Bos mutus (wild yak): 102285317 Help Entry 102285317         CDS       T02919                                  Symbol INSR Name (RefSeq) insulin receptor   KO K04527   insulin receptor [EC:2.7.10.1] Organism bom  Bos mutus (wild yak) Pathway bom04010   MAPK signaling pathway bom04014   Ras signaling pathway bom04015   Rap1 signaling pathway bom04022   cGMP-PKG signaling pathway bom04066   HIF-1 signaling pathway bom04068   FoxO signaling pathway bom04072   Phospholipase D signaling pathway bom04150   mTOR signaling pathway bom04151   PI3K-Akt signaling pathway bom04152   AMPK signaling pathway bom04211   Longevity regulating pathway bom04213   Longevity regulating pathway - multiple species bom04520   Adherens junction bom04910   Insulin signaling pathway bom04913   Ovarian steroidogenesis bom04923   Regulation of lipolysis in adipocytes bom04930   Type II diabetes mellitus bom04931   Insulin resistance bom04932   Non-alcoholic fatty liver disease bom04960   Aldosterone-regulated sodium reabsorption bom05010   Alzheimer disease bom05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:bom00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     102285317 (INSR)    04014 Ras signaling pathway     102285317 (INSR)    04015 Rap1 signaling pathway     102285317 (INSR)    04066 HIF-1 signaling pathway     102285317 (INSR)    04068 FoxO signaling pathway     102285317 (INSR)    04072 Phospholipase D signaling pathway     102285317 (INSR)    04022 cGMP-PKG signaling pathway     102285317 (INSR)    04151 PI3K-Akt signaling pathway     102285317 (INSR)    04152 AMPK signaling pathway     102285317 (INSR)    04150 mTOR signaling pathway     102285317 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     102285317 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     102285317 (INSR)    04923 Regulation of lipolysis in adipocytes     102285317 (INSR)    04913 Ovarian steroidogenesis     102285317 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     102285317 (INSR)   09149 Aging    04211 Longevity regulating pathway     102285317 (INSR)    04213 Longevity regulating pathway - multiple species     102285317 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     102285317 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     102285317 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     102285317 (INSR)    04932 Non-alcoholic fatty liver disease     102285317 (INSR)    04931 Insulin resistance     102285317 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:bom01001]     102285317 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:bom04090]     102285317 (INSR) Enzymes [BR:bom01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      102285317 (INSR) Protein kinases [BR:bom01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    102285317 (INSR) CD molecules [BR:bom04090]  Proteins   102285317 (INSR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like DUF4476 B2 Motif Other DBs NCBI-GeneID:  102285317 NCBI-ProteinID:  XP_005890820 LinkDB All DBs Position Un AA seq 1382 aa AA seqDB search MGAGGGRGAAAVLLMVVVAALLVGAAGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHL QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTSEGLCCHSECL GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHNKCKNSRRQG CHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC TIINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE RNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQ NVTEFDGQDACGSNSWTVVDIDPPTRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE RQAEDSELYELDYCLKGLKLPSRTWSPPFESEGSQKHNQSEYEESAGECCSCPKTDSQIL KELEESSFRKTFEDYLHNVVFIPRKSSSGPVAEDARPSRKRRALGDVGNVTAAVPTALGL PNTSSTSTPMSSEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPEERCSVAAYV SARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGEEELHLCV SRRHYALERGCRLRGLLPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDVPSNIAKIIIG PLIFVFLFSVVIGSICLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPR EKITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKTVNESASLRERIEFLNEASVMKG FTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMA AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV RWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDN CPERVTDLMRMCWQFNPKMRPTFLEIVDLLKDDLHPSFPEVSFFHSEENKAPESEELEME FEDMESVPLDRASHAQREEAGGRDGGSALGLKRNYDEHIPYTHMNGGKKNGRILTLPRSN