KEGG   Castor canadensis (American beaver): 109687824
Entry
109687824         CDS       T04791                                 
Symbol
Map2k1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
ccan  Castor canadensis (American beaver)
Pathway
ccan01521  EGFR tyrosine kinase inhibitor resistance
ccan01522  Endocrine resistance
ccan04010  MAPK signaling pathway
ccan04012  ErbB signaling pathway
ccan04014  Ras signaling pathway
ccan04015  Rap1 signaling pathway
ccan04022  cGMP-PKG signaling pathway
ccan04024  cAMP signaling pathway
ccan04062  Chemokine signaling pathway
ccan04066  HIF-1 signaling pathway
ccan04068  FoxO signaling pathway
ccan04071  Sphingolipid signaling pathway
ccan04072  Phospholipase D signaling pathway
ccan04114  Oocyte meiosis
ccan04140  Autophagy - animal
ccan04148  Efferocytosis
ccan04150  mTOR signaling pathway
ccan04151  PI3K-Akt signaling pathway
ccan04210  Apoptosis
ccan04218  Cellular senescence
ccan04270  Vascular smooth muscle contraction
ccan04370  VEGF signaling pathway
ccan04371  Apelin signaling pathway
ccan04380  Osteoclast differentiation
ccan04510  Focal adhesion
ccan04540  Gap junction
ccan04550  Signaling pathways regulating pluripotency of stem cells
ccan04613  Neutrophil extracellular trap formation
ccan04620  Toll-like receptor signaling pathway
ccan04650  Natural killer cell mediated cytotoxicity
ccan04660  T cell receptor signaling pathway
ccan04662  B cell receptor signaling pathway
ccan04664  Fc epsilon RI signaling pathway
ccan04666  Fc gamma R-mediated phagocytosis
ccan04668  TNF signaling pathway
ccan04720  Long-term potentiation
ccan04722  Neurotrophin signaling pathway
ccan04725  Cholinergic synapse
ccan04726  Serotonergic synapse
ccan04730  Long-term depression
ccan04810  Regulation of actin cytoskeleton
ccan04910  Insulin signaling pathway
ccan04912  GnRH signaling pathway
ccan04914  Progesterone-mediated oocyte maturation
ccan04915  Estrogen signaling pathway
ccan04916  Melanogenesis
ccan04917  Prolactin signaling pathway
ccan04919  Thyroid hormone signaling pathway
ccan04921  Oxytocin signaling pathway
ccan04926  Relaxin signaling pathway
ccan04928  Parathyroid hormone synthesis, secretion and action
ccan04929  GnRH secretion
ccan04934  Cushing syndrome
ccan04935  Growth hormone synthesis, secretion and action
ccan05010  Alzheimer disease
ccan05022  Pathways of neurodegeneration - multiple diseases
ccan05034  Alcoholism
ccan05132  Salmonella infection
ccan05135  Yersinia infection
ccan05160  Hepatitis C
ccan05161  Hepatitis B
ccan05163  Human cytomegalovirus infection
ccan05164  Influenza A
ccan05165  Human papillomavirus infection
ccan05166  Human T-cell leukemia virus 1 infection
ccan05167  Kaposi sarcoma-associated herpesvirus infection
ccan05170  Human immunodeficiency virus 1 infection
ccan05200  Pathways in cancer
ccan05205  Proteoglycans in cancer
ccan05206  MicroRNAs in cancer
ccan05207  Chemical carcinogenesis - receptor activation
ccan05208  Chemical carcinogenesis - reactive oxygen species
ccan05210  Colorectal cancer
ccan05211  Renal cell carcinoma
ccan05212  Pancreatic cancer
ccan05213  Endometrial cancer
ccan05214  Glioma
ccan05215  Prostate cancer
ccan05216  Thyroid cancer
ccan05218  Melanoma
ccan05219  Bladder cancer
ccan05220  Chronic myeloid leukemia
ccan05221  Acute myeloid leukemia
ccan05223  Non-small cell lung cancer
ccan05224  Breast cancer
ccan05225  Hepatocellular carcinoma
ccan05226  Gastric cancer
ccan05230  Central carbon metabolism in cancer
ccan05231  Choline metabolism in cancer
ccan05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ccan00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    109687824 (Map2k1)
   04012 ErbB signaling pathway
    109687824 (Map2k1)
   04014 Ras signaling pathway
    109687824 (Map2k1)
