Canis lupus familiaris (dog): 488473 Help Entry 488473            CDS       T01007                                  Symbol CASP8 Name (RefSeq) caspase-8   KO K04398   caspase 8 [EC:3.4.22.61] Organism cfa  Canis lupus familiaris (dog) Pathway cfa01524   Platinum drug resistance cfa04115   p53 signaling pathway cfa04210   Apoptosis cfa04215   Apoptosis - multiple species cfa04217   Necroptosis cfa04620   Toll-like receptor signaling pathway cfa04621   NOD-like receptor signaling pathway cfa04622   RIG-I-like receptor signaling pathway cfa04623   Cytosolic DNA-sensing pathway cfa04625   C-type lectin receptor signaling pathway cfa04657   IL-17 signaling pathway cfa04668   TNF signaling pathway cfa04932   Non-alcoholic fatty liver disease cfa04936   Alcoholic liver disease cfa05010   Alzheimer disease cfa05016   Huntington disease cfa05022   Pathways of neurodegeneration - multiple diseases cfa05132   Salmonella infection cfa05134   Legionellosis cfa05142   Chagas disease cfa05145   Toxoplasmosis cfa05152   Tuberculosis cfa05160   Hepatitis C cfa05161   Hepatitis B cfa05162   Measles cfa05163   Human cytomegalovirus infection cfa05164   Influenza A cfa05165   Human papillomavirus infection cfa05167   Kaposi sarcoma-associated herpesvirus infection cfa05168   Herpes simplex virus 1 infection cfa05169   Epstein-Barr virus infection cfa05170   Human immunodeficiency virus 1 infection cfa05200   Pathways in cancer cfa05203   Viral carcinogenesis cfa05416   Viral myocarditis cfa05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:cfa00001]  09130 Environmental Information Processing   09132 Signal transduction    04668 TNF signaling pathway     488473 (CASP8)  09140 Cellular Processes   09143 Cell growth and death    04210 Apoptosis     488473 (CASP8)    04215 Apoptosis - multiple species     488473 (CASP8)    04217 Necroptosis     488473 (CASP8)    04115 p53 signaling pathway     488473 (CASP8)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     488473 (CASP8)    04621 NOD-like receptor signaling pathway     488473 (CASP8)    04622 RIG-I-like receptor signaling pathway     488473 (CASP8)    04623 Cytosolic DNA-sensing pathway     488473 (CASP8)    04625 C-type lectin receptor signaling pathway     488473 (CASP8)    04657 IL-17 signaling pathway     488473 (CASP8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     488473 (CASP8)    05203 Viral carcinogenesis     488473 (CASP8)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     488473 (CASP8)    05161 Hepatitis B     488473 (CASP8)    05160 Hepatitis C     488473 (CASP8)    05164 Influenza A     488473 (CASP8)    05162 Measles     488473 (CASP8)    05168 Herpes simplex virus 1 infection     488473 (CASP8)    05163 Human cytomegalovirus infection     488473 (CASP8)    05167 Kaposi sarcoma-associated herpesvirus infection     488473 (CASP8)    05169 Epstein-Barr virus infection     488473 (CASP8)    05165 Human papillomavirus infection     488473 (CASP8)   09171 Infectious disease: bacterial    05132 Salmonella infection     488473 (CASP8)    05134 Legionellosis     488473 (CASP8)    05152 Tuberculosis     488473 (CASP8)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     488473 (CASP8)    05142 Chagas disease     488473 (CASP8)   09164 