KEGG   PATHWAY: bmaz00920
Entry
bmaz00920                   Pathway                                
Name
Sulfur metabolism - Burkholderia mallei NCTC 10247
Description
Sulfur is an essential element for life and the metabolism of organic sulfur compounds plays an important role in the global sulfur cycle. Sulfur occurs in various oxidation states ranging from +6 in sulfate to -2 in sulfide (H2S). Sulfate reduction can occur in both an energy consuming assimilatory pathway and an energy producing dissimilatory pathway. The assimilatory pathway, which is found in a wide range of organisms, produces reduced sulfur compounds for the biosynthesis of S-containing amino acids and does not lead to direct excretion of sulfide. In the dissimilatory pathway, which is restricted to obligatory anaerobic bacterial and archaeal lineages, sulfate (or sulfur) is the terminal electron acceptor of the respiratory chain producing large quantities of inorganic sulfide. Both pathways start from the activation of sulfate by reaction with ATP to form adenylyl sulfate (APS). In the assimilatory pathway [MD:M00176] APS is converted to 3'-phosphoadenylyl sulfate (PAPS) and then reduced to sulfite, and sulfite is further reduced to sulfide by the assimilatory sulfite reductase. In the dissimilatory pathway [MD:M00596] APS is directly reduced to sulfite, and sulfite is further reduced to sulfide by the dissimilatory sulfite reductase. The capacity for oxidation of sulfur is quite widespread among bacteria and archaea, comprising phototrophs and chemolithoautotrophs. The SOX (sulfur-oxidation) system [MD:M00595] is a well-known sulfur oxidation pathway and is found in both photosynthetic and non-photosynthetic sulfur-oxidizing bacteria. Green sulfur bacteria and purple sulfur bacteria carry out anoxygenic photosynthesis with reduced sulfur compounds such as sulfide and elemental sulfur, as well as thiosulfate (in some species with the SOX system), as the electron donor for photoautotrophic growth. In some chemolithoautotrophic sulfur oxidizers (such as Thiobacillus denitrificans), it has been suggested that dissimilatory sulfur reduction enzymes operate in the reverse direction, forming a sulfur oxidation pathway from sulfite to APS and then to sulfate.
Class
Metabolism; Energy metabolism
Pathway map
bmaz00920  Sulfur metabolism
bmaz00920

Module
bmaz_M00176  Assimilatory sulfate reduction, sulfate => H2S [PATH:bmaz00920]
Other DBs
GO: 0006790
Organism
Burkholderia mallei NCTC 10247 [GN:bmaz]
Gene
BM44_2262  sulfate ABC transporter, sulfate-binding family protein [KO:K23163]
BM44_2261  cysT; sulfate ABC transporter, permease protein CysT [KO:K02046]
BM44_2260  cysW; sulfate ABC transporter, permease protein CysW [KO:K02047]
BM44_2259  cysA; sulfate ABC transporter, ATP-binding family protein [KO:K02045] [EC:7.3.2.3]
BM44_5037  substrate binding domain of ABC-type glycine betaine transport system family protein [KO:K15551]
BM44_5035  binding--dependent transport system inner membrane component family protein [KO:K15552]
BM44_5036  ABC transporter family protein [KO:K10831] [EC:7.6.2.7]
BM44_5038  taurine catabolism dioxygenase TauD, TfdA family protein [KO:K03119] [EC:1.14.11.17]
BM44_4182  ABC transporter, substrate-binding , aliphatic sulfonates family protein [KO:K15553]
BM44_627  bacterial extracellular solute-binding s, 3 family protein [KO:K15553]
BM44_2250  NMT1-like family protein [KO:K15553]
BM44_2285  binding--dependent transport system inner membrane component family protein [KO:K15554]
BM44_2247  binding--dependent transport system inner membrane component family protein [KO:K15554]
BM44_625  binding--dependent transport system inner membrane component family protein [KO:K15554]
BM44_2284  ABC transporter family protein [KO:K15555] [EC:7.6.2.14]
BM44_2248  ABC transporter family protein [KO:K15555] [EC:7.6.2.14]
BM44_626  ABC transporter family protein [KO:K15555] [EC:7.6.2.14]
BM44_2286  ssuD; alkanesulfonate monooxygenase, FMNH(2)-dependent [KO:K04091] [EC:1.14.14.5 1.14.14.34]
BM44_4847  NADPH-dependent FMN reductase family protein [KO:K00299] [EC:1.5.1.38]
BM44_1518  cysN; sulfate adenylyltransferase, large subunit [KO:K00956] [EC:2.7.7.4]
BM44_1517  cysD; sulfate adenylyltransferase, small subunit [KO:K00957] [EC:2.7.7.4]
BM44_1738  cysD; sulfate adenylyltransferase, small subunit [KO:K00957] [EC:2.7.7.4]
BM44_1496  cysC; adenylylsulfate kinase [KO:K00860] [EC:2.7.1.25]
BM44_1721  cysC; adenylylsulfate kinase [KO:K00860] [EC:2.7.1.25]