   04015 Rap1 signaling pathway
    109687824 (Map2k1)
   04370 VEGF signaling pathway
    109687824 (Map2k1)
   04371 Apelin signaling pathway
    109687824 (Map2k1)
   04668 TNF signaling pathway
    109687824 (Map2k1)
   04066 HIF-1 signaling pathway
    109687824 (Map2k1)
   04068 FoxO signaling pathway
    109687824 (Map2k1)
   04072 Phospholipase D signaling pathway
    109687824 (Map2k1)
   04071 Sphingolipid signaling pathway
    109687824 (Map2k1)
   04024 cAMP signaling pathway
    109687824 (Map2k1)
   04022 cGMP-PKG signaling pathway
    109687824 (Map2k1)
   04151 PI3K-Akt signaling pathway
    109687824 (Map2k1)
   04150 mTOR signaling pathway
    109687824 (Map2k1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    109687824 (Map2k1)
   04148 Efferocytosis
    109687824 (Map2k1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    109687824 (Map2k1)
   04210 Apoptosis
    109687824 (Map2k1)
   04218 Cellular senescence
    109687824 (Map2k1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    109687824 (Map2k1)
   04540 Gap junction
    109687824 (Map2k1)
   04550 Signaling pathways regulating pluripotency of stem cells
    109687824 (Map2k1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    109687824 (Map2k1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    109687824 (Map2k1)
   04620 Toll-like receptor signaling pathway
    109687824 (Map2k1)
   04650 Natural killer cell mediated cytotoxicity
    109687824 (Map2k1)
   04660 T cell receptor signaling pathway
    109687824 (Map2k1)
   04662 B cell receptor signaling pathway
    109687824 (Map2k1)
   04664 Fc epsilon RI signaling pathway
    109687824 (Map2k1)
   04666 Fc gamma R-mediated phagocytosis
    109687824 (Map2k1)
   04062 Chemokine signaling pathway
    109687824 (Map2k1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    109687824 (Map2k1)
   04929 GnRH secretion
    109687824 (Map2k1)
   04912 GnRH signaling pathway
    109687824 (Map2k1)
   04915 Estrogen signaling pathway
    109687824 (Map2k1)
   04914 Progesterone-mediated oocyte maturation
    109687824 (Map2k1)
   04917 Prolactin signaling pathway
    109687824 (Map2k1)
   04921 Oxytocin signaling pathway
    109687824 (Map2k1)
   04926 Relaxin signaling pathway
    109687824 (Map2k1)
   04935 Growth hormone synthesis, secretion and action
    109687824 (Map2k1)
   04919 Thyroid hormone signaling pathway
    109687824 (Map2k1)
   04928 Parathyroid hormone synthesis, secretion and action
    109687824 (Map2k1)
   04916 Melanogenesis
    109687824 (Map2k1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    109687824 (Map2k1)
  09156 Nervous system
   04725 Cholinergic synapse
    109687824 (Map2k1)
   04726 Serotonergic synapse
    109687824 (Map2k1)
   04720 Long-term potentiation
    109687824 (Map2k1)
   04730 Long-term depression
    109687824 (Map2k1)
   04722 Neurotrophin signaling pathway
    109687824 (Map2k1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    109687824 (Map2k1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109687824 (Map2k1)
   05206 MicroRNAs in cancer
    109687824 (Map2k1)
   05205 Proteoglycans in cancer
    109687824 (Map2k1)
   05207 Chemical carcinogenesis - receptor activation
    109687824 (Map2k1)
   05208 Chemical carcinogenesis - reactive oxygen species
    109687824 (Map2k1)
   05230 Central carbon metabolism in cancer
    109687824 (Map2k1)
   05231 Choline metabolism in cancer
    109687824 (Map2k1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109687824 (Map2k1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    109687824 (Map2k1)
   05212 Pancreatic cancer
    109687824 (Map2k1)
   05225 Hepatocellular carcinoma
    109687824 (Map2k1)
   05226 Gastric cancer
    109687824 (Map2k1)
   05214 Glioma
    109687824 (Map2k1)
