KEGG   Budorcas taxicolor (takin): 128054045
Entry
128054045         CDS       T08909                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
btax  Budorcas taxicolor (takin)
Pathway
btax01521  EGFR tyrosine kinase inhibitor resistance
btax01522  Endocrine resistance
btax04010  MAPK signaling pathway
btax04012  ErbB signaling pathway
btax04014  Ras signaling pathway
btax04015  Rap1 signaling pathway
btax04022  cGMP-PKG signaling pathway
btax04024  cAMP signaling pathway
btax04062  Chemokine signaling pathway
btax04066  HIF-1 signaling pathway
btax04068  FoxO signaling pathway
btax04071  Sphingolipid signaling pathway
btax04072  Phospholipase D signaling pathway
btax04114  Oocyte meiosis
btax04140  Autophagy - animal
btax04148  Efferocytosis
btax04150  mTOR signaling pathway
btax04151  PI3K-Akt signaling pathway
btax04210  Apoptosis
btax04218  Cellular senescence
btax04270  Vascular smooth muscle contraction
btax04370  VEGF signaling pathway
btax04371  Apelin signaling pathway
btax04380  Osteoclast differentiation
btax04510  Focal adhesion
btax04540  Gap junction
btax04550  Signaling pathways regulating pluripotency of stem cells
btax04613  Neutrophil extracellular trap formation
btax04620  Toll-like receptor signaling pathway
btax04650  Natural killer cell mediated cytotoxicity
btax04660  T cell receptor signaling pathway
btax04662  B cell receptor signaling pathway
btax04664  Fc epsilon RI signaling pathway
btax04666  Fc gamma R-mediated phagocytosis
btax04668  TNF signaling pathway
btax04720  Long-term potentiation
btax04722  Neurotrophin signaling pathway
btax04725  Cholinergic synapse
btax04726  Serotonergic synapse
btax04730  Long-term depression
btax04810  Regulation of actin cytoskeleton
btax04910  Insulin signaling pathway
btax04912  GnRH signaling pathway
btax04914  Progesterone-mediated oocyte maturation
btax04915  Estrogen signaling pathway
btax04916  Melanogenesis
btax04917  Prolactin signaling pathway
btax04919  Thyroid hormone signaling pathway
btax04921  Oxytocin signaling pathway
btax04926  Relaxin signaling pathway
btax04928  Parathyroid hormone synthesis, secretion and action
btax04929  GnRH secretion
btax04934  Cushing syndrome
btax04935  Growth hormone synthesis, secretion and action
btax05010  Alzheimer disease
btax05022  Pathways of neurodegeneration - multiple diseases
btax05034  Alcoholism
btax05132  Salmonella infection
btax05135  Yersinia infection
btax05160  Hepatitis C
btax05161  Hepatitis B
btax05163  Human cytomegalovirus infection
btax05164  Influenza A
btax05165  Human papillomavirus infection
btax05166  Human T-cell leukemia virus 1 infection
btax05167  Kaposi sarcoma-associated herpesvirus infection
btax05170  Human immunodeficiency virus 1 infection
btax05200  Pathways in cancer
btax05205  Proteoglycans in cancer
btax05206  MicroRNAs in cancer
btax05207  Chemical carcinogenesis - receptor activation
btax05208  Chemical carcinogenesis - reactive oxygen species
btax05210  Colorectal cancer
btax05211  Renal cell carcinoma
btax05212  Pancreatic cancer
btax05213  Endometrial cancer
btax05214  Glioma
btax05215  Prostate cancer
btax05216  Thyroid cancer
btax05218  Melanoma
btax05219  Bladder cancer
btax05220  Chronic myeloid leukemia
btax05221  Acute myeloid leukemia
btax05223  Non-small cell lung cancer
btax05224  Breast cancer
btax05225  Hepatocellular carcinoma
btax05226  Gastric cancer
btax05230  Central carbon metabolism in cancer
btax05231  Choline metabolism in cancer
btax05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:btax00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    128054045 (MAP2K1)
   04012 ErbB signaling pathway
    128054045 (MAP2K1)
   04014 Ras signaling pathway
    128054045 (MAP2K1)
   04015 Rap1 signaling pathway
    128054045 (MAP2K1)
   04370 VEGF signaling pathway
    128054045 (MAP2K1)
   04371 Apelin signaling pathway
    128054045 (MAP2K1)
   04668 TNF signaling pathway
    128054045 (MAP2K1)
   04066 HIF-1 signaling pathway
    128054045 (MAP2K1)
   04068 FoxO signaling pathway
    128054045 (MAP2K1)
   04072 Phospholipase D signaling pathway
    128054045 (MAP2K1)
   04071 Sphingolipid signaling pathway
    128054045 (MAP2K1)
   04024 cAMP signaling pathway
    128054045 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    128054045 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    128054045 (MAP2K1)
   04150 mTOR signaling pathway
    128054045 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    128054045 (MAP2K1)
   04148 Efferocytosis
    128054045 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    128054045 (MAP2K1)
   04210 Apoptosis
    128054045 (MAP2K1)
   04218 Cellular senescence
    128054045 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    128054045 (MAP2K1)
   04540 Gap junction
    128054045 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    128054045 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    128054045 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    128054045 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    128054045 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    128054045 (MAP2K1)
   04660 T cell receptor signaling pathway
