Camelus dromedarius (Arabian camel): 105094715
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Entry
105094715 CDS
T04642
Symbol
PDE8A
Name
(RefSeq) high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1
KO
K18437
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:
3.1.4.53
]
Organism
cdk
Camelus dromedarius (Arabian camel)
Pathway
cdk00230
Purine metabolism
cdk01100
Metabolic pathways
cdk04927
Cortisol synthesis and secretion
cdk04934
Cushing syndrome
cdk05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
cdk00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
105094715 (PDE8A)
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
105094715 (PDE8A)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
105094715 (PDE8A)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
105094715 (PDE8A)
Enzymes [BR:
cdk01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
105094715 (PDE8A)
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GFIT
Motif
Pfam:
PDEase_I
PAS_9
PAS
PAS_4
PAS_3
DUF5894
PAS_8
Sina_ZnF
Response_reg
Motif
Other DBs
NCBI-GeneID:
105094715
NCBI-ProteinID:
XP_010985101
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Position
27:18107133..18224268
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AA seq
765 aa
AA seq
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MRFHPDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQTVLGCFLDKHHDIIIIDH
RNPRQLDAEALCRSIRSSKLSENTVIIGVVRRADREESSVMSLLAAGFTRRYVENPSPMA
CYNELLQLEFGEVRSQLKLRACNSIFTALEKSQEAIEITSEDHIIQYANPAFETTMGYQS
GELIGKELAEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNIQQNVKIIPVTGQ
GGKIRHYVSIIRVCNGSNKAEKITECVQSDTHTDNQSGKHKDRRKSSLDVRTVGSRASEV
SSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLEILRTTELYSPQF
GAKDDDPHANDLVGGLVSDGLRRLSGNEYVLSTKNLQQMSSTIITPISLHDIPPRITRAM
ENEEYWDFDIFELEAATHKRPLIYLGLKMFSRFGVCEFLNCSETTLRSWLQIIEANYHSS
NPYHNSTHSADVLHATAYFLCKERIKQTLDPLDEAAALIAATIHDVDHPGRTNSFLCNAG
SELAILYNDTAVLESHHAALAFQLTNGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTK
HFEHVNKFVNSINKPLAALEENRETDKDQEAINTMLRTPENRTLIKRMLIKCADVSNPCR
PLEQCIEWAARISEEYFSQTDEEKQQDLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDA
WDAFVDLPELMQHLDNNFKYWKGLDELKLRTLRPPPHRAQPCPGP
NT seq
2298 nt
NT seq
+upstream
nt +downstream
nt
atgagatttcatccagatcaactccaggtacttttagtgtttaccaaagaagataaccag
tgtaatggattctgtagggcatgtgaaaaagcagggtttaagtgtacagttaccaaggag
gctcagactgtccttggctgtttcctggacaaacatcatgacatcattatcatagaccac
agaaatccccggcagctggatgcagaggcgctatgcaggtctatcagatcatcaaaactc
tcagaaaacacagttattattggtgtagttcgcagggctgatagagaagaatcatccgta
atgtccctccttgctgctggctttacaaggaggtatgtagaaaaccccagccccatggcc
tgttacaatgaactgctccagctggagtttggagaggtgcgatcacagctaaaactcagg
gcttgtaactcaatattcactgcattagagaaaagtcaagaagcaattgaaattacaagt
gaagaccacattatacagtatgcaaacccggcatttgaaacaacaatgggctatcagtca
ggtgaattaatagggaaggagttagcagaagtgcctataaatgaaaaaaaggctgatttg
ctcgatactataaattcatgcatcaggataggcaaggagtggcaaggaatttactatgcc
aaaaagaaaaacggagataatatacaacaaaatgtgaagataatacctgtcactggacag
ggaggaaaaattagacactatgtgtccattatcagagtgtgcaatggcagcaataaggct
gagaaaataactgaatgtgttcagtctgacacccatacagataatcagtcgggcaaacat
aaagacaggagaaaaagctccctagatgtcagaactgttggctctcgagcaagcgaagtt
tccagccagagacgacactcctccatggctcggatacattccatgacgatcgaggcgccc
atcaccaaggtaatcaatattatcaatgctgcacaggagagcagtcccatgcctgtgaca
gaagccttagaccgtgtgctggaaattctaagaaccactgaattatattcgccgcaattc
ggtgctaaggatgatgatcctcatgccaacgacctcgttgggggcttagtgtctgatggt
ttgcgaagactatctgggaatgagtatgttctttcaacaaaaaaccttcaacagatgtcc
agcactataatcacccccatctcccttcatgacatcccaccgcggataactcgggccatg
gaaaatgaggaatactgggactttgatatttttgagttggaggctgccactcataaaagg
cctttgatttatcttggtctcaaaatgttttctcgctttggagtctgtgaattcttaaac
tgctccgagacaacactgagatcgtggctacaaattatcgaagccaattaccactcttct
aacccctaccacaactccacgcattctgccgacgtgctgcatgccactgcctattttctc
tgcaaggagaggataaagcaaactttagatccacttgatgaggccgctgccctcattgca
gccaccattcacgacgtggaccaccctgggagaaccaactccttcctgtgtaatgctggc
agcgagctggccatcctgtacaacgacactgcggtgctggagagccaccacgcggccttg
gccttccagctgaccaatggagatgacaaatgcaatatctttaaaaacatggagaggaat
gactaccggaccctgcgccagggtattatcgacatggtcttagccacagaaatgacaaag
cacttcgagcacgtcaacaaatttgtcaacagcatcaacaagcccttggcagcattagag
gaaaacagggaaactgataaagatcaagaagccataaacactatgcttaggactccagag
aaccgaactctgatcaaacgaatgctgattaagtgtgctgatgtgtccaacccctgccga
cccctggagcagtgcattgagtgggccgcacggatctcagaagagtatttttctcagaca
gatgaagagaagcaacaagacttgcctgtggtgatgccagttttcgacagaaatacctgc
agcatccccaaatcccaaatctctttcattgactacttcatcacagacatgttcgacgct
tgggacgcctttgtagacctgcctgagttaatgcagcatcttgacaacaactttaagtac
tggaaaggactggacgaactgaagctgcggaccctgcgcccacccccgcatcgtgcgcag
ccctgcccggggccctga
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