BM44_3519  cysC; adenylylsulfate kinase [KO:K00860] [EC:2.7.1.25]
BM44_1516  adenylylsulfate reductase, thioredoxin dependent family protein [KO:K00390] [EC:1.8.4.8 1.8.4.10]
BM44_3719  molybdopterin oxidoreductase Fe4S4 domain protein [KO:K21307] [EC:1.8.5.6]
BM44_3718  4Fe-4S dicluster domain protein [KO:K21308]
BM44_3717  DMSO reductase anchor subunit family protein [KO:K21309]
BM44_4651  flavodoxin family protein [KO:K00380] [EC:1.8.1.2]
BM44_4359  FAD binding domain protein [KO:K00380] [EC:1.8.1.2]
BM44_1514  nitrite and sulphite reductase 4Fe-4S domain protein [KO:K00381] [EC:1.8.1.2]
BM44_2503  nitrite and sulphite reductase 4Fe-4S domain protein [KO:K00381] [EC:1.8.1.2]
BM44_3372  rhodanese-like domain protein [KO:K01011] [EC:2.8.1.1 2.8.1.2]
BM44_3616  hypothetical protein [KO:K00640] [EC:2.3.1.30]
BM44_4486  bacterial transferase hexapeptide family protein [KO:K00640] [EC:2.3.1.30]
BM44_1704  cysE; serine O-acetyltransferase [KO:K00640] [EC:2.3.1.30]
BM44_3078  metX; homoserine O-acetyltransferase [KO:K00641] [EC:2.3.1.31 2.3.1.46]
BM44_3226  metZ; O-succinylhomoserine sulfhydrylase [KO:K10764] [EC:2.5.1.-]
BM44_1903  AMP-binding enzyme family protein [KO:K20034] [EC:6.2.1.44]
BM44_4530  AMP-binding enzyme family protein [KO:K20034] [EC:6.2.1.44]
BM44_2772  hypothetical protein [KO:K20035] [EC:1.3.99.41]
BM44_881  hypothetical protein [KO:K20035] [EC:1.3.99.41]
Compound
C00033  Acetate
C00042  Succinate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00065  L-Serine
C00084  Acetaldehyde
C00087  Sulfur
C00094  Sulfite
C00097  L-Cysteine
C00155  L-Homocysteine
C00224  Adenylyl sulfate
C00245  Taurine
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00320  Thiosulfate
C00409  Methanethiol
C00580  Dimethyl sulfide
C00979  O-Acetyl-L-serine
C01118  O-Succinyl-L-homoserine
C01861  Trithionate
C02084  Tetrathionate
C03920  2-(Methylthio)ethanesulfonate
C04022  S,S-Dimethyl-beta-propiothetin
C08276  3-(Methylthio)propanoate
C11142  Dimethyl sulfone
C11143  Dimethyl sulfoxide
C11145  Methanesulfonic acid
C15521  Alkanesulfonate
C17267  S-Sulfanylglutathione
C19692  Polysulfide
C20870  3-(Methylthio)propanoyl-CoA
C20955  3-(Methylthio)acryloyl-CoA
C22834  Protein-trisulfide
Reference
  Authors
Grein F, Ramos AR, Venceslau SS, Pereira IA
  Title
Unifying concepts in anaerobic respiration: Insights from dissimilatory sulfur metabolism.
  Journal
Biochim Biophys Acta 1827:145-60 (2013)
DOI:10.1016/j.bbabio.2012.09.001
Reference
  Authors
Fauque GD, Barton LL
  Title
Hemoproteins in dissimilatory sulfate- and sulfur-reducing prokaryotes.
  Journal
Adv Microb Physiol 60:1-90 (2012)
DOI:10.1016/B978-0-12-398264-3.00001-2
Reference
  Authors
Sakurai H, Ogawa T, Shiga M, Inoue K
  Title
Inorganic sulfur oxidizing system in green sulfur bacteria.
  Journal
Photosynth Res 104:163-76 (2010)
DOI:10.1007/s11120-010-9531-2
Reference
  Authors
Falkenby LG, Szymanska M, Holkenbrink C, Habicht KS, Andersen JS, Miller M, Frigaard NU
  Title
Quantitative proteomics of Chlorobaculum tepidum: insights into the sulfur metabolism of a phototrophic green sulfur bacterium.
  Journal
FEMS Microbiol Lett 323:142-50 (2011)
DOI:10.1111/j.1574-6968.2011.02370.x
Reference
  Authors
Gregersen LH, Bryant DA, Frigaard NU
  Title
Mechanisms and evolution of oxidative sulfur metabolism in green sulfur bacteria.
  Journal
Front Microbiol 2:116 (2011)
DOI:10.3389/fmicb.2011.00116
Reference
  Authors
Beller HR, Chain PS, Letain TE, Chakicherla A, Larimer FW, Richardson PM, Coleman MA, Wood AP, Kelly DP.
  Title
The genome sequence of the obligately chemolithoautotrophic, facultatively anaerobic bacterium Thiobacillus denitrificans.
  Journal
J Bacteriol 188:1473-88 (2006)
DOI:10.1128/JB.188.4.1473-1488.2006
Reference
PMID:9695921
  Authors
Pott AS, Dahl C
  Title
Sirohaem sulfite reductase and other proteins encoded by genes at the dsr locus of Chromatium vinosum are involved in the oxidation of intracellular sulfur.
  Journal
Microbiology 144 ( Pt 7):1881-94 (1998)
DOI:10.1099/00221287-144-7-1881
Reference
  Authors
Frigaard NU, Dahl C
  Title
Sulfur metabolism in phototrophic sulfur bacteria.
  Journal
Adv Microb Physiol 54:103-200 (2009)
DOI:10.1016/S0065-2911(08)00002-7
Related
pathway
bmaz00260  Glycine, serine and threonine metabolism
bmaz00270  Cysteine and methionine metabolism
bmaz00680  Methane metabolism
bmaz00720  Carbon fixation pathways in prokaryotes
KO pathway
ko00920   
LinkDB

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