    128054045 (MAP2K1)
   04662 B cell receptor signaling pathway
    128054045 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    128054045 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    128054045 (MAP2K1)
   04062 Chemokine signaling pathway
    128054045 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    128054045 (MAP2K1)
   04929 GnRH secretion
    128054045 (MAP2K1)
   04912 GnRH signaling pathway
    128054045 (MAP2K1)
   04915 Estrogen signaling pathway
    128054045 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    128054045 (MAP2K1)
   04917 Prolactin signaling pathway
    128054045 (MAP2K1)
   04921 Oxytocin signaling pathway
    128054045 (MAP2K1)
   04926 Relaxin signaling pathway
    128054045 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    128054045 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    128054045 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    128054045 (MAP2K1)
   04916 Melanogenesis
    128054045 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    128054045 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    128054045 (MAP2K1)
   04726 Serotonergic synapse
    128054045 (MAP2K1)
   04720 Long-term potentiation
    128054045 (MAP2K1)
   04730 Long-term depression
    128054045 (MAP2K1)
   04722 Neurotrophin signaling pathway
    128054045 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    128054045 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    128054045 (MAP2K1)
   05206 MicroRNAs in cancer
    128054045 (MAP2K1)
   05205 Proteoglycans in cancer
    128054045 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    128054045 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    128054045 (MAP2K1)
   05230 Central carbon metabolism in cancer
    128054045 (MAP2K1)
   05231 Choline metabolism in cancer
    128054045 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    128054045 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    128054045 (MAP2K1)
   05212 Pancreatic cancer
    128054045 (MAP2K1)
   05225 Hepatocellular carcinoma
    128054045 (MAP2K1)
   05226 Gastric cancer
    128054045 (MAP2K1)
   05214 Glioma
    128054045 (MAP2K1)
   05216 Thyroid cancer
    128054045 (MAP2K1)
   05221 Acute myeloid leukemia
    128054045 (MAP2K1)
   05220 Chronic myeloid leukemia
    128054045 (MAP2K1)
   05218 Melanoma
    128054045 (MAP2K1)
   05211 Renal cell carcinoma
    128054045 (MAP2K1)
   05219 Bladder cancer
    128054045 (MAP2K1)
   05215 Prostate cancer
    128054045 (MAP2K1)
   05213 Endometrial cancer
    128054045 (MAP2K1)
   05224 Breast cancer
    128054045 (MAP2K1)
   05223 Non-small cell lung cancer
    128054045 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    128054045 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    128054045 (MAP2K1)
   05161 Hepatitis B
    128054045 (MAP2K1)
   05160 Hepatitis C
    128054045 (MAP2K1)
   05164 Influenza A
    128054045 (MAP2K1)
   05163 Human cytomegalovirus infection
    128054045 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    128054045 (MAP2K1)
   05165 Human papillomavirus infection
    128054045 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    128054045 (MAP2K1)
   05135 Yersinia infection
    128054045 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    128054045 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    128054045 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    128054045 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    128054045 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    128054045 (MAP2K1)
   01522 Endocrine resistance
    128054045 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:btax01001]
    128054045 (MAP2K1)
Enzymes [BR:btax01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     128054045 (MAP2K1)
Protein kinases [BR:btax01001]
 Serine/threonine kinases: STE group
  STE7 family
   128054045 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Seadorna_VP7 Haspin_kinase
Other DBs
NCBI-GeneID: 128054045
NCBI-ProteinID: XP_052502552
LinkDB
Position
10:13436442..13512346
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggccccggacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagctcgatgaacagcagcggaagcgcctcgaggcctttctgacccagaagcagaaggtg
ggggaactgaaggatgatgactttgagaagatcagtgagctgggtgccggcaacggaggt
gtggtgttcaaggtctcccacaagccgtccggactcgttatggccagaaagctaattcac
ctggagatcaaacctgccatccggaaccagatcataagggagctgcaggttctgcatgag
tgcaactcgccgtacatcgtgggcttctacggggccttctacagcgacggcgagatcagc
atctgcatggagcacatggatgggggttccttggatcaagttctgaagaaagctggaaga
atccctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccgtccaacatcctagtgaacagc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactctttcgtgggcaccaggtcctacatgtcgccagagcgactccaggggacccattac
tccgtgcagtcggacatctggagcatggggctctctctggttgagatggcggtcgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagaccccgcccaggccaaggacccccgggaggcccctcagctcttat
ggaatggacagccgacctccaatggcaatttttgagttgttggattacattgtcaatgag
cctcctccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagacctgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacacccacccatgcagctggtgtctaa

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