Bos taurus (cow): 525246
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Entry
525246 CDS
T01008
Symbol
JAK2
Name
(RefSeq) tyrosine-protein kinase JAK2 isoform X1
KO
K04447
Janus kinase 2 [EC:
2.7.10.2
]
Organism
bta
Bos taurus (cow)
Pathway
bta01521
EGFR tyrosine kinase inhibitor resistance
bta04062
Chemokine signaling pathway
bta04148
Efferocytosis
bta04151
PI3K-Akt signaling pathway
bta04217
Necroptosis
bta04550
Signaling pathways regulating pluripotency of stem cells
bta04630
JAK-STAT signaling pathway
bta04658
Th1 and Th2 cell differentiation
bta04659
Th17 cell differentiation
bta04725
Cholinergic synapse
bta04917
Prolactin signaling pathway
bta04920
Adipocytokine signaling pathway
bta04933
AGE-RAGE signaling pathway in diabetic complications
bta04935
Growth hormone synthesis, secretion and action
bta05140
Leishmaniasis
bta05145
Toxoplasmosis
bta05152
Tuberculosis
bta05161
Hepatitis B
bta05164
Influenza A
bta05167
Kaposi sarcoma-associated herpesvirus infection
bta05168
Herpes simplex virus 1 infection
bta05200
Pathways in cancer
bta05207
Chemical carcinogenesis - receptor activation
bta05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
bta05417
Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
bta00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
525246 (JAK2)
04151 PI3K-Akt signaling pathway
525246 (JAK2)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
525246 (JAK2)
09143 Cell growth and death
04217 Necroptosis
525246 (JAK2)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
525246 (JAK2)
09150 Organismal Systems
09151 Immune system
04658 Th1 and Th2 cell differentiation
525246 (JAK2)
04659 Th17 cell differentiation
525246 (JAK2)
04062 Chemokine signaling pathway
525246 (JAK2)
09152 Endocrine system
04920 Adipocytokine signaling pathway
525246 (JAK2)
04917 Prolactin signaling pathway
525246 (JAK2)
04935 Growth hormone synthesis, secretion and action
525246 (JAK2)
09156 Nervous system
04725 Cholinergic synapse
525246 (JAK2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
525246 (JAK2)
05207 Chemical carcinogenesis - receptor activation
525246 (JAK2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
525246 (JAK2)
09172 Infectious disease: viral
05161 Hepatitis B
525246 (JAK2)
05164 Influenza A
525246 (JAK2)
05168 Herpes simplex virus 1 infection
525246 (JAK2)
05167 Kaposi sarcoma-associated herpesvirus infection
525246 (JAK2)
09171 Infectious disease: bacterial
05152 Tuberculosis
525246 (JAK2)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
525246 (JAK2)
05140 Leishmaniasis
525246 (JAK2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
525246 (JAK2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
525246 (JAK2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
525246 (JAK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
bta01001
]
525246 (JAK2)
Enzymes [BR:
bta01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
525246 (JAK2)
Protein kinases [BR:
bta01001
]
Non-receptor tyrosine kinases
JAK family [OT]
525246 (JAK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
FERM_F2
FERM_F1
Jak1_Phl
SH2
ABC1
FERM_C_FAK1
RIO1
Kinase-like
FERM_M
Pkinase_fungal
Motif
Other DBs
NCBI-GeneID:
525246
NCBI-ProteinID:
XP_003586433
BGD-bta:
BT10737
Ensembl:
ENSBTAG00000012047
VGNC:
30365
UniProt:
E1BCP6
LinkDB
All DBs
Position
8:complement(39380542..39498855)
Genome browser
AA seq
1132 aa
AA seq
DB search
MGMACLTMTEMEGTSTSPVHQNGDISGNANSVKQIDPVLQVYLYHSLGNAEGDYLQFLTG
EYVAEEICIAASKACGITPVYHSMFALMSETERIWYPPNHVFHIDESTRQNVLYRIRFYF
PYWYCNGSNRTYRHGIARGAEAPLLDDFVMSYLFAQWRHDFLHGWIKVPVTHETQEECLG
MAVLDMMRIAKEKNQTPLDIYSSISYKTFLPKCVRAKIQEYHILTRKRIRYRFRRFIEQF
SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPDIIDISIKQANQEGANESRIVTIHKQDGKSLEIELKSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPISMDFAISKLKKTGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNC
YQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGISDVPTSPTLQRHNNVNQMVFHKI
