KEGG   Bos indicus (zebu cattle): 109561751
Entry
109561751         CDS       T04792                                 
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
biu  Bos indicus (zebu cattle)
Pathway
biu01521  EGFR tyrosine kinase inhibitor resistance
biu01522  Endocrine resistance
biu04010  MAPK signaling pathway
biu04012  ErbB signaling pathway
biu04014  Ras signaling pathway
biu04015  Rap1 signaling pathway
biu04022  cGMP-PKG signaling pathway
biu04024  cAMP signaling pathway
biu04066  HIF-1 signaling pathway
biu04068  FoxO signaling pathway
biu04071  Sphingolipid signaling pathway
biu04072  Phospholipase D signaling pathway
biu04140  Autophagy - animal
biu04148  Efferocytosis
biu04150  mTOR signaling pathway
biu04151  PI3K-Akt signaling pathway
biu04210  Apoptosis
biu04218  Cellular senescence
biu04270  Vascular smooth muscle contraction
biu04370  VEGF signaling pathway
biu04371  Apelin signaling pathway
biu04540  Gap junction
biu04550  Signaling pathways regulating pluripotency of stem cells
biu04613  Neutrophil extracellular trap formation
biu04620  Toll-like receptor signaling pathway
biu04650  Natural killer cell mediated cytotoxicity
biu04660  T cell receptor signaling pathway
biu04662  B cell receptor signaling pathway
biu04664  Fc epsilon RI signaling pathway
biu04720  Long-term potentiation
biu04722  Neurotrophin signaling pathway
biu04730  Long-term depression
biu04810  Regulation of actin cytoskeleton
biu04910  Insulin signaling pathway
biu04912  GnRH signaling pathway
biu04915  Estrogen signaling pathway
biu04916  Melanogenesis
biu04917  Prolactin signaling pathway
biu04919  Thyroid hormone signaling pathway
biu04921  Oxytocin signaling pathway
biu04926  Relaxin signaling pathway
biu04929  GnRH secretion
biu04934  Cushing syndrome
biu04935  Growth hormone synthesis, secretion and action
biu05010  Alzheimer disease
biu05022  Pathways of neurodegeneration - multiple diseases
biu05132  Salmonella infection
biu05135  Yersinia infection
biu05160  Hepatitis C
biu05161  Hepatitis B
biu05163  Human cytomegalovirus infection
biu05164  Influenza A
biu05165  Human papillomavirus infection
biu05166  Human T-cell leukemia virus 1 infection
biu05167  Kaposi sarcoma-associated herpesvirus infection
biu05170  Human immunodeficiency virus 1 infection
biu05200  Pathways in cancer
biu05205  Proteoglycans in cancer
biu05206  MicroRNAs in cancer
biu05207  Chemical carcinogenesis - receptor activation
biu05208  Chemical carcinogenesis - reactive oxygen species
biu05210  Colorectal cancer
biu05211  Renal cell carcinoma
biu05213  Endometrial cancer
biu05214  Glioma
biu05215  Prostate cancer
biu05216  Thyroid cancer
biu05218  Melanoma
biu05219  Bladder cancer
biu05220  Chronic myeloid leukemia
biu05221  Acute myeloid leukemia
biu05223  Non-small cell lung cancer
biu05224  Breast cancer
biu05225  Hepatocellular carcinoma
biu05226  Gastric cancer
biu05230  Central carbon metabolism in cancer
biu05231  Choline metabolism in cancer
biu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:biu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    109561751 (MAP2K2)
   04012 ErbB signaling pathway
    109561751 (MAP2K2)
   04014 Ras signaling pathway
    109561751 (MAP2K2)
   04015 Rap1 signaling pathway
    109561751 (MAP2K2)
   04370 VEGF signaling pathway
    109561751 (MAP2K2)
   04371 Apelin signaling pathway
    109561751 (MAP2K2)
   04066 HIF-1 signaling pathway
    109561751 (MAP2K2)
   04068 FoxO signaling pathway
    109561751 (MAP2K2)
   04072 Phospholipase D signaling pathway
    109561751 (MAP2K2)
   04071 Sphingolipid signaling pathway
    109561751 (MAP2K2)
   04024 cAMP signaling pathway
    109561751 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    109561751 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    109561751 (MAP2K2)
   04150 mTOR signaling pathway
    109561751 (MAP2K2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    109561751 (MAP2K2)
   04148 Efferocytosis
    109561751 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    109561751 (MAP2K2)
   04218 Cellular senescence
    109561751 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    109561751 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    109561751 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    109561751 (MAP2K2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    109561751 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    109561751 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    109561751 (MAP2K2)
   04660 T cell receptor signaling pathway
    109561751 (MAP2K2)
   04662 B cell receptor signaling pathway
    109561751 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    109561751 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    109561751 (MAP2K2)
   04929 GnRH secretion
    109561751 (MAP2K2)
   04912 GnRH signaling pathway
