KEGG   PATHWAY: cse00260
Entry
cse00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Caulobacter segnis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cse00260  Glycine, serine and threonine metabolism
cse00260

Module
cse_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cse00260]
cse_M00621  Glycine cleavage system [PATH:cse00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Caulobacter segnis [GN:cse]
Gene
Cseg_0894  aspartate kinase [KO:K00928] [EC:2.7.2.4]
Cseg_3902  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
Cseg_0221  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
Cseg_1683  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
Cseg_0330  homoserine kinase [KO:K02204] [EC:2.7.1.39]
Cseg_0866  Threonine aldolase [KO:K01620] [EC:4.1.2.48]
Cseg_1657  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Cseg_2978  Hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
Cseg_2912  phosphoglycerate mutase 1 family [KO:K01834] [EC:5.4.2.11]
Cseg_0938  cytosolic protein [KO:K15918] [EC:2.7.1.31]
Cseg_0705  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Cseg_2984  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Cseg_0704  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Cseg_1328  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
Cseg_1655  5-aminolevulinic acid synthase [KO:K00643] [EC:2.3.1.37]
Cseg_1163  amine oxidase [KO:K00274] [EC:1.4.3.4]
Cseg_0980  amine oxidase [KO:K00274] [EC:1.4.3.4]
Cseg_0337  Glycine dehydrogenase (decarboxylating) [KO:K00282] [EC:1.4.4.2]
Cseg_0338  Glycine dehydrogenase (decarboxylating) [KO:K00283] [EC:1.4.4.2]
Cseg_0335  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
Cseg_3801  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Cseg_1971  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Cseg_0336  glycine cleavage system H protein [KO:K02437]
Cseg_1720  Aldehyde Dehydrogenase [KO:K00130] [EC:1.2.1.8]
Cseg_0852  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
Cseg_4124  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
Cseg_3018  alanine racemase domain protein [KO:K01753] [EC:4.3.1.18]
Cseg_0644  aspartate racemase [KO:K25316] [EC:5.1.1.10]
Cseg_0142  tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
Cseg_0141  tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cse00010  Glycolysis / Gluconeogenesis
cse00020  Citrate cycle (TCA cycle)
cse00230  Purine metabolism
cse00250  Alanine, aspartate and glutamate metabolism
cse00270  Cysteine and methionine metabolism
cse00290  Valine, leucine and isoleucine biosynthesis
cse00300  Lysine biosynthesis
cse00330  Arginine and proline metabolism
cse00460  Cyanoamino acid metabolism
cse00470  D-Amino acid metabolism
cse00564  Glycerophospholipid metabolism
cse00600  Sphingolipid metabolism
cse00620  Pyruvate metabolism
cse00630  Glyoxylate and dicarboxylate metabolism
cse00640  Propanoate metabolism
cse00680  Methane metabolism
cse00860  Porphyrin metabolism
cse00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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