KEGG   Cervus canadensis (wapiti): 122443062
Entry
122443062         CDS       T07554                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
ccad  Cervus canadensis (wapiti)
Pathway
ccad01521  EGFR tyrosine kinase inhibitor resistance
ccad01522  Endocrine resistance
ccad04010  MAPK signaling pathway
ccad04012  ErbB signaling pathway
ccad04014  Ras signaling pathway
ccad04015  Rap1 signaling pathway
ccad04022  cGMP-PKG signaling pathway
ccad04024  cAMP signaling pathway
ccad04062  Chemokine signaling pathway
ccad04066  HIF-1 signaling pathway
ccad04068  FoxO signaling pathway
ccad04071  Sphingolipid signaling pathway
ccad04072  Phospholipase D signaling pathway
ccad04114  Oocyte meiosis
ccad04140  Autophagy - animal
ccad04148  Efferocytosis
ccad04150  mTOR signaling pathway
ccad04151  PI3K-Akt signaling pathway
ccad04210  Apoptosis
ccad04218  Cellular senescence
ccad04270  Vascular smooth muscle contraction
ccad04370  VEGF signaling pathway
ccad04371  Apelin signaling pathway
ccad04380  Osteoclast differentiation
ccad04510  Focal adhesion
ccad04540  Gap junction
ccad04550  Signaling pathways regulating pluripotency of stem cells
ccad04613  Neutrophil extracellular trap formation
ccad04620  Toll-like receptor signaling pathway
ccad04650  Natural killer cell mediated cytotoxicity
ccad04660  T cell receptor signaling pathway
ccad04662  B cell receptor signaling pathway
ccad04664  Fc epsilon RI signaling pathway
ccad04666  Fc gamma R-mediated phagocytosis
ccad04668  TNF signaling pathway
ccad04720  Long-term potentiation
ccad04722  Neurotrophin signaling pathway
ccad04725  Cholinergic synapse
ccad04726  Serotonergic synapse
ccad04730  Long-term depression
ccad04810  Regulation of actin cytoskeleton
ccad04910  Insulin signaling pathway
ccad04912  GnRH signaling pathway
ccad04914  Progesterone-mediated oocyte maturation
ccad04915  Estrogen signaling pathway
ccad04916  Melanogenesis
ccad04917  Prolactin signaling pathway
ccad04919  Thyroid hormone signaling pathway
ccad04921  Oxytocin signaling pathway
ccad04926  Relaxin signaling pathway
ccad04928  Parathyroid hormone synthesis, secretion and action
ccad04929  GnRH secretion
ccad04934  Cushing syndrome
ccad04935  Growth hormone synthesis, secretion and action
ccad05010  Alzheimer disease
ccad05022  Pathways of neurodegeneration - multiple diseases
ccad05034  Alcoholism
ccad05132  Salmonella infection
ccad05135  Yersinia infection
ccad05160  Hepatitis C
ccad05161  Hepatitis B
ccad05163  Human cytomegalovirus infection
ccad05164  Influenza A
ccad05165  Human papillomavirus infection
ccad05166  Human T-cell leukemia virus 1 infection
ccad05167  Kaposi sarcoma-associated herpesvirus infection
ccad05170  Human immunodeficiency virus 1 infection
ccad05200  Pathways in cancer
ccad05205  Proteoglycans in cancer
ccad05206  MicroRNAs in cancer
ccad05207  Chemical carcinogenesis - receptor activation
ccad05208  Chemical carcinogenesis - reactive oxygen species
ccad05210  Colorectal cancer
ccad05211  Renal cell carcinoma
ccad05212  Pancreatic cancer
ccad05213  Endometrial cancer
ccad05214  Glioma
ccad05215  Prostate cancer
ccad05216  Thyroid cancer
ccad05218  Melanoma
ccad05219  Bladder cancer
ccad05220  Chronic myeloid leukemia
ccad05221  Acute myeloid leukemia
ccad05223  Non-small cell lung cancer
ccad05224  Breast cancer
ccad05225  Hepatocellular carcinoma
ccad05226  Gastric cancer
ccad05230  Central carbon metabolism in cancer
ccad05231  Choline metabolism in cancer
ccad05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ccad00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122443062 (MAP2K1)
   04012 ErbB signaling pathway
    122443062 (MAP2K1)
   04014 Ras signaling pathway
    122443062 (MAP2K1)
   04015 Rap1 signaling pathway
    122443062 (MAP2K1)
   04370 VEGF signaling pathway
    122443062 (MAP2K1)
   04371 Apelin signaling pathway
    122443062 (MAP2K1)
   04668 TNF signaling pathway
    122443062 (MAP2K1)
   04066 HIF-1 signaling pathway
    122443062 (MAP2K1)
   04068 FoxO signaling pathway
    122443062 (MAP2K1)
   04072 Phospholipase D signaling pathway
    122443062 (MAP2K1)
   04071 Sphingolipid signaling pathway
    122443062 (MAP2K1)
   04024 cAMP signaling pathway
    122443062 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    122443062 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    122443062 (MAP2K1)
   04150 mTOR signaling pathway
    122443062 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    122443062 (MAP2K1)
   04148 Efferocytosis
    122443062 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    122443062 (MAP2K1)
   04210 Apoptosis
    122443062 (MAP2K1)
   04218 Cellular senescence
    122443062 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122443062 (MAP2K1)
   04540 Gap junction
    122443062 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    122443062 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    122443062 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    122443062 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    122443062 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    122443062 (MAP2K1)
   04660 T cell receptor signaling pathway
    122443062 (MAP2K1)
   04662 B cell receptor signaling pathway