   05216 Thyroid cancer
    109687824 (Map2k1)
   05221 Acute myeloid leukemia
    109687824 (Map2k1)
   05220 Chronic myeloid leukemia
    109687824 (Map2k1)
   05218 Melanoma
    109687824 (Map2k1)
   05211 Renal cell carcinoma
    109687824 (Map2k1)
   05219 Bladder cancer
    109687824 (Map2k1)
   05215 Prostate cancer
    109687824 (Map2k1)
   05213 Endometrial cancer
    109687824 (Map2k1)
   05224 Breast cancer
    109687824 (Map2k1)
   05223 Non-small cell lung cancer
    109687824 (Map2k1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    109687824 (Map2k1)
   05170 Human immunodeficiency virus 1 infection
    109687824 (Map2k1)
   05161 Hepatitis B
    109687824 (Map2k1)
   05160 Hepatitis C
    109687824 (Map2k1)
   05164 Influenza A
    109687824 (Map2k1)
   05163 Human cytomegalovirus infection
    109687824 (Map2k1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109687824 (Map2k1)
   05165 Human papillomavirus infection
    109687824 (Map2k1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    109687824 (Map2k1)
   05135 Yersinia infection
    109687824 (Map2k1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109687824 (Map2k1)
   05022 Pathways of neurodegeneration - multiple diseases
    109687824 (Map2k1)
  09165 Substance dependence
   05034 Alcoholism
    109687824 (Map2k1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    109687824 (Map2k1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109687824 (Map2k1)
   01522 Endocrine resistance
    109687824 (Map2k1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ccan01001]
    109687824 (Map2k1)
Enzymes [BR:ccan01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     109687824 (Map2k1)
Protein kinases [BR:ccan01001]
 Serine/threonine kinases: STE group
  STE7 family
   109687824 (Map2k1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Seadorna_VP7 Kinase-like Haspin_kinase
Other DBs
NCBI-GeneID: 109687824
NCBI-ProteinID: XP_020021494
UniProt: A0A8B7URH9
LinkDB
Position
Unknown
AA seq 413 aa
MVLTCGLPLSRTNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGA
GNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSD
GEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNI
LVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEM
AVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDY
IVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLC
STIGLNQPSTPTHAAGMGQYAEMNLYFNTIFTSNTSHSFCSCPLFKNLIMIPL
NT seq 1242 nt   +upstreamnt  +downstreamnt
atggtgctgacttgtggactccctttgagcaggaccaacctggaggccttacagaagaag
ctggaggagctggagcttgatgagcagcagcggaagcgccttgaggcctttttgactcag
aagcagaaggtgggagagctgaaggatgacgactttgagaagatcagtgaactgggcgct
ggcaatggcggcgtagtattcaaagtctcccataagccttctggcctagtcatggccaga
aagctcattcacctggagataaaacctgcaatccggaaccagatcatcagagagctgcaa
gttctgcatgagtgcaactccccgtacatcgtgggcttctatggtgcattctacagcgac
ggcgagatcagcatctgcatggaacacatggatgggggttccttggatcaagtcctgaag
aaagctggaagaattcctgaacaaattttaggaaaagttagcattgctgtgataaaaggt
ctgacgtacctcagagagaagcacaagattatgcacagagatgtcaagccttctaacatc
ctagtcaactcccgtggggagatcaagctctgtgactttggggtcagtgggcagctcatc
gactccatggccaactccttcgtgggaacaagatcctacatgtcgccagaaagactccag
gggactcactactctgtgcaatcggatatctggagcatggggctctctctggtggagatg
gcagtggggaggtatcccatccctcctccggatgccaaggagctggagctgatgtttgga
tgccaggtggagggagatgcggctgagacaccacctaggccaaggacccctgggaggccc
cttagctcatatggaatggacagcagacctcccatggcaatttttgagttgttggactac
atagtcaatgagcctcctccaaaactgcccagtggagtattcagtctggaatttcaagat
tttgtgaataaatgtttaataaaaaaccctgcagagagagcagatttgaagcaactcatg
gttcatgcttttatcaagagatctgatgctgaggaagtagattttgcaggttggctctgc
tccaccattggcctcaaccagcccagcacaccaacccatgcagccggcatgggacaatat
gcagaaatgaatctttacttcaacacaatctttacttcaaacacaagccactcattctgt
agctgtcctctctttaagaacctcatcatgattcctctctaa

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