEHVNKFVNIINKPLVALEEEEETDKDQEAINTMLRAPENRTLIKRMLI
KCADVSNPCRPLEQCIEWAARISEEYFSQTDEEKQRDLPVVMPVFDRNTCSIPKSQISFI
DYFITDMFDAWDAFVDLPELMQHLDNNFKYWKGLDDMKLRSLRPPPE
NT seq
2304 nt
NT seq
+upstream
nt +downstream
nt
atgcggccatgggtagcaatagctgatgtgcaatttggccccatgagatttcatccagat
caactccaggtacttttagtgtttaccaaagaagataaccagtgtaatggattctgcagg
gcgtgtgaaaaagcagggtttatgtgtacagttaccaaggaggctcagactgccctcgcc
tgtttcttggacaaacaccatgacatcatcatcatagatcacagaaattcccgacatctg
gatgctgaggcactgtgcaggtcaatcagatcatcaaaactctcagaaaacacagttatt
attggtgtagtacgcagagtggatagagaagagtcatgtgtaatgtccctcattgctgct
ggcttcacaaggaggtatatagaaaaccccagccccatggcctgttacaatgaactgctc
cagctggagtttggagaggtgcgctcacagctgaaactcagggcttgtaattcaatgttc
gctgcattagagaaaagtcaagaagcaattgaaattacaagtgaagaccacattatccag
tatgcaaatccagcatttgaaacgacaatgggctatcagtcaggtgaattaatagggaag
gagatagcagaagtgcctataaacgaaaaaaaggctgatttgctcgatactataaattca
tgcaaggaatggcaaggaatttactctgtcaggaagaaaaatggagataacgtacaacaa
aatgtgaagataatacctgtcattggacagggaggaaaaattagacactatgtgtccatt
atcagagtgtgcaatggcaacaataaggcggagacgatagctgaatgtgttcagacggac
agttacgcagataatcagtcaggcaaacataaagacaggagaaaaagctccctcgatgtc
aaaactgttgcctcgagaacaaatgaagtttccagccagagacgacactcttccatggcc
cggatccattccatgacgatcgaggcgcccatcaccaaggtcatcaatatcatcaatgct
gcccaggaaagcagtcccatgcctgtgacagaagctttagaccgtgtgttggaaattcta
agaaccactgaattatattcaccacagttcggtgctaaggacgatgatcctcatgccaac
gacctcgtcgggggcctggtgtctgatggtttgcgaagattatccggaaatgagtatgtt
ctaacaacaaaaaaccttcagcaggctcccagcagcagcatcgtccccatctcccttcac
gacgttccatcacagataactcgggccatggaaaaggaggagtactgggacttcaatatt
tttgaactggaggctgccactcataaaaggcctttgatttaccttggtctcaaagtgttc
gctcgcttcggagtctgtgaattcttaaaatgccccgaggcaacgctgagatcctggtta
caggtgatcgaagccaattatcacgcttccaacccctaccacaactccacacactctgct
gatgtgctgcatgccactgcctactttctctgcaaagagaggatcaagcaaactttagac
ccacttgatgaggttgctgccctcatcgcagccactatccacgatgtggaccaccccggg
aggaccaactccttcctctgcaatgccgggagcgagctggccattctctacaacgacatg
gctgtgctggagcaccaccatgcagccttggccttccagctgaccaccggcgatgacaaa
tgcaacatctttaaaaacatggagcggaacgactaccagacgctgcgccagggtatcatc
gacatggtcttagccacagaaatgacaaagcactttgagcacgtcaacaaatttgtcaac
atcatcaacaagcccttggtagcattagaagaagaggaggaaactgataaagatcaagaa
gccataaataccatgctcagggctccagagaaccggactctgatcaaaaggatgctgatc
aagtgtgctgacgtgtccaacccctgccggcccctggagcagtgcatcgagtgggctgca
cgtatctcagaagagtatttctctcagacagacgaagagaagcaacgggacttgcctgtg
gtgatgccggtttttgacagaaatacctgcagcatccccaaatcccagatctctttcatt
gactacttcatcacagacatgtttgatgcctgggacgcctttgtagacctgcctgagcta
atgcagcatctcgacaacaactttaaatactggaaaggactggatgacatgaagctgcgg
agcctgcgcccgcctcccgaatag
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