    122443062 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    122443062 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    122443062 (MAP2K1)
   04062 Chemokine signaling pathway
    122443062 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122443062 (MAP2K1)
   04929 GnRH secretion
    122443062 (MAP2K1)
   04912 GnRH signaling pathway
    122443062 (MAP2K1)
   04915 Estrogen signaling pathway
    122443062 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    122443062 (MAP2K1)
   04917 Prolactin signaling pathway
    122443062 (MAP2K1)
   04921 Oxytocin signaling pathway
    122443062 (MAP2K1)
   04926 Relaxin signaling pathway
    122443062 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    122443062 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    122443062 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    122443062 (MAP2K1)
   04916 Melanogenesis
    122443062 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    122443062 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    122443062 (MAP2K1)
   04726 Serotonergic synapse
    122443062 (MAP2K1)
   04720 Long-term potentiation
    122443062 (MAP2K1)
   04730 Long-term depression
    122443062 (MAP2K1)
   04722 Neurotrophin signaling pathway
    122443062 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    122443062 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122443062 (MAP2K1)
   05206 MicroRNAs in cancer
    122443062 (MAP2K1)
   05205 Proteoglycans in cancer
    122443062 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    122443062 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    122443062 (MAP2K1)
   05230 Central carbon metabolism in cancer
    122443062 (MAP2K1)
   05231 Choline metabolism in cancer
    122443062 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122443062 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122443062 (MAP2K1)
   05212 Pancreatic cancer
    122443062 (MAP2K1)
   05225 Hepatocellular carcinoma
    122443062 (MAP2K1)
   05226 Gastric cancer
    122443062 (MAP2K1)
   05214 Glioma
    122443062 (MAP2K1)
   05216 Thyroid cancer
    122443062 (MAP2K1)
   05221 Acute myeloid leukemia
    122443062 (MAP2K1)
   05220 Chronic myeloid leukemia
    122443062 (MAP2K1)
   05218 Melanoma
    122443062 (MAP2K1)
   05211 Renal cell carcinoma
    122443062 (MAP2K1)
   05219 Bladder cancer
    122443062 (MAP2K1)
   05215 Prostate cancer
    122443062 (MAP2K1)
   05213 Endometrial cancer
    122443062 (MAP2K1)
   05224 Breast cancer
    122443062 (MAP2K1)
   05223 Non-small cell lung cancer
    122443062 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    122443062 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    122443062 (MAP2K1)
   05161 Hepatitis B
    122443062 (MAP2K1)
   05160 Hepatitis C
    122443062 (MAP2K1)
   05164 Influenza A
    122443062 (MAP2K1)
   05163 Human cytomegalovirus infection
    122443062 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122443062 (MAP2K1)
   05165 Human papillomavirus infection
    122443062 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122443062 (MAP2K1)
   05135 Yersinia infection
    122443062 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122443062 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    122443062 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    122443062 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    122443062 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122443062 (MAP2K1)
   01522 Endocrine resistance
    122443062 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ccad01001]
    122443062 (MAP2K1)
Enzymes [BR:ccad01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     122443062 (MAP2K1)
Protein kinases [BR:ccad01001]
 Serine/threonine kinases: STE group
  STE7 family
   122443062 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Seadorna_VP7 Haspin_kinase
Other DBs
NCBI-GeneID: 122443062
NCBI-ProteinID: XP_043326802
LinkDB
Position
6:12318101..12393597
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCATIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggccccggacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagctcgatgaacagcagcggaagcgcctcgaggcctttctgacccagaagcagaaggtg
ggggaactgaaggatgatgactttgagaagatcagtgagctgggtgccggcaatggaggt
gtggtgttcaaggtctcccacaagccgtccggactcgttatggccagaaagctaattcac
ctggagatcaaacctgccatccggaaccagatcataagggagctgcaggtcctccatgag
tgcaactcgccttacatcgtgggcttctacggggcgttctacagcgatggcgagatcagc
atctgcatggagcacatggatgggggttccttggatcaagttctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctg
agggagaagcacaagattatgcacagagacgtcaagccgtccaacatcctagtgaacagc
cgtggagagatcaagctctgtgacttcggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcaccaggtcctacatgtcgccagagcgactccaggggacccattac
tccgtgcagtcggacatctggagcatggggctctctctggttgagatggcggtcgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagaccccgcccaggccaaggacccccgggaggcccctcagctcttat
ggaatggacagccgacctccaatggcaatttttgagttgttggattacatagtcaatgag
cctcctccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgctttc
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgcgccaccatcggc
cttaaccagcccagcacgcccacccatgcggctggcgtctaa

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