Delphinapterus leucas (beluga whale): 111165931 Help Entry 111165931         CDS       T05885                                  Symbol INSR Name (RefSeq) insulin receptor   KO K04527   insulin receptor [EC:2.7.10.1] Organism dle  Delphinapterus leucas (beluga whale) Pathway dle04010   MAPK signaling pathway dle04014   Ras signaling pathway dle04015   Rap1 signaling pathway dle04022   cGMP-PKG signaling pathway dle04066   HIF-1 signaling pathway dle04068   FoxO signaling pathway dle04072   Phospholipase D signaling pathway dle04150   mTOR signaling pathway dle04151   PI3K-Akt signaling pathway dle04152   AMPK signaling pathway dle04211   Longevity regulating pathway dle04213   Longevity regulating pathway - multiple species dle04520   Adherens junction dle04910   Insulin signaling pathway dle04913   Ovarian steroidogenesis dle04923   Regulation of lipolysis in adipocytes dle04930   Type II diabetes mellitus dle04931   Insulin resistance dle04932   Non-alcoholic fatty liver disease dle04960   Aldosterone-regulated sodium reabsorption dle05010   Alzheimer disease dle05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:dle00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     111165931 (INSR)    04014 Ras signaling pathway     111165931 (INSR)    04015 Rap1 signaling pathway     111165931 (INSR)    04066 HIF-1 signaling pathway     111165931 (INSR)    04068 FoxO signaling pathway     111165931 (INSR)    04072 Phospholipase D signaling pathway     111165931 (INSR)    04022 cGMP-PKG signaling pathway     111165931 (INSR)    04151 PI3K-Akt signaling pathway     111165931 (INSR)    04152 AMPK signaling pathway     111165931 (INSR)    04150 mTOR signaling pathway     111165931 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     111165931 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     111165931 (INSR)    04923 Regulation of lipolysis in adipocytes     111165931 (INSR)    04913 Ovarian steroidogenesis     111165931 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     111165931 (INSR)   09149 Aging    04211 Longevity regulating pathway     111165931 (INSR)    04213 Longevity regulating pathway - multiple species     111165931 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     111165931 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     111165931 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     111165931 (INSR)    04932 Non-alcoholic fatty liver disease     111165931 (INSR)    04931 Insulin resistance     111165931 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:dle01001]     111165931 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:dle04090]     111165931 (INSR) Enzymes [BR:dle01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      111165931 (INSR) Protein kinases [BR:dle01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    111165931 (INSR) CD molecules [BR:dle04090]  Proteins   111165931 (INSR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like DUF4476 B2 Motif Other DBs NCBI-GeneID:  111165931 NCBI-ProteinID:  XP_022412709 UniProt:  A0A2Y9LSN6 LinkDB All DBs Position Unknown AA seq 1392 aa AA seqDB search MMAEALLSKYLLGYFFRFRHKRRSVMRRKGSRREETEAPQFPDVCPGMDIRNNLTRLHEL ANCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIR GSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDN YIVLNKDDNEECGDICPGAAKGKTNCPATVINGQFVERCWTHSHCQKVCPTVCKSHGCTA EGLCCHSECLGNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLH NKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSDLMCTPCLGPCPKVCHLLEGEKTIDS VTSAQELRGCTIINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFR KLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKME EVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWEPYWPPDFRDLLGF MLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPMRSNDPKSQNHPGWLMRGLKPWTQYA IFVKTLVTFSDERRTYGAKSDIIYVQTSLADPSVPLDPISVSNSSSQIILKWKPPSDPNG NITHYLVFWERQEEDGELYELDYCLKGLKLPSRTWSPPFESEGSQKHNQSEYEESAGECC SCPKTDSQILKELEESSFRKTFEDYLHNVVFIPRKSSSGPVAEDTRPSRKRRALGDVGNV TAAVPTIPGFPNTSSTSAPTSSEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSP EERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRR YGEEELHLCVSRRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDV PSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSV YVPDEWEVPREKITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKTVNESASLRERIE FLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPP PTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYY RKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVM DGGFLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVDLLKDELHPSFPEVSFFHSEENK VPESEELEMEFEDMESVPLDRSSHVQREEAGGRDGGSALGLKRNYQEHIPYTHMNGGKKN GRILTLPRSNPS NT seq 4179 nt NT seq  +upstreamnt  +downstreamnt atgatggctgaggccctgctttcaaaatatctgttgggttacttcttcagatttcgccat aaaaggagatcagtcatgaggaggaaggggtcaaggagggaagaaaccgaagctcctcag ttccctgacgtgtgccccggcatggatatccggaataacctcacccggctgcacgagctg gccaactgctcggtcatcgaaggacatttgcagatcctattgatgttcaaaacgagacct gaggacttccgagacctcagtttccccaagctcatcatgatcactgattacttgctgctc ttccgggtctatgggctggagagcctgaaggacctgttccccaacctcacggtcatccgg ggctcccgcctcttctttaactacgcgctggtcatcttcgagatggttcacctgaaggag cttggcctctacaacttgatgaacattacccggggctccgttcgcatcgagaagaacaat gaactctgctacctggccactatcgactggtctcgcatcctggattccgtggaggataat tacatcgtgctgaacaaagacgacaatgaggagtgtggggacatttgtccaggcgctgcg aagggcaagaccaactgccctgccaccgtcatcaatgggcaatttgtggagcggtgttgg acgcacagccactgccagaaagtgtgtccgaccgtctgtaagtctcacggctgcaccgct gagggtctctgttgccacagtgagtgcttgggcaactgctctgagcctgacgaccccacc aagtgtgtggcctgtcgcaacttctacctggatggcaggtgcgtggagacctgcccgccc ccctactaccacttccaagactggcgctgtgtgaacttcagcttctgccaggacctgcac aacaaatgcaagaactctcggaggcagggctgccaccagtatgtcattcacaataacaag tgcatccctgagtgcccctccgggtacacgatgaattccagcgacttgatgtgtactcca tgcctgggcccctgtcccaaggtgtgccacctcctggaaggcgagaagaccattgactca gtgacatctgcccaggagctccgaggctgcaccatcattaatggaagcttgatcatcaac attcgagggggcaacaacctggcagctgagctagaggccaaccttggactcattgaagaa atttcagggtatctgaaaatccgccgatcatatgccctcgtgtcactttccttcttccgg aagttacgtctgattcgaggggagaccttggaaatcgggaactactctttctatgccttg gacaaccagaacctaaggcagctgtgggactggagcaaacacaacctcaccatcactcag gggaaactcttcttccactataatcccaaactctgcttgtcagaaattcacaagatggag gaagtttcaggaaccaaggggcgccaggagagaaacgacattgccctgaagaccaatggg gaccaggcgtcctgtgaaaatgaattacttaaattttcttacattcggacatcttatgac aagatcttgctgaaatgggagccgtattggccccccgacttccgagaccttctgggattc atgctcttctacaaagaggccccttatcagaacgtgacggagtttgatgggcaggatgca tgtggctccaacagctggaccgtggtggatattgacccgcctatgaggtccaacgacccc aagtcacagaaccaccccgggtggctaatgcgtggtctcaagccctggacccagtacgcc atctttgtcaagaccttggtcaccttttctgatgaacgccgcacatacggggccaagagc gacatcatctatgtccagacctccttggcagatccttctgtccccctggatcccatctcg gtgtctaattcttcgtctcagattattctgaagtggaagcctccctctgaccccaatggc aacatcacacactacttggtattctgggagagacaggaggaagacggtgaactgtatgaa ttagattattgcctcaaagggttgaagctgccctcccggacctggtctccaccgttcgag tctgaggggtcccagaagcacaatcagagtgagtacgaagagtctgccggtgaatgctgt tcctgcccgaagaccgactctcagatcctcaaggagttggaggagtcctcattcaggaaa acattcgaagattacctgcacaatgtcgtcttcatccccagaaaatcctcttcaggccct gttgccgaggacactaggccgtcgaggaaacgcagggcccttggtgatgtggggaatgtg acagcggccgtgcccaccattccgggattccccaatacgtcctcaaccagcgcacctacg agctcagaggagcacagaccgttcgagaaagtggtgaacaaggagtctctggtcatctct ggcctgcgccactttactggctatcgcattgagctgcaggcttgcaaccaagattccccc gaggagaggtgcagtgtggctgcatatgtcagtgccaggaccatgcccgaagccaaggca gatgatatcgttggccccgtgacccacgaaatcttcgagaacaacgtcgttcacttgatg tggcaggagcccaaggaacccaatggtctgatcgtgctgtacgaagtgagttatcgacga tacggcgaagaggagctgcacctctgcgtctcccgcaggcattttgctctggagcggggc tgcaggctgcgtggtctgccacccgggaactacagtgtgcgagttcgggccacctccctg gcgggcaatggctcctggacggaagctacctatttctacgtcacagactatttagacgtg ccgtcaaatattgcaaaaattatcatcggccccctcatctttgtctttctcttcagtgtc gtgatcggaagtatttatctattcctgagaaagaggcagccggatgggccactgggaccg ctgtatgcttcttcaaaccccgagtacctcagtgccagcgatgtgtttccctgctctgtg tacgtgccggatgagtgggaggtgcctcgagagaagatcacactcctgcgagaactgggg cagggctccttcggcatggtgtacgagggcaacgccagggacattgtcaagggcgaggcg gagacccgagtggcggtgaagacagtgaacgagtctgccagcctgcgagagcggatcgaa tttctcaacgaggcctcagtcatgaagggcttcacctgccaccacgtggtccgcctcctg ggggtggtatccaaaggccagccaacgctggtggtgatggagttgatggctcatggggac ttgaagagctacctccgttccctgcggcctgaggccgagaataaccccggccgccctccc cctaccctgcaagagatgattcagatggctgcggagatagccgacgggatggcatacctg aacgccaagaagtttgtacaccgggacctcgcagctcgaaactgcatggtcgcccacgat tttaccgtcaaaattggagactttggaatgaccagagacatctacgaaacggattactac cggaaagggggaaagggtctgctccccgtgaggtggatggcacccgaatcgctgaaggac ggggtctttaccacttcttcggacatgtggtcctttggcgtggtcctttgggaaattacc agcttggcagaacagccttaccaaggcctatcaaacgagcaggtgttaaaatttgtcatg gatggagggtttctggatcaacccgacaactgtcctgagagagtcaccgacctgatgcgc atgtgttggcagttcaaccccaagatgcggccgaccttcctggaaattgtcgacctgctc aaggacgagctgcaccccagttttcccgaagtttccttcttccacagcgaggagaacaag gtgcccgagagcgaggagctggagatggaatttgaggacatggagagtgtccccctggac cggtcctcacatgtgcagagggaggaggccgggggccgggatggagggtccgcactgggg ctaaagagaaactatcaggaacacatcccctacacccacatgaacgggggcaagaaaaac ggacgcattctgactctgccccggtctaatccttcctaa

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