Neurodegenerative disease    05010 Alzheimer disease     488473 (CASP8)    05016 Huntington disease     488473 (CASP8)    05022 Pathways of neurodegeneration - multiple diseases     488473 (CASP8)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     488473 (CASP8)    05416 Viral myocarditis     488473 (CASP8)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     488473 (CASP8)    04932 Non-alcoholic fatty liver disease     488473 (CASP8)   09176 Drug resistance: antineoplastic    01524 Platinum drug resistance     488473 (CASP8)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:cfa01002]     488473 (CASP8) Enzymes [BR:cfa01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.22  Cysteine endopeptidases     3.4.22.61  caspase-8      488473 (CASP8) Peptidases and inhibitors [BR:cfa01002]  Cysteine peptidases   Family C14: caspase family    488473 (CASP8) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Peptidase_C14 DED Motif Other DBs NCBI-GeneID:  488473 NCBI-ProteinID:  NP_001041494 Ensembl:  ENSCAFG00000025192 VGNC:  38736 UniProt:  A0A8C0NB97 Q38JA9 LinkDB All DBs Position 37:11274820..11285607 Genome browser AA seq 486 aa AA seqDB search MDFSKCLYNIGEQLDSDELASLKFLSLDYIPQKKQEPIKDPLMLFQRLQEKRMLEESNLF FLKELLFRINRLDLLMTYLDTSKEDMQQELQIPGRAQISAYRVMLFQISEDVSKLELKSF KFLLSREISRCKLDDDLNLLDIFIEMEKRVILGERNLDTLKRICDQINKSLLKKITDYEE LNREQTMNLQRSLDEISNDMSQLPIREGSVKILPMSDSLGEQDYESETSDKVYRMKSKPR GYCLIFNNYDFSVARREVPKLQSIKDRNGTDLDADALSKTFSELHFEIVHFKDATAKKIC EVLQSYQSMDHSSKDCFICCILSHGDKGIIYGSDGQEAPIYELTSYFTGSKCPSLAGKPK IFFIQACQGDKYQKGIAVETDSEQKEAYLEMDSSYQKRYIPEDADFLLGMATVNNCVSYR NPMEGTWYIQSLCQSLRERCPRGEDILTILTEVNFEVSNKDDRKNMGKQMPQPTFTLRKK LFFPPN NT seq 1461 nt NT seq  +upstreamnt  +downstreamnt atggatttcagcaaatgcctctacaatattggggaacagctggacagtgacgaactggcc tccctcaaattcctgagcttggactacatcccacagaagaagcaggagcccatcaaggat cccttgatgttattccagagactccaggaaaagagaatgttggaggaaagcaacctgttc tttttgaaggagctgcttttccgaattaatagactggatctgctgatgacctacctggac accagcaaggaagacatgcagcaggagcttcagataccaggcagagcccagatctctgcc tacagggtcatgctttttcagatttcagaagatgtaagcaaattggaattgaaatccttt aagtttctcttgagccgggagatctccagatgtaaattggatgatgatttgaacttgctt gatattttcatagagatggagaagagggtcattctaggggaaagaaatttggacaccctg aaaagaatctgtgaccaaatcaacaaaagcctgctgaagaaaatcacagattacgaagaa ttaaacagagagcaaacaatgaaccttcaaagaagtctagatgaaatttcaaatgatatg tctcagttgcctataagggagggatccgtgaagatattgccaatgtcggactctctagga gaacaggactatgaatcagagacatcggacaaagtttaccgaatgaaaagcaaacctcga ggatattgtttgatcttcaacaattatgattttagtgtagcacggagggaagtgcccaaa cttcagagcattaaggataggaatggaacagacttggatgcagatgcgttgagtaagacc tttagtgagcttcattttgagatagtgcatttcaaagatgctacagcaaagaaaatctgt gaagttctgcaatcctaccaaagcatggaccacagtagcaaggattgcttcatctgctgc atcctctcccatggagacaagggcatcatctatggctctgatgggcaggaagcccctatc tatgagctgacctcttacttcactggttcaaagtgcccttcccttgcaggcaagcccaaa atcttttttattcaggcttgtcaaggggataaataccagaaaggaatagctgttgagact gactctgaacagaaggaagcctatttagaaatggactcatcatatcagaagagatatatc ccagaggatgctgactttctgctggggatggccactgtgaacaactgtgtttcctaccga aaccccatggaggggacatggtatatacaatcactttgccagagcctaagagaaagatgt cctaggggtgaagatattctcaccatccttaccgaggtgaactttgaagtgagcaataaa gatgacaggaaaaacatgggaaaacaaatgccacaaccaactttcacactgagaaaaaaa ctcttcttccctcctaattga

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