RNEDLVFNESLGQGTFTKIFKGIRREIGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSQLSHKHLILNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWA
MHFLEEKTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRHNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIDKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYVIMTECWNNNVNQRPSFRDLAVRVDQIRDNMTG
NT seq
3399 nt
NT seq
+upstream
nt +downstream
nt
atgggaatggcttgccttacaatgacagaaatggaaggaacatccacatcccctgtacat
cagaatggtgatatttctggaaatgctaactctgtgaagcaaatagatccagtcctacag
gtctatctttatcattcccttgggaacgctgagggggattatctgcagtttctaactgga
gagtatgttgctgaagagatctgtattgctgcttctaaagcttgtggaatcacacctgta
tatcacagtatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaaccat
gtcttccatatagatgaatcaaccaggcaaaacgtactctacagaatcagattttacttc
ccttactggtattgtaatggcagcaacagaacctatcgacatggaatagctcgaggtgct
gaagctcctcttcttgatgactttgtcatgtcttacctttttgctcagtggcggcatgat
tttttacatggatggataaaagtacctgtgactcatgaaacacaggaagaatgtcttggg
atggcagtgttagatatgatgagaatagccaaagaaaaaaatcaaaccccactggacatc
tatagctctatcagctacaagacatttttgccaaaatgtgttcgagcaaagatccaagag
tatcatattttgacaaggaagagaataaggtacagatttcgcagatttattgagcaattc
agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact
cttcagtctgccttctacacagagcaatttgaagtaaaagaacctggaagaggtccttca
ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga
gggaaacataaagaaagtgagacactgacagaacaggatttacagttgtattgtgatttt
cctgatattattgatatcagtattaaacaagcaaatcaagaaggcgcaaatgaaagcaga
attgtaactattcataagcaagatggtaaaagtctagaaattgagcttaagtcattaaga
gaagctttgtcttttgtgtcattaattgatggatattatagattaactgcagatgcacat
cattatctttgtaaagaagtagcacctccaatggtgcttgaaaatatacaaagcaactgt
catggcccaatttcaatggattttgctatcagtaaactgaagaaaacaggtaatcagact
ggactctatgtacttcgatgcagtcctaaggactttaataaatattttctgacttttgct
gttgagcgagaaaatgttattgaatataagcactgtttgattaccaaaaatgagaatgga
gaatacaacctcagtggtactaagaagaacttcagtaatcttaaagatcttctgaattgc
taccagatggaaactgttcgctcagacagtataattttccagtttactaaatgctgtccc
ccaaagccaaaagacaaatcaaaccttctagtcttcagaaccaatggtatttctgatgta
ccaacctcaccaactttacaaaggcataataatgtgaaccaaatggtgttccacaaaatt
agaaatgaagatttggtatttaatgaaagccttggccaaggaacttttacaaaaattttt
aaaggtataagaagagaaataggagactatggtcagctgcatgaaacagaagttctttta
aaagttctggataaagcacatagaaactattcagagtctttctttgaagcagcaagcatg
atgagccagctttctcacaaacatctgattttaaattatggagtatgtgtctgtggagag
gagaatattctggttcaggaatttgtaaaatttggatcactagatacgtatctgaaaaag
aataaaaattctataaatatattatggaaacttgaagtggctaaacagttggcatgggcc
atgcattttctagaagaaaaaacccttattcatgggaatgtgtgcgccaaaaatattctt
cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct
ggcattagtattacagttttgccaaaagacatcctgcaggagagaataccatgggtacca
cctgaatgcattgaaaatcctaaaaatctaaacctggcaacagacaaatggagttttggt
accacattgtgggaaatctgcagtggaggagataagcctctgagtgctttggattctcaa
agaaaactacagttttatgaagataggcaccagcttcctgcgccaaagtggacagaatta
gcaaatcttattaataattgcatggattatgaaccagattttaggccttctttcagagcc
attataagagatcttaatagtttgtttactccagattatgaactattaacagaaaatgac
atgttaccaaatatgagaataggtgccctaggattttctggtgcttttgaagaccgagac
cctacacaatttgaagaaagacacttgaaatttctacagcaacttggcaagggtaatttt
gggagtgtggagatgtgccggtatgaccctctacaagacaatactggggaggtggtggct
gtgaaaaagctccagcacagtactgaagagcacctcagagacttcgaaagagaaattgaa
atccttaaatccttgcagcatgacaacattgtaaaatacaaaggagtctgctacagtgct
ggccggcataatctaagattaattatggagtatttaccatatggaagtttacgagactat
ctccaaaaacataaagaacggatagatcataaaaaacttctgcaatacacatctcagata
tgcaaggggatggaatatcttggtacaaaaagatatatccacagggatctggcaacaagg
aatatattagtggagaatgaaaacagagttaaaataggagattttggattaaccaaagtc
ttgccacaagacaaagagtactacaaagtgaaagagcctggtgaaagtcccatattctgg
tatgcaccagaatcactgacagagagcaagttttctgtggcttcagatgtttggagcttt
ggagtggttctgtatgaacttttcacatatattgacaagagtaaaagcccaccagcggaa
tttatgcgtatgattggcaatgacaaacaaggacagatgattgtgttccatttgatagaa
ctcctgaagaataatggaagattaccaagaccagatggatgcccagatgagatatatgtg
attatgacagaatgctggaacaataatgtaaaccagcgcccctctttcagagacctagca
gttcgagttgatcaaataagggacaacatgactggatga
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