Bos indicus (zebu cattle): 109561751
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Entry
109561751 CDS
T04792
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
KO
K04369
mitogen-activated protein kinase kinase 2 [EC:
2.7.12.2
]
Organism
biu
Bos indicus (zebu cattle)
Pathway
biu01521
EGFR tyrosine kinase inhibitor resistance
biu01522
Endocrine resistance
biu04010
MAPK signaling pathway
biu04012
ErbB signaling pathway
biu04014
Ras signaling pathway
biu04015
Rap1 signaling pathway
biu04022
cGMP-PKG signaling pathway
biu04024
cAMP signaling pathway
biu04066
HIF-1 signaling pathway
biu04068
FoxO signaling pathway
biu04071
Sphingolipid signaling pathway
biu04072
Phospholipase D signaling pathway
biu04140
Autophagy - animal
biu04148
Efferocytosis
biu04150
mTOR signaling pathway
biu04151
PI3K-Akt signaling pathway
biu04210
Apoptosis
biu04218
Cellular senescence
biu04270
Vascular smooth muscle contraction
biu04370
VEGF signaling pathway
biu04371
Apelin signaling pathway
biu04540
Gap junction
biu04550
Signaling pathways regulating pluripotency of stem cells
biu04613
Neutrophil extracellular trap formation
biu04620
Toll-like receptor signaling pathway
biu04650
Natural killer cell mediated cytotoxicity
biu04660
T cell receptor signaling pathway
biu04662
B cell receptor signaling pathway
biu04664
Fc epsilon RI signaling pathway
biu04720
Long-term potentiation
biu04722
Neurotrophin signaling pathway
biu04730
Long-term depression
biu04810
Regulation of actin cytoskeleton
biu04910
Insulin signaling pathway
biu04912
GnRH signaling pathway
biu04915
Estrogen signaling pathway
biu04916
Melanogenesis
biu04917
Prolactin signaling pathway
biu04919
Thyroid hormone signaling pathway
biu04921
Oxytocin signaling pathway
biu04926
Relaxin signaling pathway
biu04929
GnRH secretion
biu04934
Cushing syndrome
biu04935
Growth hormone synthesis, secretion and action
biu05010
Alzheimer disease
biu05022
Pathways of neurodegeneration - multiple diseases
biu05132
Salmonella infection
biu05135
Yersinia infection
biu05160
Hepatitis C
biu05161
Hepatitis B
biu05163
Human cytomegalovirus infection
biu05164
Influenza A
biu05165
Human papillomavirus infection
biu05166
Human T-cell leukemia virus 1 infection
biu05167
Kaposi sarcoma-associated herpesvirus infection
biu05170
Human immunodeficiency virus 1 infection
biu05200
Pathways in cancer
biu05205
Proteoglycans in cancer
biu05206
MicroRNAs in cancer
biu05207
Chemical carcinogenesis - receptor activation
biu05208
Chemical carcinogenesis - reactive oxygen species
biu05210
Colorectal cancer
biu05211
Renal cell carcinoma
biu05213
Endometrial cancer
biu05214
Glioma
biu05215
Prostate cancer
biu05216
Thyroid cancer
biu05218
Melanoma
biu05219
Bladder cancer
biu05220
Chronic myeloid leukemia
biu05221
Acute myeloid leukemia
biu05223
Non-small cell lung cancer
biu05224
Breast cancer
biu05225
Hepatocellular carcinoma
biu05226
Gastric cancer
biu05230
Central carbon metabolism in cancer
biu05231
Choline metabolism in cancer
biu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
biu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
109561751 (MAP2K2)
04012 ErbB signaling pathway
109561751 (MAP2K2)