    109561751 (MAP2K2)
   04915 Estrogen signaling pathway
    109561751 (MAP2K2)
   04917 Prolactin signaling pathway
    109561751 (MAP2K2)
   04921 Oxytocin signaling pathway
    109561751 (MAP2K2)
   04926 Relaxin signaling pathway
    109561751 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    109561751 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    109561751 (MAP2K2)
   04916 Melanogenesis
    109561751 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    109561751 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    109561751 (MAP2K2)
   04730 Long-term depression
    109561751 (MAP2K2)
   04722 Neurotrophin signaling pathway
    109561751 (MAP2K2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109561751 (MAP2K2)
   05206 MicroRNAs in cancer
    109561751 (MAP2K2)
   05205 Proteoglycans in cancer
    109561751 (MAP2K2)
   05207 Chemical carcinogenesis - receptor activation
    109561751 (MAP2K2)
   05208 Chemical carcinogenesis - reactive oxygen species
    109561751 (MAP2K2)
   05230 Central carbon metabolism in cancer
    109561751 (MAP2K2)
   05231 Choline metabolism in cancer
    109561751 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109561751 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    109561751 (MAP2K2)
   05225 Hepatocellular carcinoma
    109561751 (MAP2K2)
   05226 Gastric cancer
    109561751 (MAP2K2)
   05214 Glioma
    109561751 (MAP2K2)
   05216 Thyroid cancer
    109561751 (MAP2K2)
   05221 Acute myeloid leukemia
    109561751 (MAP2K2)
   05220 Chronic myeloid leukemia
    109561751 (MAP2K2)
   05218 Melanoma
    109561751 (MAP2K2)
   05211 Renal cell carcinoma
    109561751 (MAP2K2)
   05219 Bladder cancer
    109561751 (MAP2K2)
   05215 Prostate cancer
    109561751 (MAP2K2)
   05213 Endometrial cancer
    109561751 (MAP2K2)
   05224 Breast cancer
    109561751 (MAP2K2)
   05223 Non-small cell lung cancer
    109561751 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    109561751 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    109561751 (MAP2K2)
   05161 Hepatitis B
    109561751 (MAP2K2)
   05160 Hepatitis C
    109561751 (MAP2K2)
   05164 Influenza A
    109561751 (MAP2K2)
   05163 Human cytomegalovirus infection
    109561751 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109561751 (MAP2K2)
   05165 Human papillomavirus infection
    109561751 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    109561751 (MAP2K2)
   05135 Yersinia infection
    109561751 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109561751 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    109561751 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    109561751 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109561751 (MAP2K2)
   01522 Endocrine resistance
    109561751 (MAP2K2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:biu01001]
    109561751 (MAP2K2)
Enzymes [BR:biu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     109561751 (MAP2K2)
Protein kinases [BR:biu01001]
 Serine/threonine kinases: STE group
  STE7 family
   109561751 (MAP2K2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7 CAMSAP_CC1 Kdo APH
Other DBs
NCBI-GeneID: 109561751
NCBI-ProteinID: XP_019820011
UniProt: A0A6P5C371
LinkDB
Position
7:18543204..18564325
AA seq 400 aa
MLARRKPVLPALTINPAIAEGPSPTSEGASEAHLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPMVDGAEGEPPSISPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADL
KMLMNHTFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAV
NT seq 1203 nt   +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcaccatcaaccccgccatcgccgag
ggcccgtcccctaccagcgagggcgcctccgaagcacatctggtggacctccagaagaag
ctagaggagctagagctcgacgagcagcagaagaagcggctggaagccttccttacccag
aaggccaaggttggtgagctcaaggacgatgactttgaacggatctccgagctgggagcc
ggcaatggcggagtggtcaccaaggtccagcacagaccttcgggcctcatcatggccaga
aagctgatccacctggagatcaagccggccatccggaaccagatcatccgagagctacag
gtgctgcatgagtgcaactccccgtacattgtgggcttctacggggccttctacagcgac
ggcgagatcagcatctgcatggagcacatggatggcggctccctggaccaggtgttgaaa
gaagccaagagaatccctgaagagatcctgggcaaggtcagcattgcggttctgcggggc
ctggcatacctccgggagaaacaccagatcatgcaccgagacgtgaagccgtccaacatc
ctggtcaactcccggggggagatcaagctgtgtgacttcggggtgagcggccagctsatc
gactccatggccaactccttcgtggggacgcggtcctacatgtctccggagcggctacaa
ggcacacactactcggtgcagtcagacatctggagcatgggcctgtccctggtggaactg
tccatcggcaggtaccccatccccccgccggacgccaaggagctggaggccatattcggc
cggcccatggttgatggcgcagaaggagaacctcctagcatctctccacggccgaggccc
cctggacgccccatcagcggtcacgggatggacagccggcctgccatggcgatctttgag
ctgctggactacattgtgaacgagcctcctcccaagctgcccaacggtgtgttcacccag
gacttccaggagtttgtaaataaatgcctaattaagaacccagctgagcgagcagacctg
aagatgctcatgaaccacaccttcatcaagcggtccgaggtggaagaagtggattttgct
ggctggttgtgtaaaacactgcggctaaaccagcccagcacgcccacacgcaccgccgtg
tga

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