PS NT seq 4149 nt NT seq  +upstreamnt  +downstreamnt atgggcgccgggggcgggaggggggcggcagccgtgctgctgatggtggtcgtcgccgcg ctgctggtgggcgccgcgggccacctgtaccctggagaagtgtgccccggtatggatatc cggaataatctcacccggctgcatgagctggccaactgctcagtcatcgaaggacatttg cagattctgttgatgttcaaaacgagacctgaggacttccgagacctcagtttccccaaa ctcatcatgatcactgattacttgctgctcttccgggtctatgggctggagagcctgaag gacttgttccccaacctcacggttatccgaggctcacgcctcttctttaattatgcgctg gtcatctttgagatggttcacctgaaggagcttggcctctacaacctgatgaacatcacc cgggggtctgtccgcattgagaagaacaatgaactctgctacctggccaccatcgactgg tctcgcatcctggattccgtggaggataattatatcgtgctgaacaaagacgacaatgag gagtgtggggacatttgtccaggcaccgccaagggcaagaccaactgccctgccactgtc atcaacgggcaatttgtggagcggtgctggacacacagccactgccagaaagtgtgtccg accatctgcaagtcacatggctgcacctctgagggtctctgctgccacagcgagtgcttg ggcaactgctcagagcccgacgaccccaccaagtgtgtggcctgtcgcaacttctacctg gacggcaggtgtgtggagacctgcccgcccccttactaccacttccaagactggcgctgc gtgaacttcagcttctgccaggacctgcacaacaaatgcaagaactctcggaggcaaggc tgccaccagtatgtcattcacaataacaagtgcatccccgagtgcccctctggctacacg atgaattccagcaacttgatgtgtaccccttgcctgggcccctgtcccaaggtatgccac ctcctggaaggcgagaagaccatcgattcggtgacatctgcccaggagctccgaggctgc accatcatcaacggaagcttaatcatcaacattcgagggggcaacaacctggcagctgag ctagaggccaaccttggactcattgaagaaatttcaggatatctgaaaatccgccggtcc tatgccctggtgtcactttccttcttccggaagttacgtctgattcgaggggagaccttg gaaattgggaactactctttctacgccttggacaaccagaacctaaggcagctgtgggac tggagcaaacacaacctcaccatcactcaggggaaactcttcttccactataaccccaaa ctctgcctgtcggaaattcacaagatggaggaagtttcaggaaccaaggggcgccaggag agaaatgacattgctctaaagaccaatggggaccaggcatcctgtgaaaatgaattactt aaattttcttacattcggacatcttacgacaagatcttgctgaaatgggagccgtattgg cctcctgacttccgagacctcctggggttcatgttgttctacaaagaggccccttaccag aacgtgacagaattcgatgggcaggatgcgtgcggctccaacagctggacagtggtggat attgacccgcctacgaggtccaacgaccccaagtcacagaaccaccctgggtggctgatg cgtggtctcaagccctggacccagtatgccatctttgtcaagaccctggtcaccttttct gatgaacgccgtacatacggggccaagagtgacatcatctatgtccagacagacgccact aatccttccgtgcccctggatcccatctcagtttctaattcctcgtcccagattattctg aaatggaagcctccctccgaccccaatggcaatatcacacactacttggtgttctgggag agacaggcggaagacagtgagctgtatgaactggattattgcctcaaagggttgaagctg ccctcccggacctggtctccaccattcgagtcggagggctcccagaagcacaatcagagt gagtatgaggagtctgctggtgaatgctgctcctgcccaaagaccgactcgcagatcctc aaggagctggaggagtcctcgttcaggaaaacgtttgaagattacctgcacaacgtggtt tttatccccagaaaatcatcttcaggccctgttgccgaggacgctaggccttcgaggaaa cgcagagcccttggtgacgtggggaatgtgacagcagccgtgcccaccgctctggggctc cccaatacctcctccaccagcacgcccatgagctcggaggagcacagacccttcgagaaa gtggtgaacaaggagtcgctggtcatctccggcctgcgtcactttactggctatcgaatc gagcttcaggcttgcaaccaagattcccccgaggagaggtgtagcgtggctgcctatgtc agcgccaggaccatgcctgaagccaaggcagatgatattgttggccccgtgacccatgaa atcttcgagaacaacgttgttcacttgatgtggcaggagcccaaggaacccaacggtctg attgtgctgtatgaagtgagttaccgacgatacggcgaggaggagctgcacctctgcgtc tcccgccgacattatgctctggagcgtggctgccggctgcgtgggctgctgcctgggaat tacagtgtgcgagttcgggccacctccctggcaggcaatgggtcttggacggaagccacc tatttctacgtgacagactatttagacgtgccatcaaatattgcaaaaatcatcatcggt cccctcatctttgtctttctcttcagtgttgtgattggaagtatttgtctattcctgaga aagaggcagccagatgggccattgggaccactgtatgcttcttcaaacccagagtacctc agtgccagcgatgtgtttccatgctctgtgtatgtgccggacgagtgggaggtgcctcga gagaagatcacactcctgcgagaattggggcaaggctcctttggcatggtgtacgagggc aacgccagggacattgtcaagggtgaggcggagacgcgcgtggcagtgaagacggtcaac gagtcagccagcctgcgagagcggatcgagtttctcaacgaggcttcggtcatgaagggc ttcacctgccaccatgtggtccgcctcctgggggtggtgtccaaaggccagccaacgctg gtggtgatggagttgatggctcacggagacctgaagagttacctccgttccctgcggcct gaggctgagaataaccccggccgccctccgcctaccctgcaagaaatgattcagatggcg gcagagatcgccgatgggatggcatacctgaacgctaagaagttcgtgcaccgggatctt gcagcccggaactgcatggttgcccacgactttacagtcaaaattggagactttggaatg acaagagacatctatgaaacggattactaccggaaagggggcaaaggtctgctccccgtg cggtggatggcacctgaatccctgaaggacggagtcttcaccacctcttcagacatgtgg tcttttggtgtggtcctttgggaaattaccagcttggcagaacagccttaccaaggtcta tcaaatgagcaggtgctgaaatttgtcatggatggagggtacctggatcaacctgacaat tgtccagagagagtcaccgacctgatgcggatgtgctggcagttcaaccccaagatgcgt ccaaccttcctggagatcgtggacctgctcaaggacgacctgcaccccagctttcccgaa gtgtccttcttccacagcgaggagaacaaggcgcccgagagcgaggagctggagatggag tttgaggacatggagagcgtgcccctggaccgggcctcgcacgcgcagagagaggaggcc gggggccgggatggagggtcggcgctggggctaaagcgaaactatgacgagcacatcccc tacacccacatgaacgggggcaagaaaaacggacggattctgactttgccccggtcaaat ccttcctaa

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