04014 Ras signaling pathway
109561751 (MAP2K2)
04015 Rap1 signaling pathway
109561751 (MAP2K2)
04370 VEGF signaling pathway
109561751 (MAP2K2)
04371 Apelin signaling pathway
109561751 (MAP2K2)
04066 HIF-1 signaling pathway
109561751 (MAP2K2)
04068 FoxO signaling pathway
109561751 (MAP2K2)
04072 Phospholipase D signaling pathway
109561751 (MAP2K2)
04071 Sphingolipid signaling pathway
109561751 (MAP2K2)
04024 cAMP signaling pathway
109561751 (MAP2K2)
04022 cGMP-PKG signaling pathway
109561751 (MAP2K2)
04151 PI3K-Akt signaling pathway
109561751 (MAP2K2)
04150 mTOR signaling pathway
109561751 (MAP2K2)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
109561751 (MAP2K2)
04148 Efferocytosis
109561751 (MAP2K2)
09143 Cell growth and death
04210 Apoptosis
109561751 (MAP2K2)
04218 Cellular senescence
109561751 (MAP2K2)
09144 Cellular community - eukaryotes
04540 Gap junction
109561751 (MAP2K2)
04550 Signaling pathways regulating pluripotency of stem cells
109561751 (MAP2K2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
109561751 (MAP2K2)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
109561751 (MAP2K2)
04620 Toll-like receptor signaling pathway
109561751 (MAP2K2)
04650 Natural killer cell mediated cytotoxicity
109561751 (MAP2K2)
04660 T cell receptor signaling pathway
109561751 (MAP2K2)
04662 B cell receptor signaling pathway
109561751 (MAP2K2)
04664 Fc epsilon RI signaling pathway
109561751 (MAP2K2)
09152 Endocrine system
04910 Insulin signaling pathway
109561751 (MAP2K2)
04929 GnRH secretion
109561751 (MAP2K2)
04912 GnRH signaling pathway
109561751 (MAP2K2)
04915 Estrogen signaling pathway
109561751 (MAP2K2)
04917 Prolactin signaling pathway
109561751 (MAP2K2)
04921 Oxytocin signaling pathway
109561751 (MAP2K2)
04926 Relaxin signaling pathway
109561751 (MAP2K2)
04935 Growth hormone synthesis, secretion and action
109561751 (MAP2K2)
04919 Thyroid hormone signaling pathway
109561751 (MAP2K2)
04916 Melanogenesis
109561751 (MAP2K2)
09153 Circulatory system
04270 Vascular smooth muscle contraction
109561751 (MAP2K2)
09156 Nervous system
04720 Long-term potentiation
109561751 (MAP2K2)
04730 Long-term depression
109561751 (MAP2K2)
04722 Neurotrophin signaling pathway
109561751 (MAP2K2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
109561751 (MAP2K2)
05206 MicroRNAs in cancer
109561751 (MAP2K2)
05205 Proteoglycans in cancer
109561751 (MAP2K2)
05207 Chemical carcinogenesis - receptor activation
109561751 (MAP2K2)
05208 Chemical carcinogenesis - reactive oxygen species
109561751 (MAP2K2)
05230 Central carbon metabolism in cancer
109561751 (MAP2K2)
05231 Choline metabolism in cancer
109561751 (MAP2K2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
109561751 (MAP2K2)
09162 Cancer: specific types
05210 Colorectal cancer
109561751 (MAP2K2)
05225 Hepatocellular carcinoma
109561751 (MAP2K2)
05226 Gastric cancer
109561751 (MAP2K2)
05214 Glioma
109561751 (MAP2K2)
05216 Thyroid cancer
109561751 (MAP2K2)
05221 Acute myeloid leukemia
109561751 (MAP2K2)
05220 Chronic myeloid leukemia
109561751 (MAP2K2)
05218 Melanoma
109561751 (MAP2K2)
05211 Renal cell carcinoma
109561751 (MAP2K2)
05219 Bladder cancer
109561751 (MAP2K2)
05215 Prostate cancer
109561751 (MAP2K2)
05213 Endometrial cancer
109561751 (MAP2K2)
05224 Breast cancer
109561751 (MAP2K2)
05223 Non-small cell lung cancer
109561751 (MAP2K2)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
109561751 (MAP2K2)
05170 Human immunodeficiency virus 1 infection
109561751 (MAP2K2)
05161 Hepatitis B
109561751 (MAP2K2)
05160 Hepatitis C
109561751 (MAP2K2)
05164 Influenza A
109561751 (MAP2K2)
05163 Human cytomegalovirus infection
109561751 (MAP2K2)
05167 Kaposi sarcoma-associated herpesvirus infection
109561751 (MAP2K2)
05165 Human papillomavirus infection
109561751 (MAP2K2)
09171 Infectious disease: bacterial
05132 Salmonella infection
109561751 (MAP2K2)
05135 Yersinia infection
109561751 (MAP2K2)
09164 Neurodegenerative disease
05010 Alzheimer disease
109561751 (MAP2K2)
05022 Pathways of neurodegeneration - multiple diseases
109561751 (MAP2K2)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
109561751 (MAP2K2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
109561751 (MAP2K2)
01522 Endocrine resistance
109561751 (MAP2K2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
biu01001
]
109561751 (MAP2K2)
Enzymes [BR:
biu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
109561751 (MAP2K2)
Protein kinases [BR:
biu01001
]
Serine/threonine kinases: STE group
STE7 family
109561751 (MAP2K2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Haspin_kinase
Seadorna_VP7
CAMSAP_CC1
Kdo
APH
Motif
Other DBs
NCBI-GeneID:
109561751
NCBI-ProteinID:
XP_019820011
UniProt:
A0A6P5C371
LinkDB
All DBs
Position
7:18543204..18564325
Genome browser
AA seq
400 aa
AA seq
DB search
MLARRKPVLPALTINPAIAEGPSPTSEGASEAHLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPMVDGAEGEPPSISPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADL
KMLMNHTFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAV
NT seq
1203 nt
NT seq
+upstream
nt +downstream
nt
atgctggcccggaggaagccggtgctgccggcgctcaccatcaaccccgccatcgccgag
ggcccgtcccctaccagcgagggcgcctccgaagcacatctggtggacctccagaagaag
ctagaggagctagagctcgacgagcagcagaagaagcggctggaagccttccttacccag
aaggccaaggttggtgagctcaaggacgatgactttgaacggatctccgagctgggagcc
ggcaatggcggagtggtcaccaaggtccagcacagaccttcgggcctcatcatggccaga
aagctgatccacctggagatcaagccggccatccggaaccagatcatccgagagctacag
gtgctgcatgagtgcaactccccgtacattgtgggcttctacggggccttctacagcgac
ggcgagatcagcatctgcatggagcacatggatggcggctccctggaccaggtgttgaaa
gaagccaagagaatccctgaagagatcctgggcaaggtcagcattgcggttctgcggggc
ctggcatacctccgggagaaacaccagatcatgcaccgagacgtgaagccgtccaacatc
ctggtcaactcccggggggagatcaagctgtgtgacttcggggtgagcggccagctsatc
gactccatggccaactccttcgtggggacgcggtcctacatgtctccggagcggctacaa
ggcacacactactcggtgcagtcagacatctggagcatgggcctgtccctggtggaactg
tccatcggcaggtaccccatccccccgccggacgccaaggagctggaggccatattcggc
cggcccatggttgatggcgcagaaggagaacctcctagcatctctccacggccgaggccc
cctggacgccccatcagcggtcacgggatggacagccggcctgccatggcgatctttgag
ctgctggactacattgtgaacgagcctcctcccaagctgcccaacggtgtgttcacccag
gacttccaggagtttgtaaataaatgcctaattaagaacccagctgagcgagcagacctg
aagatgctcatgaaccacaccttcatcaagcggtccgaggtggaagaagtggattttgct
ggctggttgtgtaaaacactgcggctaaaccagcccagcacgcccacacgcaccgccgtg
tga
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